열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

사람 세포거대바이러스 당단백 gB의 특성

황응수,김진희,박정규,차창룡 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

閑山·巨濟灣 굴, 진주담치 및 海水의 重金屬含量

黃奎喆,李應昊,金成晙 釜山水産大學校 1984 釜山水産大學 硏究報告 Vol.24 No.1

1982년 7월부터 12월까지 南海岸의 閑山·巨濟灣에서 양식되고 있는 굴 및 自生하고 있는 진주담치와 海水에 대한 重金屬(Hg, Cd, Cu, Pb 및 Zn) 含量을 調査하고 成長過程, 水深別 그리고 굴과 진주담치의 重金屬含量을 相互 比較하였다. 1. 海水에 있어 구리 含量은 대체로 表層이 5m層보다 높았고 그 平均값은 각각 5.0, 3.3ppb였으며, 水銀은 0.132, 0.137ppb로 表層과 5m層間에 差異가 거의 없었다. 2. 굴의 成長에 따른 重金屬含量은 대체로 아연과 구리는 增加하는 반면 카드뮴, 납 및 水銀은 특징적인 變化는 나타나지 않는다. 그리고 水深別(表層 및 5m層)굴의 重金屬含量은 아연과 구리에서 약간의 差異가 있을 뿐 다른 重金屬은 같은 수준이었다. 3. 閑山·巨濟灣에 있어 굴과 진주담치의 重金屬含量(1982年 10月 基準)은 각각 카드뮴 0.55, 0.21ppm, 구리 6.42, 0.66ppm, 납 0.69, 0.41ppm, 아연 101.6, 18.4ppm, 水銀0.009, 0.006ppm으로 굴이 진주담치보다 높았으며, 美國貝類衛生 7次 workshop 推薦暫定基準値인 카드뮴 1.5∼3.5ppm, 구리 42∼175ppm,납 2.0ppm, 아연 1,000∼2,000ppm, 水銀 0.2ppm에 比하여 낮은 값이었다. The quantitive analysis of heavy metals(Hg, Cd, Cu, Pb and Zn) in oyster, Crassostrea gigas, and blue mussel, Mytilus edulis, and growing water associated with hanging culture in Hansan-Geoje Bay on the south coast of Korea were conducted during the period of July to December in 1982. The content of heavy metals in shellfish by growth, water depth, and species were discussed. In sea water, copper content of surface water was in general highe than that of five meter depth to some extent with average of 5.0 and 3.3 ppb, respetively. There were little differences of mercury content between the two water depth, and averaged 0.132 and 0.137, respectively. Cadmium, lead and zinc were indeterminable. In oyster, the contents of copper and zinc by growth showed a trend of gradual increasing with increasing of meat weight, whereas there were little differences in cadmium, lead and mercury during the study period. And there were no differences between surface and five meter depth. The levels of heavy metal in oyster were consistently higher then that in blue mussel. Heavy metal content of both oyster and blue mussel in Hansan-Geoje Bay taking the results in October that it showed higher metal concentration in shellfish during the study period, were 0.55 and 0.21 ppm for cadmium, 6.42 and 0.66 and ppm for copper, 0.69 and 0.41 ppm for lead, 101.6 and 18.4 ppm for zinc and 0.09 and 0.006 ppm for mercury, respectively. They were much less than the alert levels for oyster proposed by the Chemical Task Force of U.S. FDA 7th National Shellfish Sanitation workshop in 1977 that were 1,000-2,000 ppm for zinc 42-175 ppm for copper, 1.5-3.5 ppm for cadmium, 2.0 ppm for lead and 0.2 ppm for mercury.

마을하수도의 정비 및 효율적 관리방안

서규태,김응호 진주산업대학교 환경문제연구소 1998 環境硏究論文集 Vol.1 No.-

This paper is the result of a study conducted to provide a guide line for sewerage system construction and maintenance in small community. The Characteristics of small communities in Korea is that the residents are scattered in a large area. Therefore the sewerage system in such area is significantly different from that of the municipal sewerage facility. In this study, the wastewater facilities of such small community is defined as "Maeul Hasudo". Two types of treatment facilities could be considered. One is combined treatment using public sewer and the other is On-site treatment system for several households. The former is reliable for communities having 20 integrated residentes. On-site treatment is more economical for the sporadic residents in large area. Proper processes and effective management are suggested for the Maeul Hasudo by the type of treatment facilities in this study.

통조림용 가다랑어육의 식품성분

오광수,김정균,김인수,이응호,김복규 國立統營水産專門大學 附設 水産科學硏究所 1990 수산과학연구소보고 Vol.2 No.-

가다랑어 혈합육을 보다 효율적으로 이용하기 위한 일련의 기초연구로서, 가다랑어 혈합육의 지질성분, 함질소엑스분 및 구성아미노산 등을 보통 육과 함께 분석하여 비교, 검토하였다. 보통육은 혈합육에 비해 수분, 조단백질 함량은 약간 많은 반면, 조지방과 회분 함량은 혈합육이 약간 많았다. 휘발성염기질소량은 보토육이 22.7mg/100g, 혈합육이 46.9mg/100ㅎ으로 혈합육이 보통육에 비해 선도저하가 훨씬 빨랐다. 보통육과 혈합육의 총지질 조성은 각각 중성지질 79.7%, 71.9%, 당지질, 6.8%, 9.5%, 인지질13.5%, 18.6%로 이루어져 있었다. 중성지질의 성분은 free fatty acid ac triglyceride, 인지질은 phosphatidyl ethanolamine, phosphatidyl, 인지질은 phosphatidyl choline이 주성분이었고, lysogud 인지질의축적도 확인되었다. 총지지르 중성, 당 및 인지질의 축적도 확인되었다. 종지질, 중성, 당 및 인지질의 지반산 조성에서 보통육은 16:0 및 18:1을 주체로 한 포화산 및 모노엔산의 조성비가 혈합육보다 높았으며, 혈합육은 폴리엔산, 특히 22:6의 비율이 월등히 높았다. 16:0. 18:0, 18:1, 20:5 및 22:6 등이 주요 구성지방산이었다. 유리아미노산의 조성은 총함량에서 보통육 쪽이 많았고, 보통육에는 histidine, 혈합육에는 tauring의 보통육에서는 680.9mg.100g 정도 전존해 있었으나, 혈합육에서는 IMP의 분해가 급속히 진행되어 73.1mg/100g에 지나지 않았다. TMAO 및 TMA는 보통육에 비해 혈합육에 휠씬 많이 함유되어 있었고, total creatinine은 보통육 쪽이 많았다. 구성아미노산의 조성은 양시료 간에 별차이가 없었고, glutamic acid, aspartic acid, lysine, leucine, alanine, isoleucine 및 arginine 등이 주요 구성아니노산이었다. The lipid components, nitrogenous extracts and amino acids of dark muscle(DM) of skipjack (Katsuwonus pelamis) were analyzed and compared with those of white muscle(WM). WM was higher in moisture and crude protein content, and lower in crude lipid and ash content than those of DM. Contents of volatile basic nitrogen in WM and DM were 22.7mg/100g and 46.9mg/100g. Total lipid(TL) of WM and DM consisted of 79.7%, 71.9% neutral lipid(NL), 6.8%, 9.5% glycolipid(GL), and 13.5%, 18.6% phospholipid(PL), respectively. NL was mainly composed of free fatty acid, triglyceride, and PL was mainly occupied by phosphatidyl ethanolamine, phosphatidyl choline. Also lysophosphatidyl choline and lysophosphatidyl ethanolamine were identified in PL. In fatty acid composition of TL, NL, GL and PL, WM revealed higher contents in saturates and monoenes such as 16 : 0, 18 : 1, while DM showed higher contents in polyenes such as 22 : 6 especially. The major fatty acids of these samples were generally 16 : 0, 18 : 0, 18 : 1, 20 : 5 and 22 : 6. Contents of total free amino acids from WM and DM were 5,982.3mg/100g and 4,450.7mg/100g (dry base). Of free amino acids, Tau concentration was much higher in DM than in WM, Ala, Gly, Met, Arg, Thr were also high in DM. But His was much higher in concentration in WM. Content of inosinic acid(IMP) in WM(680.9mg/100g) was higher than that of DM(73.1mg/100g). The degradations of IMP proceeded very rapidly in DM. DM contained much higher trimethylamine oxide and trimethylamine than those of WM. The profile of combined amino acids in these samples were very similar, and main amino acids were Glu, Asp, Lys, Ala, Ile and Arg.

위팔근육 위축 양측마비 2예

안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-

Brachial amyotrophic diplegia, a relatively stable variant of motor neuron disease, is characterized by weakness that is isolated to upper limbs and spared lower extremities, respiratory and bulbar musculature. This disease should be differentiated from other disease such as multifocal motor neuropathy, amyotrophic lateral sclerosis, monomelic amyotrophy and progressive muscular atrophy. We report two cases of brachial amyotrophic diplegia.

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

세균성 수막염에서 발생한 치명적 뇌경색 1례

안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bacterial meningitis is frequently fetal or lead to severe neurological impairment. Cerebral infarction is a well known sequele of meningitis, occurring in as many as 10-20% of patients. But fetal cerebral infarction in bacterial meningitis is rare. We report a 61 year old woman who was admitted due to fever, headache and mental change for 3 days. On admission 7 days follow up Brain-CT revealed large and massive infarctions on both hemispheres. When bacterial meningitis is caused by Streptococcus pneumonia, there is a high prevalence of cerebral infarctions. The underlying mechanisms of cerebral infarction in bacterial meningitis are vasculitis, thrombosis, arachnoiditis, and compression of the arterial supply at the foramen magnum by herniation of the cerebellar tonsil.

왜소음경증과 남성 성기능에 관한 연구

송윤섭,김민의,이남규,박영호,전윤수,김응구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Micropenis is defined as a normally formed penis with a size greater than 2 standard deviations below the mean. Twenty three patients with micropenis were managed at Soonchunhyang University Hospital from January 1988 to December 1995 We interviewed and examined them with micropenis to investigate the cause of micropenis, concomitant diseases, the efficacy of treatment and their sexual activity in postpubertal men. The patients were divided into 2 groups: 16 prepubertal and 7 postpubertal men. 9 patients had cryptorchidism, 3 of them were bilateral and 5 patients had hypospadias. Etiology was determined by hormonal assay including HCG stimulation test ; 8 as hypogonadotrophic hypogonadism, 4 as primary testicular dysfunction and 5 as idiopathic. However etiology was undetermined in 6 patients. All patients had endocrine therapy using HCG or depot testosterone. All except 4 cases responded satisfactorily. All postpubertal patients(group 2) were below the 10th percentile. Puberty was delayed in 3 patients in the older group. All patients were heterosexual and they have had erections and orgasms. Five patients have had ejaculations, 3 of them were sexually active and they have experienced vaginal penetration, Nevertheless, their sexual partners have had complaints and the patients themselves have felt ashamed and dissatisfied. Fortunately, they were mentally healthy. None of these patients were married or had a child.

리니어모터 이송시스템의 진동저감을 위한 이송속도 최적화

최영휴,최응영,김규탁 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper presents feed rate optimizaton of a PMLSM driven feed-slide for mininum vibrations by smoothing velocity curve with finite jerk. First of all, the PMLSM was designed and made to reduce detent force. Next, a PMLSM driven feed-slide system was mathematically modeled as a 4-degree-of-freedom lumped parameter model. The key idea of our vibration minimization method is to find out the most appropriate smooth velocity curve with finite jerk. The validity of our proposed method has been verified by comparing computer simulation results of the feed-slide model with experimental ones.