Choline Acetyltransferase 유전자 다형성이 경도인지손상 발현에 미치는 영향

이정재,박준혁,이석범,허윤석,김태희,윤종철,주진형,이동영,박경운,김기웅,Lee, Jung-Jae,Park, Joon-Hyuk,Lee, Seok-Bum,Huh, Yoon-Seok,Kim, Tae-Hui,Youn, Jong-Chul,Jhoo, Jin-Hyeong,Lee, Dong-Young,Park, Koung-Un,Kim, Ki-Woong 대한생물정신의학회 2010 생물정신의학 Vol.17 No.4

Objectives : The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample. Methods : We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI. Results : The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No significant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055). Conclusion : The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE ${\varepsilon}4$ allele was not significant with regard to the development of MCI.

선천성 코눈물관 막힘 환자에서 내시경적 실리콘관 삽입술의 치료효과

이정재,안재환,김정림,양재욱,Jung Jae Lee,Jae Hwan Ahn,Jung Lim Kim,Jae Wook Yang 대한안과학회 2012 대한안과학회지 Vol.53 No.7

Purpose: To evaluate the surgical results and clinical effectiveness of silicone tube intubation through Hasner’s valve under intranasal endoscopic guidance in children with congenital nasolacrimal duct obstruction (CNDO). Methods: The present study enrolled a total of 58 eyes of 46 children over 12 months of age diagnosed with CNDO in the Department of Ophthalmology, Inje University College of Medicine from 2003 to 2010. Patients who had previously undergone ineffective probing or had a combination of an anatomical abnormality such as secondary nasolacrimal duct obstruction were also included. The silicone tube was intubated through the Hasner’s valve and observed with intranasal endoscopy; tube retention time was planned for at least 12 weeks. Results: A total of 20 eyes were previously probed preoperatively (mean 1.7 times). After the average follow-up period of 13.5 months, the overall success of silicone intubation was 57 of 58 eyes (98%). In one failed eye, nasolacrimal obstruction was already combined preoperatively, and unintentional tube removal by the patient occurred within one week. Silicone tube reintubation was performed after four months, and CNDO symptoms improved. Conclusions: Intranasal endoscopic observation to ensure the passage of a silicone tube through Hasner’s valve decreases anatomical injury. When considering patient age and former treatment, silicone tube intubation with intranasal endoscopic observation could produce desirable results with a higher success rate. J Korean Ophthalmol Soc 2012;53(7):929-933

쯔쯔가무시 감염에서 발생한 양안성 시신경염 1예

이정재,박재영,서원문.Jung Jae Lee. MD. Jae Yeong Park. MD. Won Moon Seo. MD 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To report a case of bilateral optic neuritis in a child after tsutsugamushi infection. Case summary: An eight-year-old boy diagnosed with tsutsugamushi infection was referred to the ophthalmology clinic at our institution. A typical eschar was detected on his right clavicle. The patient complained of severely decreased visual acuity. The initial best corrected visual acuity (BCVA) in his right eye was 0.08, and in his left eye was negative light perception. Fundus exam showed bilateral optic disc swelling and hyperemia. Optic neuritis was diagnosed after tsutsugamushi infection, and high-dose intravenous steroid therapy was initiated according to the ONTT study protocol. Twelve months after treatment, the right eye BCVA improved to 1.0, but the left eye BCVA was only 0.06. Conclusions: The authors of the present study experienced a case of bilateral optic neuritis after tsutsugamushi infection with a relatively positive response to the steroid therapy. J Korean Ophthalmol Soc 2012;53(6):901-905

알츠하이머병의 최신지견

이정재,이석범,Lee, Jung Jae,Lee, Seok Bum 대한생물정신의학회 2016 생물정신의학 Vol.23 No.2

Alzheimer's disease (AD) is a neurodegenerative disorder in which neuronal loss causes cognitive decline and other neuropsychiatric problems. It can be diagnosed based on history, examination, and appropriate objective assessments, using standard criteria such as the Diagnostic and Statistical Manual of Mental Disorders or the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Brain imaging and biomarkers are making progress in the differential diagnoses among the different disorders. The cholinesterase inhibitors, donepezil, rivastigmine and galantamine and N-methyl-D-aspartate receptors antagonist memantine are approved by the US Food and Drug Administration for AD. Recently some acetylcholinesterase inhibitors gained approval for the treatment of severe AD and became available in a higher dose formulation or a patch formulation. Optimal care in AD is multifactorial and it should include early diagnosis and multidisciplinary care with pharmacological and nonpharmacological interventions including exercise interventions, cognitive interventions and maintenance of social networks.

의료 WBAN 환경을 위한 IEEE 802.15.4 MAC 성능 개선

이정재,홍재희,Lee, Jung-Jae,Hong, Jae-Hee 한국전자통신학회 2015 한국전자통신학회 논문지 Vol.10 No.1

WBAN(Wireless Body Area Network)는 인체주변 2-3m 영역에서 의료 및 비의료 디바이스들로 구성된 다양한 환자 모니터링 분야를 지원하기 위한 무선센서네트워크이다. WBAN 환경을 위해서는 저전력 소비, QoS, 듀티사이클등의 요구사항을 만족하고 주파수 대역을 효율적으로 분배하며 트래픽 로드에 강하면서 에너지를 절약하는 MAC(Medium Access Control)이 설계되어야 한다. 본 논문에서는 트래픽 로드가 증가할 때를 고려해 에너지에 효율적인 AQ(Adaptive Queuing) MAC 슈퍼프레임 구조를 제안한다. 또한 시뮬레이션 결과 제안하는 AQ(Adaptive Quenuing)MAC를 IEEE 802.15.4 MAC과 비교 하였을 때 전송처리율, 평균MAC 지연율 측면에서 향상된 결과를 얻을 수 있었다. WBAN(Wireless Body Area Network) is a Wireless Sensor Network for supporting various applications around body within 2~3m which consists of medical and non-medical device. MAC in WBAN environment should satisfy requirements such as low power consumption, various transmission rate, QoS, and duty-cycle, efficiently distribute frequency band, be strong at traffic load and save energy. This paper proposes AQ(Adaptive Queuing) MAC superframe structure for efficient energy use, considering the increase of traffic load. The simulation result also show that transmission rate and average MAC delay rate is improved comparing IEEE 802.15.4 MAC with AQ MAC.

웨이블렛 변환과 HMM을 이용한 고유공간 기반 얼굴인식에 관한 연구

이정재,김종민,Lee, Jung-Jae,Kim, Jong-Min 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.10

본 논문은 Wavelet 변환을 이용한 실시간 얼굴 영역 검출을 제안하였으며, 계산의 효율성과 검출 성능을 동시에 만족시키는 강인한 검출 알고리즘을 제안하였다. 검출된 얼굴 영상은 주성분 분석을 통해 저차원 얼굴 심볼로 구성하여 얼굴을 인식한다. 제안된 방법은 기존의 기하학적인 특징 기반 방법이나 외관기반 방법의 비해 많은 계산 량이 요구 되지 않고 최소한의 정보를 사용하고도 높은 인식률을 유지 할 수 있기에 실시간 시스템 구축에 매우 적합하다. 또한 얼굴 인식 시 발생하는 잘못된 인식이나 인식 오차를 줄이기 위해 고유 공간상에 투영된 모델 특징 값을 군집화 알고리즘을 통해 특정한 기호로 구성하여 은닉마르코프 모델의 입력 기호로 사용하였다. 이렇게 함으로써 임의의 입력 얼굴은 확률 값이 가장 높은 해당 얼굴 모델로 인식하게 된다. 실험 결과 기존의 방식인 Euclidean과 Mahananobis방법 보다 제안한 방법이 잘못된 매칭이나 매칭 실패에서 우수한 인식 성능을 보였다. This paper proposed the real time face area detection using Wavelet transform and the strong detection algorithm that satisfies the efficiency of computation and detection performance at the same time was proposed. The detected face image recognizes the face by configuring the low-dimensional face symbol through the principal component analysis. The proposed method is well suited for real-time system construction because it doesn't require a lot of computation compared to the existing geometric feature-based method or appearance-based method and it can maintain high recognition rate using the minimum amount of information. In addition, in order to reduce the wrong recognition or recognition error occurred during face recognition, the input symbol of Hidden Markov Model is used by configuring the feature values projected to the unique space as a certain symbol through clustering algorithm. By doing so, any input face will be recognized as a face model that has the highest probability. As a result of experiment, when comparing the existing method Euclidean and Mahananobis, the proposed method showed superior recognition performance in incorrect matching or matching error.

IEEE 802.15.6 기반 CSMA/CA 성능 향상에 관한 연구

이정재,김인환,Lee, Jung-Jae,Kim, Ihn-Hwan 한국전자통신학회 2015 한국전자통신학회 논문지 Vol.10 No.11

WBAN을 위한 MAC 프로토콜은 의료용 센서 노드의 가변적인 데이터를 효율적으로 처리하기 위해서 응급상황에서 발생하는 트래픽을 가장 높은 우선순위로 처리하는 CSMA/CA(: Carrier Sense Multiple Access with Collision Avoidance) 알고리즘을 수행하게 된다. 노드가 전송하는 응급 메시지는 충돌이 발생하게 되고 응급 메시지 재전송으로 인한 전송 지연이 발생할 수 있으며 재전송으로 인한 에너지 낭비를 가져올 수 있다. 본 논문에서는 이러한 문제점들을 개선하기 위해서 우선순위 큐잉을 적용한 CSMA/CA 알고리즘의 경우 MAC 명령어 프레임과 데이터 프레임의 우선순위를 정하여 서로 다른 백오프 파라미터를 적용하고 충돌로 인한 프레임 손실을 최소화하는 알고리즘을 제안하였다. 성능평가 결과 제안한 MAC 프로토콜을 사용했을 때가 IEEE 802.15.6을 사용했을때 보다 충돌 확률이 감소하여 패킷 전송 처리율이 증가하고 패킷 손실량이 감소함을 보였다. MAC protocol for WBAN performs CSMA/CA(:Carrier Sense Multiple Access with Collision Avoidance)algorithm that handles traffic which occurs in emergency with top priority in order to deal with variable data of sensor node for medicine. Emergency message that node sends undergoes collision and delay of transmission by retransmission of emergency message and waste of energy by retransmission. This paper suggests algorithm that minimizes loss of frame caused by collision and applies different backoff parameters by setting order of priority between MAC instruction frame and data frame in CSMA/CA algorithm case which applies order of priority queuing to improve aforementioned problem. According to performance evaluation, it has been found that using suggested MAC protocol showed lower collision probability, higher packet transmission processing ratio and lower packet loss compared with using IEEE 802.15.6.

〈이승복 기념관〉의 공간 스토리텔링을 통해 본 반공이데올로기 전시구현

이정재(Lee Jung Jae),박민하(Park Min Ha) 건국대학교 인문학연구원 2010 통일인문학 Vol.50 No.-

〈이승복 기념관〉은 기존의 반공관 형태에서 현재의 기념관 형태로 재건립되면서, 자연스레 반공이데올로기를 정착화 시킨 공간이다. 일종의 ‘국가적 기획’이며 다방면의 지원을 통해 이를 고착화해 나갔다. 이 글에서는 기존 연구들이 ‘반공’이라는 담론에 치우쳐 반공을 내포하는 대상과 그 맥락에 대한 연구가 미비했음을 문제의식으로 삼는다. 이에 기존의 연구 공백을 메우고자 문화콘텐츠적 관점으로 실증적 연구를 심화시켰으며, 사례분석은 공간 스토리텔링 방법론을 사용하였다. 연구과정을 통해 〈이승복 기념관〉의 권장관람 동선과 기념관의 핵심이라고 할 수 있는 본관전시실의 전시구조가 쌍둥이 구조를 이루고 있음을 확인할 수 있었다. 동상→생가→본관→학교→군용장비산책로→묘소오름길(야생화단지)에서 나타내는 환시와 교육의 경험이 본관 내에서 다시 반복된다. 이승복이 다니던 학교가 위치하고 있는 강원도 평창군 용평면에서 장소성을 획득하고, 이승복 사건이라는 테마가 더해진다. 이것은 복원·재현·창조의 과정을 거쳐 지정관람의 동선의 형태로 완성된다. 큰 이야기와 작은 이야기가 공존하는 쌍둥이 이야기 구조를 만들어 내고 그 안에서 환시와 교육의 중첩 구조를 이룬다. 이로써 기념관은 반공이데올로기를 강화시키고 재생산해낸다. 현재의 반공과 평화를 객관화 시키지 못한다면 한 단계 발전한 모습으로 나아가지 못할 것이다. 기존의 전시와 함께 평화통일의 관점에서 과거와 현재 그리고 미래를 함께 내다볼 수 있는 전시구현을 모색해 나가야 한다. 〈Lee Seung-Bok Memorial〉 has naturally made Anti-communism Ideology settle by being rebuilt from the existing anti-communism hall to the current memorial. The settlement of anti-communism ideology is one of 'national project and has been fixed by multidisciplinary supports.' The researchers of this study had a critical mind that the studies for the target implying anti-communism and the context by leaning toward the discourse of "Anti-Communism" were insufficient. This study tried to deepen performance studies in the viewpoint of cultural content in order to fill in the blank of the existing studies and used spatial storytelling for spatial analysis. This study could confirm that the recommended tour course of 〈Lee Seung-Bok Memorial〉 and the display structure of the exhibition hall in the main building which may be regarded as the core of the memorial consist of a twin structure each other. Both the visual hallucination and educational experiences showing in the course of 'the Statue of Lee, Seung-Bok'→'Model of His House'→'Exhibition Hall'→'His Primary School'→'Outdoor Exhibition'→'Ascending tract to his Tomb(Wildflower Estate)' are again repeated in the main building. The placity was acquired at Yongpyeong-myeon, Pyeongchang-gun, Gangwon Province, Korea where his school was located and the theme of 'Lee, Seung-Bok Case' was added. Such factors were completed in the form of visitor's movement of an appointed tour passing through the process of restoration/reproduction/creation. They make the structure of a twin story that both a large story and a small story coexist and the overlay structure of visual hallucination and education in the story structure. Thus, this memorial makes anti-communism ideology strengthen and reproduces it. If it cannot objectify the ideology for the current anti-communism and peace, it will be difficult to advance further to the development of one step. The implementation of the exhibition should be planned so that it is possible to look ahead into the past, current and future for correct and peaceful reunification together with the existing exhibitions.

신입사원의 멘토링과 조직적응: 적극성을 조절변수로

이정재 ( Jung Jae Lee ) 한국인력개발학회 2006 HRD연구 Vol.8 No.2

코로나19 이후 : 교리적 예배와 1-2세기 예수 공동체의 예배

이정재(Jung-Jae Lee) 한신대학교 신학사상연구소 2020 신학사상 Vol.0 No.191

수개월이 넘게 지속되고 있는 코로나19는 평범했던 우리 사회의 여러 풍경들에 많은 영향을 미치고 있다. 주요한 모임과 만남을 요구하는 학교, 회사 등은 즉각 비대면으로 바뀌었고 문화 회관, 도서관, 카페 등의 모임 장소는 이제 더 이상 휴식과 배움, 교제의 장소가 아닌 위험과 불안의 장소가 되었다. 코로나19는 이러한 사회적 영향뿐만 아니라 대부분 개신교 교회들의 예배 형식에도 영향을 주고 있다. 실제로 예배의 형식이 비대면으로 전환되면서 가장 큰 이슈 중에 하나는 단연 ‘주일 성수’ 라는 단어의 무색함일 것이다. 지금까지 한국 교회는 ‘주일 성수를 잘 지켜야 하나님이 기뻐하신다’ 또는 ‘주일 성수를 잘하면 복을 받는다’는 등의 신앙적 의미를 강조하며 일요일 11시 예배를 고수해왔다. 하지만 코로나 시대는 비대면을 요청함으로써 그동안 한국 교회들이 고수해오던 예배와 교회에 관한 본질적인 질문들을 묻고 있다. 다시 말해 지금까지 일종의 행사처럼 장소적 공간을 교회라 부르고 ‘교회에 예배를 드리러’ 혹은 ‘예배를 보러’ 갔던 것은 아닌지 재고를 요청하고 있는 것이다. 오늘날 우리가 드리는 예배의 형식은 기독교가 국교화 된 4세기 이후에 종교적으로 정형화된 모습들이 많은 부분 반영되었다는 점을 감안할 때, 우리는 초기 기독교가 어떻게 시작되었으며, 그들의 예배는 어떠한 형태였고, 또한 그 의미는 무엇이었는지 연구해 볼 필요가 있다. 1-2 세기 초기 기독교 공동체 예배 모습의 탐구는 그들의 예배가 오늘날과는 다른 장소, 다른 리더십의 구조, 다른 예배의 모습으로 이루어졌다는 사실만으로도 현대 예배와의 차이점들을 쉽게 발견할 수 있을 것이다. 하지만 단순한 차이점을 넘어 그들의 예배가 갖고 있던 본질적인 의미는 무엇이었는지, 예배가 이루어지던 1-2세기의 정치적, 사회적 배경은 어떠했는지, 그리고 그 의미가 오늘날 현대 교회들에게 전하는 메시지는무엇인지 본 연구를 통해 살펴보고자 한다. 그리고 1-2세기 초기 기독교 공동체 모델을 따른 미국과 한국 교회들의 사례를 탐구하고, 마지막으로 그들의 사례가 코로나19 이후의 그리스도인들과 한국 교회에 어떠한 변화와 가능성들을 제시할 수 있을지 살펴볼 것이다. COVID-19, which has lasted more than a few months, is having a lot of influence on the various landscapes of our ordinary society. Schools and companies that require major gatherings and meetings were immediately went remote, and the meeting places such as activity centers, libraries, cafes, and so on have become places of danger and anxiety rather than places of rest, learning, or socializing. COVID-19 is not only affecting these social spaces, but is also having an impact on the form of the worship service in most Protestant churches in Korea. In fact, one of the biggest issues with the transition of worship to the remote format will overshadow “주일 성수”, which means the practice of keeping the Sunday Worship Service. Until today, the Korean church has adhered to Sunday’s 11:00 am service, emphasizing the religious teaching that “God is pleased, if we keep the Sunday service well” or “If we keep the Sunday service well, we will be blessed by God.” However, the COVID-19 era requires remote virtual meetings and forces us to ask questions about the true meaning of worship and church that Korean churches have emphasized. In other words, COVID-19 requires us to reconsider whether ‘we have gone to church for worship’ and/or whether ‘we have gone to church for observing worship’. Given that the forms of worship we offer today reflect many of the earlier Christian practices that were formalized in the fourth century, we need to study how the early Christianity began, what form their worship took, and what its meaning was to early Christians. The exploration of worship in the early Christian community of the first and second centuries will reveal easytospot differences from modern worship. Their worship consisted of different places, different structures of leadership, and different forms. However, beyond simple and ostensible differences, I would like to examine in this study what was the essential meaning of their service, what was the political and social background of the first and second centuries when the service was held, and what is the message that it conveys to modern churches today. After that, I will explore the examples of U.S. and Korean churches following the early Christian community model in the first and second centuries; and finally, I will suggest what changes and possibilities their example suggests to modern Christians and Korean churches after COVID-19.