Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

육가공 제품에 대한 인식현황과 인식에 관한 조사

조정순,김성희 명지대학교 자연과학연구소 1994 자연과학논문집 Vol.11 No.-

본 연구소에는 서울시내 학교급식을 하고 있는 5학년 어린이와 학부모를 대상으로 하여 육가공제품의 이용현황과 인식에 대한 조사를 통해 육가공 제품에 대한 식품 선택 기준의 중요성을 어느 요소에 두고 있음녀 선호하는 조리방법은 무엇이고 육가공 제품의 영양적인 면, 위생적인 면, 첨가물에 대한 올바른 인식이 얼마나 되었나를 알아보았다. 또, 영양교육 차우너에서 육가공 제품의 선택, 이용방법, 영양, 위생 그리고 첨가물에 대한 올바른 인식을 조사하였다. This was to investigate utilization state and cognition of cured-meats inas public elementary school and a private elementary school children attenting school lunch program. The subjects of this study consisted of 551 children and 495 parents. 1. An alterativ motive if cured-meats; 1)45.4% of public elementary school children and 48.8% of private school children liked hams in cured -meats. 2)public elementary school children ate cured -meats once per week and private elementary school children ate cured -meats 2-3 times per week. It is described that 43%of respondents ate cured-meats at evening meal. 3)A kind of cured -meats using a snack was described that boys liked in the order of hamburger (21.5%)>jot dog(12.0%). 4)Children and parents made themost use of cured- measts because they are convenient.

2년간의 융모막융모생검 성적

조태호,차상헌,이임순,유훈 순천향대학교 1989 논문집 Vol.12 No.3

Chonionic villus sampling for the first trimester prenatal diagnosis has the potential of becoming an attractive alternative to midtrimester amniocentesis. Prior to becoming a standard, however, considerable caution and monitoring is necessary to establish the accuracy and safety of the procedure. In this pursuit, we wish to present our experience and trial in the technical aspects and safety of chorionic villus sampling. Chorionic villi were obtained by transcervical catheter(Trophocan and S-1) or transabdominal 19 gauge spinal needle under the real-time ultrasound guidance. Both direct and cultivation method of chorionic villus for chromosome preparation were performed. The patients consisted of 135 pregnant women who did genetic chorionic villus sampling in 8 to 14 weeks gestation with genetic indications The results obtained were as follows: 1) The chromosomal abnormality was found in 7 cases(5.2%): 1 in 47, XX, +21, 2 in 46, XY, inv(9)(p11q 21), 1 in 15q partial trisomy, 2 in 47, XXY and 1 in 45, X/47, XXX. 2) The fetal loss was found in 4 cases(3.0%). These results suggest that chorionic villus sampling now be considered a vialbe and quite possibly an equal safe alternative to second trimester amniocentesis.

측두골 골절 : 임상적 및 방사선학적 분석 Clinical and Radiological Analysis

조성원,최순관,조성진,김범태,신원한,윤일규,변박장 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

The objective of this study is to review of the incidence of temporal bone fractures and complications resulting from temporal bone fractures and to analyze the correlation between clinical and radiological findings. A series of 49 patients who were diagnosed temporal bone fracture with rhinorrhea, bloody otorrhea, admitted to Soonchunhyang University Chon-an Hospital from January 1997 to September 1999, were studied retrospectively. Clinical analyses were focused on age, sex, type of accident, external wound site, CSF leakage, hearing loss and facial nerve palsy. The high resolution CT scan consisted of a series of 3-mm thick sections through the temporal bone using the GE CT scanner (General Electric Inc.). In radiologic analyses, fracture types of temporal bone were divided into longtudinal fracture(LF), transverse fracture(TF) and mixed fracture(MF) respectively. The CT scans were examined for mastoid antral haziness(MH), middle ear cavity haziness(MeH), ossicular chain disruption(OD), otic capsule fracture(OF), pneumocephalus(Pn). The type of facial canal fracture was classified as fracture of internal auditory canal portion(FIAC), fracture of perigeniculate portion(FPG), fracture of tympanic portion(FT), fracture of mastoid portion(FM). The correlation between clinical and radiological findings was analysed. A total of 49 fractured temporal bones resulted in 9 CSF fistula, 23 hearing loss( 13 conductive type, 7 sensorineural type), 17 facial nerve injuries ranging from mild paresis to complete paralysis. The mose common etiology of the injury was from a motor vehicle accident(28%). The type of fracture observed on high resolution CT scanning was a LF in 39(78%) patients, a TF in 7(14%) patients and a MF in 3(6%) patients. The majority of fractures terminate in the floor of the middle cranial fossa in LF and passed lateral to the otic capsule in TF. Average time of onset of delayed facial palsy was 3.5 days. No patient developed prolonged otorrhea or meningitis during hospitalization and there was no requirement of surgical management. Hearing loss was the most common complication of temporal bone fracture(48%). Conductive hearing loss was associated with middle ear cavity haziness and ossiclular chain disruption. in temporal bone CT. A total of 29 cases facial canal fracture in temporal bone CT resulted in 14 perigeniculate portion(FPG), 12 tympanic portion(FT), 3 mastoid portion(FM). There was no correlation between radiological facial canal fracture and clinical facial nerve palsy. Four of 17 patients with facial nerve injury required facial nerve exploration under general anesthesia. We thought that prognosis and therapeutic planning in patients with temporal bone fractures were based on the clinical and radiological findings.

원적산 봉수대 주변정비 기본계획

이상진,김기수,강영조,조승래,홍순연 東亞大學校 建設技術硏究所 2006 硏究論文集 Vol.29 No.2

문화재란 문화가치가 있는 사물로서 국가 가 종교적·세속적 근거에 따라 특별히 지정 한 재산이다. 문화재는 그것이 구현하는 정신적 가치와 시각적 음향적으로 표현하는 수단으로서 그 나라의 독특하고, 다양한 주체성을 보존하는 중요한 매체이기도 하다. 그러므로 문화재는 한나라의 민족역사와 문화로서 과거의 모습을 통해 현재 그리고 나아가 미래를 연결시키는 하나의 매개체인 것이다. 또한 문화재는 그 지역민에게 향토사적 인 자긍심 및 연대의식을 고취시키는 동시에 나아가 한 나라, 세계적인 관심사로 여겨 야 할 것이다. 원적산 봉수대는 양산군청 소재지에서 북쪽으로 약 9.2㎞, 통도사입구 마을인 신평에서 남쪽으로 8㎞지점에 있다. 이 봉수대는 경상남도 기념물 제 118호로써 원적산봉수대 보존회에 의해 복원된 문화재이다. 즉 다른 지역의 문화재와 달리 잊혀 져가는 문화재의 재생을 통해 다시 태어난 문화재인 것이다. 원적산 봉수대 주변정비 기본계획의 목적 은 지역민의 자긍심으로 복원된 봉수대와 주 변과 접근로를 체계적으로 정비를 함으로써 접근성, 전통성, 보존성을 높이고자 한다. 특히, 문화재보호를 위한 제반 법규 및 현지여건에 부합하는 정비방향을 설정하고, 전문 인력과 관련문헌을 바탕으로 문화재 주변을 역사성과 주민친화성, 기능성, 관광성을 함께 갖춘 문화공간으로서의 미래지향적 문화재정비 계획을 추구하고자 한다.

대구시 하수도 설계를 위한 기본 조사연구

조병하,이상렵,이순탁,함능수,나인엽,오창언,김자홍 경북대학교 1971 生産技術 Vol.5 No.-

This study is a "reconnaissance" of "preliminary" grade survery with the objectives of compiling and analyzing drainage systems, river pollution, hydraulic and hydrologic characteristics of sewage, and conservation of public water supplies for design of sewer systems in Taegu. In addition, it contains basis information for design of new sanitary sewage and drainage systems for Taegu. The results are shown as follows;1) Before attempting to design a sewage system, it was necessary to set up reliable standards for estinating sewage amounts. 2) The results of analysis and examination of Taegu's drainage systems. 3) The investigation of "sewage quality and river pollution in Taegu. 4) In order to maintain the B.O.D. value of the Kumho River below 8 ppm, a sewage treatment plant will be necessary. The basic information necessary in planning a treatment plant is given. This study is a summary of reseach that was conducted jointly by Kyung-Pook National Univ ersity's Insttute of Industrial Sciences and Young-Nam Universty's Institute of Industrial Sciences and Young-Nam University's Department of Civil Engineering. The study was begun on Novemver 4,1969 and completed on November 3,1970. By an agreement between the United States Agency for International Development and the Ministry of Science and Technology of the Republic of Korea, the work was financial out of the MO ST/USAID Trust Fnnd.

환경정책의 분권화를 통한 지역환경보전방안

조진상,조순철 동신대학교 환경연구소 2001 환경연구 Vol.6 No.1

그동안 학계, 관계, 환경운동단체 등에서 지방자치와 환경보존의 관계와 관련하여 많은 논의가 진행되었다. 지금까지의 논의를 살펴보면 지방자치가 환경보존에 미치는 부정적 영향에 대해 많은 우려를 표명하고 있음을 알 수 있다. 물론 악영향을 미리 예측하고 철저히 대비하는 자세는 필요하다. 그러나, 긍정적 영향을 올바르게 인식하고 관련된 정책목표와 수단을 개발하는 것도 똑같이 필요하다. 환경보존과 관련한 정부의 관심은 소위 '지역이기주의'의 극복방안, 광역환경 행정체제의 강화, 환경기초시설설치의 의무화 등 지방자치단체의 권한의 축소를 겨냥한 시도가 대부분으로 지방자치의 근본정신과는 상반되는 것들이다. 반면에 지방자치가 갖는 장점을 살리기 위한 각종 방안 예를 들면 지방자치단체의 환경보존 기능 또는 재정의 확충방안, 사전예방적 환경정책수단으로서의 지방환경영향평가제도의 도입, 지역환경관리계획의 수립, 지역환경기준의 설정, 환경행정절차에 있어서 주민참여 폭의 증대나 민주화 등에 관한 대책과 논의는 극히 제한적으로 이루어져 왔다. 지방자치와 환경보존의 두 기능이 서로 상충할 때 어느 정도까지 지방자치의 이념이나 가치를 포기할 것인가에 대해 답하기가 쉬운 것은 아니지만 양자의 목표를 조화롭게 달성하려는 노력이 절실하다고 하겠다. There was a lot of discussions about the theme of relations between local autonomy and environmental protection in Korea in the last decades. They have been focused on the negative effects of local autonomy on the environmental problems. For example, the central and local governments have interested in the matters about solving of so called 'regional egoism' in construction of environmental facilities, centralization of functions and finance for the environmental protection. and obligatory construction of communal environmental facilities. In the meanwhile, they have comparatively less interests in enrichment of functions and finance of local governments, introduction of local environmental impact assessment system, making and implementing of local environmental planning, setting up of the local environmental standards and strengthening of citizen participation process. In case of conflicts among the values of local autonomy and environmental protection, harmony among the both values is very important.

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

뇌졸중환자의 사회적 재적응과 관련요인

조남옥,서문자,김금순,김인자,최희정,정성희 성인간호학회 2001 성인간호학회지 Vol.13 No.1

Social readjustment is very important in rehabilitation of stroke survivors. The purpose of this study was to examine the level of social readjustment and related factors in stroke survivors. Especially, to find the most useful predictor for social readjustment is a major point of this research. The study included 254 outpatients who were given follow-up care after discharge from. Occupational rehabilitation and resumption of the perceived meaningful social activity prios to the stroke were used to measure social readjustment. The resumptions of first meaningful social activity was the best predictor for life satisfaction in stroke survivors(r=.245, p<.01). The substance of perceived meaningful social activities were job, meeting with friends, hobby and activities for the family. The sum of meaningful social activities (r = 175. p<.01) and occupational rehabilitation (r= 116, p<.05) were significantly related to life satisfaction. There were significant difference in IADL, depression and life satisfaction according to resumption of meaningful social activity. But, occupational rehabilitation was not related to depression. The level of social readjustment was different between occupational rehabilitation and resumption of meaningful social activity. It was 45.7% in the first meaningful social activity and 36.6% in occupational rehabilitation. The related factors with resumption of the first meaningful social activity were that of IADL, depression, illness intrusiveness and cognitive function. And the level of IADL, illness intrusiveness, cognitive function, and age were significantly related to occupational rehabilitation. In conclusion, we suggest that the resumption of the first meaningful activity in stroke survivors is the best predictor of social rehabilitation. Thus. nurses need to work for resumption of meaningful activity as well as occupational rehabilitation.

복령(茯笭)의 지방산 조성 및 항미생물 활성

조덕봉,마상조,최춘순,이송주,최옥범 광주보건대학 1997 論文集 Vol.22 No.-

The various components and antimicrobial activities of Pona cocos were studied to obtain the basic data as giving many applications. In the results of analysis of fatty acids compositions, it consist of stearic acid as saturated fatty acid, and oleic acid, linoleic acid as unsaturated one. The Pona cocos was extracted with methanoi and its extracts were determined to be antimicrobial activities against bacteria and yeast. Methanoi extracts of the Poria cocos showed stronger antimicrobial activities on Staphylococcus aureus, Staphylococcus epidermidis. Bacillus subtilis, Micrococcus luteus, Leuconostoc mesenteroides, Escherichia coli, Salmonella typhimurium, and Pseudomonas aeruginosa than control, benzoic acid. In conclusion, Poria cocos extracts showed antimicrobial activities and will be required to isolate and identify substance with antimicrobial activity as functional materials.