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朴宣東,朴賢俊,朱旺錫 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
This study was performed to research the antioxidant activities of Guibitang and its component groups. The experimental group was divided into six group: Guibitang (GB), Gamiguibitang (GA), Hyul-yak group (GB1), Gi-yak group (GB2), Ansinhaenggi-yak group (GB3) and Gami-yak group (GA1). The results were obtained as follows: In vitro All experimental groups had antioxidant activity in linoleic acid system on concentration in comparison with control group. And in DPPH radical scavenging experiment, all experimental groups had scavenging activity on concentration, especially GA1 group was higher than any others. The inhibitory effect experimental groups had inhibitory effects of superoxide generation on concentration, and the effect of Guibitang was better than Gamiguibitang. In component groups GA1 was highest and GB1 was lowest respectively. The inhibitory effect experiment on lipid peroxidation reaction in H₂O₂-Fe^2+ system showed that each experimental groups had inhibitory effects on lipid peroxidation reaction compared with control group. And GA1 group exhibit the best inhibition effect on lipid peroxidation reaction. In vivo the amounts of lipid peroxide rat on the level of serum was reduced in comparison with control group, especially gamiguibitang. The amounts of LPO on the level of liver was also reduced compared with control group. espeially gamiguibitang, guibitang, GB1 group. In hepatic catalase activity test, all experimental groups increased catalase activity, and that of guibitang, gamiguibitang, GB1 group were evident. The amounts of hepatic glutathione of experimental group increased in comparison with control group. And that of gamiguibitang, guibitang was more significant than component group.
위성 ATM 망에서 ABR 서비스를 위한 트래픽 전송방식에 관한 연구
최병석,박재현,박현민,안현석,유재욱 동국대학교 산업기술연구원 1997 산업기술논문집 Vol.9 No.-
ATM의 ABR 서비스는 기본적으로 전달지연이 작은 지상망에 적합하게 개발되었기 때문에 위성 망과 같이 전달지연이 큰 상황에서는 망의 심각한 폭주나 링크의 채널 전송률 저하 등이 발생될 수 있다. 또한 위성채널은 지상 ATM 망에 비해 대역이 제한되어 있으므로 폭주를 미연에 방지하기 위해 보다 치밀하고, 지연에 덜 민감한 대역할당 알고리즘이 필요하다. 본 논문에서는 EPRCA 기반의 위성탑재 ATM 교환기로 구성된 위성 ATM 망에서 BECN과 큐의 상태정보를 이용하여 위성 ATM 망에서 ABR 서비스를 제공할 수 있는 방안을 제안하였다.
半夏瀉心湯이 CCl4 로 유도된 간중독 흰쥐에 미치는 영향
朱旺錫,朴賢俊,尹炳局,鄭成伊,朴宣東 대한본초학회 1999 大韓本草學會誌 Vol.14 No.2
The purpose of this study is to observe the effect of Banhasasimtang on serum reaction in CCI₄ treated rats. In this study the experimental rats divided five group(Normal, Control, Sample A, Sample B and Sample C group) Under the same condition Normal group was fed basal diet and water, Control group was injected carbon tetrachloride(CCI₄ 0.5㎖/㎏) and basal diet for 2 weeks, Sample A group was injected carbon tetrachloride(CCI₄0.5㎖/㎏) and fed the Bahasasimtang extract(10㎖/㎏) for 2 weeks, Sample A group was injected carbon tetrachloride(CCI₄ 0.5㎖/㎏) and fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks, Sample B group was fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks and injected carbon tetrachloride(CCI₄ 0.5㎖/㎏), Sample C group was fed the Banhasasimtang extract(10㎖/㎏) for 2 weeks. The change of GOT, GPT, γ-GPT, ALP, LDH activity and Bilirubin level in blood serum. The obtained results are summarized as follows : 1. In the change of GOT GPT contents, as compared with control group, sample group was significantly decreased. 2. In the change of γ-GPT contents, as compared wth control group, sample group was significantly decreased. 3. In the change of ALP contents, as compared with control group, sample group was significantly decreased. 4. In the change of LDP contents, as compared with control group, sample group was significantly decreased. 5. In the change of Bilirubin contents, as compared with control group, sample group was significantly decreased.
비혈연간 동종골수이식에 의해 치료된 중증 재생불량성빈혈 1예
김현중,이홍기,이방훈,이창근,이종태,정현식,김원석,윤성수,강원기,박근칠,김대식,고영혜,박찬형 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1
비혈연간 동종골수이식은 혈연간 동종골수이식이 불가능한 환자에서 기존의 면역역제요법으로 효과가 없었던 경우나 재발한 경우에 적응증이 될수 있다. 이식 거부와 이식편대숙주병의 발생이 골수 이식의 성공률을 감소시키므로, 보다 강력한 conditioning regimen의 사용과 T cell이 제거된 골수를 사용하는 것이 필요하다. 기존의 high dose corticosteroid나 cyclosporine에 대하여 불응성인 이식편대숙주병의 치료를 위해서 ATG와 Mycophenolate mofetil (Cellcept®) 의 사용이나 Tacrolimus, Methotrexate와 같은 다른 면역억제제치료를 고려해 볼 수 있다. It is known that allogenic bone marrow transplantation is the most effective treatment for aplastic anemia. However, this treatment is only applicable to a minority of patients because the proportion of patients who have HLA-matched siblings about 25% to 30% of all the aplastic anemia patients. In the case of the absence of HLA-matched donor, unrelated allogenic bone marrow transplantation is considered. However, (because of severe acute and chronic GVHD and graft failure) the success rate of this approach is only 20~30%. Recently, it was reported that increased immunosuppressive condition combined with T cell depletion of the marrow graft would result in greater success. There was no case of successfully treated aplastic anemia patient by unrelated allogenic bone marrow transplantation in Korea. Here, we report a case of severe aplastic anemia successfully treated with unrelated allogenic bone marrow transplantation.
Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예
남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6
We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.
Park, Chanhee,Lee, Soojin,Cho, Ik-Hyun,Lee, Hyun Kyoung,Kim, Donghoon,Choi, Se-Young,Oh, Seog Bae,Park, Kyungpyo,Kim, Joong Soo,Lee, Sung Joong Wiley Subscription Services, Inc., A Wiley Company 2006 GLIA Vol.53 No.3
<P>Viral infection is one of the leading causes of brain encephalitis and meningitis. Recently, it was reported that Toll-like receptor-3 (TLR3) induces a double-stranded RNA (dsRNA)-mediated inflammatory signal in the cells of the innate immune system, and studies suggested that dsRNA may induce inflammation in the central nervous system (CNS) by activating the CNS-resident glial cells. To explore further the connection between dsRNA and inflammation in the CNS, we have studied the effects of dsRNA stimulation in astrocytes. Our results show that the injection of polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, into the striatum of the mouse brain induces the activation of astrocytes and the expression of TNF-α, IFN-β, and IP-10. Stimulation with poly(I:C) also induces the expression of these proinflammatory genes in primary astrocytes and in CRT-MG, a human astrocyte cell line. Furthermore, our studies on the intracellular signaling pathways reveal that poly(I:C) stimulation activates IκB kinase (IKK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) in CRT-MG. Pharmacological inhibitors of nuclear factor-κB (NF-κB), JNK, ERK, glycogen synthase kinase-3β (GSK-3β), and dsRNA-activated protein kinase (PKR) inhibit the expression of IL-8 and IP-10 in astrocytes, indicating that the activation of these signaling molecules is required for the TLR3-mediated chemokine gene induction. Interestingly, the inhibition of PI3 kinase suppressed the expression of IP-10, but upregulated the expression of IL-8, suggesting differential roles for PI3 kinase, depending on the target genes. These data suggest that the TLR3 expressed on astrocytes may initiate an inflammatory response upon viral infection in the CNS. © 2005 Wiley-Liss, Inc.</P>
Composition dependence of structural and optical properties of Cd1-xMnxGa2S4 mixed crystals
Hyun Park,Chang-Dae Kim,Duck-Tae Kim,Hyung-Gon Kim,Moon-Seog Jin,Seung-Cheol Hyun 한국물리학회 2004 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.45 No.2
The composition dependence of the structural and the optical properties of Cd1MnxGa2S4mixed crystals prepared by using the melt technique was investigated in the region of 0:00 x 1:00 by using X-ray powder diraction and optical absorption measurements. An analysis of the X-ray powder diraction spectra showed that the crystals in the region of 0:00 x 0:67 crystallized into a defect chalcopyrite structure and in the region of 0:90 x 1:00 crystallized into an orthorhombic structure. In the region of 0:67 < x < 0:90, a miscibility gap existed. The lattice constants showed a linear variation with composition x in the corresponding regions. We observed two absorption bands, 2.52 and 2.68 eV, near the fundamental absorption edge of the optical absorption spectra at 300 K. These absorption bands were assigned to the transitions 6A1 (6S) ! 4T2 (4G) and 6A1(6S) ! 4E(4G) of Mn2+ ions. We also observed the composition dependence of the optical energy gaps,with an abrupt and downward bowing for the region of 0:00 x 0:67 and a linear variation for the region of 0:90 x 1:00. This anomalous dependence was related to a peculiar behavior of the manganese transition metals in the Cd1xMnxGa2S4 system.
Profiling of miRNA expression in mice kidney with diabetic nephropathy
Park, Hye Rim,Lee, Seung Eun,Kim, Hyemi,Jeon, Seeun,Han, Dongkyo,Jin, Young-Ho,Cho, Jeong-Je,Ahn, Hyun-Jong,Park, Cheung-Seog,Lee, Jongsung,Park, Yong Seek THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRP 2018 MOLECULAR AND CELLULAR TOXICOLOGY Vol. No.
Park, Hyun Jun,Choi, Hyung Ki,Ahn, Tai Young,Park, Jong Kwan,Chung, Woo Sik,Lee, Sung Won,Kim, Sae Woong,Hyun, Jae Seog,Park, Nam Cheol Blackwell Pub 2010 JOURNAL OF SEXUAL MEDICINE Vol.7 No.8
<P>Mirodenafil is a newly developed selective phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED).</P>
Park, Chan-Mi,Kim, Hye-Min,Kim, Dong Hyun,Han, Ho-Jin,Noh, Haneul,Jang, Jae-Hyuk,Park, Soo-Hyun,Chae, Han-Jung,Chae, Soo-Wan,Ryu, Eun Kyoung,Lee, Sangku,Liu, Kangdong,Liu, Haidan,Ahn, Jong-Seog,Kim, Y Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.12
Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-${\kappa}B$ ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts in vitro. Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner. In an in vivo zebrafish model, aqueous ginseng extract and ginsenoside Re had anti-osteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health.