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Song, Bing,Li, Zhen,Lu, Houyuan,Mao, Limi,Saito, Yoshiki,Yi, Sangheon,Lim, Jaesoo,Li, Zhen,Lu, Anqing,Sha, Longbing,Zhou, Rui,Zuo, Xinxin,Pospelova, Vera Cambridge University Press 2017 Quaternary research Vol.87 No.2
<B>Abstract</B><P>We reconstructed the centennial climate changes for the period of 9-7 cal ka BP in the upper region of the Changjiang (Yangtze) River Delta plain. A general warming and wetting trend from 8560 to 7220 cal yr BP was indicated by the decrease in <I>Quercus</I> (deciduous) and increases in <I>Quercus</I> (evergreen), <I>Pinus</I>, and Polypodiaceae spores. However, there were several brief climate fluctuations. A notable palynological change, from regional assemblages dominated by arboreal pollen to local assemblages mainly consisting of nonarboreal pollen, reflects climate fluctuations. The key indices of <I>Quercus</I> (deciduous), <I>Pinus</I>, herbs, fern spores, and palynological concentrations showed similar signs of centennial climate fluctuations. We suggest that the climate changes of the Dongge Cave and Yangtze River Delta regions were mainly affected by the East Asian summer monsoon (EASM) during the period of 9-7 cal ka BP. The general warming trend may be associated with an intensified EASM, and solar activity may be one of the important factors driving the centennial climate changes. The ~8.2 ka event was also recorded in the Yangtze River Delta region, which suggests that there was a close relationship between the EASM and Greenland climate during the early Holocene.</P>
Lu Lu,Jia Li,Dickon H.L. Ng,Ping Yang,Peng Song,Min Zuo 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-
Hierarchically porous Fe3O4@MgAl–LDH magnetic microspheres were reported as novel efficientadsorbent for the removal of anionic dye from water. The as-prepared microspheres had vertically/slantly/horizontally oriented platelets-coated morphology, and exhibited superb adsorption capacity of813.0 mg/g for Congo red (CR), which was the highest reported value of magnetic adsorbents. Theadsorption kinetics and isotherm of CR on microspheres followed the pseudo-second-order andLangmuir model, respectively, and the adsorption processes were spontaneous and endothermic innature. The adsorbed samples could be regenerated by methanol, and easily magnetically separated fromaqueous solution. The synthesized materials might act as excellent adsorbents for environmentalprocesses.
The XRCC1 Arg280His Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-analysis
Li, Lu-Ping,Wu, Wei,Li, Xing-Hai,Song, Shu-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Many studies have suggested that the XRCC1 Arg280His gene polymorphism might be involved in the development of hepatocellular carcinoma (HCC). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the association between XRCC1 Arg280His and HCC susceptibility. Published literature from PubMed, EMBASE and CNKI Data was searched. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effects models when appropriate. Begg's test was used to measure publication bias. A total of 7 case-control studies covering 1,448 HCC cases and 1,544 controls were included. No significant variation in HCC risk was detected in any of the genetic models overall. In the stratified analysis, four studies with sample sizes over 300 produced similar results. The corresponding pooled ORs were not substantially altered after the exclusion of three studies deviating from Hardy-Weinberg equilibrium in the control group, which indicated reliability for our meta-analysis results.
Xiao-Li Song,Yue-Qi Zhu,Hai-Tao Lu,Fang Liu,Li-Ming Wei,강형근,Jun-Gong Zhao 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.6
Objective: To prospectively investigate predictors for good restoration of blood flow of below-the-knee (BTK) chronic total occlusions (CTOs) after endovascular therapy in diabetes mellitus (DM) patients. Materials and Methods: A total of 120 long-segmental (≥ 5 cm) BTK, CTOs in 81 patients who underwent recanalization were included in this study. After angioplasty, blood-flow restoration was assessed using modified thrombolysis in myocardial ischemia grades and classified as good flow (grade 3) and poor flow (grade 1/2). One hundred and six CTOs with successful recanalization were divided into a good flow group (GFG; n = 68) and poor flow group (PFG; n = 38). Multivariate logistic regression analyses were undertaken to determine independent predictors of blood-flow restoration. Receiver operating characteristic curves were constructed to determine the best cutoff value. The prevalence of target-lesion restenosis during follow-up was compared between two groups. Results: Univariate analyses suggested that CTOs in GFG were characterized by lighter limb ischemia (p = 0.03), shorter course of ischemic symptoms (p < 0.01) and lesion length (p = 0.04), more frequent use of intraluminal angioplasty (p = 0.03), and higher runoff score (p < 0.01) than those in PFG. Multivariate regression analyses suggested that distal runoffs (p = 0.001; odds ratio [OR], 10.32; 95% confidence interval [CI]: 4.082–26.071) and lesion length (p < 0.001; OR, 1.26; 95% CI: 1.091–1.449) were independent predictors for good flow restoration. Kaplan-Meier analyses at 12 months showed a higher prevalence of non-restenosis in GFG (p < 0.01). Conclusion: Distal runoffs and lesion length are independent predictors for good flow restoration for long-segmental BTK, CTOs in DM patients who receive endovascular therapy.
Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy
Xianghui Li,Haoran Wang,Zhiyan Li,Dandan Li,Xiaofeng Lu,Shichao Ai,Yuxiang Dong,Song Liu,Jinhui Wu,Wenxian Guan 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: Mitochondria play an essential role in cellular redox homeostasis maintenance and meanwhile serve as an important target for organelle targeted therapy. Photodynamic therapy (PDT) is a promising strategy for organelle targeted therapy with noninvasive nature and highly spatiotemporal selectivity. However, the efficacy of PDT is not fully achieved due to tumor hypoxia. Moreover, aerobic respiration constantly consumes oxygen and leads to a lower oxygen concentration in mitochondria, which continuously limited the therapeutic effects of PDT. The lack of organelle specific oxygen delivery method remains a main challenge. Methods: Herein, an Oxygen Tank is developed to achieve the organelle targeted synergistic hypoxia reversal strategy, which not only act as an oxygen storage tank to open sources and reduce expenditure, but also coated with red blood cell membrane like the tank with stealth coating. Within the oxygen tank, a mitochondrion targeted photosensitizer (IR780) and a mitochondria respiration inhibitor (atovaquone, ATO) are co-loaded in the RBC membrane (RBCm) coated perfluorocarbon (PFC) liposome core. Results: Inside these bio-mimic nanoparticles, ATO effectively inhibits mitochondrial respiration and economized endogenous oxygen consumption, while PFC supplied high-capacity exogenous oxygen. These Oxygen modulators reverse the hypoxia status in vitro and in vivo, and exhibited a superior anti-tumor activity by mitochondria targeted PDT via IR780. Ultimately, the anti-tumor effects towards gastric cancer and colon cancer are elicited in vivo. Conclusions: This oxygen tank both increases exogeneous oxygen supply and decreases endogenous oxygen consumption, may offer a novel solution for organelle targeted therapies.
Liu, Zhiming,Song, Taeseup,Kim, Joo Hyun,Li, Zhangpeng,Xiang, Juan,Lu, Tianchi,Paik, Ungyu Elsevier Inc. 2016 Electrochemistry Communications Vol.72 No.-
<P><B>Abstract</B></P> <P>One-dimensional (1-D) carbon nanofibers anchored with partially reduced SnO<SUB>2</SUB> nanoparticles (SnO<SUB>2</SUB>/Sn@C) were successfully synthesized through a simple electrospinning method followed by carbon coating and thermal reduction processes. The partially reduced Sn frameworks, combined with the carbon fibers, provide a more favorable mechanism for sodiation/desodiation than SnO<SUB>2</SUB>. As a result, SnO<SUB>2</SUB>/Sn@C exhibits a high reversible capacity (536mAhg<SUP>−1</SUP> after 50cycles) and an excellent rate capability (396mAhg<SUP>−1</SUP> even at 2C rate) when evaluated as an anode material for sodium-ion batteries (SIBs).</P> <P><B>Highlights</B></P> <P> <UL> <LI> The partially reduced Sn framework provides both favorable Na-ion diffusion dynamics and high specific capacity. </LI> <LI> The conductive Sn framework, bonded with carbon fiber, provides an efficient pathway for electron transport. </LI> <LI> The discrete SnO<SUB>2</SUB>/Sn nanoparticles provide sufficient space to accommodate the large volume expansion. </LI> <LI> The strategy of partial reduction may open up new ways to improve the electrochemical performance of metal oxides. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Identification of Specific Gene Modules in Mouse Lung Tissue Exposed to Cigarette Smoke
Xing, Yong-Hua,Zhang, Jun-Ling,Lu, Lu,Li, De-Guan,Wang, Yue-Ying,Huang, Song,Li, Cheng-Cheng,Zhang, Zhu-Bo,Li, Jian-Guo,Xu, Guo-Shun,Meng, Ai-Min Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Exposure to cigarette may affect human health and increase risk of a wide range of diseases including pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), asthma, lung fibrosis and lung cancer. However, the molecular mechanisms of pathogenesis induced by cigarettes still remain obscure even with extensive studies. With systemic view, we attempted to identify the specific gene modules that might relate to injury caused by cigarette smoke and identify hub genes for potential therapeutic targets or biomarkers from specific gene modules. Materials and Methods: The dataset GSE18344 was downloaded from the Gene Expression Omnibus (GEO) and divided into mouse cigarette smoke exposure and control groups. Subsequently, weighted gene co-expression network analysis (WGCNA) was used to construct a gene co-expression network for each group and detected specific gene modules of cigarette smoke exposure by comparison. Results: A total of ten specific gene modules were identified only in the cigarette smoke exposure group but not in the control group. Seven hub genes were identified as well, including Fip1l1, Anp32a, Acsl4, Evl, Sdc1, Arap3 and Cd52. Conclusions: Specific gene modules may provide better understanding of molecular mechanisms, and hub genes are potential candidates of therapeutic targets that may possible improve development of novel treatment approaches.