선천성 기형을 동반한 단일 제대동맥 신생아 2례

정대봉,박동호,김명철,문경래,박영봉,박상기 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

A single umbilical artery is present in about 2/1,000 births. Approximately 10-15% of Infants with a single umbilical artery have congenital abnormalities, usually more than one, chromosomal abnormalities, fetal growth retradation, prematurity, perinatal mortality and many such infants are stillborn or die shortly after birth. We experienced two cases of single umbilical artery. One had congenital malformation of left ectopic fused kidney, but hadn't cytogenetic abnomality. The other had cytogenetic abnormality of 46XY,inv(6)(q11q16), morphologic abnormalities of polydactyly & lower palpebral fissure and congenital abnormalities of tracheoesophageal atresia & TOF. We reported these cases with a related literature review.

건톳 제조에 관한 연구

정창화,오창경,송대진,김수현,오명철 濟州大學校工科大學産業技術硏究所 1999 尖端技術硏究所論文集 Vol.10 No.1

고품질의 건톳제품을 제조할 목적으로 블랜칭 처리조건, 염도, 색도, 톳의 건조조건 등을 연구하였다. 생톳의 최적 블랜칭 조건은 열탕에서 5초간 처리하였고 이때의 염도는 1.8(NaCl%)로 68%의 염분 제거율을 보였다. 건톳 제조의 최적 건조조건은 열풍건조기로 60 에서 2시간 건조시켰을 때이다. 건톳제품의 수분함량은 10%로 조절하였고 색도는 a(-2.61), b(3.58)이었다. For process dried Hizikia fusiforme product of excellent quality, condition of blanching treatment, salinity, color, and dry condition were investigated. The optimum blanching condition of fresh Hizikia fusiforme was 5 seconds at boiling water. Salinity was 1.8(NaCl%), and effect of salinity elimination was 68%. The optimum drying condition was 2 hours at 60℃ in hot-air drying oven. Moisture content of dried Hijizia fusiforme product was control to 10%, Color was a(-2.61), b(3.58).

장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향

서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin

건강인에서 결핵균 30-kDa항원이 말초혈액 임파구증식에 미치는 영향

최대경,고석신,김화중,조은경,백태현,신철식 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

T lymphocytes are thought to play a central role in cell mediated immune response. To Study the T lymphocyte proliferative response to 30-kDa antigen purified from Mycobacterium tuberculosis H37Rv, peripheral blood lymphocytes isolated from healthy subjects were stimulated with the 30kDa antigen, crude antigen or PHA. Healthy subjects were divided into three groups so that PPD(+), PPD(±) and PPD(-). The proliferations of lymphocytes were measured by the incroporation of ^3H-thyrnidine. The results were summarized as follows: 1. For the PPD(+) person, at concentration of < 1 ㎍/ml, the proliferative response to 30-kDa antigen resulted in a mild reduction but crude antigen showed relatively rapid reduction. For the PPD(-) person, decreasing the concentration of the both antigens showed rapid reduction of proliferation 2. The lymphocytes proliferations to 30-kDa antigen and crude antigen were significantly increased in PPD(+) group when compared to those in PPD(-) group, but PHA response was no significant difference. 3. The sensitivity and specificity of lymphocyte proliferation assay to 30-kDa antigen and crude antigen when compared with skin test results were 92.3%, 100% and 76.9%, 50%, respectively.

Cd(Ga_(0.65)Cr_(0.35))_(2)S_(4)단결정의 결정구조 및 광학적 특성 연구

이정식,현승철,김창대 木浦大學校 基礎科學硏究所 2001 基礎科學硏究誌 Vol.19 No.-

The structural and optical properties of Cd(Ga_(0.65)Cr_(0.35))_(2)S_(4)single crystals, which were grown by the chemical transport reaction method using iodine as a transporting material with an excess sulfur of 10 mol%, were inverstigated from the maesurements of XRD, optical absorption and photoluminescence. The X-ray diffraction analysis for the Cd(Ga_(0.65)Cr_(0.35))_(2)S_(4) single crystals powder showed that the crystals have a defect chalcopyrite with the lattice constants of a=5.5277Å and c=10.1305Å. The analysis of optical absorption specta measured near the fundamental absorption edge revealed that the crystal has a direct band gap. The direct band gap was found to be 3.138 eV at 300K. The photoluminescence spectra at 10K showed a strong emission band centered at 663mn. The emission band was assigned as due to donor acceptor pair recombination.

관상동맥 스텐트 시술 후의 재협착에 관한 연구

김윤철,이정우,김보영,강정아,임대승,이민수,김정희,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Coronary stent implacement is known as an effective treatment in the intimal dissection after percutaneous transluminal coronary angioplasty and the prevention of restenosis. However, In-stent restenosis still remains a major concern in clinical stenting. The stents were placed in 103 patients from July 1996 to March 1999 and performed follow-up coronary angiograms in 59(57.3%) patients. To identify the clinical, angiographic and procedurerelated variables 'which predict late restenosis within the stented artery, 59 patients(58.3±9.9, M:F= 41:18) were studied. The clinical characteristics of the patients were stable angina in 23(39.0%), unstable angina in 14(23.7%), acute myocardial infarction in 21(35.6%) and old myocardial infarction in 1(1.7%). Coronary stenting was performed in 1 patient(1.7%) for primary lesion, 50 patients(84.7%) for suboptimal results after PTCA, 6 patients(10.2%) for bail-out procedure, and 2 patients(3.4%) for restenotic lesions. All patients were treated with aspirin and ticlopidinc. The follow-up angiograms were obtained at 7±4 months. The overall in-stent restenosis rate was 27.1%. The coronary angiographic findings were 32 single vessel(54.2%), 19 two vessel(32.2%) and 8 three vessel disease(13.6%). The angiographic morphological characteristics were type A in 33(55.9%), type B in 14(23.7%), type C in 12(20. 3%) cases. Variables of 16 patients with restenosis were compared with those of 43 patients without restenosis. Previously known predictors for in-stent restenosis were multiple stenting, stenting for restenotic lesions, residual stenosis after stenting, stenting for total occlusion lesions, reference diameter, balloon to vessel ratio, acute gain and minimal luminal diameter after procedure, design and characteristics of stents, ostial lesion of aorta, high pressure method for stenting, lesion length, diabetes mellitus, size of artheroma, saphenous vein grafts, ulcerlating lesions and calcified lesions. In this study, Reference diameter before stenting(2.43±0.54mm vs. 2.88±0.65mm, p=0.016) and balloon-to-artery ratio(1.28±0.26 vs. 1.11±0.18, p=0.006) were predictors for in-stent restenosis. 1) The overall in-stent restenosis rate was 27.1%. 2) In the analysis of predictors for in-stent restenosis, there was no significant differences in clinical, angiographic factors between group with restenosis and without restenosis. But, Only reference diameter before stenting and balloon-toartery ratio were predictors of late in-stent restenosis. In conclusion, stenting is effective revascularisation method for selected patients with ischemic heart disease, and to minimize in-stent restenosis rate, stent implanting is achieved in a large vessel on the basis of an artery-to-stnet ration of 1:1, if possible.

건톳 제조에 관한 연구

오명철,정창화,오창경,송대진,김수현 濟州大學校 産業技術硏究所 1999 산업기술연구소논문집 Vol.10 No.1

소프트웨어 품질평가에 관한 연구 : 행정전산화용 소프트웨어 중심으로

문병기,정철원,고형대 木浦大學校 情報産業硏究所 1994 情報産業硏究誌 Vol.2 No.-

In this paper, we analyze the cohesion and coupling-a functional quality evaluation model that must be considered from the design phase by the programmer-based on the National administration information's software programmed by the C language. And we measure items. That is able to evaluate the quality of affairs of National administration by the criterion of five software quality measuring methods and five testing methods. Among quality measuring items, we additionally propose the efficient parts in doing affairs of National administration such as the number of blocks in function, the number of case blocks in switch statement, the complexity of menu, the logical complexity of main menu. Making quality evaluation more detailed, we reduce the system maintenance cost and make it possible to develope qualified software.

Effects of high-intensity circuit training on muscle strength, irisin, FGF-21, and adiponectin in obese female college students

Jun-Soo Lee,Hee-Cheol Kim,Sun-Young Jung2,Dae-Young Kim 한국운동재활학회 2019 한국운동재활학회 학술대회 Vol.2019 No.05

This study was to examine the effects of high-intensity circuit training on muscle strength, blood irisin, fibroblast growth factor (FGF)-21, and adiponectin in obese female college students. The subjects (n=10) of this study performed high-intensity circuit training (jogging, stretching, squat jump, arm walking & push up, lunge jump, burppe test, mountain climber, side step, crunch & side crunch). The exercise program in this study corresponded to an intensity of 60 to 80% of the maximum oxygen consumption and was performed three times per week for 4 weeks. Obesity and metabolic syndrome markers, including blood pressures, lipid profiles, fasting glucose and serum irisin, FGF-21, total adiponectin and HMW adiponectin were measured at baseline and after exercise intervention. Paired t-test were used to assess the effects of high-intensity circuit training. Following 4 weeks, body weight, body fat (%), body mass index (BMI), waist circumference (WC) significantly decreased, whereas Irisin significantly increased. These results suggested that high-intensity circuit training may be useful for improving Irisin and obesity index in obese women.

한국인에서 혈소판 당단백 Ⅱb/Ⅲa 유전자 다형성과 관동맥 성형술 후 재 협착과의 관계

이민수,이정우,김보영,임대승,강정아,김정희,김윤철,성보영,최성준,성인환,전은석 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

Platelet aggregation is the final pathway of acute coronary syndrome such as acute myocardial infarction and unstable angina. Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and yon Willebrand factor and it plays an important role in platelet aggregation and in the pathogenesis of acute coronary syndrome. It is known that polymorphism of the gene that encoding platelet glycoprotein IIb/IIIa(PI^A1/A2) is strongly related to acute coronary syndrome in Caucasian, but not in Koreans. We investigated relationship between platelet glycoprotein llb/Illa gene polymorphism and restenosis of coronary artery after angioplasty in Koreans. Total 371 patients(M=251. F=120) were enrolled. Angioplasty group comprised 143 patients who underwent coronary angioplasty, and in the angioplasty group, restenosis group comprised with the 65 patients who had restenotic lesion over 50% of luminal diameter in follow-up coronary angiography. Normal group comprised 153 patients who had no significant angiographic lesion and variant angina group comprised 75 patients who were positive in ergonovine test. Genomic DNA was extracted from peripheral arterial blood. To determine the frequency of P1^A1/A2 genotype, polymerase chain reaction(PCR) was done and the product was restricted with Mspl. 3%. agarrose gel electrophoresis showed restriction fragment length polymorphism. Clinical profile and risk factor were also reviewed. Among all 371 patients of study group, genotype of only one patients in restenosis group if is proven to be PI^A1/A2 heterozygote. All patients of normal study group, no restenosis group, and the other patients in restenosis group have an PI^A1 homozygote genotype. In our study, platelet glycoprotein IIb/Illa polymorphism has no relationship with restenosis of the coronary artery after angioplasty in Koreans. But the genotypic frequency of platelet glycoprotein IIb/IIIa gene polymorphism in Koreans is concordant with that of previous studies.