봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

산업단지 및 일반생활 지역의 공기 중 톨루엔에 대한 개인노출 및 생체시료의 상관성 분석

이병준(Byoungjun Lee),허 정(Jung Heo),정다영(Dayoung Jung),김순신(Sunshin Kim),류현수(Hyeon-Su Ryu),최민지(Min-Ji Choi),솨이지엔페이(Jian-Fei Shuai),임성국(Sung-Guk Im),양원호(Wonho Yang) 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.4

Objectives: The purpose of this study was to assess the correlation relationship between personal exposure and urinary hippuric acid in biological monitoring for airborne toluene in an industrial complex and in general environments. Methods: Personal exposure to toluene and its metabolite, hippuric acid, in urine were simultaneously measured in occupational environments area near an industrial complex and in general environments. The study subjects were divided into three types: 137 workers who use organic solvents in the workplace, 210 residents living near a dyeing industrial complex, and 379 residents living in general environments. The toluene exposures of workers and residents were measured by a passive sampler for four days. The urine of participants was sampled when the passive samplers of personal exposure were collected. Results: The toluene and hippuric acid concentrations of workers were the highest, followed by the concentrations of residents living near a dyeing industrial complex and residents living in general environments. The coefficient of correlation between the concentrations of toluene and hippuric acid among workers was 0.749 (p<0.01) in the workplace. On the contrary, correlations between the concentrations of toluene and hippuric acid among residents living near a dyeing industrial complex and residents living in general environments were all not significant. The relationship between the concentrations of hippuric acid and toluene in three types could be described by the exponential growth model. Conclusions: This study analyzed the relationships between toluene exposure and the concentrations of hippuric acid in urine in high, middle, and low exposure environments, and could be described by the exponential growth model.

고포도당이 백서 사구체 메산지움 배양세포에서 p38 MAPK 활성화 및 Fibronectin 생성에 미치는 영향

유태현 ( Yu Tae Hyeon ),허종호 ( Heo Jong Ho ),류동열 ( Lyu Dong Yeol ),김현욱 ( Kim Hyeon Ug ),이수현 ( Lee Su Hyeon ),김진주 ( Kim Jin Ju ),정동섭 ( Jeong Dong Seob ),최규헌 ( Choe Gyu Heon ),이호영 ( Lee Ho Yeong ),한대석 ( Han 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.5

목 적 : 고포도당으로 자극한 백서 메산지움 배양세포에서 p38 mitogen activated protein kinase (MAPK)의 활성화와 p38 MAPK의 상부와 하부인자로 알려져 있는 MAPK kinase 3/6 (MKK3/6)와 c-AMP responsive element binding protein (CREB)의 활성화, 그리고 fibronectin 합성을 자극 시간에 따라 관찰하고, p38 MAPK 경로와 fibronectin 합성 사이의 연관성을 규명함으로서 당뇨병성 신증의 병태생리를 규명하고자 하였다. 방 법 : 백서 메산지움 배양세포를 정상 포도당 (5.6 mM), 고포도당 (30 mM), 또는 정상 포도당+만니톨 (24.4 mM)로 자극한 후 첫째 p38 MAPK; 둘째 p38 MAPK의 상부 인자인 MKK3/6; 셋째 p38 MAPK의 하부인자인 CREB; 넷째 MAPK phosphatase-1 (MKP-1)의 변화를 자극 시간 (3분-48시간)에 따라 Western blot을 이용하여 관찰하였으며, 다섯째 fibronectin의 변화는 RT-PCR과 ELISA를 이용하여 확인하였다. 결 과 : 고포도당으로 자극한 백서 사구체 메산지움 배양세포에서 p38 MAPK 경로가 활성화 되었다. Total p38 MAPK 단백은 변화가 없었으나, 활성화된 phospho-p38 MAPK 단백은 고포도당군에서 자극 10분 후부터 정상 포도당군에 비해 의의있게 증가되었으며 (평균 1.9배), phospho-CREB 단백 역시 고포도당군에서 자극 10분 후부터 의미있게 증가되었다 (평균 2.5배). 이에 비해 p38 MAPK의 상부인자인 phospho-MKK3/6는 고포도당군에서 자극 3분 후부터 의의있게 증가되었다 (평균 2.4배). 또한, MKP-1 단백 발현은 고포도당군에서 p38 MAPK의 활성이 증가하기 시작한 시기와 동일한 시기 (자극 10분 후)부터 증가하기 시작하였다 (평균 1.9배). Fibronectin mRNA와 세포 배양액내 fibronectin은 고포도당군에서 자극 48시간 후에 각각 1.7배와 1.5배 증가되었으며, 이러한 증가는 p38 MAPK 억제제인 SB203580 (1 μM)에 의해 각각 73%와 69% 억제되었다. 결 론 : 고포도당으로 자극한 백서 사구체 메산지움 배양세포에서 p38 MAPK 경로의 활성화를 확인하였으며, p38 MAPK 억제제가 고포도당에 의한 fibronectin의 합성 증가를 억제시키는 것으로 보아 당뇨병성 신증에서 관찰되어지는 fibronectin의 축적에 p38 MAPK 경로가 관여할 것으로 생각된다. Background : The p38 mitogen-activated protein kinase (MAPK) pathway is activated by several stress factors, potentially leading to cellular apoptosis and growth. Little is known about the pattern of p38 MAPK pathway activation in mesangial cells under high glucose conditions. We examined the activity and expression of p38 MAPK members, 1x78 MAPK, MAPK kinase 3/6 (MKK3/6), c-AMP responsive element binding protein (CREE), and MAPK phosphatase-l (MKP-1) in cultured rnesangial cells exposed to high glucose. Methods : Mesangial cells were subcultured from rat glomeruli isolated by sieving technique. After serum restriction for 48 hours rnesangial cells were exposed to 5.6 mM glucose (low glucose, LG), 5.6 mM glucose+24.4 mM mannitol (LG+M), or 30 mM glucose (high glucose, HG) for 3 minutes to 48 hours with or without SU203580. Western blot was performed to determine the activity and protein expression of p38 MAPK members. R`I-I`CR and ELISA were performed for fibronectin mRNA expression and fibronectin synthesis, respectively. Results : p38 MAPK and CREB activities were significantly increased in rnesangial cells exposed to FIG compared with LG or LG+M after 10 minutes and was sustained at higher levels to 48 hours (p<0.05), but total p38 MAPK and CREB protein expressions did not differ. MKP--1 showed a similar pattern as p 3 MAPK and CREE (p<O.O.i). MKK3/6 acitvity was significantly higher in HG cells after 3 minutes and remained at higher levels throught the study period (p<0.05). Fibronectin mRNA expression and fibronectin synthesis were significantly increased in mesangial cells exposed to HG after 48 hours (p<0.05). SB203580 (1 pM) pretreatment for 1 hour significantly reduced HG-induced fibronectin mRNA expression and fibronectin synthesis by 73% and 69%, respectively (p<0.05). Conclusion : p38 MAPK activity was increased in mesangial cells exposed to HG in parallel with increased MKK3/6 activity, resulting in CREB activation and increased fibronectin synthesis. This activated p38 MAPK may play a role in the pathogenesis of diabetic nephropathy.

3,4-Dihydroxyphenyl-L-alanine의 효소적 생산에 대한 반응첨가물의 영향

이승구,노현수,홍승표,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

재조합 대장균에서 과발현된 Citrobacter freundii KCTC 2006 유래의 tyrosine phenol-lyase(E.C.4.1.99.2) 이용 3,4-dihydroxyphenyl-L-alanine (L-DOPA)의 생산에 대한 반응첨가물의 영향을 조사하였다. 반응액 중 효소 및 조효소 농도의 영향을 조사한 결과, 효소농도는 약 2 units/ml이 적합하였으며, 조효소인 pyridoxal -5-phosphate 는 0.1 mM 이상이 필요하였다. Pyrocatechol과 결합하여 안정한 복합체를 형성하는 sodium borate는 pyrocatechol에 의한 효소의 불활성화를 감소시키는 효과가 있었으나, 효소의 반응성을 현저히 저하시켜 L-DOPA 생산의 관점에서는 불리한 단점도 있었다. 한편, 알콜류 등의 유기용매가 L-DOPA 합성반응에 미치는 영향을 조사한 결과 methanol을 5% 농도로 반응액에 첨가하였을 때, 효소의 반응과 안정성이 크게 증가하여 L-DOPA 합성반응이 지속적으로 수행됨으로써 고농도의 L-DOPA를 효율적으로 생산할 수 있게 되었다. 생산된 L-DOPA의 약 77%가 불용성 상태로 침전되어 쉽게 회수할 수 있었으며, 침전된 L-DOPA를 1N HCI에 용해한 후 재결정화 함으로써 최종적으로 99.96%의 고순도 L-DOPA를 생산할 수 있었다. The enzymatic synthesis of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) was examined for the effects of the reaction additives such as sodium borate, alcohol, and organic solvents. The enzyme used was tyrosine phenol-lyase of Citrobacter freundii KCTC 2006 produced in Escherichia coli. The amounts of tyrosine phenol-lyase and pyridoxal -5-phosphate were optimized to 2.0 units/ml and 0.1 mM, respectively, for the synthetic reaction. Sodium borate, a substance that forms a complex with pyrocatechol, reduced the enzyme deactivation by pyrocatechol although it seriously inhibited the enzyme activity. Among the organic solvents tested, dimethylsulfoxide, dimethylformamide, and alcohol increased the productivity of the L-DOPA synthesis. In a reaction system with 5% methanol, L-DOPA concentration increased up to 210 mM after 24 hours, and 77.1% of which was separated as precipitates. The L-DOPA was purified to 99.96%

극장 관람료의 합리적 분배에 관한 연구

이현승,맹수현 영상예술학회 2009 영상예술연구 Vol.15 No.-

부율이란 부금비율의 약칭으로 극장에서 거두어들인 입장수입에서 세금을 제한 후, 배급사와 극장 측이 약정에 따라 수입을 분배하는 비율을 의미한다. 국내에서는 통상 서울 지역의 경우 한국영화는 5:5, 외국영화의 경우 6:4(배급사:극장)로 배분하고 있으며, 지방의 경우 한국 영화와 외국영화의 구분없이 5:5의 배분을 하고 있다. 이는 1980년대 후반 할리우드 영화의 직접배급이 시작되면서 할리우드 영화에 비해 한국 영화의 경쟁력이 취약하여 생긴 관행이다. 하지만 한국 영화의 점유율이 15~30%를 유지했던 8·90년대와는 달리, 평균 50~60%의 점유율을 기록하고 있는 2000년대 이후까지 과거의 관행이 유지되고 있다는 것에는 문제가 있다. 또한 2002년부터 한국 영화의 투자 수익률이 하락하고, 투자, 제작, 배급, 홍보 및 마케팅 등 1차 상영관련 시장의 수익률이 적게는 10%에서 많게는 60% 이상의 마이너스 행진을 기록하고 있는 상황 속에서, 극장 상영부분만이 유일하게 이익을 보고 있다는 것은 산업내 왜곡된 수익구조가 존재한다는 의미이기도 하다. 미국이나 일본, 프랑스에서 극장의 관람료 수익 분배 비율은 10~50% 정도이다. 이를 한국 부율 관행과 비교한다면 그리 나쁘지 않은 수익 분배라고 생각할 수 있으나 사실은 그렇지 않다. 세계적으로 윈도우별 영화시장의 규모 중 극장 매출은 31%이다. 즉 극장 이외의 다른 수익 창출 구조가 안정적으로 유지되고 있다는 뜻이다. 하지만 한국의 경우 부가판권 시장의 몰락으로 투자자에게 돌아가는 수익 중 극장 매출이 차지하는 비율은 전체 매출의 약 80%이다. 그렇기 때문에 극장 관람 수입의 합리적인 배분은 그 어느 나라보다 절실한 실정이다. 영화 산업 내 각 분야의 주체들에게 합리적으로 수익이 분배되기 위해서는 다음의 네 가지 사안들이 고려되어야 한다. 첫째, 제작비, 작품의 가치, 흥행 예상 기대치, 마케팅 규모 등을 두로 고려하여 각각의 작품들은 개별적인 부율 책정에 들어가야 한다. 둘째, 미국의 슬라이딩 시스템이나 프랑스의 ‘월요일 협상(au lundi)’, ‘극장의 ‘통로’(Les ‘couloirs’ de salles)’ 방식과 같이 기간에 따라 차별적인 부율을 적용해야 할 것이다. 셋째, 한국 영화산업의 특수성을 고려한 부율 조정이 필요하다. 넷째, 공정한 거래 절차를 유지하여 바람직한 계약 관행을 확립해야 할 것이다. 한국 영화 산업 내에서 부율 책정은 그동안의 오랜 관행으로 각각의 이익집단간의 이해가 상충하여 쉽게 개선이 될 수 있는 문제는 아닐 것이다. 그러나 이는 한국 영화의 투자·제작 기반을 튼튼히 하여 극장에서도 지속적으로 양질의 콘텐츠를 수급할 수 있도록 하기 위함이며, 나아가 각 사업 분야 모두 합리적인 이익 창출을 통한 안정적인 수익 구조를 실현하여 영화 산업 전반의 성장을 구현하기 위함이다. 또한 합리적 부율 책정을 통해 한국 영화계의 과제인 다양성 영화의 안정적 제작·배급의 풍토 역시 마련될 수 있을 것임을 기대해본다. Box-office split stands for the rate of distribution of box-office earnings between a distributor and a movie theater according to an agreement between them after deducing tax from the earnings. In Seoul, box-office split is usually 5:5 (distributor:movie theater) for domestic movies and 6:4 for foreign movies. In domestic local areas, it is 5:5 in general, regardless of the origins of movies. The difference of box-office split between domestic and overseas movies has been derived from the lower competitiveness of domestic movies than Hollywood movies since Hollywood movies were directly distributed in the late days of the 1980s. The market share of domestic movies was only 15~30% in the 1980s and 1990s, but it has changed to 50~60% since the 2000s. In this vein, still maintaining the past practice is problematic. Besides, since 2002, the investment returns of domestic movies have decreased gradually and the earning rates of primary screening-related market activities, such as investment, production, distribution, publicity and marketing, has been reduced in the rate of minimal 10% to maximal 60%. However, there still exist profits in the part of movie theaters. It means that there is a distorted earning structure in the domestic film industry. The rate of distribution of box-office earnings in the United States, Japan and France is 10~50%. Comparing to the domestic rate, it seems to be not bad. However, it is not the case in reality. In the world, the sales amount of movie theaters occupies only 31% of total earnings which come from all the sales windows of movie market. This means that in overseas film industry there are stable earning structures other than movie theaters. However, with the destruction of domestic additional copyright market, the sales amount of movie theaters occupies 80% of investors' total income in the domestic film industry. Therefore, it is urgent to rationally distribute the box-office earnings of domestic movie theaters. In order for the box-office earnings of domestic movie theaters to be rationally distributed among all the parties of film industry, following four alternatives must be taken into account:First, each movie must have its own box-office split considering production cost, the value of movie, expected box-office value, marketing scale and so on;second, like American sliding system or French ‘au lundi’ and ‘Les couloirs de salles’ systems, differentiated distribution rates must be applied on the basis of the period; third, we need an adjustment considering Korean films industry's speciality; and fourth, fair transaction procedures and proper contract practices must be established. Since the existing box-office split is a practice of long standing and the interest of every party is contrary, the establishment and improvement of rational box-office split in domestic film industry seems to be not easy. However, to establish a rational box-office split is necessary for strengthening the investment and production base of domestic movies and supplying quality movies to movie theaters. In addition, it is necessary to establish a rational investment return-based stable earning structure for all the related fields of film industry and thus realize the growth of the film industry in general. The investigator hopes that with the establishment of rational distribution rate, the environment of stable production and distribution of diverse movies, a task of long standing in the domestic film industry, will be created in the future.

풍촌 석회암의 소성에 관한 연구

이재장,노범식,장경호,정수현 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

본 연구는 여러 가지 용도에 적합한 생석회를 생산하기 위하여 풍촌 석회석을 대상으로 소성시험을 하였다. 시료의 형상은 주로 정방형이나 때로는 구형을 나타내며, 배색 내지 회백색을 띈다. 소성시험에 사용한 시료의 크기는 45∼50㎜ 이며, 소화시험에서는 3.3mm(6mesh) 이하로 분쇄하여 소성하였다. 시료의 광물학적 특성을 보기위하여 편광현미경 관찰, X-ray 분석, 열분석을 하였다. 시료는 거의 순수한 CaCO₃이었으며, 600℃ 부터 열분해가 시작되어 850℃에서 완결되었다. 화학분석 결과 CaO 98.27%인 잠재적 순도를 갖는 생석회를 얻을 수 있음을 알 수 있다. 대략 50 ㎜ 정도의 석회석은 전기로의 온도가 실온에서 1,050℃에 도달하였을 때 99%이상이 소성되었다. 이 때 얻어진 생석회는 거의 순 백색이며 갈라짐이 없었다. 소화시험 결과 ASTM C-110에 의하면 반응성이 우수한 생석회인 것을 알 수 있으며, 1분 이내의 상승온도는 63℃ 이었다. In this study, the calcination characteristics of Pungchon limestone was investigated to produce the optimum quick lime for various uses. The shape of limestone sample was mainly cubic, but sometimes longish. Approximate size range for the calcination tests was from 45 to 50 mm. For the slaking test, it was crushed by cobbing method and screened by 3.3 mm(6 mesh) screen. Mineralogical studies of the sample were carried out to investigate textures, X-ray diffraction analysis and thermal analysis. The result of chemical analysis shows a very high grade limestone with a CaO potential of 98.27%. Approximate 50 mm size's of limestone, about 250 g was calcined more than 99% when the calcination temperature arrived at 1,050 ℃ from room temperature in the electric laboratory furnace. Lumpy lime in nearly white colour with nearly no cracks was observed during calcining test. and during calcination process the limestone places kept their shape. Slaking test(ASTM C-110 ) results indicate a high reactivity product. In slaking, a 63℃ temperature rise was achieved within the first one minutes.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

RT-LAMP를 이용한 콩황화일반모자이크바이러스의 진단

배대현, 이영훈, 김봉섭, 윤영남, 강범규, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

Soybean yellow common mosaic virus (SYCMV) has been recently reported, it has been occurred a lot with Soybean mosaic virus (SMV) and Soybean yellow mottle mosaic virus (SYMMV) in soybean field. SYCMV belongs to genus of Sobemovirus and induced viral symptoms with yellowing, mottle and mosaic. A reverse transcription loop-mediated isothermal amplification (RT-LAMP) method allowed one-step detection of gene amplification by simple procedure and needed only a simple incubator for isothermal template. This RT-LAMP method allowed direct detection of RNA from virus-infected plants without thermal cycling and gel electrophoresis. In this study, we designed RT-LAMP primers named SYCML-F3/B3/FIP/BIP from coat protein gene sequence of SYCMV. After the reaction of RTLAMP, products were identified by electrophoresis and with the detective fluorescent dye, SYBR Green I. under daylight and UV light. Optimal reaction condition was at 63 for 60min and the primers of RTLAMP showed the specificity for only SYCMV tested in this study.

치아전돌자와 치아밀집자의 측모두부방사선학적 비교

이연수,황현식,강병철 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.4

The purpose of this study was to examine the difference of lateral cephalometric charateristics between dental protrusion and crowding individuals and to find out the possible etiologic factors of each malocclusion. Twenty nine dental protrusion and twenty two crowding individuals were selected from the 4,500 patient records. The tooth size was measured from central incisor to first molar using diagonstic study cast and was compared between two groups. After tracing the lateral cephalometric radiographs, measurements for skeletal factor, hyoid bone position, and incisal position were identified. The means and standard deviations of the measurement of each group were calculated and compared between two groups. Through the comparison of the measurement between two groups, following results were obtained 1. As a result of comparing the tooth size of dental protrusion group with that of crowding group, there was no significant difference between two groups. 2. In the comparison of skeletal measurements, S-N, A'-Ptm', SNA, ANB, and facial convexity of protrusion group showed greater value than crowding group. 3. The measurements of hy-PP and hy-MP showing vertical position of hyoid bone were smaller in protrusion group than those in crowding group. 4. The measurement of hy'-Go showing anteroposterior position of hyoid bone was larger in protrusion group than that in crowding group. The results of the present study showed that dental protrusion inidviduals had the tendency of maxillary protrusion and antero-superior position of the hyoid bone compared to crowding individuals, and these features could be explained as possible etiologic factors of dental protrusion or crowding malocclusion.

인체 지방 및 간장조직 중 유기염소제류 및 PCB의 확인 및 정량기법 체계화 : 2차년도

이상기,양자열,김기욱,이수연,오승민,김대현,정규혁 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-