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Sustained Drug Release on PNIPAm-integrated HAP
장정호,심창한 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
A hybrid temperature-responsive hydroxyapatite-poly(N-isopropylacrylamide) (HAP-PNIPAm) gelhas been synthesized by the interpenetration of PNIPAm into a sintered HAP disk through a radical initiated polymerization of NIPAm monomers under nitrogen atmosphere, and shows a sustained positive thermosensitive release profile when the temperature was maintained above the LCST. The sustained release is caused by the attractive interaction between Ca ion in HAP and carboxylate of indomethacin drug. This concept can be applied for biodegradable polymers in osteophoresis.