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Haiyu Guo,반영환,차예슬,안은석,최지은,서다움,박동선,최은경,김윤배 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.5
Anti-thrombotic activity and safety of nattokinase, an enzyme produced by Bacillus subtilis during soybean fermentation, were investigated in comparison with tissue-type plasminogen activator (t-PA). Carotid arterial thrombosis was produced with a FeCl3-soaked paper, followed by intravenous injection of nattokinase or t-PA. Nattokinase and t-PA delayed thrombus formation, near-fully (> 90%) inhibiting at 75 and 8.5 mg/kg, respectively. As adverse effects, t-PA induced petechial haemorrhage at 10 mg/kg in the lungs and thymus, and extensive bleeding at 20 mg/kg. Nattokinase also caused pulmonary haemorrhage from 300 mg/kg. Collectively, the standard safety margins (SSMs) for t-PA and nattokinase were calculated to be 1.2 and 4.0, respectively. Combinational treatment with dexamethasone (2 mg/kg) increased the efficacy and safety of t-PA and nattokinase, widening their SSMs to 2.4 and 8.0, respectively. The results indicate that nattokinase delayed thrombus formation and dissolved thrombi, and that nattokinase could be a good candidate anti-thrombotic agent with relatively-low haemorrhagic risk.
Design and Development of Superimposed Directional Comparison Protection Scheme
Guo Ziye,Crossley Peter A.,Li Haiyu 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.4
To achieve the UK Net Zero future by 2050, National Grid needs to integrate significantly more renewable generation into the power grid. This increases the level of harmonics, reduces system inertia and adversely affects the fault level and the performance of existing protection relays. One solution to the protection problem is the use of new types of protection that use the change in the voltage and current caused by the fault, often referred to as a superimposed or incremental based protection technique. This paper describes how a superimposed directional comparison protection scheme performed when applied to a reduced section of the full UK National Grid network and relates this to the operating performance of traditional protection. Tests are performed using the simulators DIgSILENT and RelaySimTest configured with different source levels, fault types, fault locations and fault resistances. Results show the superimposed based protection scheme achieves faster fault detection and tripping than conventional protection and is capable of detecting higher resistive faults on networks where the source capacities vary from strong to weak.
Feedback Linearization Control Approach for Brushless Doubly-Fed Machine
Xia Chaoying,Guo Haiyu 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
This paper presents a novel decoupling control strategy, corresponding to the vector control of induction motors, for the Brushless Doubly-Fed Machine (BDFM). The affine nonlinear state equation of the BDFM within an arbitrary rotating reference frame is also given for the first time. To achieve decoupling control over torque and flux, an input-output feedback linearization control strategy is used. A new control arithmetic, realized in the synchronous reference frame oriented by the control motor rotor flux, is developed. The necessary condition for implementation of the proposed control strategy is demonstrated. Simulation results confirm the feasibility and superb performance of the proposed strategy.
Bit-Level Image Encryption Algorithm Based on Composite Chaotic Mapping
Cai Yang,Haiyu Zhang,Jinliang Guo,Songhao Jia,Fangfang Li 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.8
Because the single chaotic mapping easily creates security weaknesses in the image encryption algorithm, the security needs to be improved. Aiming at this problem, a bit-level image encryption algorithm based on composite chaotic mapping (CCM-IEA) is proposed. First of all, the algorithm scrambles the plain image on bit level through the Cat mapping for the first time. And then the Henon mapping of two dimensional discrete is used to scramble for the second time. Finally, image diffusion is operated through the one dimensional Logistic mapping, and the data sensitivity is enhanced. The experimental results show that the performance of the CCM-IEA algorithm is better on the histogram, information entropy and correlation analysis. Compared with the single chaotic images encryption algorithm, the CCM-IEA algorithm has the ability to resist the information entropy analysis and correlation analysis. It can be seen that the CCM-IEA algorithm has high safety performance and good encryption effect.
Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet
차예슬,장자영,반영환,Haiyu Guo,신경하,김태수,이성표,최지은,안은석,서다움,연정민,최은경,김윤배 한국실험동물학회 2016 Laboratory Animal Research Vol.32 No.3
Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation. Perilla oil not only attenuated hypercholesterolemia and atheroma formation, but also reduced fat accumulation and lipid peroxidation in hepatic and renal tissues. The results indicate that perilla oil prevents atherosclerosis and fatty liver by controlling lipid metabolism, and that it could be the first choice oil to improve diet-induced metabolic syndrome.