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브랜딩·스타일링·마케팅을 결합한 스페이스 디자인 프로세스 연구 - 작품‘Fill the Red, Feel the Red'를 중심으로 -
은다솜,장효실,최해원,홍지현,이진민,장미정,이성애 숙명여자대학교 디자인연구소 2018 숙명디자인학 연구 Vol.25 No.-
본 연구는 디자인 분야와 마케팅 분야의 전략을 종합하여 전략적 연결점을 찾아내 요소들 간 융합을 이루는 사례를 제시하여 브랜드·스페이스·마케팅에서 새로운 방향성과 아이디어를 제시하는데 목적을 둔다. 이에 본 연구는 2017년 9월~12월까지 ㈜애경과 산업 연계하여 진행된 숙명여대 환경디자인학과 ‘브 랜딩·스타일링·마케팅’ 교과목에서 도출된 ‘fill the red, feel the red’ 프로젝트를 마케팅 및 디자인 프로세스, 결과물을 도출하여 그 과정들을 밝힌다. 아울러 본 연구는 브랜드 스페이스 마케팅에 대한 이론적 고찰을 통해, 브랜드 스페이스(팝업스토어)를 개발 및 스타일링하며 ㈜애경의 화장품 브랜드 ‘LUNA’를 브 랜딩, 스타일, 마케팅적 측면에서 종합적으로 연계하여 도출되는 과정들을 제안함으로서 향후 브랜드 스페이스 디자인과 마케팅 분야에 체계적이고 창의적인 방법들로 결과물을 도출하는데 기초자료로 활용하는데 의의가 있다.
Identification of the most active interleukin-32 isoform
Choi, Ji-Da,Bae, Su-Young,Hong, Jae-Woo,Azam, Tania,Dinarello, Charles A.,Her, Erk,Choi, Whan-Soo,Kim, Bo-Kyung,Lee, Chang-Kwon,Yoon, Do-Young,Kim, Sun-Jong,Kim, Soo-Hyun Blackwell Publishing Ltd 2009 Immunology Vol.126 No.4
<P>Summary</P><P>Cytokines are crucial in host defence against pathogens such as bacteria, viruses, fungi and parasites. A newly described cytokine, interleukin-32 (IL-32), induces various proinflammatory cytokines (tumour necrosis factor-&agr;, IL-1&bgr;, IL-6) and chemokines in both human and mouse cells through the nuclear factor-&kgr;B and p38 mitogen-activated protein kinase inflammatory signal pathway. The IL-32 primarily acts on monocytic cells rather than T cells. In an attempt to isolate the IL-32 soluble receptor, we used an IL-32 ligand-affinity column to purify neutrophil proteinase 3, which is a serine proteinase involved in many inflammatory diseases. IL-32 has biological activity associated with <I>Mycobacterium tuberculosis</I> and chronic proinflammatory diseases such as rheumatoid arthritis. IL-32 is transcribed as six alternative splice variants and the biological activity of each individual isoform remains unknown. Here, we cloned the complementary DNA of the four IL-32 isoforms (&agr;, &bgr;, &ggr; and &dgr;) that are the most representative IL-32 transcripts. To produce recombinant protein with a high yield, the amino acids of two cysteine residues were mutated to serine residues, because serine residues are not conserved among different species. The multi-step purified recombinant IL-32 isoform proteins were assessed for their biological activities with different cytokine assays. The &ggr; isoform of IL-32 was the most active, although all isoforms were biologically active. The present study will provide a specific target to neutralize endogenous IL-32, which may contribute to basic and clinical immunology.</P>
Diagnostic value of peripheral blood immune profiling in colorectal cancer
Joungbum Choi,Hyung Gun Maeng,Su Jin Lee,Young Joo Kim,Da Woon Kim,Ha Na Lee,Ji Hyeon Namgung,Hyun-Mee Oh,Tae Joo Kim,Ji Eun Jeong,Sang Jean Park,Yong Man Choi,Yong Won Kang,Seo Gue Yoon,Jong Kyun Lee 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.6
Purpose: Little is known about the clinical value of peripheral blood immune profiling. Here, we aimed to identify colorectal cancer (CRC)-related peripheral blood immune cells and develop liquid biopsy-based immune profiling models for CRC diagnosis. Methods: Peripheral blood from 131 preoperative patients with CRC and 174 healthy controls was analyzed by flow cytometry and automated hematology. CRC-related immune factors were identified by comparing the mean values of immune cell percentages and counts. Subsequently, CRC diagnostic algorithms were constructed using binary logistic regression. Results: Significant differences were observed in percentages and counts of white blood cells, lymphocytes, neutrophils, regulatory T cells, and myeloid-derived suppressor cells (MDSCs) of patients and controls. The neutrophil/lymphocyte and Th1/Th2 ratios were also significantly different. Likewise, the percentages and counts of peripheral blood programed death 1, cytotoxic T lymphocyte antigen 4, B- and T-lymphocyte attenuator, and lymphocyte activation gene-3 were higher in patients with CRC. The binary logistic regression model included 12 variables, age, CD3<SUP><SUP>+</SUP></SUP>%, NK%, CD4<SUP>+</SUP>CD279<SUP>+</SUP>%, CD4<SUP>+</SUP>CD25<SUP>+</SUP>%, CD4<SUP>+</SUP>CD152<SUP>+</SUP>%, CD3<SUP>+</SUP>CD366<SUP>+</SUP>%, CD3<SUP>+</SUP>CD272<SUP>+</SUP>%, CD3<SUP>+</SUP>CD223<SUP>+</SUP>%, CD158b<SUP>-</SUP>CD314<SUP>+</SUP>CD3<SUP>-</SUP>CD56<SUP>+</SUP>%, Th2%, and MDSCs cells/μL, for the prediction of cancer. Results of retrospective and prospective evaluation of the area under the curve, sensitivity, and specificity were 0.980 and 0.940, 91.53% and 85.80%, and 93.50% and 86.20%, respectively. Conclusion: Peripheral blood immune profiling may be valuable in evaluating the immunity of CRC patients. Our liquid biopsy-based immune diagnostic method and its algorithms may serve as a novel tool for CRC diagnosis. Future largescale studies are needed for better characterization of its diagnostic value and potential for clinical application.
Skin whitening and anti-wrinkle activities of white rose petal extracts
JIEUN CHOI,EUN SUK AN,YOUNG-HWAN BAN,YESEUL CHA,HAIYU GUO,JI YOUNG LEE,NU RY HAN,EUN SANG CHO,EUN SU JEON,DA WOOM SEO,JUNG-MIN YON,HAE CHEON IM,JAE KWON CHOI,YOON BOK LEE,EHN-KYOUNG CHOI,YUN-BAE KIM 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08