건강 검진자에서 과민성 장 증후군의 빈도 및 연관 인자

황상연 ( Sang Yon Hwang ),최창환 ( Chang Hwan Choi ),이수연 ( Su Yeon Rhie ),도미영 ( Mi Young Do ),이승현 ( Seong Hyun Lee ),김형준 ( Hyung Joon Kim ),김정욱 ( Jung Uk Kim ),김재규 ( Jae Kyu Kim ),장세경 ( Sae Kyung Chang ),박실 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2

목적: 우리나라에서 과민성 장 증후군의 빈도와 이와 연관된 인자를 알아보기 위하여 단일기관에서 건강 검진을 받는 사람들을 대상으로 설문조사를 시행하였다. 대상 및 방법: 2005년 3윌부터 2005년 8윌까지 관동대학교 의과대학 명지병원에서 건강 검진을 받는 사람들을 대상으로 하여, 미리 제작된 설문지를 작성하게 하였다. 설문지는 로마 기준 II를 우리말로 번역하여 질문형식으로 바꾸었으며 설사형, 변비형, 혼합형의 아형과 세부적인 증상을 확인할 수 있는 항목, 인구통계학적인 항목 등을 포함하였다. 기본적인 문진, 말초혈액검사, 혈청생화학검사, 갑상선가능검사, 대변잠혈검사, 상부소화관내시경검사, 복부초음파검사 등의 건강 검진 자료를 분석하여 기질적인 질환에 대한 평가를 하였으며, 과민성 장 증후군 발생과 연관된 인자를 분석하였다. 결과: 총 3083명의 대상자들 가운데 설문지 작성을 거부하거나 제외기준에 해당하는 사람을 제외하고 총 2,345명(76.1%)의 대상자가 연구에 포함되었다. 이 중 남자는 1,298명(55.4%), 여자는 1,047명(44.6%) 이었고 이들의 평균 연령은 49.0±13.6세였다. 로마기준 Ⅱ에 따른 과민성 장 증후군의 빈도는 8.3%였다. 증상에 따른 아형은 설사형 30.8%, 변비형 23.6%, 그라고 설사-변비 혼합형이 45.6%로 혼합형이 가장 많았다. 35세 미만의 젊은 연령에서 과민성 장 증후군의 빈도가 13.1%로 유의하게 높았고, 또한 체질량지수가 18.5 미만인 저체중에서의 빈도가 21.0%로 유의하게 높았다(p<0.01). 그러나 연령, 거주지역, 직업군, 흡연 및 음주력, 당뇨와 고혈압의 과거력, 빈혈의 유무, 혈액형, 역류성 식도염, 소화성궤양 및 지방간 유무, 그라고 헬리코박터 균 감염 유무에 따라서는 과민성 장 증후군 빈도에 차이가 없었다. 결론: 로마기준 II를 적용하여 건강 검진자를 대상으로 조사한 우리나라 과민성 장 증후군의 빈도는 8.3%이며, 35세 미만의 젊은 연령과 저체중에서 유의하게 빈도가 높았다. Background/Aims: Irritable bowel syndrome (IBS) is a common health problem affecting a substantial proportion of the population. The aims of this study were to evaluate the frequency of IBS that satisfied the ROME II criteria and to analyze the factors that could be associated with the frequency of IBS in subjects who underwent health check-ups in South Korea. Methods: We included a total of 2345 (76.1%) subjects among the 3083 subjects who visited the Health Promotion Center of Kwandong University College of Medicine, Myongji hospital from March 2005 through August 2005. They were interviewed by using a questionnaire that was comprised of the demographic features, the ROME II criteria and the probable associated factors. The frequency of IBS was analyzed according to various factors such as the demographic characteristics, the past history, the body mass indexes (BMI), blood tests and the endoscopic and abdominal sonographic findings. Results: The frequency of IBS was 8.3% (7.9% in males and 8.8% in females). Of the IBS patients, 30.8% had characteristics of diarrhea-predominance, 23.6% had characteristics of constipation-predominan while 45.6% had alternating symptoms. The most frequent symptom was a sense of incomplete evacuation (60.0%), followed by bloating or distention (54.9%), straining (36.9%), urgency (29.7%), and mucus in stool (9.2%). The frequency of IBS was significantly higher for the younger age subjects (age<35) and for the under-weight subjects (BMI<18.5), and these were the factors independently related with the presence of IBS on logistic regression analysis. The frequencies of IBS were not different in terms of gender, area of residence, occupation, smoking, alcohol intake, the diabetes mellitus and hypertension histories, anemia, ABO blood groups, Helicobacter pylori infection and the presence of reflux esophagitis, peptic ulcer or fatty liver disease. Conclusions: The frequency of IBS was 8.3%, according to the ROME II criteria, in the subjects who underwent health-check ups in our region. IBS was more common in the younger age subjects and the under-weight people. (Kor J Neurogastroenterol Motil 2006;12:136-143)

대장 및 직장암 환자에서 말초혈, 하장간막정맥혈, 담즙 및 직장 분비물 간의 CEA치의 의의와 상관관계

도병수,정연웅,김상운,김재황,심민철,권굉보 대한대장항문학회 1991 Annals of Coloproctolgy Vol.7 No.2

Effect of intravenous ascorbic acid infusion on fatigue after laparoscopic myomectomy: A randomized, double-blind, placebo-controlled trial

( Woo Yeon Hwang ),( Kidong Kim ),( Hye Yon Cho ),( Eun Joo Yang ),( Dong Hoon Suh ),( Jae Hong No ),( Jung Ryeol Lee ),( Jung Won Hwang ),( Sang Hwan Do ),( Yong Beom Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Fatigue is a common symptom found after surgery. Several studies have reported that intravenous vitamin C treatment alleviates fatigue among cancer patients and even in healthy office workers. Similar to that our study aimed to assess the effect of intravenous ascorbic acid infusion on fatigue undergoing laparoscopic myomectomy. Methods: A total of 50 women undergoing laparoscopic myomectomy conducted in this randomized, double-blind parallel-group, placebo-controlled trial. The patients were randomly assigned in a 1:1 ratio to undergo laparoscopic myomectomy either with or without intravenous ascorbic acid. Starting 30 minutes before anesthesia, the study group received 2 grams of ascorbic acid with normal saline intravenously, while the placebo group were administered same volume of normal saline only for 2 hours intraoperatively. We measured fatigue score by using the Brief Fatigue Inventory-Korean version(BFI-K) consisting of 9 items. Results: Among the 50 randomized women, 2 and 3 in the study and control group, respectively, were excluded due to withdrawal of consent, cancellation of surgery or non-measurement of the endpoint. The baseline and operative characteristics were similar between each group. The fatigue scores were measured on postoperative day 2. Both the vitamin C group (n=23) and placebo group (n=22) had moderate level of global fatigue score (4.56±2.63, 5.21±2.02, P=0.351). Overall, in the vitamin C group, fatigue score tended to be lower for each item than placebo group, but there were no statistically significant differences. Conclusion: We anticipated that the intravenous ascorbic acid administration would reduce fatigue as in previous studies. The fatigue score measured by the BFI-K was lower in vitamin C group. However there were no statistically significant differences between trial and placebo groups in postoperative fatigue score.

급성 췌장염의 진단에 있어서 Urinary Trypsinogen-2 Dipstick 검사의 유용성

황성준 ( Seoung Joon Hwang ),정준표 ( Jun Pyo Chung ),김영균 ( Young Gyun Kim ),송대훈 ( Dae Hoon Song ),이재성 ( Jae Sung Lee ),백승석 ( Seung Seok Baek ),김도연 ( Do Yun Kim ),이덕용 ( Dok Yong Lee ),정연수 ( Yon Soo Jeong ) 대한소화기학회 2004 대한소화기학회지 Vol.43 No.6

Background/Aims: The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis. Methods: Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls. Results: On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992. Conclusions: Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity. (Korean J Gastro-enterol 2004;43:364-369)

위아전절제술 후 위공장문합부에서 발생한 선편평상피암종

황남철 ( Nam Cheol Hwang ),김경곤 ( Kyong Gon Kim ),임수진 ( Su Jin Lim ),박상준 ( Sang Joon Park ),김윤권 ( Yun Kwon Kim ),김소연 ( So Yon Kim ),김영중 ( Young Jung Kim ),조민구 ( Min Koo Cho ),이권전 ( Gwon Jun Lee ),서동엽 ( Do 대한소화기학회 2002 대한소화기학회지 Vol.40 No.5

노화촉진마우스의 텔로미어 함량 분석

이미랑(Mi-Rang Lee),도경탁(Kyoung-Tag Do),한정주(Jyung-Ju Han),문소현(So-Hyun Moon),강한석(Han-Seok Kang),김선구(Seon-Ku Kim),신택순(Teak-Soon Shin),이홍구(Hong-Goo Lee),황대연(Dae-Yon Hwang),김용균(Yong-Gyun Kim),손시환(Sea-Hwan Soh 한국생명과학회 2009 생명과학회지 Vol.19 No.10

Telomeres, comprised of tandem repeats of TTAGGG sequences, are special nucleoprotein structures that protect and stabilize chromosome ends. These structures form the crux of the telomere concept of aging, senescence and genomic instability. The classic terminal restriction fragment (TRF) analysis to quantify the amount of telomeric DNA is disadvantageous in species containing ultra long telomeres like in mice (100Kb). In this study, we used a more sensitive quantitative fluorescence in situ hybridization (Q FISH) technique to quantify telomeric DNA, and used it as a biological aging marker in mice. 12 litters each of Senescence-Resistant (SAMR1) and ?Prone (SAMP1) known as senescence accelerated mouse strains were purchased from Central Lab, Animal Inc. We quantified the amount of telomeric DNA using telomere specific DNA probes on the two strains of male mice at 8 weeks, 18 weeks and 26 weeks of age. The amount of telomeric DNA correlated with aging and age associated changes in body and organ weight between SAMR1 and SAMP1 strains of mice. These data suggest the usefulness of the amount of telomeric DNA as a biological aging marker in human aging studies.

축산물 및 가공 : 말고기의 육질 등급에 따른 부위별 일반성분, 이화학적 특성 및 지방산 성분 비교

정진형 ( Jin Hyung Cheong ),선창완 ( Chang Wan Sun ),황도연 ( Do Yon Hwang ),권기문 ( Ki Mun Kwon ),이재청 ( Jae Cheong Lee ),김효선 ( Hyo Sun Kim ),김용준 ( Young Jun Kim ),이상근 ( Sang Kun Lee ),류연철 ( Young Chul Ryu ) 한국동물자원과학회(구 한국축산학회) 2013 한국축산학회지 Vol.55 No.3

본 연구는 말고기 응급(1등급과 2등급)에 따른 품질을 비교하여 향후 부위별 및 등급별 구분 판매시 등급간 육질 특성의 기초자료로 활용하기 의해 이화학적, 관능적, 지방산조성 분석을 실시하였다. 등심에 대한 일반성분분석 결과에서는 1등급이 2등급에 비해 높은(p<0.05) 조지방 함량을 보인 반면, 전단력은 1등급이 5.87(kg/cm²)으로 2등급 10.86(kg/cm²)에 비해 유의적으로 낮았다 (p<0.05). 육질등급별등심, 목심, 넓적다리에 대한 보수력 측정결과 등급간 및 부의간에 유의적 차이가 없었고(p<0.05), 육색에 대한 육질등급별 부위간 비교에서는 L* 값, a* 값 및 b*값에서 차이가 없었으나, 2등급의 경우 등심, 목심, 넚적다리의 L*, a* 및 b* 값은 유의적 차이가 있는 것으로 나타났다(p<0.05). 지방산 조성에 대한 분석결과 등심에서 palmitoleic acid (C16:1)는 1등급이 11.39%, 2등급이 5.36%으로 1등급이 2등급에 비해 유의 적으로 높았다 (p<0.05). 반면 stearic acid(C18:0)는 1등급이 2등급에 비해 유의 적으로 낮게 나타났으나(p<0.05), oleic acid(C18:1)는 등급간에 유의적 차이(p<0.05)가 없는 것으로 나타났다. 관능검사결과 육질 등급간에는 전체적인 기호도는 유의적인 차이가 없는 것으로 나타났다(p<0.05). 이상의 결과에서 냉동된 말고기의 육질 1등급과 2등급에서는 조지방 함량, 전단력, palmitoleic acid (C16:1)와 stearic acid(C18:0)는 등급별 육질을 판별할 수 있는 요소로 이용이 가능할 것으로 사료된다. 또한 품질을 향상시키고 부위 및 등급에 따른 차별화를 위해서는 40개월 이상의 장기간 사육은 바람직하지 않을 것으로 사료된다. The objective of this study was to investigate the physical and chemical composition, fatty acid profile and sensory property of horse meat according to meat quality grade (1 and 2) and cuts (loin, chuck roll and top round). The lipid content of loin was significantly higher (p<0.05) in grade 1 (4.65%) compared with grade 2 (2.31%), whereas moisture content was lower (p<0.05) in grade 1 than in grade 2. The pH value was significantly lower (p<0.05) in loin than in other cuts regardless of meat quality grade. Shear force value of loin was significantly different (p<0.05) between grades 1 (5.87kg/cm²) and 2 (10.86kg/cm²). Water-holding capacity values of loin, chuck roll and top round were not different (p<0.05) between grades 1 and 2. Meat color values (L*, a* and b*) of loin, chuck roll and top round were not different (p<0.05) between grades 1 and 2. Palmitoleic acid of loin in grade 1 (11.39%) was higher (p<0.05) than that in grade 2 (5.36%). Stearic acid of loin in grade 1(3.58%) was lower (p<0.05) than that in grade 2(7.02%). Overall palatability of loin, chuck roll and top round did not differ (p<0.05) between grades 1 and 2. Therefore, meat quality grade had mainly affected lipid and moisture contents, shear force, palmitoleic acid and stearic acid of horse loin; and horse loin of grade 2 had lower pH and higher L*, a* and b* than the other cuts.

사과와 배추 중 Carpropamid의 잔류 분석법 확립

김병준 ( Byung Joon Kim ),이진범 ( Jin Beun Lee ),황연진 ( Yon Gin Hwang ),이혜리,김은혜 ( Eun Hye Kim ),도정아 ( Jung Ah Do ),오재호 ( Jae Ho Oh ),김정한 ( Jeong Han Kim ) 한국환경농학회 2012 한국환경농학회 학술대회집 Vol.2012 No.-

Perioperative Risk Assessment in Patients Aged 75 Years or Older: Comparison between Bilateral and Unilateral Total Knee Arthroplasty

( Young Joon Choi ),( Hyun Il Lee ),( Ho Jong Ra ),( Do Yon Hwang ),( Tae Kyung Kim ),( Sang Jun Shim ) 대한슬관절학회 2014 대한슬관절학회지 Vol.26 No.4

purpose: The purpose of this study is to evaluate the risk of sequential bilateral total knee arthroplasty (TKA) under 1 anesthesia in patients 75 years or older. materials and methods: Patients aged 75 years or older who underwent sequential bilateral TKA (bilateral group, n=159) and unilateral TKA (unilateral group, n=159) between 2002 and 2012 were selected. All patients were evaluated for underlying medical diseases, such as cardiac, pulmonary, and renal problems, and high-risk patients were recommended to postpone the surgery. We compared the underlying diseases, major postoperative complications, and the length of hospital stay between bilateral and unilateral groups. results: The prevalence of underlying diseases of the bilateral group was 74.8% and major complications occurred in 6 patients (3.8%). The prevalence of underlying diseases of the unilateral group was 52.4% and complications were observed in 4 patients (2.4%). Although the complication rate of the bilateral group was slightly higher than that of the unilateral group, the difference was not statistically meaningful (p=0.204). The length of hospital stay was 21.9 days for the bilateral group and 24.9 days for the unilateral group. conclusions: There was no significant difference in postoperative complications between groups. The result shows that bilateral TKA can be relatively safe compared with unilateral TKA in patients 75 years or older. However, careful selection of low-risk patients is advised.

Clinical Article : 자가 골-슬개건-골을 이용한 전방십자인대 재건술 시수술 전 슬개건 길이의 예측

최영준 ( Young Joon Choi ),이기원 ( Ki Won Lee ),이현일 ( Hyun Il Lee ),황도연 ( Do Yon Hwang ),조형권 ( Hyung Kwon Cho ),강정호 ( Jeong Ho Kang ) 대한스포츠의학회 2013 대한스포츠의학회지 Vol.31 No.2

Preoperative prediction of patellar tendon length is important during anterior cruciate ligament (ACL) reconstruction using bone-patellar tendon-bone (BPTB) autograft. Three methods of imaging analysis to predict patellar tendon length were compared in this study. One hundred and twenty-three patients who underwent ACL reconstruction using BPTB autograft by single surgeon during October 2002 through April 2011 were included. We measured the patellar tendon length from true and oblique lateral simple radiographs (classified according to degree of rotation) and magnetic resonance image (MRI). These values were compared with actual length measured during operation and assessed accuracy by calculating the coefficient of determination. The mean length of patellar tendon measured during operation and by true lateral and oblique lateral radiographs and MRI were 42.4±0.45 mm (range, 32.0.54.0 mm), 41.7±0.61 mm (range, 24.2.55.3 mm), 40.7±0.57 mm (range, 24.8.51.5 mm), and 41.7±0.52 mm (range, 28.7. 56.0 mm), respectively. The correlation of patellar tendon length was the most strong between actual length and value from true lateral radiograph (coefficient of determination, r2=0.660) according to simple linear regression analysis. R2 values were 0.361 and 0.332 for oblique lateral radiograph and MRI compared to actual value, respectively. In conclusion, Patellar tendon length measured on true lateral radiograph was the best method to coincide with actual patellar tendon length among various preoperative prediction methods.