Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

가르친다는 것(Teaching)의 세 가지 접근

박수연 이화여자대학교 교육과학연구소 2001 교육과학연구 Vol.32 No.1

이 논문에서는 가르친다는 것(교수:teaching)에 대한 세 가지 접근을 가지고 교사의 교수 역할을 이론적으로 분석하고 이에 따른 비평을 하였다.가르친다는 것을 (1) 관리자로서의 접근; (2) 치료자로서의 접근; 그리고 (3) 자유주의자로서의 접근으로 설명을 하였다.이 접근들은 각각 교사를 (1) 가장 효과적인 기술을 이용하여 학생들의 학습이 이루어지게 하는 사람으로; (2) 학생들을 개인적으로 자라게 하고 자기실현, 자기수용에 도달하게 하는 인정 있는 사람으로; 그리고 (3) 학생들을 무지와 편견으로부터 자유롭게 하고, 자율적이며 합리적이며 도덕적으로 발전시켜 주는 사람으로 보게 한다.이 세 가지 접근은 가르친다는 것이 무엇인가라는 개념 이해에 도움을 주며 개념 이해는 실제 상황에서 개인적, 교육적 문제 그리고 윤리적 문제를 해결하는 데 응용될 수 있는 중요한 역할을 한다. 이 연구는 실제 가르치는 위치에서 이 접근들을 유용하게 적용할 수 있는지에 대한 논의도 시도하였다.현실적으로 교사는 어떤 때에는 관리자가 될 수 있고 다른 때에는 치료자가 될 수 있으며, 또 다른 때에는 자유주의자가 될 수 있다는 것이다.사실상, 교수 상황이 그렇게 해야 될 수밖에 없을 때도 있게 된다는 것이다.학생들이 학교에서의 경험으로부터 가능한 한 가장 많이 얻을 수 있게 하기 위하여 이 세 가지 접근을 어느 정도 통합해야 할 것이다. This article analyzes teaching on the basis of three new approaches.The three approaches on which this theoretical analyzation is based include the executive approach, the therapist approach and the liberationist approach.The executive approach views the teacher as an executor, a person charged with bringing about certain learnings, using the best skills and techniques available.Contemporary research on the effects of teaching and learning is very important to this approach.The therapist approach views the teacher as an empathetic person charged with helping individuals grow personally and reach a high level of self-actualization, understanding and acceptance.Humanistic psychology and existential philosophy underwrite this view, which focuses on students' developing their own selves as authentic persons through personally meaningful educational experiences.The liberationist approach views the teacher as a liberator, a freer of the individual's mind and a developer of well-rounded, autonomous, rational and moral human beings.The classical idea of a liberal education underwrites the contemporary mainstream version of this approach. This conceptual understanding is significant in that it stimulates teachers to think about ways to conceive their teaching role.How teachers conceive of their teaching role has a great effect on what they do as a teacher.What a teacher thinks teaching is determines what kind of teacher he is going to be.Conceptual understanding also helps teachers when they make practical applications and face personal, pedagogical and moral educational issues. This study also discusses how teachers can apply the theoretical conceptions in practical situations in teaching.A teacher can, for example, be an executive at times, a therapist at others, a liberationist at still others.In fact, there seem to be situations in teaching that call on a teacher to do that.This study suggests that in order to let students gain to the fullest extent possible from their experiences at school, teachers must try to integrate these three approaches to certain degrees.

구내방사선사진의 프랙탈 분석을 이용한 골다공증 예측

박금미,정연화,나경수 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : The purpose of this study was to investigate whether the fractal dimension and radiographic image brightness of periapical radiograph were useful in predicting osteoporosis. Materials and Methods : Ninety-two postmenopausal women were classified as normal, osteopenia and osteoporosis group according to the bone mineral density of lumbar vertebrae and periapical radiographs of both mandibular molar areas were taken. The ROIs of 358 areas were selected at periapical and interdental areas and fractal dimension and radiographic image brightness were measured. Results : The fractal dimension in normal group was significantly higher than that in osteoporosis group at periapical ROI (P<0.05). The radiographic image brightness in normal group was higher than that in osteopenia and osteoporosis group. There was significant difference not only between normal and osteopenia group (P<0.05) but also within osteopenia and osteoporosis group (P<0.01) at periapical ROI. Significant difference was observed not only between normal and osteopenia group but also between normal and osteoporosis group at interdental ROI (P<0.01). Positive linear relationship was weakly shown at Pearson correlation analysis between fractal dimension and radiographic image brightness. BMD significantly correlated with fractal dimension at periapical ROI (P<0.01), and BMD and radiographic image brightness significantly correlated at both periapical and interdental ROIs (P<0.01). Conclusion : This study suggests that the fractal dimension and radiographic image brightness of periapical ROI may predict BMD.

Cone-beam CT를 이용한 안면비대칭자에서 이부편위에 따른 치성보상의 양상분석

박수병,박정희,정연화,조봉혜,김용일 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

Objective: The purpose of this study was to evaluate the correlation between menton deviation and dental compensation in facial asymmetry. Methods: Tooth axis and distance of first molar and canine to the reference plane were investigated by cone-beam computerized tomography. The subjects consisted of 50 patients with asymmetric mandibles (male 21, female 29, mean age 24.3 years). Control groups were also assessed (male 11, female 9, mean age 25.6 years). Nine measurements (5 linear measurements and 4 angular measurements) were measured in order to evaluate the correlation between menton deviation and the linear and angular difference of first molar and canine in the deviated and none-deviated sides using the defined MPR images. The differences between deviated and non-deviated side, according to menton deviation, were statistically analyzed using stepwise multiple regression analysis. Results: From the result, Menton deviation was negatively correlated with mandibular first molar's angular measurement (Δ∠LM6-Mn plane (dev.-ndev.)) and positively with maxillary fist molar's angular measurement (Δ∠UM6-FH plane (dev.-ndev.)) (p < 0.01). Two angular measurements (Δ∠ LM6-Mn plane (dev.-ndev.), Δ∠UM6-FH plane (dev.-ndev.)) explained the variability in menton deviation with a significant r² value of 0.589. Conclusions: This study suggests that the tooth axis of upper and lower first molars leans towards the deviated side of Menton when there is mandibular asymmetry with Menton deviation. 본 연구는 Cone-beam CT의 MPR이미지상에서 하악골 평면에 대한 하악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이 그리고 FH 평면에 대한 상악 제1대구치와 견치의 편위측과 비편위측의 높이와 각도차이를 계측함으로써 안면비대칭자에서 이부편위에 따른 편위측과 비편위측의 제1대구치와 견치의 높이와 협설측 경사도를 CBCT를 이용하여 분석하고 그 관련성을 알아보는 데 있다. 연구대상은 하악골의 이부편위를 동반한 안면비대칭 환자 50명(여자 29명, 남자 21명, 평균나이 24세 4개월)으로 하였다. 대조군으로 평균나이 25세 7개월인 20명(남자 11명, 여자 9명)을 분석하였다. 결과는 이부편위에 대해 FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 길이 및 각도 차이(편위측 - 비편위측)는 대조군에 대해 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 비대칭군에서 상악 제1대구치 각도는 편위측이 비편위측보다 평균 8.62 ± 5.95˚ 컸다 (p < 0.01). 상악 견치의 경우에도 편위측과 비편위측의 각도차이가 평균 4.48 ± 5.05˚로 통계적으로 유의한 차이가 존재하였다 (p < 0.01). 하악골 평면에 대한 하악 제1대구치의 수직 길이와 각도는 편위측과 비편위측에서 통계적으로 유의할 만한 차이가 존재하였다 (p < 0.01). 각도의 차이는 평균 -11.92 ± 5.79˚로 나타났다. 이부편위에 대한 상하악 제1대구치와 견치의 수직거리 및 각도의 Pearson 상관분석 및 회귀분석 결과, FH 평면에 대한 상악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠ UM6-FH plane (dev.-ndev.))는 통계적으로 유의한 양의 상관관계를 나타내었고, 하악골 평면에 대한 하악 제1대구치의 편위측과 비편위측의 각도차이(Δ∠LM6-Mn plane (dev.-ndev.))는 통계적으로 유의한 음의 상관관계를 나타내었다. 이상의 결과에서 이부편위를 동반한 하악골 비대칭이 존재하는 경우, 이부가 편위되는 방향으로 상하악 제1대구치의 치아장축의 각도가 변화되는 것으로 나타났다.

소장 질환이 의심되는 환자에서 캡슐내시경과 CT 소견의 비교

이성수,홍성숙,김정훈,김연수,김진오,권석범,박성태,장윤우,최득린,권귀향 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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여성 하부요관석환자에서 무마취하 요관경하 배석술

박영호,송윤섭,임용순,김영호,이남규,구자현,서병욱,김민의,전윤수 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Although ureteroscopy(URS) has been used widely to remove ureteral calculi, there is an argument against the belief that anesthesia or admission is needed for URS. We evaluated the experience of URS without anesthesia in female patients. From September 1997 to July 1998, URS was performed in 31 female patients without anesthesia. EHL(Electrohydraulic Lithotripsy) was used in 21 patients with impacted or large stone over 5mm. All patients were given oral antibiotics for 3 days and follow-up KUB was taken to confirm successful removal of the stone one week after the procedure. Successful treatment was defined as complete removal of the stone or residual fragments less than 2mm. Overall success rate was 96.7%(30 cases among 31 cases). All but one patient tolerated with analgesia through the entire procedures. There were only minimal complications such as mild flank pain and hematuria. So, we recommend that non-anesthetic ureteroscopic removal of stone as the first choice for treatment of lower ureteral stones in female based on the minimal morbidity, high success rate and low cost.

산지하천의 강우특성에 의한 부유물질 유출에 관한 연구

윤인규,박수진,최한규 강원대학교 산업기술연구소 2007 産業技術硏究 Vol.27 No.A

In this research, we have selected the region of Jawoon river that is the area of high land vegetable growing in the upper Soyang Reservoir and we have observed actual floating materials that generate negative nutrition and turbidity of the Reservoir water and the changes of water quality by raining of each month for one year of 2005 in order to monitor the relationship of pollution sources by the outflow of rain water. In addition, we also have conducted statistical inspection methods such as correlation analysis and regression analysis on strength of raining force and rain continuance time among the elements affecting the outflow of floating materials.

Bioceramics 종합공영균이 과채류 생육에 미치는 영향

박평수,채윤석,최황 진주산업대학교 농업기술연구소 1997 農業技術硏究所報 Vol.10 No.-

Bioceramics 종합공영균양액의 처리가 오이의 생육 및 수량, 방울토마토와 부강고추의 생육에 미치는 영향을 연구하여 얻은 결과는 다음과 같다. Bioceramics 양액 시여구에는 대조구에 비해 오이, 방울토마토 및 부강고추의 엽수, 초장, 경경, 근장, 전체중량, 엽장 및 엽폭이 양호한 편으로 건강한 식물체를 생산할 수 있었고, 오이의 수확량도 상당히 많은 증수의 결과를 얻었다. 향후 Bioceramics 양액의 시여가 토양에 미치는 영향과 양액의 조성 및 시여방법 등에 관한 보다 세밀한 연구가 필요할 것으로 사료된다. This study was carried out to find the effect of bioceramic contained complex microorganisms on the growth and yields of cucumber, small bell type tomato and pepper plants. The number of the leaf, length of the plant and the root, total weight, the length and width of the leaf of treated plants had shown their significant effects than those of nontreated plants. Bioceramic solution produeced healthy plants and the higher yields especially in cucumber plants. It is required futher study for soil effectiness, the composition and applying methods of Bioceramic fertilizer.

행동억제(behavioral inhibition) 연구의 최근 동향

박성연,박수연 이화여자대학교 생활환경대학 인간생활환경연구소 2004 인간생활환경연구소 논집 Vol.- No.2

The purpose of this study was to review empirical research on behavioral inhibition in children. This study examined a stream of preceding researches by taking a view of relationships of behavioral inhibition in children and characteristics of children and parents. Characteristics of children included temperament, sex, change of age, order of birth and characteristics of parents included parenting behavior such as sensitive parenting, controlled parenting, disapproval parenting, and overprotective Parenting. Moreover, this study analyzed thee cross-cultural researches of behavioral inhibition.

동일한 시료에 대한 국내 기관간의 STR 분석결과 비교 : STR 유전자좌 분석법의 표준화 설정을 위하여

박종태,신경진,양윤석,우광만,이숭덕,이승환,이정빈,정연보,조승희,한길로,한면수,홍승범 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

This paper described a collaborative exercise intended to see what kinds of short tandem repeat (STR) loci are used in different DNA typing laboratories in Korea and to compare their results for the demonstration whether uniformity of DNA profiling results from different laboratory could be achieved in Korea Laboratories were asked to test five tissue DNAs using methods routinely used in each laboratory and to report the results to the coordinating laboratory. The exercise demonstrated that each laboratory was using different STR loci for the typing with different STR numbers,2 VNTRS,36 STRs and amelogenin in total, and the direct comparison of the results from all the laboratory for the 18 loci could not be done as only one laboratory submitted typing results. Among 21 loci for which several laboratories submitted typing results, results for 14 loci were the same and results for the other 7 loci were different depending on the participating laboratory. D1S80, F13A01, D16S539, D21S11, D18S51, D3S1744 were the loci with different typing results. Even in the cases where commercial kits were used, the results were not the same depending on the machines used, that is the capillary electrophoresis or the gel based electrophoresis. The reason for the different results, points about the standardization of the methods arid the profiling data were described.