Blade shape optimization for transonic axial flow fan

Peng Song,선진주 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.3

Transonic axial flow fan has relatively high blade tip speed and produces higher pressure ratio than the subsonic. However, considerablelosses are brought about by the shock waves close to blade tip and over part of span, leading to deteriorated overall efficiency andoperating flow range. The present study is to mitigate shock wave and reduce losses through simultaneous variation of blade sectionalprofiles and their stacking line in blade design. Both sectional profiles and stacking line are varied simultaneously to provide more flexibleblade shape tuning. To achieve a best blade shape and produce maximum performance gains, a global optimization method is incorporatedin the blade shape design. It includes an improved CCEA (cooperative co-evolution algorithm) optimizer and one-stage ExpectedImprovement (EI) based adaptively updated Kriging surrogate model. The former has divided the high-dimension optimization problemsinto readily solved low-dimension ones, while the later has enabled the optimizer to jump out of from the local optima and search thesolution towards the global optima. The optimization is conducted for Rotor67 at design condition with a single workstation, and considerableoverall efficiency and pressure ratio gains are simultaneously obtained, while the flow range is also extended. This is supported bythe significantly improved flow behavior in the optimized blade passages, where the chordwise shock wave is mitigated, leading to anincrease in overall efficiency; the spanwise static pressure distribution is improved evidently and this improves the overall pressure ratio.

Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines

Peng Cao,Dong-Sheng Pan,Song Han,Chun-Yong Yu,Qing-Jie Zhao,Yan Song,Yong Liang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8

Phytochemical investigation of the ethanolextract of the bulbs of Lycoris caldwellii afforded fournew alkaloids, (?)-N-methoxylcarbonyl-nandigerine (1),(?)-N-methoxycarbonyl-lindcarpine (2), (?)-10-O-methylhernovineN-oxide (3), and (?)-3-hydroxy-anhydrolycorineN-oxide (4). Structural elucidation of all the compounds wereperformed by spectral methods such as 1D and 2D (1H-1HCOSY, HMQC, and HMBC) NMR spectroscopy, in additionto high resolution mass spectrometry. All the alkaloids werein vitro evaluated for their cytotoxic activities against eighttumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1and 2 exhibited particular cytotoxic activities against astrocytomaand glioma cell lines with IC50 of 9.2–11.3 lM and10.4–12.2 lM respectively.

Realgar transforming solution suppresses angiogenesis and tumor growth by inhibiting VEGF receptor 2 signaling in vein endothelial cells

Peng Song,Yang Hai,Xin Wang,Longhe Zhao,Baoqiang Chen,Peng Cui,Qin-Jian Xie,Lan Yu,Yang Li,Zhengrong Wu,Hong Yu Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.4

Realgar (As4S4), as an arsenic sulfide mineraldrug, has a good therapeutic reputation for anticancer inTraditional Chinese Medicine, and has recently beenreported to inhibit angiogenesis in tumor growth. However,considering the poor solubility and low bioavailability ofrealgar, large dose of realgar and long period of treatmentare necessary for achieving the effective blood medicineconcentration. In present study, we resolved the crucialproblem of poor solubility of realgar by using intrinsicbiotransformation in microorganism, and investigatedunderlying mechanisms of realgar transforming solution(RTS) for antiangiogenesis. Our results demonstrated thatRTS had a strong activity to inhibit HUVECs proliferation,migration, invasion, and tube formation. Moreover, RTSinhibited VEGF/bFGF-induced phosphorylation ofVEGFR2 and the downstream protein kinases includingERK, FAK, and Src. In vivo zebrafish and chickenchorioallantoic membrane model experiments showed thatRTS remarkably blocked angiogenesis. Finally, comparedwith the control, administration of 2.50 mg/kg RTSreached more than 50% inhibition against H22 tumorallografts in KM mice, but caused few toxic effects in thehost. The antiangiogenic effect was indicated by CD31immunohistochemical staining and alginate-encapsulatedtumor cell assay. In summary, our findings suggest thatRTS inhibits angiogenesis and may be a potential drugcandidate in anticancer therapy.

Bioinformatic Prediction of SNPs within miRNA Binding Sites of Inflammatory Genes Associated with Gastric Cancer

Song, Chuan-Qing,Zhang, Jun-Hui,Shi, Jia-Chen,Cao, Xiao-Qin,Song, Chun-Hua,Hassan, Adil,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Wang, Kai-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Polymorphisms in miRNA binding sites have been shown to affect miRNA binding to target genes, resulting in differential mRNA and protein expression and susceptibility to common diseases. Our purpose was to predict SNPs (single nucleotide polymorphisms) within miRNA binding sites of inflammatory genes in relation to gastric cancer. A complete list of SNPs in the 3'UTR regions of all inflammatory genes associated with gastric cancer was obtained from Pubmed. miRNA target prediction databases (MirSNP, Targetscan Human 6.2, PolymiRTS 3.0, miRNASNP 2.0, and Patrocles) were used to predict miRNA target sites. There were 99 SNPs with MAF>0.05 within the miRNA binding sites of 41 genes among 72 inflammation-related genes associated with gastric cancer. NF-${\kappa}B$ and JAK-STAT are the two most important signaling pathways. 47 SNPs of 25 genes with 95 miRNAs were predicted. CCL2 and IL1F5 were found to be the shared target genes of hsa-miRNA-624-3p. Bioinformatic methods could identify a set of SNPs within miRNA binding sites of inflammatory genes, and provide data and direction for subsequent functional verification research.

논문 : 非漢語環境下的漢語口語敎學探討 -以韓國翰林大學口語敎學위例-

( Song Peng ) 한림대학교 인문학연구소 2013 인문학 연구 Vol.18 No.-

A novel aminopeptidase with potential debittering properties in casein and soybean protein hydrolysates

Peng Song,Lei Cheng,Kangming Tian,Meng Zhang,Suren Singh,Dandan Niu,Bernard Prior,Nokuthula Peace Mchunu,Zheng-Xiang Wang 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.11

A new aminopeptidase (An-APa) was identified and biochemically characterized from Aspergillus niger CICIM F0215. It had maximal activity at 40 °C and pH 7.0 and exhibited a broad substrate specificity both on hydrophilic and hydrophobic amino acid residues at N-terminals. With An-APa hydrolysis for 1 h, the casein-pepsin and soybean protein isolates (SPI)-pepsin hydrolysates released both hydrophilic and hydrophobic amino acids and the hydrophobic amino acids having Q values (degree of hydrophobicity) greater than 1500 cal/mol were remarkably released. Leu, Ile, Phe, Tyr, Trp, Pro, Val and Lys in the casein hydrolysate after treatment with An-APa increased 18.61, 0.84, 11.35, 13.18, 3.34, 6.30, 7.46, and 8.19 mg/100 mL, respectively, and 19.72, 1.47, 18.37, 11.72, 4.61, 4.10, 8.13, and 5.85 mg/100 mL, respectively, in the SPI hydrolysate. Both accounted for 65.0% and 64.4% of total released free amino acids from casein and SPI hydrolysates, respectively. This indicated that An-APa could be potentially applicable in debittering protein hydrolysates.

스마트폰 게임 특성이 몰입, 이용자의 만족도와 충성도에 미치는 영향

송붕(Peng Song),이종호(Lee, Jong-Ho),정병무(Jung, Byoung-Moo) 국제e-비즈니스학회 2014 e-비즈니스 연구 Vol.15 No.1

Bamboo- and pig-derived biochars reduce leaching losses of dibutyl phthalate, cadmium, and lead from co-contaminated soils

Qin, Peng,Wang, Hailong,Yang, Xing,He, Lizhi,Mü,ller, Karin,Shaheen, Sabry M.,Xu, Song,Rinklebe, Jö,rg,Tsang, Daniel C.W.,Ok, Yong Sik,Bolan, Nanthi,Song, Zhaoliang,Che, Lei,Xu, Xiaoya Elsevier 2018 CHEMOSPHERE - Vol.198 No.-

<P><B>Abstract</B></P> <P>Biochar effect on the potential mobility of dibutyl phthalate (DBP), cadmium (Cd), and lead (Pb) in co-contaminated soils is not well investigated. A laboratory leaching study was conducted to evaluate the effect of biochars derived from bamboo (BB) and pig (PB) on the leachability of DBP, Cd, and Pb through soil columns packed with two soils with low or high organic carbon content (LOC; 0.35% C: HOC; 2.24% C) and spiked with DBP, Cd, and Pb. Application of PB to the LOC soil significantly (<I>P</I> < 0.05) reduced the leaching loss by up to 88% for DBP, 38% for Cd, and 71% for Pb, whereas its impact was insignificant in the HOC soil. The higher efficacy of PB in reducing the leaching of DBP, Cd, and Pb in the LOC soil than that of BB might be related to PB's higher specific surface area, surface alkalinity, pH, and mineral contents compared to those of BB. Co-contamination of Cd and Pb enhanced leaching of DBP in the LOC soil treated with PB, possibly by competition for the sorption sites. Leaching of DBP, Cd, and Pb were significantly (<I>P</I> < 0.05) higher in the LOC soil than in the HOC soil. This study revealed that the effectiveness of biochars was dependent on the soil organic carbon content. Application of PB to the LOC soil was effective in reducing the leaching risk of DBP, Cd, and Pb.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pig biochar reduced leaching of DBP, Cd, and Pb in the low organic carbon (LOC) soil. </LI> <LI> Contaminant leaching was higher in the LOC soil than in the high organic carbon soil. </LI> <LI> Existence of Cd and Pb enhanced mobility of DBP in the pig biochar-treated LOC soil. </LI> <LI> Alkalinity and phosphate in biochar controlled the leaching loss of Cd and Pb. </LI> <LI> Impact of pig biochar on leaching of DBP, Cd, and Pb is stronger than bamboo biochar. </LI> </UL> </P>

The Characteristics and Distribution of Eukaryotic Phytoplankton Community in Liaodong Bay, China

Lun Song,Jing Wu,Jing Du,Nan Li,GuangJun Song,Kun Wang,Ming Sun,Peng Wang 한국해양과학기술원 2019 Ocean science journal Vol.54 No.2

Brown tides have occurred in the Bohai Sea of China since 2009 and caused serious losses in aquaculture. In recent years, phytoplankton identification has been greatly promoted by the development of high-throughput sequencing technologies. In this study, V4 region of 18S rDNA was used as the target gene to design the primer V4 (F/R), and high-throughput sequencing technology was adopted to evaluate the diversity of composition and characteristics of the eukaryotic phytoplankton community. A total of 93 alga species were identified, and about 60% (56 out of 93) of them were undetected or unreported in Chinese waters. There were 59% of the total algal species identified as autotrophy in trophic mode while heterotrophy and mixotrophy accounted for 12% and 29% of the total algal species, respectively. 8 species of picophytoplankton that were mainly distributed in the south and a partial area of the east and west formed the scientific basis for the quality and safety early-warning in aquatic products and brown rides study. Diversity index analysis also revealed a trend of fluctuations of marine phytoplankton diversity in different sample sites in Liaodong Bay. In conclusion, our work provides a detailed evaluation of eukaryotic phytoplankton diversity in Liaodong Bay, suggesting the need for long-term monitoring to further study and guard against the potential risk of harmful algal blooms.

A Comprehensive Review of Lipidomics and Its Application to Assess Food Obtained from Farm Animals

Yinghua Song,Changyun Cai,Yingzi Song,Xue Sun,Baoxiu Liu,Peng Xue,Mingxia Zhu,Wenqiong Chai,Yonghui Wang,Changfa Wang,Mengmeng Li 한국축산식품학회 2022 한국축산식품학회지 Vol.42 No.1

Lipids are one of the major macronutrients essential for adequate growth and maintenance of human health. Their structure is not only complex but also diverse, which makes systematic and holistic analyses challenging; consequently, little is known regarding the relationship between phenotype and mechanism of action. In recent years, rapid advancements have been made in the fields of lipidomics and bioinformatics. In comparison with traditional approaches, mass spectrometry-based lipidomics can rapidly identify as well as quantify >1,000 lipid species at the same time, facilitating comprehensive, robust analyses of lipids in tissues, cells, and body fluids. Accordingly, lipidomics is now being widely applied in various fields, particularly food and nutrition science. In this review, we discuss lipid classification, extraction techniques, and detection and analysis using lipidomics. We also cover how lipidomics is being used to assess food obtained from livestock and poultry. The information included herein should serve as a reference to determine how to characterize lipids in animal food samples, enhancing our understanding of the application of lipidomics in the field in animal husbandry.