Cathepsin B in Eutopic and Ectopic Endometrial Tissues of Patients with Endometriosis

김정훈,You-Jeong Lee,Jun-Bum Kim,Young-Jin Lee,안준우,김성훈,채희동,강병문 한국발생생물학회 2013 발생과 생식 Vol.17 No.2

This study was performed to investigate the expression of cathepsin B mRNA and protein in eutopic and ectopic endometrial tissues of patients with endometriosis and in normal endometrial tissues and to clarify the association between the cathepsin B expression and endometriosis. A total of 40 women with histologically confirmed endometriosis were recruited for study group. For controls, 20 women undergoing operative treatment for uterine myoma, cervical intraepithelial neoplasia (CIN) or benign gynecologic conditions other than endometriosis were recruited. Eutopic endometrial tissues of both groups and ectopic endometrial tissue of study group were collected during the operations. We employed real time reverse transcriptase - polymerase chain reaction (RT-PCR) to quantify mRNA levels of cathepsin B in these tissues. Then, we performed western blot analysis to measure the protein levels of cathepsin B. The expressions of cathepsin B mRNA and protein were significantly higher in both eutopic and ectopic endometrial tissues of women with endometriosis than in endometrial tissues of controls. These data suggest that the higher expression of cathepsin B in the endometrial tissues might be associated with the development of endometriosis. In addition, eutopic endometrium itself with higher expression cathepsin B may play a pivotal role in the histogenesis of endometriosis.

태양광 모듈 표면 온도 제어에 따른 백시트 박리 거동

김정훈,이준규,안영수,여정구,이진석,강기환,조철희,Kim, Jeong-Hun,Lee, Jun-Kyu,Ahn, Young-Soo,Yeo, Jeong-Gu,Lee, Jin-Seok,Kang, Gi-Hwan,Cho, Churl-Hee 한국재료학회 2019 한국재료학회지 Vol.29 No.11

In this study, we investigate the relationship between the peeling behavior of the backsheet of a photovoltaic(PV) module and its surface temperature in order facilitate removal of the backsheet from the PV module. At low temperatures, the backsheet does not peel off whereas, at high temperatures, part of the backsheet remains on the surface of the PV module after the peeling process. The backsheet material remaining on the surface of the PV module is confirmed by X-ray diffraction(XRD) analysis to be poly-ethylene(PE). Differential scanning calorimetry(DSC) is also performed to investigate the interfacial characteristics of the layers of the PV module. In particular, DSC provides the melting temperature($T_m$) of laminated ethylene vinyl acetate(EVA) and of the backsheet on the PV module. It is found that the backsheet does not peel off below the $T_m$ of ethylene of EVA, while the PE layer of the backsheet remains on the surface of the PV module above the $T_m$ of the PE. Thus, the backsheet is best removed at a temperature between the $T_m$ of ethylene and that of PE layer.

손바닥을 이용한 쿨링이 심부 체온에 미치는 효과

김정훈,박지은,박유진,원철호,지인희,김지인,이종민,Kim, Jung-Hun,Park, Ji-Eun,Park, Yu-Jin,Won, Chul-Ho,Ji, In-Hee,Kim, Ji-In,Lee, Jong-Min 대한의용생체공학회 2017 의공학회지 Vol.38 No.4

The purpose of this study is to perform integrated body temperature cooling of the arteriovenous anastomosis site. In the arteriovenous anastomosis site, heart cooling was performed using the palm of the hand, Cooling was achieved by using Peltier and copper plates to cool the palm of the hand with the heat transferred. The control range of the conducted heat is adjustable from 25 degrees to 30 degrees. The experimental environment was to place the treadmill in the house, The temperature in the house was set at 40 degrees and the experimenter treadmill at a speed of 5 Km. The subjects were exercised until the body temperature reached about $39^{\circ}C$. As a method to lower the body temperature after the experiment, the data of the body temperature was obtained by the general rest, onehand cooling, two-hand cooling. Experiment result better than normal rest when Two hands cooling and an average decrease of 0.66 degrees. if you develop a cooling glove with Peltier, it will be an epoch-making athletic assistant to achieve thermal fatigue.

Recurrence and Extraneural Metastasis in 31 Meningeal Hemangiopericytomas

김정훈,김준수,김창진,황승균,정희원,권병덕,Kim, Jeong Hoon,Kim, Joon Soo,Kim, Chang Jin,Hwang, Sung Kyun,Jung, Hee Won,Kwun, Byung Duk The Korean Neurosurgical Society 2001 Journal of Korean neurosurgical society Vol.30 No.3

목 적 : 높은 재발율과 전이 가능성의 특징을 갖고 있는 수막 혈관외세포종은 perivascular pericytes에서 기원하는 드문 종양으로, 저자들이 경험한 수막 혈관외세포종에 있어서 종양의 재발 및 신경계외 전이에 대하여 알아 보고자 한다. 연구 대상 및 방법 : 1982년부터 1999년까지 수술을 시행하여 수막 혈관외세포종으로 진단받은 31명의 환자를 대상으로 후향적 연구를 시행하였다. 진단 후 재발까지의 기간, 재발에 영향을 미칠 수 있는 여러 가지 인자들, 그리고 신경계외 전이의 기간 및 부위 등을 분석하였다. 결 과 : 총 31명의 환자들 중 12명의 환자들에서 원발성 부위에 종양이 재발하였다(38.7%). 전체의 환자들에서 재발이 발생하지 않았던 평균 기간(recurrence-free period : RFP)은 104개월이었으며 처음 수술 후 5년, 그리고 10년의 재발이 발생하지 않았던 율(recurrence free period : RFP)은 각각 59.2%, 33.6% 이었다. 원발성 부위에 종양의 재발을 보였던 12명의 환자들 중 4명의 환자들에서 첫 수술 후 5년 이후에 재발을 관찰 할 수 있었다. 처음 수술시의 절제 정도가 재발에 가장 큰 영향을 미쳤다. 처음 수술시에 완전 절제한 군의 RFP는 111 개월이었으며, 추적 관찰 5년째 RFR는 완전 절제한 경우 72.7%, 불완전 절제한 경우 20.8%로 그 차이는 통계 적으로 유의하였다(p=0.0060). 통계적으로 유의성은 없었지만 완전 절제 후 부가적인 방사선 치료를 시행하였을 경우가 완전 절제만을 시행한 경우보다 RFR가 높아 추적 관찰 5년째의 RFR는 각각 100%, 그리고 70.3% 이었다(p=0.3359). 4명의 환자들(12.9%)에서 수막 혈관외세포종의 신경계외 전이가 발생하였으며, 이 경우 신경계 외 전이의 평균 기간은 107개월, 그리고 추적 관찰 5년, 10년째의 신경계외 전이율은 각각 4.4%, 24.9% 이었다. 결 론 : 수막 혈관외세포종은 수술적 제거 후 원발성 부위에 또는 원발성 부위에서 멀리 떨어진 부위에 재발의 가능성이 무척 높은 종양이다. 이러한 재발의 가능성을 줄이는 가장 중요한 인자는 수술적 제거 정도로 처음 수술시에 가능한 완전 절제를 시도하여야 한다. 그리고 처음 수술시에 완전 절제가 가능하였다고 하여도 완전 절제 후 부가적인 방사선 치료를 시행하는 것이 재발의 위험성을 낮출 수 있을 것으로 생각한다. 원발성 부위의 재발 또는 신경계외 전이는 오랜 시간이 지난 후에도 가능할 수 있으므로 장기간의 추적 관찰이 필요하다고 생각한다. Purpose : Meningeal hemangiopericytoma(M-HPC), characterized by a high local recurrency and metastatic potential, is a rare neoplasm arising from perivascular pericytes. A retrospective study was performed to identify the recurrence and extraneural metastasis in M-HPC. Materials and Methods : We reviewed the records of 31 M-HPC patients treated from 1982 through 1999 at our institution. The time to recurrence and the various parameters affecting recurrence were determined. Extreneural metastasis was also analyzed. Results : The rate of local recurrency was 38.7%(12/31). The overall average recurrence-free period(RFP) before the first recurrence was 104 months, with overall recurrence-free rates(RFRs) at 5 and 10 years after first surgery of 59.2% and 33.6%, respectively. Of the 12 patients who experienced local recurrence, 4 had recurrences 5 years later after the first surgery. Complete excision at the first operation significantly extended the average time before first recurrence from 43 to 111 months. The 5-year RFRs for the groups of complete excision and incomplete excision were 72.7% and 20.8%, respectively(p=0.0060). Although there was no statistical significance, complete excision followed by adjuvant radiotherapy of more than 50Gy extended the RFP. The 5-year RFRs for the groups of complete excision and complete excision with adjuvant radiotherapy were 70.3% and 100%, respectively(p=0.3359). Four patients(12.9%) presented one or more extraneural metastases that were developed at an average of 107 months after the first operation with the 5- and 10-year metastasis rates of 4.4% and 24.9%, respectively. Conclusions : M-HPC has a propensity to recur either locally or at distant sites after surgical resection. Complete excision is the most important factor to reduce recurrence. However, even with complete excision, adjuvant radiotherapy of more than 50Gy significantly reduces the risk of recurrence. Local and distant recurrences may occur after a prolonged disease-free interval, emphasizing the need for long-term follow-up.

유료 콘텐츠의 N-스크린 서비스를 위한 일시적 시청권한 위임 기법

김정훈,이훈정,김상진,오희국,Kim, Jung-Hoon,Lee, Hoon-Jung,Kim, Sang-Jin,Oh, Hee-Kuck 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.3

최근, 통신기술의 급속한 발전으로 인해 때와 장소에 구애받지 않고 콘텐츠를 소비하고자 하는 사용자의 욕구와 새로운 비즈니스 모델을 찾고자 하는 사업자의 바람이 맞물려 N-스크린 서비스 전략이 주목 받고 있다. N-스크린은 TV, 컴퓨터, 휴대용 단말 등 다양한 기기에서 끊김 없이 콘텐츠를 공유, 소비할 수 있도록 지원하는 스크린 확장 개념의 서비스로서 미국의 통신회사인 AT&T에서 처음 제안했던 3-스크린 서비스 전략이 발전된 형태이다. 유료 콘텐츠에 대한 N-스크린 서비스에서 유료 콘텐츠에 대한 끊김없는 스크린 전환을 지원하기 위해서는 스크린을 전환하고자 하는 기기로 일시적인 시청권한을 부여해야 한다. 하지만 접근제어 시스템을 사용하고 있는 현재의 방송환경에서는 일시적으로 권한을 부여하는 것이 불가능하다. 본 논문에서는 현재 방송환경에서 유료콘텐츠에 사용하고 있는 접근제어 기법에 대해 살펴보고 일시적인 권한 부여를 할 수 없는 이유에 대해서 살펴본 뒤 현재 사용 중인 접근제어 기법을 기반으로 추가적인 키를 사용해 시청권한 문제를 해결하는 방법을 제안한다. Recently, the strategy for N-screen service is in the spotlight along with the consumer's need to use contents regardless of time and place due to the rapid development of communication technology, which is meshing with the desire of service providers seeking a new business model. N-screen, as a screen-extension-concept service which enables consumers to continuously share and use contents in various equipments such as TV, computer and portable terminals, is an advanced type of 3-screen service strategy initially proposed by AT&T, an American telecommunication company. In the N-screen service for pay-contents, in order to support continuous screen changes to and from various equipments, temporary watching right should be given to the equipment intended for screen change. However, it is impossible to give the temporary watching right in the present broadcasting environment, adopting an access-control system. In this paper, the access-control technology being used for pay-contents in the present broadcasting environment and the reason for not being able to give temporary watching right, will be examined. After the examination, the solution for delegation of watching right by using an additional key on the basis of currently used access-control technology, will be proposed.

Down's Syndrome(몽고증)의 세포유전학적 연구

김정훈,오선경,김정구,문신용,이진용,장윤석,Kim, Chung-Hoon,Oh, Sun-Kyung,Kim, Jung-Koo,Moon, Shin-Yong,Lee, Jin-Yong,Chang, Yoon-Seok 대한생식의학회 1986 Clinical and Experimental Reproductive Medicine Vol.13 No.2

The purpose of this study is to investigate the cytogenetic characteristics of Down's syndrome in Korea. For this study, selected were 92 patients who were diagnosed as Down's syndrome by the chromosomal analyses, among 115 patients who were supected of Down's syndrome and referred to the Cytogenetic Laboratory, Institute of Reproductive Medicine and Population, Seoul National University, for 2 years from January 1984 to December 1985. Among 92 patients with Down's syndrome 83 (90.2%) had G-trisomy, 4 (4.3%) had translocation, and 2 (2.2%) had mosaicism of normal and G-trisomic cell lines. Two patients of the remaining 3 had both G-trisomic and translocation, 47, XX, t (1:21) (p32:q22), +21, 47, XX, t (9:11) (q34:q14), +21. The remaining 1 patient had 47, XY, +mar.

수두증을 동반한 송과체 부위 종양에 대한 내시경적 치료

김정훈,나영신,김준수,안재성,김창진,권병덕,Kim, Jeong Hoon,Ra, Young Shin,Kim, Joon Soo,Ahn, Jae Sung,Kim, Chang Jin,Kwun, Byung Duk 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5

Purpose : In general, pineal region tumors are managed by using microsurgical approach or stereoctactic biopsy. However, in selected cases endoscopic approach to pineal lesions might prove to be as effective as microsurgery and less invasive. We report an alternative surgical strategy for managing certain patients with pineal neoplasms that allows treatment of the symptomatic hydrocephalus as well as tumor biopsy under direct vision in the same sitting. Materials and Methods : Twenty-two patients with pineal region tumors with associated hydrocephalus were treated in one session by endoscopic third ventriculostomy and endoscopic tumor biopsy at our institution from October 1996 to January 2000. All patients were retrospectively evaluated. Results : There was no operative mortality. There was one cause of significant bleeding during biopsy, but was controlled endoscopically, and the patient recovered completely without neurologic deficit resulting from intra-operative bleeding. The symptoms related to increased intracranial pressure(ICP) have resolved in all patients, and the need for a shunt is completely eliminated. Histological diagnosis was achieved in 21 of the 22 patients by this procedure. A biopsy was not obtained in one patient. Although this pineal region tumor was seen endoscopically, this could not be biopsied because of technical difficulties in working around an enlarged massa intermedia. The lesions included fourteen germinomas, three mixed germ cell tumors, and one each of the followings: pineocytoma, pineoblastoma, pineocytoma/pineoblastoma(intermediate type), meningioma, and low grade glioma. Five of the 22 patients subsequently underwent formal microsurgical tumor removal. Additional chemotherapy or radiotherapy could then be initiated according to the histological diagnosis. Conclusion : We consider that endoscopy affords a minimally invasive way of reaching three objectives by one-step surgery in the management of pineal region tumors with associated hydrocephalus : 1) cerebrospinal fluid(CSF) sample for analysis of tumour markers and cytology, 2) treatment of hydrocephalus by third ventriculostomy, and 3) several biopsy specimens can be obtained identifying tumors which will require further open surgery or adjuvant radiation and/or chemotherapy. However, complications and morbidities should be emphasized so as to be avoided with further technical experience.

Design of Magneto-Rheological Fluid Based Device

김정훈,이종운,정병보,박용진,Kim, Jeong-Hun,Lee, Jong-Un,Jeong, Byeong-Bo,Park, Yong-Jin 대한기계학회 2001 KSME International Journal Vol.15 No.11

The effect of power supply voltage on the performance limits in a laboratory magneto-rheological fluid based device was identified by experiments. It suggests that the frequency range of motion for control is limited by the voltage attenuation due to the coil inductance and the maximum power supply voltage set for practical use of an MRF devices. In this work, the magnetic and electrical characteristics of the MRF device are investigated and a design procedure is formulated to achieve the desired performance for a given power supply.

설계시공일괄방식 프로세스 성공모델에 관한 연구

김정훈,구교진,현창택,Kim Jeong-Hoon,Koo Kyo-Jin,Hyun Chang-Taek 한국건설관리학회 2003 건설관리 : 한국건설관리학회 학회지 Vol.4 No.3

오늘날 프로젝트 수행방식 중 설계시공일괄방식은 전통적 수행방식의 대안으로 점차 선호되고 있다. 1995년 처음 도입된 설계시공일괄방식은 아직까지 많은 문제들을 발생시켜오고 있다 초기 선행연구보고서들은 여러 가지 방법으로 설계시공일괄방식 프로젝트 수행을 향상시키고자 노력해 왔으나, 아직까지는 그다지 큰 영향을 미치지 못하고 있다. 본 연구에서는 설계시공일괄방식 프로젝트 수행을 향상하기 위해 4단계에 걸쳐 설계시공일괄방식 성공모델을 제시하고자 한다. 첫째로 연구를 위한 적절한 모델링 방법을 찾고, 둘째로 설계시공일괄방식의 현황을 분석하여 현황모델을 만든다. 셋째로 현황모델과 기존연구들을 분석하여 문제점 모델을 만든다. 마지막으로 해외 설계시공일괄방식을 분석하여 성공요소와 환경을 찾아 성공적인 설계시공일괄방식의 모델을 구현한다. Among project delivery methods, Design-Build method is becoming an increasingly preferable alternative to traditional contracting method. The Design-Build delivery method was first introduced in Korea, 1975. But it still has been producing many problems. The previous researches had been suggested several ways to improve the Design-Build project delivery but it seemed to have had no effect whatsoever. This research proposes the success model for Design-Build delivery method through the 4 steps. First, find the proper modeling method. Second, establish the As-Is model for analyzing the circumstances of Design-Build method. Third, to begin with analyzing the As-Is Design-Build model and previous researches, establish the problem model. Finally, find success factors and circumstances through the overseas Design-Build system, and then establish the success Design-Build model.

BIM기반 표준시장단가 우선적용 공종 분석

김정훈 ( Jin Zheng-xun ),백승호 ( Baek Seung-ho ) 한국건축시공학회 2022 한국건축시공학회 학술발표대회 논문집 Vol.22 No.1

Recently, the application of BIM has been continuously expanded according to various government policies, and the application performance is being analyzed in BIM projects such as roads and railways. In line with this trend, the government is making additional efforts to introduce full-scale design BIM. The BIM design in the public sector is directly related to the estimated price. However, looking at the current status of BIM introduction, there is no support system in place for calculating the estimated price. Therefore, this study intends to analyze the priority activity that is easy to develop BIM unit price among the construction standard unit Price of construction work. In this study, in order to derive the BIM-based priority activity, BIM application statements and application guidelines were analyzed. As a result of the analysis, cast-in-place concrete construction (civil engineering) and reinforced concrete construction (architecture) were deduced as suitable construction activities for the preferential application of BIM. Since the results presented in this study are a rough analysis, it is judged that additional detailed analysis is necessary for the future.