급성 백혈병 환자에서 감염증의 양상 및 예후인자에 관한 연구 : 1988년∼1995년까지

정희진,김병수,신상원,김열홍,김우주,김민자,김준석,박승철,김권범 대한감염학회 1998 감염 Vol.30 No.3

목적 : 급성 백혈병의 경우 골수기능이 억제되고 항암화학요법에 따른 골수기능 저하로 감염의 위험이 증가하며 감염의 치료가 환자의 생존에 큰 영향을 미치게 된다. 이에 저자들은 1988년부터 1995년까지 고대 구로병원에 급성 백혈병으로 입원했던 환자들 중 입원 기간 내 감염이 있었던 경우를 대상으로 하여 감염의 위험인자 및 감염증의 예후를 후향적으로 분석함으로써 향후 급성 백혈병환자의 감염의 치료에 대한 지침을 얻고자 하였다. 방법 : 급성 백혈병으로 확진된 환자들 중 감염병에 이환된 경우를 대상으로 하여 각각을 미생물학적 확인감염, 임상적 확인감염, 그리고 설명 불가열로 구분하였다. 각각의 경우에서 감염 당시의 호중구 수, 호중구 감소 기간, 항암화학요법과의 연관성, 감염 병소, 배양된 검체 및 원인균, 선택적 소화관 살균법의 사용여부 및 골수회복 여부 등을 조사한 후 환자의 예후와 어떤 관계가 있는 지 조사하였다. 결과 : 연구 대상은 총 113예로 남녀비는 46:67 이었고 평균연령은 34±13세, 진단은 급성 골수성 백혈병 (AML)이 84예, 급성 림프구성 백혈병(ALL)이 29예였으며, 감염시 평균 호중구수는 663±1678/㎣이었고, 호중구 감소 기간은 평균 18±13일이었다. 감염양상은 항암화학요법과 연관된 감염이 84예로 대부분이었고 미생물학적 확인 감염이 40예로서 35%였으며, 폐렴과 원발성 패혈증이 각각 20예와 19예로 가장 많았고, 카테터 연관 감염이 7예로 나타났다. 배양된 균주는 E. coli가 10예(25%)로서 가장 많았으며, 전체적으로 E. coli, P. aeruginosa, K. pneumoniae 등의 그람음성균이 63%로 대부분을 차지하였으나 최근 그람양성구군 및 진균의 분리율이 증가하는 양상을 보였다. 감염증의 예후를 분석한 결과 진균 감염인 경우나 호중구 감소 기간이 긴 경우 사망률이 높았으며 그 중에서도 골수 기능이 회복 여부가 환자들의 생존과 통계적으로 유의한 연관이 있었다.(P=0.01). 결론 : 급성 백혈병 환자들에서의 감염은 관해유도화학요법 후 초래되는 호중구 감소와 유의한 관계가 있으며, 폐렴 및 패혈증의 임상양상을 보이는 경우가 흔하고, 원인균별로는 그람 음성균이 주류를 이루나 최근 그람 양성균 감염이 증가하는 추세를 보였다. 감염의 예후 인자로는 진균 감염인 경우나 호중구 감소 기간이 긴 경우 사망률이 높았으나 골수 기능의 회복여부가 결정적인 역할을 하는 것으로 나타나, 향후 급성 백혈병 환자의 치료에 있어 감염 빈도의 감소와 감염에서의 조속한 회복을 위해서는 골수 기능의 회복에 중점을 두어야 할 것으로 사료된다. Background : Infection is one of the most important and fatal complications in patients with acute leukemia. The characteristics of infection in acute leukemic patients are different from those in other diseases by the lack of normal inflammatory responses or distinct clinical evidence except fever. To improve the outcome of acute leukemia, it is very important to recognize the risk factors, patterns and prognostic factors of acute leukemia. Methods : We analyzed retrospectively the patterns of infection from 113 febrile patients with acute leukemia from January, 1988 to December, 1995. To determine the prognostic factors and the outcome of infection, the following variables were analyzed: the presence of neutropenia, use of chemotherapeutic agents, type and site of infections, isolated organisms, gastrointestinal decontamination, duration of neutropenia, and bone marrow recovery. Results : Out of 113 febrile patients with acute leukemia, 84 infection episodes(74%) occurred after chemotherapy. The mean duration of neutropenia was 18±13 days. The incidence of microbiologically-documented infection(MDI) was 35%(40/113). Pneumonia was the most common infection(26%), followed by primary sepsis(24%), catheter-related infection(9%). In cases of MDI, 63% were caused by gram-negative bacteria, followed by gram-positive bacteria(28%), and fungi(10%). Escherichia coli(25%) was the most common isolated in MDI. Regarding the prognostic factors in cases with infections, the recovery of bone marrow function was the only statistically significant factor(P=0.01). Conclusion : Infection has been a major cause of morbidity and mortality in acute in acute leukemic patients. To prevent infection and thereby improve the prognosis of acute leukemia, restoration of bone marrow function at early stage is important.

폐구리염화물용액의 분무열분해반응에 의한 생성분말의 특성에 관한 연구

박희범,최재권,한진아,유재근 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

본 연구의 목적은 폐 구리염화물 용액을 원료로 사용하여 분무열분해 공정에 의해 평균입도가 1 ㎛ 이하이며 입도분포가 균일하고 치밀한 조직을 나타내는 미립의 구리산화물 분말을 제조하는데 있다.또한 본 연구에서는 분무열분해 공정에 의해 생성되는 분말의 특성에 영향을 미치는 반응 온도, 원료용액의 유입속도, 분위기기체 및 공기의 유입속도, nozzle tip 크기 및 원료용액의 농도 등의 반응인자들의 영향을 검토하였다.

빛에 대한 국민학교 학생들의 개념조사

김한호,정진우,최병순,김범기,권재술 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

The purpose of this study was to investigate children's(K-5) conceptions about light in Korea. The two aspect of children's conceptions about light were identified: the sources of light, the nature of vision. Data were collected from 92 children by a mixture of writing, drawing and interview, and were analysed by systematic networks. The major findings of this study were as follows: 1. Children showed an awareness of a wide variety of sources of light. The predominant sources exampled by children were primary sources. 2. Children explained vision as intentional actvivty of seeing Seeing. means action that move their heal or eyes to the objects. Infants(K-1) did not recognize that light are needed for vision. 3. A notable features in children's conceptions about light were context-dependent

빛에 대한 국민학교 학생들의 개념조사

김한호,권재술,김범기,정진우,최병순 한국교원대학교 과학교육연구소 1992 청람과학교육연구논총 Vol.2 No.1

The purpose of this study was to investigate children's(K-5) conceptions about light in Korea. The two aspect of children's conceptions about light were identified: the sources of light, the nature of vision. Data were collected from 92 children by a mixture of writing, drawing and interview, and were analysed by systematic networks. The major findings of this study were as follows: 1. Children showed an awareness of a wide variety of sources of light. The predominant sources exampled by children were primary sources. 2. Children explained vision as intentional of seeing Seeing. means action that move their heal or eyes to the objects. Infants(K-1) did not recognize that light are needed for vision. 3. A notable features in children's conceptions about light were context-dependent

가용화 조성물을 함유한 PVP형 고체분산체의 제조 및 특성 : Based Solid Dispersion Systems Containing Solubilizers

Cao, Qing-Ri,김태완,최춘영,권경애,이범진 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.1

The PVP-based solid dispersion systems (SDs) containing lovastatin (LOS) and solubilizers (sodium lauryl sulfate, tween 80 and oleic acid) were prepared to enhance dissolution rate of practically water insoluble LOS using solvent evaporation method. Two different organic cosolvents either acetone/ethanol or acetonitrile/ethanol were used for the preparation of SDs. The LOS contents were highly decreased when acetone/ethanol cosolvents were used. The decrease of LOS contents was not caused by acetonitrile or acetone, based on HPLC data. The surface morphology as investigated by scanning electron microscope (SEM) and angle of repose as an index of flowability of SDs were highly dependent of the type and amount of solubilizers used. Base on differential scanning calorimetry (DSC) and X-ray powder diffraction data, the SDs made crystalline LOS into amorphous structure or partially eutectic mixtures. The simultaneous use of the solubilizers in SDs was also useful to increase dissolution rate of LOS in gastric or intestinal fluid. The SDs containing solubilizers reached 76% and 60% in gastric and intestinal fluid, respectively but the commercial tablet gave only less that 4%. These solubilizers in SDs could be also applicable for enhancing dissolution and bioavailability of poorly water-soluble drugs.

가용화 조성물과 난용성 약물군을 함유하는 고체분산체의 용출양상

김태완,최춘영,Cao, Qing-Ri,권경애,이범진 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.3

Polymer based physical mixtures or solid dispersions containing solubilizing compositions[OA, tween80 and SLS] were prepared using a spray-dryer. Lovastatin(LOS), simvastatin(SIMS), aceclofenac(AFC) and cisapride(CSP) were selected as poorly water-soluble drugs. Dextrin, poly(vinylalcohol)(PVA), poly(vinylpyrrolidone)(PVP) and polyethylene glycol(PEG) were chosen as solubilizing carriers for solid dispersions. The solid dispersions containing solubilizing compositions without drug were prepared without using organic solvents or tedious changes of formulation compositions. This system could be used to quickly screen the dissolution profiels of poorly water-soluble drugs by simply mixing with drugs thereafter. In case of solid dispersion containing drug, organic solvent systems could be used to solubilize model drugs. The dissolution rates of the drugs were higher when mixed with drug and solid dispersions containing solubilizing compositions. However, solid dispersions of LOS, AFC, CSP simultaneously containing drug and solubilizing compositions in organic solvent systems were more useful than physical mixtures of drug and solid dispersions without drug except SIMS. Based on solubilizing capability of polymer based physical mixtures in gelatin hard capsules, optimal solid dispersion system of poorly water-soluble drugs could be formulated. However, it should be noted that dissolution rate of poorly water-soluble drugs were highly dependent on drug properties, solubilizing compositions and polymeric carriers.

Low concentration, multi taste detectable taste sensor using the high transconductance of a cascoded gated lateral bipolar junction transistor

Kwon, Jin-Beom,Jeong, Hyun-Min,Kwon, Hyurk-Choon,Lee, Sang-Won,Lee, Jae-Sung,Kim, Sae-Wan,Kim, Ok-Sik,Kwon, Dae-Hyuk,Kang, Shin-Won Elsevier 2017 Sensors and actuators. B Chemical Vol.248 No.-

<P><B>Abstract</B></P> <P>People are interested in eating good foods as a way of increasing their quality of life. Research conducted on the quantitative detection and characterization of the taste components of foods has received significant attention in recent years. However, taste sensors with higher sensitivities are needed because the expectations of the public are constantly increasing. In this study, a cascoded gated lateral bipolar junction transistor (C-GLBJT) was developed and used in taste sensor applications for detecting five taste substances. The results showed that the sensitivity of the C-GLBJT taste sensor was 0–2.55μA/decade, and it can detect very low concentrations (down to 1fM) of five taste solutions. The developed integrated C-GLBJT sensor could be able to provide more precise information about foods to consumers and patients who are interested in their well-being. Also, it may be of great help to advertisers and businessmen by providing them with reproducible quantitative information about their products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The cascaded gated lateral bipolar junction transistor (C-CLBJT) that has the high transconductance was developed and used in the taste sensor. </LI> <LI> The proposed taste sensor can detect five kinds of taste solutions which are very low concentration up to 1fM. </LI> <LI> Also, the proposed taste sensor has the sensitivities of 0–2.55μA/decade according to the types of lipid sensing membranes. </LI> <LI> The measuring capability of the proposed sensor is very large, and it can detect concentrations that are lower than the 1μM limit of human’s limit. </LI> <LI> Therefore, it can satisfy human expectations and may be of great help to enterprises through the quantification of the five kinds of tastes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Characterization of rDNAs and Tandem Repeats in the Heterochromatin of Brassica rapa

Beom-Seok Park,임기병,Hans de Jong,Tae-Jin Yang,Jee-Young Park,Soo-Jin Kwon,Jung Sun Kim,Myung-Ho Lim,Jin A Kim,Mina Jin,Yong-Moon Jin,Seog Hyung Kim,임용표,방재욱,Ho-Il Kim 한국분자세포생물학회 2005 Molecules and cells Vol.19 No.3

We describe the morphology and molecular organization of heterochromatin domains in the interphase nuclei, and mitotic and eiotic chromosomes, of Brassica rapa, using DAPI staining and fluorescence in situhybridization (FISH) of rDNA and ericentromere tandem repeats. We have developed a simple method to distinguish the centromeric regions of mitotic metaphase chromosomes by prolonged irradiation with UV light at the DAPI excitation wavelength. Application of this bleached DAPI band (BDB) karyotyping method to the 45S and 5S rDNAs and 176 bp centromere satellite repeats distinguished the 10 B. rapa chromosomes. We further characterized the centromeric repeat sequences in BAC end sequences. These fell into two classes, CentBr1 and CentBr2, occupying the centromeres of eight and two chromosomes, respectively. The centromere satellites encompassed about 30% of the total chromosomes, particularly in the core centromere blocks of all the chromosomes. Interestingly, centromere length was inversely correlated with chromosome length. The morphology and molecular organization of heterochromatin domains in interphase nuclei, and in mitotic and meiotic chromosomes, were further characterized by DAPI staining and FISH of rDNA and CentBr. The DAPI fluorescence of interphase nuclei revealed ten to twenty conspicuous chromocenters, each composed of the heterochromatin of up to four chromosomes and/or nucleolar organizing regions.

Air-stable and ultrasensitive solution-cast SWIR photodetectors utilizing modified core/shell colloidal quantum dots

Kwon Jin-Beom,김세완,Kang Byoung-Ho,Yeom Se-Hyuk,Lee Wang-Hoon,Kwon Dae-Hyuk,이재성,강신원 나노기술연구협의회 2020 Nano Convergence Vol.7 No.28

InGaAs-based photodetectors have been generally used for detection in the short-wave infrared (SWIR) region. However, the epitaxial process used to grow these materials is expensive; therefore, InGaAs-based photodetectors are limited to space exploration and military applications. Many researchers have expended considerable efforts to address the problem of SWIR photodetector development using lead sulfide (PbS) quantum dots (QDs). Along with their cost-efficient solution processability and flexible substrate compatibility, PbS QDs are highly interesting for the quantum-size-effect tunability of their bandgaps, spectral sensitivities, and wide absorption ranges. However, the performance of PbS QD-based SWIR photodetectors is limited owing to inefficient carrier transfer and low photo and thermal stabilities. In this study, a simple method is proposed to overcome these problems by incorporating CdS in PbS QD shells to provide efficient carrier transfer and enhance the long-term stability of SWIR photodetectors against oxidation. The SWIR photodetectors fabricated using thick-shell PbS/CdS QDs exhibited a high on/off (light/dark) ratio of 11.25 and a high detectivity of 4.0 × 1012 Jones, which represents a greater than 10 times improvement in these properties relative to those of PbS QDs. Moreover, the lifetimes of thick-shell PbS/CdS QD-based SWIR photodetectors were significantly improved owing to the self-passivation of QD surfaces.

전기차 급속충전 성능평가 및 알고리즘 검증기술 연구

정진범(Jin-Beom Jeong),정진영(Jin-Young Jeong),진봉수(Bong-Soo Jin),조용남(Yong-Nam Jo),안성규(Sung-Kyu Ahn),신치범(Chee-Burm Shin),최장욱(Jang-Wook Choi),김기재(Ki-Jae Kim),이권(Kwon Lee) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7