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대학생을 위한 예비 부모 교육 프로그램 개발을 위한 연구
윤기영,전효숙,박상임,이미숙,이석란,박수옥 서원대학교 학생생활연구소 1998 학생생활연구 Vol.16 No.-
The purpose of this study are to examine reference materials, existing lecture analysis, investigate how student response about new lecture model and to project the basic direction of pre-parent education program. The result of this study are as follows ; <Lecture Model : Parent and Child> Sequence Theme 1 Introduction, Positive Self-Concept 2 Love and Sex 3 Friends versus Lovers 4 Marriage 5 Parenting and Parent's Role 6 Pregnancy and Embriology 7 Brith 8 Middle Term Exam 9 Parent's Role for Infant and Toddler 10 Parent's Role for Child 11 Parent's Role for Youth 12 Society and Environment for Child Care 13 Communication for Parent-Child 14 Problem solving method for Child Care 15 Parent in Future 16 Final Exam
최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1
This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.
박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3
Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.
Ok Jeong Lee,Su-Jin Kim,박형두,이수연,Chi-Hwa Kim,Ah-Ra Ko,Yeon-Joo Yook,Su-Jin Lee,박성원,Se-Hwa Kim,Sung-Yoon Cho,Eun-Kyung Kwon,Sun Ju Han,진동규,Young Bae Sohn 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.3
Purpose: Mucopolysaccharidosis type II (MPS II or Hunter syndrome)is a rare lysosomal storage disorder caused by iduronate-2-sulfatase (IDS) deficiency. MPS II causes a wide phenotypic spectrum of symptoms ranging from mild to severe. IDS activity, which is measured in leukocyte pellets or fibroblasts, was reported to be related to clinical phenotype by Sukegawa-Hayasaka et al. Measurement of residual plasma IDS activity using a fluorometric assay is simpler than conventional measurements using skin fibroblasts or peripheral blood mononuclear cells. This is the first study to describe the relationship between plasma IDS activity and clinical phenotype of MPS II. Methods: We hypothesized that residual plasma IDS activity is related to clinical phenotype. We classified 43 Hunter syndrome patients as having attenuated or severe disease types based on clinical characteristics,especially intellectual and cognitive status. There were 27 patients with the severe type and 16 with the attenuated type. Plasma IDS activity was measured by a fluorometric enzyme assay using 4-methylumbelliferyl-α-iduronate 2-sulphate. Results: Plasma IDS activity in patients with the severe type was significantly lower than that in patients with the attenuated type (P=0.006). The optimal cut-off value of plasma IDS activity for distinguishing the severe type from the attenuated type was 0.63 nmol·4 hr-1·mL-1. This value had 88.2% sensitivity, 65.4% specificity, and an area under receiver-operator characteristics (ROC) curve of 0.768 (ROC curve analysis; P=0.003). Conclusion: These results show that the mild phenotype may be related to residual lysosomal enzyme activity.
Yoon Hyun Ju,Kim Gi-Cheon,Oh Sejin,Kim Hakhyun,Kim Yong Keon,Lee Yunji,Kim Min Seo,Kwon Gino,Ok Yeon-Su,권호근,김현석 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Immune checkpoint therapies, such as programmed cell death ligand 1 (PD-L1) blockade, have shown remarkable clinical benefit in many cancers by restoring the function of exhausted T cells. Hence, the identification of novel PD-L1 regulators and the development of their inhibition strategies have significant therapeutic advantages. Here, we conducted pooled shRNA screening to identify regulators of membrane PD-L1 levels in lung cancer cells targeting druggable genes and cancer drivers. We identified WNK lysine deficient protein kinase 3 (WNK3) as a novel positive regulator of PD-L1 expression. The kinase-dead WNK3 mutant failed to elevate PD-L1 levels, indicating the involvement of its kinase domain in this function. WNK3 perturbation increased cancer cell death in cancer cell–immune cell coculture conditions and boosted the secretion of cytokines and cytolytic enzymes, promoting antitumor activities in CD4+ and CD8+ T cells. WNK463, a pan-WNK inhibitor, enhanced CD8+ T-cell-mediated antitumor activity and suppressed tumor growth as a monotherapy as well as in combination with a low-dose anti-PD-1 antibody in the MC38 syngeneic mouse model. Furthermore, we demonstrated that the c-JUN N-terminal kinase (JNK)/c-JUN pathway underlies WNK3-mediated transcriptional regulation of PD-L1. Our findings highlight that WNK3 inhibition might serve as a potential therapeutic strategy for cancer immunotherapy through its concurrent impact on cancer cells and immune cells.
( Su Jin Choi ),( Young Soo Kim ),( Sun Ae Yoon ),( Young Ok Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Vascular access micro-calcifi cation found on pathology studies has been reported as a risk factor for cardiovascular morbidity and mortality in HD patients. However the relationship between arterial micro-calcifi cation (AMiC) detected on pathology study and the patency of vascular access has rarely been reported. The aim of this study was to determine the impact of AMiC on the patency of vascular access in HD patients. Methods: One-hundred six HD patients (Mean age: 59.6 ± 12.9 years, Male/Female: 66/40, Percent of diabetes mellitus: 68.9%) receiving arteriovenous fi stula (AVF) operation were included in this study. We obtained a partial arterial specimen intra-operatively and performed pathologic examination by von Kossa staining to identify AMiC. We investigated early AVF failure (poor maturation or severe stenosis requiring radiologic intervention or surgical correction within 1 year after the operation) between the patients with AMiC and those without AMiC. Results: The incidence of AMiC was 38.7% (n = 41) and calcifi cation was found in the medial layer. Early AVF failure occurred in 45 patients (42.5%), and the mean time between the operation and access failure was 4.1 ± 3.1 months. The access failure rate within 1 year after the operation was greater in patients with AMiC than those without AMiC (56.1% vs. 33.8%, P = 0.024). Kaplan-Meier analysis showed that the presence of AMiC signifi cantly increased the risk for AVF failure (Log rank = 4.98, P = 0.026). Presence of AMiC (hazard ratio: 1.994, 95% confi dence interval: 1.024-3.881, P = 0.042) was an independent risk factor for early AVF failure on Cox regression analysis. Conclusions: This study demonstrated that pre-existing AMiC of the vascular access was associated with early AVF failure in incident HD patients.