Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

일부 지역 주민에서 초기 신기능 저하의 지표로서 혈청 Cystatin C 농도의 유용성

원기범,김준섭,박준형,강혁주,이정호 동국대학교 의학연구소 2009 東國醫學 Vol.15 No.2

혈청 cystatin C농도는 혈청 creatinine농도에 비해 신기능을 정확히 반영한다고 알려져 있지만, 대규모 연구 자료가 제한적이었다. 따라서 저자는 다수의 일부 지역 주민을 대상으로 cystatin C를 creatinine과 비교하여 신기능의 지표로서 cystatin C의 유용성을 알아보고자 하였다. 2008년 7월부터 9월까지 포항지역의 건강 검진자 999명 (남자: 324명, 여자: 657명)을 대상으로 혈청 cystatin C, 혈청 creatmine, 나이, 체중을 측정하고, Cockcroft-Gault식으로 사구체 여과율을 계산하였다. 계산된 사구체 여과율을 National Kidney Foundation의 Kidney Disease Outcomes Quality Initiative (KDOQI)에서 제시한 만성 신장병 분류 기준에 따라 5단계로 분류하였지만 4단계 (중증의 사구체 여과율 저하) 및 5단계 (신부전 또는 투석) 에 포함되는 대상자들의 숫자가 적어 (4단계: 4명, 5단계: 1명) 연구 대상에서 제외하였다. 대상자들의 평균 나이는 52.1 ± 17.1 세, 평균 체중은 59.7 ± 11.3 Kg,평균 혈청 cystatin C농도는 0.9 ± 0.2 mg, 평균 creatinine 농도는 1.0 ± 0.2 mg/dL이었다. 사구체 여과율을 각 단계별로 비교해 본 결과는 다음과 같이 혈청 cystatin C농도는 1 단계 (정상 신기능)는 0.8 ± 0.1 mg, 2단계 (경도의 신기능 저하)는 0.9 U 0.1 mg, 3단계 (중등도의 신기능 저하)는 1.0 d=0.1mg로 각각 유의한 차이를 보였다 (p<0.05).혈청 creatinine농도는 1단계는 0.9 ± 0.2 mg/dL, 2단계는 0.9 ± 0.1 mg/dL, 3단계는 1.0 ± 0.1 mg/dL로 l단계와 2단계 간에 차이가 없었으나 (p>0.05), 2단계와 3단계 간에는 유의한 차이를 보였다 (p<0.05).혈청 cystatin C농도와 혈청 creatinine농도는 나이 (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) 및 체중 (cystatin C: r=0.075, P<0.05; creatinine: r=0.162, p<0.05) 과 양의 상관 관계를 보였다. 혈청 cystatin C 농도는 성별 간의 차이가 없었고, 혈청 creatinine농도는 남성에서 유의하게 높았다. 혈청 cystatin C농도는 혈청 creatinine농도에 비해 초기 신기능 저하를 반영하는 유용한 지표라고 생각된다. Although serum cystatin C has been suggested to be a better alternative marker than serum creatinine for estimating renal function, there have been limited data about its superiority over creatinine in a large number of populations. The aim of this study was to evaluate cystatin C as a renal marker compared to creatinine in a large population of the local community. We measured serum cystatin C, creatinine, age, body weight from 999 volunteers (Male; 324, Female; 657) of a single local cohort, Phohang, from July to September, 2008, and then calculated the GFR according to Cockcroft Gault(CG) formula. The population was divided into five stages followed by the chronic renal disease classification presented by KDOQI. The numbers in stage 4 (severe renal impairment), and 5 (renal failure) were too small (4 in stage 4, 1 in stage 5) to perform statistical analysis, so we excluded them. The mean age was 52.1 ± 17.1, and body weight 59.7 ± 11.3 Kg; serum cystatin C 0.9 ± 0.2 mg/L; serum creatmine 1.0 ± 0.2 mg/dL; CG GFR 70.6 ± 19.1 ml/min/1.73 m^(2). The tests completed for the comparison among each stage suggested the following results; serum cystatin C levels in stage 1 (normal renal function), stage 2 (mild deterioration of renal function), and stage 3 (moderate deterioration of renal function) showed the significant differences (stage 1 vs 2: 0.8 ± 0.1 vs 0.9 ± 0.1, p<0.05; stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum creatinine levels showed no significant differences between stage 1 and stage 2 (stage 1 vs 2: 0.9 ± 0.2 vs 0.9 ± 0.1, p>0.05), but showed significant differences between stage 2 and stage 3 (stage 2 vs 3: 0.9 ± 0.1 vs 1.0 ± 0.1, p<0.05). Serum cystatin C and creatinine presented positive correlation between age (cystatin C: r=0.275, p<0.05; creatinine: r=0.300, p<0.05) and body weight (cystatin C: r=0.075, p<0.05; creatinine: r=0.162, P<0.05). Serum cystatin C levels showed no significant difference in sex, but serum creatinine levels were significantly higher in men than women. Serum cystatin C level is suggested to be more useful parameter than serum creatinine level to evaluate early renal impairment.

家蠶育種을 위한 繭形質의 遺傳分析

鄭元福,朴東洵,姜弼敦 東亞大學校 1986 東亞論叢 Vol.23 No.1

蠶作安定多收性 育成의 重要性에 비추어 有用한 形質의 遺傳關係를 初期에 推定하고 效率的인 選拔을 爲한 基礎資料를 얻고자 形質相互間의 特性을 고려한 2個品種을 二面交雜하여 F??의 主要 形質에 대한 優性程度 및 組合能力 등을 檢定한 結果는 다음과 같다. 1. Vr-Wr graph에서 雌單繭重과 雄單繭重은 超優性으로, 雌繭層重, 雄繭層重, 雌繭層比率 및 雄繭層比率은 各各 不完全優性으로 推定되었다. 2. 各 形質에 대한 分散成分의 推定에서 雌繭層重, 雄繭層重, 雌繭層比率 및 雄繭層比率은 遺傳子의 相加的 效果가 優性效果보다 더 컸고, 雌單繭重과 雄單繭重은 反對의 樣相이었다. 優性程度와 平均優性程度에서도 雌雄單繭重에서 超優性이고, 雌雄繭層重과 繭層比率은 各各 不完全優性이었다. 3. 一般組合能力과 特定組合能力을 檢定한 바, 6個形質 모두 一般組合能力(GCA)이 特定組合能力(SCA)보다 높게 評價되었다. 4. GCA 效果의 경우, 蠶114가 雌單繭重이 6個形質中에서 가장 높았고, 蠶108이 雄單繭重, 雌繭層重, 雄繭層重, 雌繭層比率 및 雄繭層比率에서 各各 높게 評價되었다. SCA 效果는 蠶107×蠶113은 雌繭層比率에서, 蠶107×蠶114는 雄繭層重과 雄繭層比率에서, 蠶108×複形蠶은 雌繭層重에서, 蠶108×中14는 雄單繭重에서, 蠶113×綠東亞는 雌單繭重에서, 蠶114×複形蠶은 雌單繭重, 雄單繭重 및 雄繭層重에서, 中14×綠東亞는 雌繭層重, 雌繭層比率 및 雄繭層比率에서 各各 높게 評價되어 주로 奬勵蠶品種인 蠶108, 蠶114가 關與하는 組合에서 SCA 效果가 큰 傾向이었다. Since the estimates of the genetic relations between characters gave us effective basic informations about the selection of good strains of the silkworm, this experiment was carried out to estimate the degree of dominance and the combining ability for the some main characters of the silkworm such as cocoon weight and cocoon layer ratio and weight, using the 21 combinations of F??'s by diallel corsses of seven strains of the silkworm. As the result of this experiments, some conclusions obtained were as follows. 1. The male and female cocoon weights are inferred over dominance and their cocoon layer weights and ratio partial dominance from Vr-Wr graph. 2. The additive effect of gene on the male and female cocoon layer weights and ratio is higher than the dominance effect, on the contrary, the latter on both the cocoon weights is higher than the former. Also, in the average degree of dominance, both the cocoon weights are over dominance and the male and female cocoon layer ratio and weights are partial dominance. 3. The effect of general combing ability(GCA) on the 6 characters analysed in this experiments is higher than that of specific combining ability(SCA). 4. In the effect of GCA, the male cocoon weight of Jam 114 is the highest of 6 characters, the male and female cocoon layer ratio and weights of Jam 108 and the male cocoon weight of Jam 108 are relatively high. The effect of SCA on the female cocoon layer ratio of Jam 107×Jam 113, the female cocoon layer weight of Jam 108×Bokhyeong Jam, the male cocoon weight of Jam 108×Jung 14, the female cocoon weight of Jam 113×Nog Dong-A, the male and female cocoon weights and male cocoon layer weight of Jam 114×Bokhyeong Jam, and the female cocoon layer weight and the male and female cocoon layer ratio fo Jung 14×Nog Dong-A is estimated high. Generally, the combinations including the recommended strains of the siklworm such as Jam 108 and Jam 114 tend to be high in the effect of SCA.

米麥混食이 Cholesterol 및 無機質代射에 미치는 影響

姜信英,孫延瑗,柳總根 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

This study was devised to investigate the effect of dietary fiber of barley on cholesterol metabolism and absorption of mineral on feeding either rice diets or barley mixed diets. Wistar albino rats were administered starch, rice, rice containing balrey by 10%, 30%, and 60% and barley diets for 2, 4, and 6 weeks. 1. Serum cholesterol level was higher in the rice diet group than in the barley diet group. In the meantime, fecal steroid content was highest in the barley diet group and decreased as the proportion of barley in diets became lower. 2. Correlation coefficient between the increase of fecal n-eight and the increase of fecal steroid content was 0. 988(p<0. 001). 3. Fecal Fe and Ca content was net affected by the extent of barley and rice in diets. But fecal Ka and K content was high in the barley diet group. 4. Fecal weight and fecal moisture content was highest in the barley diet group, and became lower in the diet group where barley was added in smaller proportion. The increase of fecal weight was significantly related with the increase of fecal water content(r=0.918, p<0.001). 5. Serum lipid level was lower in the diet group containing more barley than in the rice diet group. In contrast, focal lipid content was highest in the barley diet group, and decreased in proportion to the decrease of barley addition in diets. 6. Accumulation of adipose tissue was observed In the rice diet group, 2nd the more barley mixed in diets, the lower it was. 7. Length of small intestine was longer in the barley diet group than in the rice diet group.

당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이,팽정령,서광식,안규정,우정택,김성운,양인명,김진우,김영설,김광원,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

목적 당대사의 조절 상태에 따른 생체 변화를 분자 수준에서 이해하고자 식이 조건을 달리한 정상 백서와 화학적으로 유도된 당뇨병 백서의 간조직에서 혈당수준과 인슐린치료 정도에 따라 나타나는 글루코키나제 활성도 및 유전자 발현을 분석하였다. 방법 스트렙토조토신 정맥투여 후 당뇨병의 유발을 확인하고, 인슐린을 1일 3회 3일간 복강내로 투여하여 상태를 안정시킨 후, 인슐린 투여군은 인슐린 투여 6시간이내에 그리고 인슐린 비투여군은 24시간 후 단두하여 채혈하고 복강을 열어 간조직을 채취하였다. 채취한 간조직에서 글루코키나제 활성도는 인산화된 포도당에서 NADH의 형성을 형광분광계로 측정하였으며, 글루코키나제 유전자 mRNA발현은 Northern 분석법을 이용하였다. 성적 정상 백서에서 공복상태와 식이를 섭취한 경우에 간조직의 글루코키나제 효소의 활성은 차이가 없었으나, 글루코키나제 유전자 mRNA 발현은 증가되었다. 당뇨병이 유발된 백서의 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현은 정상 백서에 비하여 낮았다. 인슐린 투쳐 후 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA 발현이 증가되었고, 특히 혈당이 정상화된 경우에서 글루코키나제 유전자의 mRNA 발현이 증가도었다. 결론 인슐린에 의한 간조직에서 글루코키나제 효소의 활성 및 글루코키나제 유전자의 mRNA을 증가를 볼수 있었다. 당뇨병 백서에서 인슐린 투여 후에 혈당조절이 안된 경우 간조직의 글루코키나제 유전자의 mRNA 발현이 증가가 없는 것으로 보아 글루코키나제 mRNA의 발현에는 인슐린 이외의 다른 요소가 관여할 것으로 생각된다. The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appears to be determined essentially by regulation of the rate of enzyme synthesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. And glucokinase activity was reduced in the liver of diabetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normoglycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expression.

지속성 외래 복막투석환자에서 발생한 장간막경색증 1예

강동구,이준상,윤재호,장원철,조영일,송종호,전혜정 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.13 No.-

The mesenteric infarction, as a abdominal disease which show acute abdominal pain and almost need to emergency operation, has very high mortality. This mesenteric infarction has been reported very rarely. Also specific clinical manifestations are not clear, therefore initial diagnosis can be missed easily so that patients usually miss their opportunities for adequate treatment. Especially CAPD patients have high mortality because of their rareness and having similar symptoms like CAPD peritonitis. The authors report that the mesenteric infarction was miss-diagnosed to the CAF'D peritonitis with unspecific symptoms.

Al₁₃과 Al₄₃ 덩어리 증착에 관한 분자동력학 연구

강정원,황호정 중앙대학교 기술과학연구소 1999 기술과학연구소 논문집 Vol.29 No.-

본 연구에서는 분자동력학 방법을 사용하여 알루미늄 덩어리 증착에 관하여 시뮬레이션. 덩어리 총 에너지가 증가할수록 기판의 최고 온도는 증가하였고, 덩어리 크기가 클수록 상관충돌효과가 커지는 것을 알 수 있었으며 덩어리의 총에너지에 따른 최고 증가 비율은 적어졌다. 비정렬 원자수 비교를 통하에 덩어리가 클수록 구조 재배열이 더 잘 이루어진다는 것을 알 수 있었다. 원자당 에너지와 덩어리 크기에 따른 증착 특성들은 살펴보았다. 덩어리 크기가 클수록 상관충돌 효과는 커지고 더욱 부드러운 증착이 이루어졌으며, 무엇보다도 덩어리 증착시 표면에서 구조 재배열이 잘 이루어지는 특징을 살펴볼 수 있었다. We simulated the aluminum cluster deposition using molecular dynamics methods. As the total energy of the cluster increases, the maximum temperature of substrate increases. However, since the correlated collisions effect is proportional to the cluster size, the rate of increase of the maximum substrate temperature decreases with the total cluster energy. As the size of cluster increases, the deposition is softer and the face-centered-cubic structure rearrangement is well occurred.

전하 제어법을 이용한 압전 액추에이터의 이력저감

정순종,이대수,송재성,홍원표,강은구,최원종 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper presents a method to reduce hysteresis in multilayer ceramic actuator by connecting the actuator with a capacitor in a series circuit. The change in hysteresis with respect to the capacitor was examined. 0.2Pb(Mg_(1/3)Nb_(2/3))O₃-0.8Pb(Zr_(0.475)Ti_(0.525)) O₃ ceramic material was used as a piezoelectric material for the actuator. Displacement of the actuator was measured in a capacitive gap sensor measuring system. In case of inserting a capacitor in a total circuit, hysteresis became dramatically decreased, and then finally the hysteresis value can be reduced below 0.2%. It was found in this present study that reducing the hysteresis in the actuator is dependent upon the characteristics of the capacitor in total circuit and also operating frequency

이담자 효모의 세포간 성응집의 특성과 표면단백질의 관련성

정영기,이태호,최용락,강원대 동의대학교 기초과학연구소 1996 基礎科學硏究論文集 Vol.6 No.1

When mating type A and a cells of heterobasidiomycetous yeast Rhodosporidium toruloides were mix-cultured, both of the mating type cells have shown strong agglutination. But this agglutination was not detactable when the A and a cell were cultured separately. From reagglutination made just after the result of disassembling the agglutination by sonication, we knew that the agglutination was sexual-agglutination, not simple physical cell agglutination. The sexual agglutination was progressed actively on logarithmic phase and, in addition, progressed faster on mating type a cell treated with rhodotorucine A. These sexual agglutination have been inhibited by several protease such as trypsin, pronase, chymotrpysin and thermolysin and inhibited by 5 mM DTT as well.