위 유문동 평활근 세포의 전기적 활동에 미치는 Vanadate의 효과

유중배,방효원,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.1

Effects of vanadate on the resting membrane potential and slow waves of the circular smooth muscle were observed using glass capillary microelectrodes. The obtained results were as follows: 1. Vanadate did not show any effects on; the slow waves of spontaneously beating preparations. 2. Variation of the resting membrane potential due to the change of outside K^+ was 20-28m V/decade which suggested the significant contribution of Na^+ to maintain the resting membrane potential. 3. Vanadate did not show any further effects on the depolarized state about l0mV by outside 20mM K^+. 4. Vanadate induced the depolarization in the low outside K^+ condition and the effect was exaggerated when Cal^(2+) was depleted. 5. Vanadate induced the depolarization in the low Na^+ and K^+ condition. It was conjectured that the effects of vanadate were enhancing the voltage-dependent calcium.

Seyferth시약의 발암성과 반응메카니즘 연구

성대동,박유미 동아대학교 환경문제연구소 1993 硏究報告 Vol.16 No.1

The reaction mechanism and molecular carcinogenetic property for the reaction of Seyferth's reagents such as phenyl(bromodichloromethyl)mercury and phenyl(tribromomethyl) mercury with food additives as dehydroacetic acid and coumarin has been studied under the conditions fo UV/vis photolysis and laser flash photolysis. 1. The reaction reactivities of Seyferth's regents as phenyl(bromodichloromethy1)mercury and phenyl(tribromomethyl) mercury are compared in all reaction conditions. The reactivity of phenyl(bromodichloromethy1) mercury is higher than the reactivity of phenyl(tribomomethy1) mercury at any reaction conditions in this research. This means that the leaving effect of : CCl₂carbene is higher than that of CBr₂carbene from mercury atom in Seyferth's reagent. 2. The yield of a highly toxic carcinogenetic carbene intermediate in the condition of UV/vis photolysis is less than those of laser flash photolysis. It is explainable that the reactions of Seyferth's reagent with the food additives are inhibited compared with the dimerization reaction of dihalogen carbenes each other. 3. The reactions of Seyferth' s reagents with dehydroacetic acid and coumarin are accelerated increasing with the negative(-) values of the bond energy of HgCCX₂and σ MO energy.

위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예

김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.

모터구동 밸브 주기적 안전성 확인을 위한 중요도 분류

강대일,성태용,김길유 한국산업안전학회 2002 한국안전학회지 Vol.17 No.2

Safety-related motor operated valve(MOV) safety significance for Ulchin Unit 3 was categorized. The safety evaluation of MOV of domestic power plants affects the generic data used for the quantification of MOV common cause failure(CCF) events in Ulchin Units 3&4 PSA> Therefore, in this paper, MGL(multiple greek letter) parameter β, used for the evaluation of MOV CCF probabilities in Ulchin Units 3&4 probabilistic safety assessment(PSA), was re-estimated and the MOV safety significance was categorized. The re-estimation results of MGL parameter show that the value of(is decreased by 30% compared with the current value used in Ulchin Unit 3&4 PSA. The categorization results of MOV safety significance using the changed value of MGL parameter(show that the number of HSSCs(high safety significant components) is decreased by 54.5% compared with those using the current value of it used in Ulchin Units 3&4 PSA>

단일 기관에서 극소 저출생 체중아의 11년 치료 성적

이대성,홍유라 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : The Outcome of Infants weighing less than 1,500 g(very low birth weight infants : VLBWI) reflect recent progress in neonatal intensive care. In this study, we evaluated mortality and morbidity of very low birth weight (VLBW) infants during the past eleven years. Methods : A retrospective review of medical record was analyzed for VLBWIs admitted to the neonatal intensive care unit of Kosin University Gospel hospital between January 1, 1996 and March 31 2007. Results : The incidence of VLBWI was 3.6%. Overall survival rate of VLBWI was 65.9%. The survival rate increased significantly over time(period Ⅰ: 49.4%, period Ⅱ : 82.4%, P<0.05). The survival rate increased as birth weight increased. The incidence of respiratory distress syndrome was 70.3%(102/171), bronchopulmonary dysplasia 32.1% (36/171), intraventricular hemorrhage 19.4%(33/171), sepsis 24.4%(41/171). The main causes of death were respiratory distress syndrome and sepsis. Conclusion : The survival rate of VLBWI during recent 11 years was 65.9%. Survival rate increased as birth weight and gestational age increased. More efforts are needed to improve the long term outcome by reducing common morbidities.

自動倉庫와 保管品의 最適配置에 관한 硏究

李相玩,申大赫,兪炳哲 동아대학교 공과대학 부설 한국자원개발연구소 1990 硏究報告 Vol.14 No.1

This paper deal with the concept of AS/RS and the closest available location is AS/RS. Travel-time model and minimum cost model have developed for automated storage/retrieval machine. In this article, it is shown that arrival loads follow Poisson process and duration times are independent of each other and have i. i. d. distribution. The objective of this study is mainly compare with existing research and propose new approach method to optimal location. We give approximate method for the K closest location.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

善순환 리더십이 軍조직 효과성에 미치는 영향 : 공군 ○○부대 전투력 측정 결과를 중심으로

李相洪,劉永大 水原大學校 2005 論文集 Vol.23 No.-

This study is to verify and analysis Good+α cycle leadership, which is empirically theorized, effected to the military organization. Good+α cycle leadership is the leadership that makes each personnels or members in system being happy through the self-dedication to achieve the objective of organization under the integrity and morality. That must be based on being good with allegiance to fundamentals, cutoff the bad rings and etc. The research was conducted by the survey through the officers and senior noncommissioned officers, and the measurement results of combat power from randomly selected 6 subordinated units, Air Force OO Command, where are currently implemented and were trained. Analysis result shows that Good+α: cycle leadership characteristics(the life with fundamentals completed. Empowerment, praise and encouragement, and win-win pursuit) and an active followership are effecting affirmatively to the personal Good+α: cycle (self-identity actualization and self control) and the effectiveness in system. Also, we found that Good+α cycle leadership characteristics and the measurement results of personal Good +α cycle and units' combat power showed that they were commonly changed.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

컴퓨터과학 교육을 중심으로 한 중등 컴퓨팅 교육과정 설계

신상국,권대용,김형신,염용철,유승욱,이원규 한국컴퓨터교육학회 2005 컴퓨터교육학회 논문지 Vol.8 No.3