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A Study on the Mechanically Equivalent Surrogate Plate of U-Mo Dispersion Fuel using Tungsten
김현중,임정식,정용진,이강희 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.2
When a new fuel is developed, various mechanical properties are absolutely necessary for a safetyanalysis of the fuel for the licensing and prediction of its mechanical behavior during operation andaccident conditions. In this paper, a mechanically equivalent surrogate plate of UeMo dispersion fuel ispresented using tungsten, substitute material of UeMo particle. A surrogate plate, composed of tungsten/aluminum dispersion meat and aluminum alloy cladding, is manufactured with the same fabricationprocess with that of fuel plate except that a tungsten powder is used instead of UeMo powder. A modaltest showed that the surrogate plate and fuel plate have similar dynamic characteristics, and a tensile testdemonstrated the similarity of the material property up to the yield strength range. The conducted testsproved that the surrogate tungsten plate has equivalent mechanical behaviors with that of a fuel plate,which leads to the acceptable use of a surrogate fuel assembly using tungsten/aluminum dispersion meatin various mechanical tests. The surrogate fuel assembly can be utilized for various out-of-pile characteristictests, which are necessary for the licensing achievement of a research reactor that uses UeModispersion fuel as a driver.
중증 허혈성 지체질환 환자에서 시행된 vascular endothelial growth factor의 혈관신생 유전자치료 1예
김현중,장신이,김종묵,김선영,김병문,김원배,김덕경 대한내과학회 2003 대한내과학회지 Vol.64 No.1
저자 등은 기존의 치료에 반응하지 않은 중증 허혈성 지체질환 환자를 대상으로 하여 vascular endothelial growth factor를 이용한 혈관신생 유전자 치료를 시행하였다. 치료 후 환자의 허혈에 의한 하지 통증이 현격하게 감소하고 상처의 진행이 측부혈관이 많이 증가됨이 관찰되어 이에 문헌고찰과 함께 보고하는 바이다. We report VEGF-induced angiogenic gene therapy in a patient with critical limb ischemia, who did not respond to conventional treatment. This patient was the first case in a dose-escalating series of phase I clinical trial. The patient had severe resting pain, gangrene and diffuse ulcer in his left foot. Total 1,000㎍ of naked DNA encoding human VEGF165 was administered intramuscularly to 8 sites of the loft lower extremity. Four weeks after the first 1,000㎛ was administered to the same sites (total dose: 2,000㎛). After gene therapy, resting pain gradually reduced and the amount of analgesics taken by the patient decreased. The ischemic wound of lower extremity slightly improved. However, there was no complete wound healing at 12 weeks of treatment. Digital subtraction angiography at 12 weeks after gene therapy showed an increase in collateral vessels at the mid-tibial, ankle and foot arch levels. Immediately and up to 12 weeks, there was no complication related to gene therapy. These findings may be cautiously interpreted to indicate that intramuscular injection of naked plasmid DNA of VEGF_165 may induce therapeutic angiogencsis in a patient with critical limb ischemia. Further clinical evaluation of VEGF-induced gene therapy is needed to evaluate the safety and efficiency of this treatment.(Korean J Med 64:85-90, 2003)
Differential effects of quercetin glycosides on GABAC receptor channel activity
김현중,나승열,최선혜,정석원,김현수,이준희,황성희,표미경,김형춘,이병환 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.1
Quercetin, a representative flavonoid, is acompound of low molecular weight found in various coloredplants and vegetables. Quercetin shows a wide rangeof neuropharmacological activities. In fact, quercetin naturallyexists as monomer-(quercetin-3-O-rhamnoside)(Rham1), dimer-(Rutin), or trimer-glycosides [quercetin-3-(2G-rhamnosylrutinoside)] (Rham2) at carbon-3 in fruitsand vegetables. The carbohydrate components are removedafter ingestion into gastrointestinal systems. The role of theglycosides attached to quercetin in the regulation of caminobutyricacid class C (GABAC) receptor channelactivity has not been determined. In the present study, we examined the effects of quercetin glycosides on GABACreceptor channel activity by expressing human GABACalone in Xenopus oocytes using a two-electrode voltageclamp technique and also compared the effects of quercetinglycosides with quercetin. We found that GABA-inducedinward current (IGABA) was inhibited by quercetin orquercetin glycosides. The inhibitory effects of quercetinand its glycosides on IGABA were concentration-dependentand reversible in the order of Rutin & quercetin & Rham1[Rham 2. The inhibitory effects of quercetin and itsglycosides on IGABA were noncompetitive and membranevoltage-insensitive. These results indicate that quercetinand its glycosides regulate GABAC receptor channelactivity through interaction with a different site from thatof GABA, and that the number of carbohydrate attached toquercetin might play an important role in the regulation ofGABAC receptor channel activity.
A weight-adjusted voting algorithm for ensembles of classifiers
김현중,김혁,Hojin Moon,Hongshik Ahn 한국통계학회 2011 Journal of the Korean Statistical Society Vol.40 No.4
We present a new weighted voting classification ensemble method, called WAVE, that uses two weight vectors: a weight vector of classifiers and a weight vector of instances. The instance weight vector assigns higher weights to observations that are hard to classify. The weight vector of classifiers puts larger weights on classifiers that perform better on hardto-classify instances. One weight vector is designed to be calculated in conjunction with the other through an iterative procedure. That is, the instances of higher weights play a more important role in determining the weights of classifiers, and vice versa. We proved that the iterated weight vectors converge to the optimal weights which can be directly calculated from the performance matrix of classifiers in an ensemble. The final prediction of the ensemble is obtained by voting using the optimal weight vector of classifiers. To compare the performance between a simple majority voting and the proposed weighted voting, we applied both of the voting methods to bootstrap aggregation and investigated the performance on 28 datasets. The result shows that the proposed weighted voting performs significantly better than the simple majority voting in general.