연골외막세포가 포함된 alginate beads를 이용한 토끼에서의 골연골결손 치료

안현정,김은미,정미현,조현철,이인범,성상철,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

최신토지피복자료를 이용한 대구시의 열환경 수치모의

이현주(Hyun-Ju Lee),이귀옥(Kwi Ok Lee1),원경미(Gyeong Mee Won),이화운(Hwa Woon Lee) 한국대기환경학회 2009 한국대기환경학회지 Vol.25 No.3

산채류의보존과 일본식 절임

오영애,하귀현,박인경,김미향,김미정,김미경,정자림,이명숙,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-

This paper showed the summarization of the preservative method of wild vegetables in the house and the precessing method of Japanese pickles. The preservative methods of wild vegetables were explained devided into long, short term, fresh state, heat treatment and drying. Salt, soybean fermented sauce, soybean fermented paste, lees of refined rice wine and residue in the preparation of bean curd were used as the materials of Japanese pickles.

병리검사 처방오류 개선 시스템 구축

이현임,최영진,구숙희,양승주,김병로,김묘정,신일근,신미옥,서임선 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

문제: 조직병리검사의 처방이 복잡하고 전문화됨에 따라 오류처방이 빈번하게 발생되고 이를 해결하기위한 프로세스가 복잡하여 부서간의 갈등과 업무의 가중, 또한 병원 수입 감소가 초래되었다. 목적: 발생된 오류처방의 유형과 발생율, 오류처방을 해결하기 위한 프로세스를 파악하여 이에 대한 문제점을 개선하여 업무의 효율성과 관련부서간의 부가업무 감소와 갈등해소, 더불어 병원수익을 향상시키는 것에 목표를 두고 활동하였다. 의료기관: 서울시에 소재한 종합병원 질 향상 활동: 조직병리검사 처방의 오류처방 발생 원인과 유형, 발생율을 조사하여 원인을 파악하고 개선을 위한 프로세스를 구축하여 질 향상을 도모하였다. 개선효과: 수술실에서 의뢰한 외과 입원환자의 일반조직병리검사 오류율은 개선 전 7.8%에서 개선 후 3.5%, 동결절편조직검사 오류율은 개선 전 28.6%에서 개선 후 0%로 이전보다 모두 개선되었다. 또한 수술실 간호사의 업무 만족도는 일반조직병리검사의 처방시 95%, 동결절편조직검사 처방시 90%로 높은 만족도를 보였다. 단 병리과의 경우 업무가 증가됨에 따라 초과근무시간이 증가하였다.

생약으로부터 산화적 결합 효소인 갑상선 peroxidase의 저해제 검색

이현정,장미영,김미리,배기환,석대은 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

Thyroid peroxidase is a biochemical target protein for the antithyroid drugs. Ethanol extracts from one hundred and thirty seven natural products were screened for the inhibition of thyroid peroxidase activity. Thyroid peroxidase was purified from porcine thyroids, and the inhibition of peroxidase activity was evaluated using guaiacol oxidation (C-C coupling) assay. Twenty one natural products expressed a remarkable inhibition (>50%) of peroxidase activity at 330㎍ solid weight/ml. The 50% inhibitory concentration (IC50) of 70% ethanol extract from six potent natural products ranged from 3.1 to 31.2㎍ solid weight/ml, in contrast to the range (0.33∼0.54㎍/ml) of IC50, values for catechin and epigallocatechin gallate as positive controls. Noteworthy, the extract of Camellia taliensis showed an irreversible inhibition of the enzyme. It is suggested that extract from some natural products such as Camellia taliensis, Rheum undulatum or Euphorbia pekinsis, exhibiting a potent inhibition of peroxidase activity, may be developed as sources of potent antithyroid agents.

이미다졸의 양성자 친화도에 미치는 치환기 효과에 대한 이론적 연구

李賢美,李甲龍 대구효성가톨릭대학교 자연과학연구소 1994 基礎科學硏究論集 Vol.1994 No.1

이미다졸 고리를 포함하는 lexitropsin에서, DNA minor groove 의 염기쌍(G-C Sequence)과 결합하는 부분인 치환이미다졸의 양성자 친화도를 확장분자궤도함수법으로 조사하였다. 그 결과 메틸이미다졸의 경우 염기중심 질소의 α 위치에 치환된 이미다졸이 N 에 치환된 이미다졸보다 양성자 친화도가 약간 더 크게 나타났으며 다른 치환이미다졸의 경우에는 N에 치환된 이미다졸이 α 우치에 치환된 이미다졸보다 양성자 친화도가 더 크게 나타났다. 예상한 바와 같이 이미다졸의 N에 전자를 미는기가 치환될 때 모두 양성자 친화도가 증가함을 알 수 있었다. The proton affinities of substituted imidazoles, relevant to the binding of lexitropsins that contain imidazole ring to the base pair(G-C sequence) of minor groove of DNA, are studied with the aid of EHT calculations. It is shown that proton affinity of imidazole substituted at position α to the basic nitrogen is slightly larger than that of imidazole substituted at N for the methylimidazole. Proton affinities of N-substituted imidazoles are found to be larger than those of imidazoles substituted at position α for a selected set of the other derivatives. As predicted the proton affinity increases when electron-donating group is attached at position N of imidazole.

클로르헥시딘과 테트라사이클린의 치주낭 세척 효과

이미정,정현주 전남대학교 치과대학 1992 전남치대논문집 Vol.4 No.1

This study aimed to evaluate the influence of subgingival irrigation with chlorhexidine and tetracycline on the effect of scaling and root planing in periodontal treatment. Fifty six sites, 5㎜ or greater in probing depth from selected patients, were divided into 4 groups : Group Ⅰ - chlorhexidine(0.1%) irrigation after scaling and root planing ; Group Ⅱ - tetracycline(0.5%) irrigation after scaling and root planing ; Group Ⅲ - saline irrigation after scaling and root planing and Group Ⅳ - scaling and root planing alone. Following thorough scaling and root planing irrigation was done and repeated every other day during two weeks for group Ⅰ, Ⅱ and Ⅲ. Clinical and microbiological monitorings were done immediately before scaling and root planing and at 2, 4, 8 and 12 weeks after scaling and root planing. Clinically, plaque index(Silness and Lo¨e), gingival crevicular fluid amount, probing depth, sulcus bleeding index(Mu¨hlemann and Son) and attachment level were recorded. Microbiologically, trypsin-like enzyme activity of subgingival microflora was monitored using benzoyl-arginine naphthylamide test. The results were as follows: 1. Plaque index score and attachment level showed no significant difference among the 4 experimental groups and during all the experimental periods. 2. Gingival crevicular fluid amount and probing depth showed significant decrease in irrigated group (Group Ⅰ, Ⅱ and Ⅲ) from week 2, and in scaling and root planing only group (Group Ⅳ) from week 4. 3. Sulcus bleeding index score in each experimental group decreased significantly during all the experimental periods. 4. The trypsin-like enzyme activity in subgingival microflora in each experimental group decreased significantly during all the experimental periods. The results suggest that the subgingival irrigation in the presence of thorough scaling and root planing has beneficial effect to the reduction in gingival crevicular fluid flow and probing depth in early post-treatment period and the antimicrobial irrigation has no additive effect.

지난 10年間 全南地城에서의 豪雨의 最大 DAD에 관한 硏究

이광호,김미현 全北大學校 敎育大學院 2002 敎育論叢 Vol.22 No.-

본 논문에서는 전남 지역에서 지난 10년간(1991년∼2000년) 하루에 100mm이상 기록된 호우 40여 개를 선정하여 호우기간 동안의 강수량이 많은 순서로 20개를 추려서 호우의 원인이 태풍이었던 9개의 호우에 대하여 WMO의 기준법에 의해 호우의 DAD를 각각 구하여 이로부터 최대 DAD를 얻었다. 본 논문에서 얻은 호우의 최대 DAD는 전남지역에서의 각종수문사업의 설계 기초 자료 뿐만 아니라 태풍이 내습할 때 강수의 양적예보에 크게 도움을 줄 것이다. This study on volumes of precipitation in typhoons is important for examining flood problems. Such information is generally presented in the form of tables of maximum average depth of storm precipitation over various standard area sizes, during standard periods of time. Maxium values for a storm are called maxium depth-area-duration data. Nine typhoons recorded from 1991 to 2000 are selected for study. The DAD enveloped curves of Jeolanam-do(province) changed according to center of precipitation. and that is related the tracks of typhoon and topography.

식이 섬유질의 첨가가 성인여자의 칼슘과 철분대사에 미치는 영향

이현옥,박미경 中央大學校 家庭文化硏究所 1995 가정문화논총 Vol.9 No.-

This study was carried out to investigate the effect of addition of dietary fiber in the daily diet on the calcium and iron metabolism in healthy young woman. The subjects were equally divided into control group(CG) and fiber group(FG) that consisted on six healthy, woman student of 19 to 24 years of age. The 12-day study was conducted on a 6-day equilibration period and 6-day experiment period(fiber intake:CG 9.4g, FG 21.1g). Except for fiber supplement the daily diet and nutrient intake of the subjects were approximately the recommended dietary allowances during both periods without significant differences. For experiment period there was no siginificant difference between CG(Ca:53%, Fe:29%) and FG(Ca:57%, Fe:44%) of fecal excretion rate of calcium, iron. The excretions of calcium, iron in the urine were not significantly different between groups. Mean calcium and iron level in serum was not significantly different between in FG and CG. This study shows that supplement of 12g fiber in the daily diet did not influence on calcium and iron excretion from fecal and urine and also on the serum calcium and iron level.

온실재배와 노지재배한 금산 깻잎의 품질 특성과 향기성분

현광욱,구교철,장정호,이재곤,김미리,이종수 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

깻잎을 이용한 건강 식품을 개발하고자 먼저 깻잎의 주산지인 금산에서 5월 온실재배한 깻잎과 8월 노지재배한 깻잎들의 품질특성과 향기성분을 조사하였다. 시료깻잎 모두 4.0%의 조단백질과 0.8%의 조지방을 함유하고 있었고, 플라보노이드의 함량은 온실재배 깻잎 25.2%, 노지재배 깻잎 26.5%로 시료깻잎간에 큰 차이는 나타나지 않았으며 조사포닌 함량도 2,7%와 2,8%로 비슷하였다. 시료깻잎의 효소 활성은 오직 알칼리성 단백질 분해효소 활성만이 8월 노지재배 깻잎에서만 물 추출물 7.1 unit, 에탄올 추출불 11.8 unit을 보였고 기타 효소 활성은 없었다. 8월 노지재배 깻잎의 조직감 특성으로 먼저 견고성과 탄력성 등은 잎의 상층부와 중층부 보다 잎받침을 포함하는 하층부에서 높았고 응집성은 하층부가 약간 약하였으며 5월 온실재배 깻잎은 씹힘성이 다서 낮았을 뿐 노지재배 깻잎과 비슷하였다. 5월 온실재배와 8월 노지재배 깻잎에는 1-octen-3-ol, linalool, β-caryorhyllene, α-caryophyllene, α-famesene, perilla ketone, nerolidol, eugenol. α-cadinol 등 14종∼15종의 향기성분을 함유하고 있었고 주요한 향기성분은 perilla ketone 이었다. Quality and flavor compounds of perilla leaves cultivated in greenhouse(May) and field (August) in Geumsan province were investigated and compared. All perilla leaves contained 4.0% crude protein and 0.8% crude lipid. C겨de flavonoid contents of perilla leaves cultivated in greenhouse and field showed 25.2% and 26.5%, respectively and each crude saponin content was cultivated in field. Hardness and chewness of bottom parts of field-perilla leaves were higher than those of top and middle part, whereas the cohesiveness of top parts and middle parts of perilla leaves were higher than that of bottom part. Furthermore, texture properties of greenhouse-perilla leaves were similar with those of field-perilla leaves except chewness. Nine kind of flavor compounds such as 1-octen-3-ol, linalool, β-caryophyllene, α-caryophylene, α-franesene, perilla ketone, nerolidol, eugennl, α-cadinol were identified in greenhouse-perilla and field-perilla leaves, showing that main flavor compound was perilla ketone.