前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

소아 대퇴 근위부 골절의 치료결과

정성택,이근배,윤택림,문은선,송은규 全南大醫大 2001 전남의대학술지 Vol.37 No.1

Smallworld를 이용한 이동 객체 이력 관리 및 위치 예측기

정영진,배종철,안윤애,류근호 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

시간에 따라 객체의 위치나 크기 등의 공간 속성이 연속적으로 변하는 특징을 가진 객체를 이동 객체라고 한다. 이와 같은 이동 객체를 일반적인 데이터베이스를 이용하여 관리할 경우, 단순히 이산적인 시간으로 샘플링 된 이동 객체 정보만을 저장하여, 질의를 처리할 때 저장되지 않은 이동 객체의 과거 및 미래에 대한 위치 정보를 전혀 제공하지 못하고 저장된 정보에 대한 단순 질의만을 처리 할 수 있는 단점을 가진다. 따라서, 이 논문에서는 이와 같은 단점을 해결하기 위해 이동 객체 정보를 저장 관리하고 샘플링 되지 않은 객체의 위치는 물론 가까운 미래의 위치를 예측하는 이동 객체 이력 관리 및 위치 예측기를 구현한다. 그리고 이를 위해 보간법과 이동객체의 속도와 방향을 고려한 삼각함수를 사용한다. 구현된 이동 객체 이력 관리 및 위치 예측기는 과거의 이력 질의와 현재의 위치 질의를 제공하고, 저장된 객체의 행위 정보를 시간에 대한 함수에 활용하여 가까운 미래에 대해 대략적인 향후 위치 질의를 제공하는 특징을 가진다. Moving objects are objects that have spatial attributes, such as position and/or extent are changing object data that are sampled with discrete time are stored only, the application has a following problem. When the queries are processed. past and future positions of the moving objects except saved data are not provided and, only simple query for saved data is processed. Therefore, in this paper, we implemented the history manager and location PFedictor of moving objects which are able to save and manacle the moving obiect data, predict positions of moving objects of about near future as well as presume ones which are not sampled. To do this, we use interpolation and trigonometrical function to well as query about historical and current position

결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현

박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.

불소배합 음용수와 불화우유 섭취에 의한 백서치아 탈회 억제효과 비교

송근배,송재상,김혜영,김정숙,김지영 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1

The purpose of this study was to investigate the inhibitory effect of fluoride in the water and milk on tooth enamel dissolution by commercial beverages. 3 weekold 60 female sprague-Dawley strain were divided into four groups and given the following dosage of fluoride in the drinking water:0,1,5 and 50ppm for six and twelve weeks ad libitum. Upper incisors were prepared for specimen with low speed dental disc.The slabs of each incisors were embedded in unsaturated polyester,polished with #1,200 silicon carbide paper and aluminisilicate powder.Three kinds of beverage were selected for test medium and enamel slabs of rat incisors were dipped for 60 and 120 minutes in each beverage.Surface microhardness was examined before and after dissolution with beverage. All collected data were analyzed using the SAS package.Differences between groups were compared by the one-way ANOVA,Duncan's multiple range test and ANCOVA procedures. Corresponding p-values were considered significant at the values less than 0.05. The obtained results were as follows: 1. Surface microhardness was significantly increased both 6 and 12 weeks groups compared with control group. Surface microhardness of high fluoride groups were also proportionally increased with increasing concentration of fluoride both in the water and milk. 2. There were significant differences of inhibitory effect of surface microhardness after 60 and 120 minutes emersion periods,and both at 6 and 12 weeks group in the veverage B and C,but not appeared in the beverage A. 3. The inhibitory effect of enamel dissolution was higher in the 12 weeks group than 6 weeks group both at the water fluoridation and milk fluoridation. 4. The differences of micro hardness between before and after emersion in the beverages were larger in the milk fluoridation groups than water fluoridation groups.

항균성 펩타이드인 Mastoparan B의 살조효과

서정길,김찬희,배윤정,문호성,김근용,박희연,윤호동,김창훈,변대석,홍용기,박남규 한국어병학회 2003 한국어병학회지 Vol.16 No.3

Mastoparan B (MPB)는 벌독으로부터 정제된 양친매성α-helical 구조를 취하면서 14개의 아미노산 잔기로 구성된 염기성 항균성 펩타이드로서 여러 가지 생물막과 작용한다. 본 연구에서는 우리 나라 연안의 적조 (HABs, harmful algal blooms)를 일으키는 4종의 적조생물 (Alexandrium tamarense, Chattonella catenatum)에 대한 MPB의 살조효과를 조사하였다. MPB의 4종의 적조생물에 대한 살조효과는 31.3㎍/㎖에서 세포의 lysis또는 ecdysis와 같은 형태로 현미경으로 관찰할 수 있었다. 또한 MPB는 C. marina 및 C. polykridorides에 대해서 A. tamarense와 G. catenatum보다 더욱 강한 살조효과를 나타내었다. 이러한 MPB의 HABs에 대한 살조효과연구는 새로운 살조물질을 개발하기 위한 자료가 될 것으로 생각된다. Mastoparan B (MPB), an antimicrobial cationic peptide isolated from the venom of the hornet Vespa basalis, is a basic amphipathic a-helical peptide composed of fourteen amino acid residues. In this study, we have investigated the algicidal effect of MPB against hatmful algae blooms (HABs) casative Alexandrium tamarense, Chattonella marina, Cochlodinium polykrikoides and Gymnodinium catenatum. The algicidal effect of MPB showed in the concentration of 31.3 ㎍/㎖ to 500 ㎍/㎖ against 4 HAB species and observed cell lysis or cell ecdysis by microscopy. MPB reacted more sensitive to C. marina and C.polykrikoides than A. tamarense and G. catenatum. The algicidal study of MPB against HABs will provides much insight into development of new algicidal substances.

교합성 골수강내 금속정술후 발생한 대퇴골 간부 골절의 불유합의 치료

이근배,문은선,송은규,최진,정성택 대한골절학회 2002 대한골절학회지 Vol.15 No.4

목적 : 교합성 골수강내 금속정술 후 발생한 대퇴골 간부 골절의 불유합의 치료 결과를 알아 보고자 하였다. 대상 및 방법 : 1990년 5월부터 2000년 7월까지 대퇴골 간부 골절에 대한 교합성 골수강내 금속정술후 발생한 불유합에 대해 치료받은 환자중 1년 이상 추시 가능하였던 33명을 대상으로 후향적으로 조사하였다. 수술 당시 평균 연령은 40세(19~68)였으며, 남자가 27례, 여자가 6례였다. 불유합의 형태는 Weber와 Brunner와 분류 방법에 따르면 과혈관형 10예(30%), 무혈관형 21예(64%), 혼합형이 2예(6%), 무혈관형중에서 감염성이 5예(23%)였다. 결과는 수술 방법에 따른 골 유합 기간 및 불유합, 부정 유합, 감염 등의 합병증의 유무로 평가하였다. 결과 : 수술 방법은 불유합의 원인과 형태에 따라 결정하였으며, 5가지 방법으로 시행하였다. 골수강내 금속정 교환술을 시행한 경우가 7예, 골수강내 금속정 교환술 및 골 이식술을 함께 시행한 경우가 11예, 외고정술 5예, 금속판 고정 및 골 이식술 3예, 해면골 이식술만을 시행한 경우가 7예였다. 골유합 기간은 각각 평균 19주, 17주, 20주, 16주, 15주로서 치료 방법 간에 통꼐학적인 의의는 없었다. 전례에서 술 후 감염이나 불유합, 부정 유합 등은 관찰되지 않았다. 결론 : 교합성 골수강내 금속정술후 발생한 대퇴골 간부 골절의 불유합의 치료에 있어서는 불유합의 원인과 형태를 잘 분석하여 그 원인에 맞는 적절한 치료 방법을 선택하는 것이 골유합을 얻는데 매우 중요하다고 생각된다. Purpose : We analyzed the results of treatment for the nonunion of femur shaft fractures after interlocking intramedullary(IM) nail fixation. Materials and Methods : Thirty-three patients who underwent interlocking IM nailing due to femur shaft fractures from May, 1990 to July, 2000 and followed up for more than one year were evaluated retrospectively. Mean age at the time of operation was 40 year(Range, 19-68). 27 cases were men and 6 cases were women. By Weber and Brunner classification of the nonunion, hypervascular type were 10 cases(30%), avascular type 21cases(64%), mixed type 2 cases(6%). Infected type among the avascular type of noumion were 5 cases(23%). Results were evaluated with bone union by treatment methods and complications. Results : According to the causes and types of nonunion, we performed IM nail exchange in seven cases, IM nail exchange and bone grafting in eleven cases, external fixation in five cases, compression plating and bone grafting in three cases, and only cancellous bone grafting in seven cases. Radiographical union was achieved in 19weeks, 17 weeks, 20 weeks, 16 weeks and 15 weeks respectively. There’s no statistically significant difference between treatment methods. There are no cases of nonunion, malunion and infection. Conclusion : The selection of appropriate treatment method by the cause and type of each nonunion is very important to achieve the bony union in the treatment for the nonunion of femur shaft fractures after interlocking intramedullary nailing.

실신을 주소로 응급의학센터에 내원한 환자에 대한 임상적 연구

박정배,김상은,배성만,정호성,박철완,이 근 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Syncope is not uncommon problem that needs broad differential diagnosis. Correct diagnosis of the cause of syncope is important, because although some causes of syncope such as vasodepressor syncope have benign prognosis, others such as ventricular tachycardia may need prompt diagnosis and treatment. We present a retrospective study of the patients with episodes of syncope brought to Emergency Medical Center of Chung Ang Gil Hospital from January 1994 to October 1994 and the results were as followings. 1. The patients with episodes of syncope accounte for 0.5% of total Emergency Department visits. 2. The male to female ratio was 4 : 6 and mean age was about 54-years old. 3. The cause of syncope was identifiable in 48% of the case and not in 52%. The noncardiac cause(56%) was more common than the cardiac(44%) and cardiac, noncardiac, SUO(Syncope of Unknown Origin) ratio was 1 : 1.4 : 2.6. 4. 29% of patients were dignosed by history taking, physical examination, and electrocardiography when they visited the Emergency Department initially, and 88% of patients with identifiable causes were diagnosed through initial Emergency Department investigation and Holter monitioring. 5. The rate of correct diagnosis can be increased if initial investigation includes Holter monitoring, and the further research for more accurate, inexpensive and noninvasive diagnostic method for syncope is needed.

무기수은 투여에 의한 백서체내의 수은축적에 대한 연구

이정택,송근배,조광헌 慶北大學校 齒科大學 1993 慶北齒大論文集 Vol.10 No.2

44마리의 Sprague-Dawley계 자성백서를 제1대군 12마리, 제2대군 12마리 및 제3대군 20마리로 나누고 다시 각각의 대군을 실험 2주, 4주 및 6주의 소군으로 나누어 제1대군은 대조군으로 일반 식수를 투여하고 제2대군은 체중 100gm당 0.945mg의 염화수은을, 제3대군은 체중 100gm당 3.780mg의 염화수은을 최종 6주까지 위장관내 투여법으로 매일 투여한 후 각 실험당일 백서의 털, 전혈, 신장 및 간을 채취하여 이를 각각 산분해용기에서 분해시켜 원자흡광광도계를 본체로 한 atomic vapour accessory를 이용하여 각 조직 장기에 축적되는 수은의 양을 정량하여 다음과 같은 결과를 얻었다. 제2 및 제3대군의 백서 털내의 수은함량은 대조군에 비해 2-4배 정도 높았다. 대조군 혈장내 수은 함량은 평균 0.09ppm(최저치 0.01ppm, 최고치 0.25ppm), 제2대군에서는 0.34ppm(최저치 0.09ppm, 최고치 0.61ppm) 및 제3대군에서는 0.76ppm(최저치 0.48ppm,최고치 1.06ppm)이었다. 신장은 체내 주요 장기중 수은의 주요 축적장기로 대조군의 평균 수은 함량은 0.16ppm(최저치 0.09ppm, 최고치 0.26ppm),제2대군에서는 60.98ppm(최저치 32.18ppm, 최고치 96.45ppm) 및 제3대군에서는 평균 102.45ppm(최저치 73.89ppm, 최고치 142.09ppm)이었다. 간내에 축적된 수은의 농도는 대조군, 제2대군 및 제3대군은 각각 0.06ppm, 2.46ppm, 3.46ppm으로 나타났다. 투여되는 수은량의 증가에 따라 각 신체 장기중에 축적되는 수은양의 상관관계를 알아본 결과 신장과 간에 축적되는 수은의 양 사이에는 상관계수가 r=0.8348로 통계적으로 유의한 양의 상관관계가 있었다. The toxicity and accumulation of mercury compounds in dentistry has been an issue of interesting concern. Relatively few data were available concerning the relation between toxicity and accumulation of inorganic mercury in vivo. The purpose of the study was to investigate the accumulation of mercury in rat tissues following exposure to different volumes of mercurous chloride. For this study, 44 Sprague-Dawley strain rats were divided into three large groups. The rats of Group I were supplied with a drinking water ad libitum, Grouop Ⅱ were fed 0.945mgHgCl_2 per 100gm of body weight and 3.780mg HgCl_2 per 100gm of body weight in Group Ⅲ. The rats were fed the mercurous chloride as solution type everyday via gastric lavage method for 2,4 and 6 weeks. The author collected the samples of hair, whole blood, kidney and liver and melted them in acid digestion bomb on the 2nd, 4th and 6th experimental week. The total mercury contents of hair, blood, kidney and liver were determined by Cold Vapour Atomic Absorption Spectrometry. The results obtained were as follows: The hair mercury contents of Group Ⅱ & Ⅲ were 2-4 times higher than that of the control . The mean mercury levels of whole blood were 0.09ppm(range 0.01-0.25) in control group, 0.34ppm(range 0.09-0.61) in Group Ⅱ and 0.76ppm (range 0.48-1.06) in Group Ⅲ during 6 weeks. The kidney was the main reservoir of mercury in body. The mean mercury levels of kidney were 0.16ppm(range 0.09-0.26) in control group, 60.98ppm(range 32.18-96.45) in Group Ⅱ and 102.45ppm(rang 73.89-142.09) in Group Ⅲ. There was significant difference of mercury content in kidney between groups(p<0.05). The mean mercury levels of liver throughout 6 weeks were 0.06, 2.46 and 3.46ppm in GroupⅠ, GroupⅡ and GroupⅢ, respectively. In control group, hair mercury content was the highest and kidney, whole blood, liver in descending order, but in GroupⅡ and Ⅲ, kidney mercury content was the highest and liver, hair, whole blood in descending order(p<0.05). There was significant correlationship between kidney mercury content and liver mercury content(r=0.8348, p<0.05), but there was no correlationship among the other samples.

중고령자에 있어서 적절한 운동처방의 연구

이배익,정일호,권만근 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

Recently, the diet of middle aged Korean men is changing. Instead of eating Korean foods exclusively, they are consuming more Western foods which are often unhealthy. In addition, they are exercising less. These factors are leading to a rise in lifestyle related disease, such as diabetes, and dangerous medical conditions like hypertension. As a result, some middle aged men have taken up light exercise, such as hiking, walking, swimming etc. However, they don't know how to set up an exercise program, i.e. frequency of exercise, intensity, duration, etc. A 15 week exercise class was set up 36 middle aged men. Before the class began, a physical fitness and blood test were administered to each subject. The same tests were repeated after the 15th week. Based on the initial results, individual programs were prepared for each participant. A step calorie counter was supplied to measure their exercise activity. The step count results were checked everday, and based on the results, the subjects were divided into three groups for analytical purposes. The firts group, sixteen subjects(44%), averaged a little over 8,000 steps per day. The second group, eight subjects(22%), averaged between 8-10,000 steps per day. The third group, twelve subjects(33%), averaged a little over 10,000 steps per day. After fifteen weeks, the total cholesterol, HDL cholesterol and LDL cholesterol of all subjects showed no significant change. The second and third group showing an especially marked decrease in blood sugar. Also, physical fitness improved for the second and third groups. In conclusion, both groups doing the most exercise showed improvement in their TG and blood sugar results. Blood pressure also decreased for these two groups, which was not true for the first group, also, physical fitness improved in the second and third groups, while the first group showed no significant change. It appears that exceeding a certain minimum level of exercise is required to achieve good results. What would happen if group 1 did the same exercise for longer than is weeks.