한국 청소년 정신의학의 연구경향

구영진,이재우,이길홍 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

For the purpose of analyzing the recent trends of adolescent psychiatric researches in Korea, the author reviewed 136 domestic articles and compared them with 161 foreign articles published from 1962 to 1990. The results are as follows : 1) The number of domestic articles published doubled during each decade ; 14 articles in 1960's, 45 articles in 1970's, 77 articles in 1980's 2) Majority of the domestic articles are about delinquent adolescents(43.4%), developmental perspectives(15.4%) and clinical study(11.8%). Studies about suicide, treatment techniques and other disorders are rane. 3) On the distribution of the domestic articles into type of article, overview is 13.2%, case review is 7.4% and reseach, most of which were done by psychosocial approaches,is 79.4%. 4) Most of the domestic research articles claims etiological(47.2%) or epidemiological aspects(27.8%) as their aims. 5) Research methods are predominantly cross-sectional(65.7%) or retrospective(32.4%). There are very few prospective-longitudinal or experimental studies. 6) The study tools used in these articles are mainly questionnaires and chart review. 7) The samples studied in domestic articles are middle or high school students(48.2%), delinquent adolescents who are in correctional institution(28.7%) and patients(21.3%). The author suggests further studies be done on the developmental perspectives of normal adeolescents by longitudinal and experimental study, the treatment and outcome for adolescent patients. adolescent suicide and the other psychiatric disorders.

강의 현대화 추진 및 활용방안 연구

구경완,이근복,장종국,김재홍,김영환,최제영,이승훈 永同大學校 1997 硏究論叢 Vol.3 No.1

본 연구는 각종 첨단 기자재를 활용한 강의 현대화 방안을 모색함으로서 공학교육의 효율성을 도모하고 학생들의 학습동기를 유발하여 창조적 능력을 갖츤 전문기술 인력을 양성하는 데 도움을 주고자 하는 것이다. 이를 위하여 현행 공학교육의 현황과 문제점을 분석하고 강의 현대화 사례를 조사하여 본 연구의 기초자료로 삼고자 하였으며, 학부·전공별 강의 현대화 추진 실태분석 및 개선방안을 모색한 후 이상의 연구결과를 종합하여 향후의 강의 형대화 추진방향을 걸정하였다. This study aims to help bring up the well-skilled and creative engineers by searching the modernization of education using various high technology facilities. For this, we analyzed the general condition and problems of current engineering education and surveyed the case study of the modernization of education as basic study. After analyzing the existing situation of promotion searching the proper improvement methods of it, we proposed the new direction of the modernization of education from now on.

20~30대 젊은 여성의 골밀도, 신체조성과 식행동 연구

구재옥,안홍석,유숙영 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study was carried out to identify bone mineral density (BMD), body composition, lifestyle and dietary habits of young women by physical measurement and questionnaires. The study subjects, 190 young women living in Seoul, were divided into three age groups: 20 ~ 24 years (93), 25 ~ 29 years (44) and 30 ~ 39 years (53). There was no significant difference in mean body muscle mass, protein, mineral, body fat and BMI among the three age groups. The rate of low weight (18%) in 20 years group was higher that of the 30 years (11.3%). The mean BMD and T-score were 0.44 g/㎠ and -0.66. BMD and T-score of the forearm bone were significantly higher in the 30 ~ 39 years group. But BMD and T-score of calcanues were not significantly different among the three age groups. The rate of normal, osteopenia and osteoporosis subjects by BMD were 60.5%, 38.4%, 1.1%, respectively. The rate of osteopenia in 20 ~ 24 years group was significantly higher than the other age groups. The rate of meal irregularity was significantly higher in 20 ~ 24 years group. The rate of women who walk and are exposed to sunlight more than 1hr per day were significantly higher in 20~24 years group than the others. However, the score of food behaviors is significantly higher (bad) in 20 ~ 24 years group than the others. The relationship between BMD and frequency of food intake showed significant differences in beans, broom, seaweed and rice wine. In conclusion, the risk rate of BMD was very high, 40% of the subjects, and the risk rate of BMD was higher in 20 years group than 30 years group, and the rate of low weight in 20 years group was higher than in 30 years group. The food habits and behaviors were not healthy enough. Therefore, nutrition education is needed for bone health.

진행 위암환자에서 Lymphokine-Activated Killer (LAK) 활성의 저하

홍원선,김영환,송재관,강윤구,이진오,강태웅,김정룡 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Natural killer(NK) and lymphokine-activated killer(LAK) activities were determined in 31 patients with unresectable stomach cancer before and immediately after chemotherapy with 5-fluorouracil, adriamycin and mitomycin C(FAM) and 31 healthy volunteers. The major purposes of the study were focused on whether peripheral blood lymphocytes(PBL) in stomach cancer patients had a similar ability in the generation of LAK activity to those in healthy volunteers and what the effect was of chemotherapy with FAM on the generation of LAK activity. LAK cells were generated in vitro by culturing human PBL with 100 U/㎖ of recombinant human interleukin-2(rH-IL-2) for 72 hours. K562(human myelogenous leukemia cell line) and MKN-45(human stomach adenocarcinoma cell line) were used as target cells for NK and LAK activities. NK activity against K562, a sensitive line, was significantly depressed in patients with stomach cancer compared with that in healthy volunteers(p<0.01). However, LAK activity against K562 was similar to that of the controls. Age, sex and performance status(ECOG 0-2 and 3-4) did not have an influence on both NK and LAK activities. LAK activity was significantly higher than NK activity, either against K562 or MKN-45, in both healthy volunteers and patients with stomach cancer(p<0.001). NK and LAK activities against MKN-45, a NK-resistant line, in patients with stomach cancer showed significantly lower levels than those in healthy volunteers. We also analyzed the effect of chemotherapy with FAM on NK and LAK activities, with no suppression of NK and LAK activities being observed. In this study, we have demonstrated that PBL of stomach cancer have a reduced ability to generate LAK activity in response to rH-IL-2. However, LAK activity generated from PBL receiving chemotherapy with FAM was similar to that of PBL without chemotherapy.

지방과 도시인의 交通手段 利用實態 및 態度 比較硏究

고재홍,안미영,홍기원,차재호,구정숙 서울大學校 社會科學大學 心理科學硏究所 1993 心理科學 Vol.2 No.-

지방과 도시인의 도로교통 이용실태 및 태도 조사 결과를 보고하였다. 지방을 대표하는 지역으로 경상남도 거창읍을, 그리고 도시는 서울특별시 강남구 대치동을 선정하였고, 각 지역에서 800명(400 부부쌍)의 무선표본을 대상으로 질문지로 조사하였다. 조사내용을 출퇴근 길의 교통수단이용, 외출시의 교통수단이용, 자가용의 이용및 소유실태, 운전면허 소지 및 취득실태, 교통사고경험, 대중교통수단에 대한 평가 및 관련 태도 등이었다. 조사결과, 도시와 지방간의 현재의 교통수단 이용에서의 차이를 파악할 수 있었을 뿐 아니라, 후속연구에서 교통수단이용의 변화를 평가할 수 있는 기저선이 마련되었다. Two representative samples of married couples. one(n=400 couples) from Dae-Chi Dong in Seoul and another(n=400 couples) from the town of Ku-Ch'ang in South Kyung-sang Province were studied through a questionnaire. The questionnaire dealt with (1)transportation uses in commuting to work (2)transportation uses on weekends. (3)types of automobiles owned and the uses to which they are put. (4)statistics related to obtaining and possessing driver licenses. (5)experience of traffic accidents, and (6)attitudes regarding the public trasportations and policies. The study as designed to provide a baseline for future studies on the transportation statistics as well as gauging the urban-rural difference in automobile culture.

감광제/광촉매에 의한 시설환경의 정화

이재구,이용필,안기창,김일근,채홍민 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

일반 생활환경 또는 원예시설 내의 공기오염물질중 하나인 잔류 농약 및 병원성 미생물을 제거하기 위한 방법으로 자연광 또는 인공광 조건에서 몇 가지의 감광제/광촉매에 의한 광분해 촉진효과와 미생물 살균효과 시험을 수행하였다. 감광제로는 quinone계 물질 PS-1, aromatic ketone계 PS-2, aromatic amine계 PS-3, organic acid salt의 PS-4, inorganic compound의 PC-1, inorganic metal compound의 PC-2와 PC3를 선발하여 사용하였다. 그리고 시험 농약으로 시설내 병해충 방제농약인 살충제 carbofuran, 살균제인 diethofencarb, metalaxyl, benomyl, thiram, propineb, iprovalicarb를 선정하였고, 유해 미생물로는 5종의 곰팡이와 3종의 세균성 식물 병원균들을 선정하였다. 농약의 광분해 촉진효과로는 대체적으로 PS-1, PS-2, PS-3, 그리고 PC-2에서 감광제/광촉매를 처리하지 않은 처리구에 비해 높은 분해율을 보였다. 미생물 현탁액에서는 광촉매에 의한 곰팡이의 살균효과는 없었으나 병원성 세균의 성장은 광촉매에 의한 저해가 뚜렷하였다. 위의 결과에서 볼 때 광조건하에서 감광제/광촉매의 사용은 농작물이나 또는 토양표면에 잔류하는 농약의 광분해나 병원성 미생물을 제거하여 보다 안전한 농산물을 생산함은 물론 토양을 위시한 주변환경중의 농약잔류물을 경감시킴으로서 환경보호 및 재배시설내의 작업자와 일반대중의 건강 증진에 커다란 도움이 되리라 기대된다. For the artificial removal of pesticide residues and pathogenic microorganisms in the greenhouse or in the living environment, the accelerated photodegradation and the biocidal effects by some photosensitizers(PS)/photocatalysts(PC) were tested under the sunlight or artificial light. The test pesticides included thiram, diethofencarb, propineb, benomyl, metalaxyl, and iprovalicarb as fungicides, carbofuran as an insecticide, and some bacteria and fungi as the pathogenic microorganisms. PS-1, PS-2, and PC-1 led to the accelerated photodegradation of all the tested pesticides compared to the control without PS/PC under the sunlight. The photocatalysts had no effect on the growth of the fungi in aqueous suspension. Whereas, the PC-2 and PC-3 added to the bacterial suspensions obviously inhibited the microbial growth under the artificial light. These results suggest that the photosensitizers/photocatalysts in the presence of light can decrease some pollutants in the facility environment and hence they can be used to reduce the exposure of the workers in the environment to the harmful pollutants. Key words: Photosensitizer, photocatalyst, photodegradation, pesticide, biocide, bacteria, fungi

正常및 異常分娩中 母體와 臍帶血漿의 β-endorphin 및 ACTH値의 變動에 關한 硏究

鄭求烈,李揆玩,李珉載,洪性鳳 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

β-endorphin and adrenocorticotrophic hormone (ACTH) are derived from the same precursor protein and they have been implicated as the modulators of pain during the labor process. To investigate their possible role during labor this study was undertaken to determine the levels of β-endorphin and ACTH during labor and delivery in healthy term pregnant women and their neonates after delivery. β-endorphin and ACTH were measured by radioimmunoassay in 22 spontaneous labors, 14 elective cesarean sections and 7 emergency cesarean sections during early and late labor, and after delivery. The results obtained are as follows: 1. In cases of spontaneous vaginal delivery and emergency cesarean section, maternal plasma β-endorphin and ACTH levels were significantly increased during late labor and remained and continuously elevated during the first postpartum hour. 2. In cases of elective cesarean sections, maternal mean plasma levels of β-endorphin and ACTH were significantly lower than levels in spontaneous vaginal deliveries and emergency cesarean sections. 3. There was a significant correlation between meternal plasma β-endorphin and ACTH levels during labor. 4. Umbilical arterial β-endorphin levels in newborn infants after spontaneous vaginal delivery and emergency cesarean section were significantly higher than levels in infants born by elective cesarean section, but only spontaneous vaginal deliveries showed higher umbilical arterial ACTH levels in newborn infants than infants born by elective cesarean section. 5. There was no relationship between meternal and umbilical cord plasma β-endorphin and ACTH. There was not significant correlation between umblical cord plasma β-endorphin and ACTH levels, and fetal weight and placental weight. 6. There was no correlation betwen umbilical arterial pH and Apgar score by mode of delivery, but statistical significance was found to exist in the umbilical arterial pH of emergency cesarean sections and elective cesarean sections. Present studies suggest that β-endorphin and ACTH are significantly increased during late labor due to stress and pain, and hypoxia may be important physiologic stiumuli controlling the release of β-endorphin and ACTH in the human fetus.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.

김치 유산균인 Lactobacillus sp. JJ-2001이 생산하는 Bacteriocin에 관한 연구

조영배,조우제,조영임,이은주,김성구,전홍기 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-

The microorganisms producing bacteriocin from kimch were screened, and among them,a strain showing the highest bacteriocin activity and stability was isolated. Based on the taxonomic characteristics of its morphological, cultural and physiological properties, the isolatef strain was characterized as Lactobacilius sp..To identify optimal conditions for the growth and the production of bacteriocin from the isolated strain,nutrient source, initial pH, and culture temperature were evaluated. Physiochemical properties of bacteriocin was also investigated. The potimal condition for the production of bacteriocin and the cell growth was obtained at 2% glucose, 1% beef extract as organic nitrogen source,1%(NH_4)_2SO_4 as inorganic nitrogen source,and 0.1% Tween 80. The isolated strain showed the maximum growth at 25℃. The inhibitory range of its antimicrobial substance aginst gram positive bacteria was marrow and its inhibitory activity was maintained between pH3.0 and pH8.0. The antimicrobial activity of bacteriocin from the isolated strain was stable at 50℃.