지역냉방 시스템용 초고효율 판형 열교환기 개발에 관한 연구

박재홍(Jae-Hong Park),임혁(Hyug-Lim),조성열(Sung-Youl Cho),강인성(In-Sung Kang),김정규(Jung-Kyu Kim),허인은(In-Eun Hur),고성규(Seong-Kyu Ko),곽승식(Sung-Sik Kwak),김종재(Jong-Jae Kim) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.10

Plate heat exchanger consists of thin, rectangular, pressed sheet metal plates that are sandwiched between full peripheral gaskets and clamped together in a frame. The frame has a fixed end-cover plate, fitted with the connecting ports, which is bolted together with a movable cover plate to hold the embossed plates in between; the top and bottom carrying bars allow proper alignment of the plate stacks. When compared with the well-established shell and tube heat exchangers, the plate heat exchanger shows a lot of advantages like high NTU values, compactness, low cost, multi duties and reduced fouling etc. Plate heat exchangers are often used to transfer heating or cooling water which is produced in the energy production( district heating or district cooling) facilities to residential areas and industrial parks. The district cooling systems of Middle East are the biggest market of plate heat exchanger, but the technical specifications for cooling system are different from the domestic one. To achieve its specifications, the new plate heat exchanger was developed, and its thermal performance results are introduced in this paper.

비인두 암종에서 Epstein-Barr virus 감염과 p53 유전자 변이의 관계

박영식,최홍란 전남대학교 치과대학 2001 구강과학 Vol.13 No.1

Nasopharyngeal carcinoma is a common neoplasm of the head and neck, and commonly found in Southeast Asia. Epstein ­ Barr virus(EBV) is found within the malignant cells in most cases of nasopharyngeal carcinoma. The p53 gene has been implicated as a tumor suppressing gene in many types of human cancers, but the frequency of mutations varies in different cancers. To find out the correlation between EBV infection and p53 mutation in nasopharyngeal carcinoma, we evaluated the presence of EBV using EBER ­ 1 in situ hybridization and a mutation of p53, using PCR ­ SSCP analysis and DAN sequencing method. We examined nasopharyngeal specimens from 33 patients, histologicaly consisting of 27 cases of nonkeratinizing squamous cell carcinoma (WHO ­ Ⅱ) and 6 cases of undifferentiated carcinoma (WHO ­ Ⅲ) according to the World Health Organization claasification. EBER1 were detected in 14 of 33 (42.4%) cases. Positive hybridization signals were restricted to the nuclei of tumor cells. Of 14 cases 14 cases, 11 out of 27 (40.7%) cases of WHO ­ Ⅱ, and 3 out 6 (50%) cases of WHO ­ Ⅲ were positive. 33 biopsy specimens were analyzed by PCR ­ SSCP for p53 gene mutations. Our study concentrated on exons 5 through 9 of the p53 gene. However, we did not detect any mobility shifts n exon 5/6, 7 and 8/9 of the p5 gene in comparison to the banding patterns of the normal control. The reliability of the SSCP analysis was confirmed by sequencing five randomly chosen specimens for the exon 5 ­ 9 region. Among five cases, 4 out 5 cases were EBER1 positive and histologially WHO ­ Ⅱ, and 1 out of 5 cases were EBER1 negative and WHO ­ Ⅲ. We detected point mutation in 3 cases were EBER ­ 1 positive and WHO ­ Ⅱ. No alteration of the exon 7 and 8/9 of the p53 sequence was observed. Alteration occurred in 2 out of 3 cases; GCC was replaced by GTC at codon 131, resulting in a change in amino acid sequence from alanine to valine. In one 3 cases, TCC was replaced by TTC at codon 149, resulting in a change from arginine to arginine. Based on the above results, this study shows correlation between the presence of EBV and mutations of the p53 gene, suggesting contributions to malignant transformation in nasopharynx. We need to futher investigate this situation to understand the stepwise progression of nasopharyngeal carcinogenesis.

腎兪 熱地黃 水鍼이 正常 및 實驗的 腎性高血壓 白鼠의 腎臟機能에 미치는 影響

朴呈培,朴喜守,김홍일,李昊燮,金庚植 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

To investigate the effect of Shudihuang(熟地黃) aqua-acupuncture at the meridian points BL 23 on the renal function in normal and two kidney one clip Goldblatt hypertensive rats. The results of this study were as follows : 1. Urine volume, free water clearance rate were significant increased after Shudihuang aqua-acupuncture in normal rats. 2. Urinary excretion on potassium and chloride, glomerular filtration rate were significant decreased after Shudihuang aqua-acupuncture in normal rats. 3. Urine volume, ruinary excretion of electrolytes were significant decreased after Shudihuang aqua-acupuncture in two kindney one clip Goldblatt hypertensive rats. 4. Free water clearance, glomerular filtration rate were significant increased after Shudihuang aqua-acupuncture in two kidney one clip Goldblatt hypertensive rats.

교류전해에칭용 에틸렌글리콜의 알루미늄박판의 부식억제 효과

박성민, 양정진, 김홍일, 김한주, 김성한, 신진식, 박수길 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

In this study, additions of aluminium foil eching characteristics were compared with sulfuric acid for capacitor. sulfuric acid and ethylene glycol is used as addition, characteristics of funtional group from addition were guessed by comparing of aluminium foil eching characteristics. When sulfuric acid was added in HCI etching solution, corrosion of aluminum metal was inhibited by the chemical adsorption of sulfate ion, when ethylen glycol was added in HCI etching solution, corrosion inhibited by the chemical adsorption of OH­^ion.

악성림프종 환자에서 복합화학요법으로 유발된 백혈구 감소증에 대한 인형 재조합 과립구 집락형성-촉진인자(rhG-CSF: Neutrogin)의 효과

박성규,전진우,기신영,유병우,김홍수,백승호,원종호,홍대식,박희숙 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Clinical effects of rhG-CSF were investigated in 17 patients receiving chemotherapy for non-Hodgkin's lymphoma. Patients were given G-CSF 2㎍/㎏/day after 2nd cycle chemotherapy for least 14 consecutive days, and clinical and laboratory results were compared to results of the first cycle. Treatment with G-CSF resulted in increase of mean WBC count(952.9±152.2㎜³vs 1882.4±350.4/㎜³) and neutrophil count(212.9±53.0/㎜³vs 841.5±238.0/㎜³), reduced the duration of leukocytopenic days(12.4±1.3 days vs 5.5±1.0 days, WBC count less than 4000/㎜³) and neutropenic days(4.5±0.9 days vs 2.3±0.7 days, neutrophil count less than 500/㎜³), and reduced the duration of neutropenic fever(5.8±1.1 days vs 0.9±0.5 days). The side effects of G-CSF were not so significant. These results demonstrated that G-CSF is safe and useful for the treatment of neutropenia induced by anticancer chemotherapy of non-Hodgkin's lymphoma and reducing the incidence of febrile periods and duration of antibiotic administration.

이갈암 성리학의 조선유학사적 의의

박홍식 영남철학회 1996 哲學論叢 Vol.12 No.-

치근단 낭종에서 염증세포와 콜레스테롤 결정의 분포양상

박영식,최홍란 전남대학교 치과대학 1995 전남치대논문집 Vol.7 No.1

Apical periodontal cysts correlate to dental caries, and derived from the epithelial rests of apical granuloma. The lesions are histologically characterized by infiltrates of monocytes/macrophages, lymphocytes, plasma cells and mast cells. In addition, cholesterol crystals and foam cells are found. The aim of this study was to investigate the relationship between chronic inflammatory cells, cholesterol crystals and foam cells. The results obtained were as follows : 1. In all apical periodontal cysts, mild to severe number of inflammatory cells could be observed, while foam cells and cholesterol crystals were found in varying number. 2. The cholesterol crystals were not always associated with foam cells. 3. The cholesterol crystals appeared as long narow spaces with pointed tips and cluster formation. 4. The foam cells and choesterol crystals surrounded by lymphocytes, plasma cells, and erythrocytes, hemosiderin pigments and giant cells were observed. 5. Vast number of the cholesterol crystals and foam cells congregated in connective tissue, less frequently crystal mass eroded the epithelial lining and empties the crystal into the cystic cavity. From above the results, it was found that cholesterol crystals and foam cells are characteristic findings and correlated to inflammatory reaction in apical periodontal cyst. It suggested that inflammation closely related to cholesterol crystals and foam cells.

전환기 헝가리 議會政治의 變化發展

朴洪植 江陵大學校統一問題硏究所 1997 統一問題硏究 Vol.13 No.-

구조적 불확실성을 가지는 시스템의 파라메터 섭동 범위 결정에 관한 연구

박용식,신홍철 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

In this thesis, As the uncertainty system that includes a parameter perturbation uncertain plant require to satisfy a performance range and to use a fixed controller, we introduce the design method of the control system to satisfy a performance range and the decision method of the maximum range of parameter perturbation to guarantee the performance range of the system, by using Edge theorem.

소아의 혈관내 응고증후군

박용훈,김홍배,강덕식,이상범 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

We have reviewed 11 cases of Disseminated Intravascular Coagulation (DIC) admitted to the Pediatric department of Kyungpook National University Hospital from January 1981 to July 1982. Age distribution showed 4 cases below, year of age including 2 neonatal cases, 2 between 1 to 5 years of age, 2 between 6 to 10 years of age and 3 between 11 to 15 years of age. Three of these 11 cases are male and the rest 8 female. DIC developed within the first 5 admission day in 7 cases, from the 6th to the 10th day in one and after the 10th in three. Factors predisposing to DIC included infection (11 cases) which were usually systemic, shock, recent surgery and malignancy. Diagnostic coagulation studies included low platelet count below 100,000/cumm (all 11 cases), prolonged PT (10 cases) and PTT (all 11 cases). All patients had abnormal hemorrhage and the majority being petechiae on the skin (8 cases) followed by oozing from the injection site (6 cases), melena (4 cases), epistaxis (3 cases), bleeding from the oral cavity (3 cases), intracranial hemorrhage (1 case) and hematuria (1 case). Local ischemic manifestations probablly due to the thrombus formation were respiratory distress (9 cases), mental disturbance (9 cases), diarrhea (8 cases), abdominal pain (7 cases) and acrocyanosis (3 cases). Shock due to systemic circulatory disturbance was also seen in 5 cases. Treatment included transfusion of fresh whole blood and Vitamin K admimistration in all cases, plalelet transfusion in 6 cases, Corticosteroid administration in 4 cases and none received Heparin. Only 3 cases showed improvement and the rest discharged hopelessly and/or died. key words: Disseminated Intravascular Coagulation.