제2형 당뇨병 환자에서의 지속적 피하 인슐린 주입 치료시 관해

최의광,최수봉,박선민 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background: It is well known that chronic hyperglycemia can deteriorate pancreatic beta cell function and insulin sensitivity in animal and human studies, and the normalization of blood glucose can reverse them. Our purpose of the study was to investigate the remission pattern after treating patients with continuous subcutaneous insulin infusion (CSII) therapy, and compare the clinical characteristics of remitted and non-remitted patients in a retrospective way. Methods: We selected 91 type 2 diabetic patients who had been admitted to KonKuk University hospital from January 1993 to August 1993. After hospitalization, all subjects were treated with insulin pump (Sooil, Seoul, Korea) for intensive blood glucose control until remission occurred. Remission is defined as long-term good glycemic control without any medication. After fifteen to seventeen months of CSII therapy, the induction of remission was examined. Serum c-peptide levels, hemoglobin A1c, and serum lipid profiles were measured after hospitalization and before discharge. Results: Overall 34.4% of all subjects had remission after 53.6±38.9 days of CSII therapy and remission lasted for average 13.6 ± 8.9 months during the study periods. Some clinical characteristics of the patients prior to CSII therapy influenced the remission occurrence. The remission was more frequently induced when patients started CSII therapy with insulin pump in younger age, higher body mass index, shorter diabetic duration, lower post-prandial blood glucose levels, higher post-pandial serum c-peptide levels, and less chronic diabetic complications. Conculsion: These findings suggest that long-term CSII therapy can induce remission in a significant proportion of mild type 2 diabetic patients. Thus, it is desirable that the intensive insulin treatment by CSII is considered as not the last treatment., but an initial management of mild type 2 diabetic patients.

유도 '되치기 본'의 개선 방안에 관한 연구

김의환,김도준,김규수,김관현,김종달,최종삼,조용철,박순진,윤익선,안병근,정 훈,김미정,한성철 龍仁大學校 武道硏究所 1999 武道硏究所誌 Vol.10 No.1

The purpose of this study was to reform practically a Korean Judo's Doechigi-Bon(Forms of Counterattack, judo's Gaeshi no Kata, Judo's Uradori no Kata, Judo's Gonosen no Kata) that was established in 1955 Korea, according to changing of techniques by Judo's modernization, in order to have Judo's carefulness and systematic diffusion. Reform procedure of Judo's Doechigi-Bon was 1st stage, Questionnaire survey 303 judokas, 2nd stage, Technical seminar by judo experts(12 judo professor) 4 times, 3rd stage, wording report for reform, 4rd stage, Discussion and judgement of Teaching and Judgement commission of Korean judo Association(KJA), 5th stage, Public hearing for reform in KJA, 6th stage, Report and decision of board of directors in KJA, 7th stage, public publication of Judo News(No.53) in KJA. Basic principle of reform of Judo's Doechigi-Bon were as table 1. Table 1. Basic principle of reform of Judo's Doechigi-Bon ------------------------------------------------------------------------------- Items Reformed Key Points of Judo's Doechigi-Bon ------------------------------------------------------------------------------- 1. Structure 1) Grand classification : Classified by 3 parts(1,2,3Gyo) 2)Medium classification : Te waza, Goshi waza, Ashi waza devided per each part(Gyo) 3)Sub-classification : Classified five techniques per each part(Gyo) 2. Contents 1) Selected established techniques as possible 2) Considered rationalty and overlapping of counterattack techniques 3. Decision of Conterattack techniques 1) Refered to results of Basic Questionnaire survey 2) Priority to decisions of Judo expert technical seminar -------------------------------------------------------------------------------- Reformed Korean Judo's Doechigi-Bon(Forms of Counterattack techniques-KJA, 1999) are as follows: 1. Gyo; ① Uki otoshi -> Uchi mata ② Harai goshi -> Harai goshi gaeshi ③ O soto gari -> O soto gake ④ Ko uchi gari -> Sasae tsurikomi ashi ⑤ O uchi gari -> Ko soto gari 2. Gyo; ① Ippon seoi nage -> Okuri eri jime ② Tsuri domi goshi -> Uki waza ③ Okuri ashi harai -> Okuri ashi harai ④ Ko soto gari -> Tai otoshi ⑤ Hiza guruma -> Hiza guruma 3. Gyo; ① Kata guruma -> Sumi gaeshi ② Tai otoshi -> Ko soto gari ③ Hane goshi -> Harai tsurikomi ashi ④ Uchi mata -> Tai otoshi ⑤ Tomoe nage -> O uchi gari

아스코르빈산의 식품생화학적 성질에 관한 연구(3) : Dimethylnitrosamine 급성투여시 흰쥐 간 지질과산화에 대한 L-Ascorbic Acid의 작용

변광의,박영현 순천향대학교 1990 논문집 Vol.13 No.2

간세포내에 생성된 과산화지질은 세포막을 파괴하거나 효소단백을 변성시켜 간조직의 급성장애를 일으키며 혈중을 방출되어 혈중 과산화지질을 상승시켜 말초조직뿐만 아니라 혈소판 응집, 혈관폐쇄, Vitamin파괴, 효소활성 억제등 많은 병태 반응들을 일으킨다. 그러므로 강력한 발암성 및 간독성을 갖는 Dimethylnitrosamine이 생체내에서 지질과산화 현상과 밀접한 상관성을 갖는지를 보고 L-Ascorbic aicd(720mg/kg)과 Dimethylnitrosamine(40mg/kg)에 의한 지질과산화 작용의 억제효과를 검토하였다. 1) 경구투여시 Ascorbic acid가 Dimethylnitrosamine으로 유도된 과산화지질의 억제효과를 보면 nucleus 분획과 post-mitochondria supernatant 분획에서 각각 39%, 32%로 유의성 있게 나타났다. 2) 복강투여시 Ascorbic acid가 Dimethylnitrosamine으로 유도된 과산화지질의 억제효과를 보면 간 homogenate, nucleus 분획, mitochondria 분획, post-mitochondria supernatant 분획에서 각각 44%, 60%, 25%, 39%로 유의성있게 나타났다. 이상의 결과로 부터 Ascorbic acid는 Dimethylnitrosamine에 대한 과산화지질 억제작용이 있다고 추정되며, 경구투여 보다 복강내 투여가 억제작용이 크며 Dimethylnitrosamine의 유도로 인한 간세포의 지질과산화작용은 nucleus 또는 microsome 분획과 밀접한 관련성이 있다고 사려된다. It is well known that lipidperoxides, formed in hepatocyte, induced the denaturation of enzyme and destruction of cell membrane to acute injury of liver. Plasma lipidperoxide that released in blood also is known to disturb peripheral tissue and results in vascular obstruction, platelet aggregation deficiency. Development of lipidperoxide inhibitory agents, therefore, provides and important dimension in assessing the ameliorationof those diseases. The hepatotoxic and carcinogenic action of dimethylnitrosamine(DMNA) have been extensively investigated, which were thought to have the relationship to lipidperoxidation. The anti-lipidperoxidative effects of L-ascorbic acid have not yet established. In this study, we examined the anti-lipidperoxidative effects of L-ascorbic acid(720mg/kg) on DMNA-induced lipidperoxidation in rats. The results obtained were as follows: 1) In rat liver homogenate intoxicated by the oral administration of DMNA at a single dose of 40mg/kg, L-ascorbic acid exhibited 10% anti-lipidperoxidative effect. In nucleus fraction, L-ascorbic acid significantly showed 39% inhibition and in postmitochondria supernatant fraction, 32% inhibition respectively. 2) In rat liver homogenate intoxicated by the intraperitoneal administration of DMNA at a single dose of 40mg/kg, L-ascorbic acid significantly exhibited 44$ anti-lipidperoxidative effect. In nucleus fraction, L-ascorbic acid significantly showed 60% inhibition and in mitochondria fraction, 25% inhibition and in postmitochondria supernatant fraction, 39% inhibition respectively. These results show that L-ascorbic acid exhibits the anti-lipidperoxidative effect on DMNA-induced lipidperoxidation in rats and the intraperitoneal administration of DMNA promotes lipidperoxidation when compared to the oral administration, and suggest that DMNA-induced lipidperoxidation, formed in hepatocyte, have relation with the nucleus fraction and the postmitochondria supernatant fraction.

골프 Putting 동작 시 프로선수와 아마추어간의 3차원 운동학적 변인 비교분석

김의환,박정현,백광현 한국운동역학회 2001 한국운동역학회지 Vol.10 No.2

The purpose of this study was to compare of the kinematic variables, as competition situation putting stroke(PS) between Korean pro. and ama.- golfers, by the 3 dimensional analysis. The subjects were three pro-golfers who are competitioning in the fields and three ama.-trainees. Kinematic variables(temporal, distance, and velocity variables of golf club-head) were computed through motion analysis system, by videography(30f/s. from the front and side view). From the data analysis and discussion, conclusions were as follows : 1. Temporal variables : The elapsed time(ET) during PS, pro(1.32sec.) was 0.10 sec. longer than ama.(1.22sec.), the ratio comparison of ET each phase during PS, pro(0.40sec.,30.38%) was 6.28% longer than ama.().30sec. 24.1%) in back-swing phase, pro(0.25sec, 17.7%) was 4.2% shorter than ama.(0.27sec., 21.9%) in down-swing phase, ratio of ET in backswing and downswing was average 1.60 : 1 by pro., and 1.11:1 by ama.-golfers, respectively. 2. Distance variables : The distance of club-head during PS, pro.(21.8cm) was 10.2cm shorter than ama.(32.0 cm), distance of 2nd half part in PS from impact to follow through top, pro.(46.2cm) was 11.6cm shorter than ama.(57.8cm), distance of 2nd half part of PS, pro(46.2/21.8cm) was 2 times over than 1st half part, ama.(32.0/57.8cm) was 2 times under than 1st half part, respectively. 3. Velocity variables : The velocity of club-head during PS, pro.(1.21m/sec.) was 1/2 times slower than ama.(2.37m/sec.) in over all, BS, DS and FT in PS, pro.(0.9, 1.6, and 1.15m/sec.) was slower than ama.(1.95, 3.19 and 1.96m/sec.), respectively. Over all, pro. was more stable than ama. in PS. <end>

악관절 수술후 안면신경 손상에 대한 임상적 연구

주재동,이의웅,김준배,박광호,김형곤 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.4

Authors have studied retrospectively the facial nerve injury after TMJ surgery through the preauricular approach routine. The study material used was 4 patients of all 113 patients who were diagnosed as internal derangement and have been operated from March 1989 to February 1991 in Youngdong severance hospital, and were induced postoperatived facial nerve injury. The patient group who had the postoperative injured facial nerve was recognized degree of injury using the diagnostic method, Electromyography(EMG) and Nerve conduction test(NCT) which are used widely at present and was treated as conservative care and we identified the recovery time as the same method. The results as follows : 1. The meticulous care and precious surgical technique are needed in both operation and postoperation. During the TMJ surgery, the excessive retraction of the flap and frequent use of nerve stimulator and electric surgical knife should be avoided as possible and postoperative hematoma and swelling should be minimized. 2. The 4 patients were experienced with the postoperative facial nerve injury of all 133 patients who had been operated the TMJ surgery through the routine preauricular approach on our hospital. And the incidence of postoperative facial nerve injury happened was about 0.3% and its incidence was relatively low comparing with any other previous reports. 3. EMG and NCT were considered as useful methods which can diagnose the nerve injury objectively and identified the effect of treatment and recovery time. 4. The faical nerve-injured patients who were induced postoperatively after TMJ surgery, were diagnosed as second-degree nere injury through the EMG and NCT. And the patient group was treated well as conservative physical therapy for about 2 to 4 months.

일 대학 병원 마취 · 회복실 간호사의 간호활동 분석

강윤경,김경미,김연이,박혜옥,서광희,송숙녀,이현숙,조의영 대한간호행정학회 2006 간호행정학회지 Vol.12 No.1

Purpose: This study was aimed to specify roles of nurses from the anesthesia and recovery room by analyzing nursing activities as well as anesthesia nursing during surgery. Method: The objects were 12 RNs working in the recovery room of a university hospital located in Incheon. Self-report was performed by measuring stop-watch for five days from May 17th to May 21st in 2004. Research method was designed to record the time and frequency of the nursing activity from anesthesia and recovery room based on nurses' statement and other references for five days. The data were analyzed with descriptive statistics, ANOVA, and t-test via SPSS Win 10.0 program. Result: Nursing activities in anesthesia recovery room were classified into two different characteristics such as direct and indirect nursing activity. The activities consisted of 11 direct nursing areas and 39 nursing activities in anesthesia preparation room. The indirect nursing was classified into 8 nursing areas and 32 nursing activities. The direct nursing was classified into 12 nursing areas and 55 nursing activity. Also, the indirect nursing was classified into 7 nursing areas and 21 nursing activities in recovery room. In terms of prevalence of nursing activities in the anesthesia preparation room, observation and cooperation of anesthesia was the most prevalent activity, drug and eqipment management the second prevalent, and drug administration the third. On the other hand, in the recovery room, the most prevalent activity was vital sign checking and observation, the second most prevalent activity informative activity, and the third body temperature control. Nursing activity time was recorded according to the nursing characteristics. In the anesthesia preparation room, the direct nursing spent for 8092.20 minutes was larger than the indirect nursing spent for 7198.50 minutes. Also, in the recovery room, the direct nursing spent for 2361.16 minutes was larger than the indirect nursing spent for 1134.13 minutes. 4. Nursing activity time was compared to duty shifts. In the anesthesia preparation room, the direct nursing was more prevalent on day shift and the indirect nursing was prevalent on evening shift. However, in the recovery room, both direct and indirect nursing activities were prevalent on day shift. Conclusion: The role of anesthesia and recovery room nurses was analysed according to the time, frequency, and its characteristics.

축출/삽입/카운터 기능을 갖는 혼합형 우선순위 제어방식에 관한 연구

한상엽,최현호,이현의,박광채 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.2

In the switching node or the ATM multiplexer of the ATM network, a good bandwith utilization can be achieved by the priority control using the 1-bit CLP(Cell Loss Priority) in ATM cell header. In this paper, the hybrid priority control scheme is proposed to make up for shortcomings of existing space priority cell in a long term. its performance is ananlyzed by the cell loss probability. We estimate CLP of medel 1,2,3, and 4 to perform of the hybrid priority control scheme which we propose. Also, to estimate CLP of each priority control scheme, we perform the simulation using the simulation package, SIMSCRIPT Ⅱ.5.

Structural features of archaeal β-phosphoglucomutase from hyperthermophilic Pyrococcus sp. ST04

Kwang-Hyun Park,Jong-Hyun Jung,Cheon-Seok Park,Eui-Jeon Woo 한국구조생물학회 2014 Biodesign Vol.2 No.3

β-Phosphoglucomutase (β-PGM) catalyzes the conversion of β-glucose-1-phosphate (β-G1P) to glucose-6-phosphate (G6P). Upon binding to the substrate, β-PGM adopts a conformational change of cap domain over the core domain with concomitant closure of the active sites located at the domain interface. Recently we have identified a novel β-PGM from Pyrococcus sp. ST04 (PsPGM) that is highly thermostable, with an optimal temperature of 95℃. The crystal structure of PsPGM shows two domains: the core domain with a typical β/α barrel-fold of haloacid dehalogenase (HAD) family, and the cap domain with α-helical bundles. The core domain contains the active site with the conserved Asp7 and cofactor Mg2+, exposing the catalytic residue to the surface. Unlike bacterial β-PGMs, the cap domain of PsPGM exists in a significantly tilted, half-closed conformation, which positions Lys82 in close proximity to the substrate binding in the absence of ligand. This unique configuration of the cap domain distinguishes this archaic enzyme from typical bacterial β-PGMs and provides a molecular basis for its enzymatic characteristics at high temperature.

중부지역 뿌리부추 하우스 재배 시 차광 정도가 생육 및 수량에 미치는 영향

박의광(Eui-Kwang Park),노재관(Jae-Gwan Noh),이민정(Min-Jeong Lee),남상영(Sang-Young Nam),홍의연(Eui-Yon Hong),이철희(Cheol-Hee Lee) (사)한국생물환경조절학회 2016 생물환경조절학회지 Vol.25 No.4

본 연구는 뿌리부추를 시설하우스에서 재배할 경우 여름철 고온기 하고현상(Summer depression)을 방지하기 위하여 차광막을 하우스 내부 또는 외부에 설치하여 차광정도를 달리하면서 생육 및 수량에 미치는 영향을 조사하기 위하여 수행되었다. 2015년 하우스 내부에 무차광, 35, 55, 75, 95% 차광막을 설치하여 정식 후 20일째 되는 날에 최종 출현 정도를 조사한 결과, 무처리, 35 및 75% 차광에서 98% 출현하였고, 55 및 95% 차광에서 100% 출현하였다. 차광 정도와는 상관없이 모든 처리에서 최종 출현은 양호하였다. 하우스 내외부에 차광막을 설치했을 경우, 2년간 평균 생중량(Fresh weight)은 75% 차광에서 6,323kg/10a으로, 무차광, 35%, 55%, 95% 차광보다 각각 5.0배, 1.8배, 1.1배, 1.7배 높았다. 하우스 외부에 차광막을 설치할 경우 생중량은 75% 차광에서 684g으로, 55%, 95% 차광보다 1.1배, 1.8배 높았다. 건중량(Dry weight), 건물율(Percentage of dry matter), 엽수(No. of leaves), 분얼수(No. of branches), 초장(Plant height), 근장(Root length) 등 분석결과 75% 차광이 다른 차광 보다 통계적으로 유의하게 높거나 절대적 수치가 높게 측정되어 중부지역에서 뿌리부추를 재배 할 경우에는 75% 차광이 가장 적합한 것으로 판단되었다. Allium hookeri is used for food and medical materials in Asia. This study was carried out to elucidate the effects of shading rates on growth and quality of A. hookeri cultivation in greenhouse. Treatments were given with 35%, 55%, 75% and 95% shading rates and non-shading (Control). Photosynthesis photon flux density (PPFD) of control, 35%, 55%, 75%, and 95% shading were 792, 515, 351, 182, and 78.2μ㏖·m·s<SUP>-1</SUP> respectively. The emergence ratio was 98% under non-shading, 35% and 75% shading condition, and it was 100% under 55% and 95% shading condition on April 20, 2016. These results showed no correlation between emergence rate and shading treatment. When shading net was set up inside at greenhouse, fresh weights in control, 35%, 55%, 75%, and 95% shading treatments were 1,142, 3,511, 5,936, 6,408 and 3,779㎏/10a, respectively. When shading net was set up outside at greenhouse, fresh weights in control, 55%, 75%, and 95% shading treatments were 1,372, 5,442, 6,238 and 3,595㎏/10a, respectively. Dry weight, percentage of dry matter, number of leavesand branches, plant height and root length in 75% shading treatment were higher than other shading treatments. From these results, we suggested that the proper shading rate in a greenhouse is 75% for A. hookeri cultivation in middle area of Korea.

시설하우스 풋고추 재배시 육묘기간이 품질 및 수량에 미치는 영향

박의광(Eui Kwang Park),노재관(Jae Gwan Noh),이민정(Min Jeong Lee),남상영(Sang Young Nam),홍의연(Eui Yon Hong) 한국원예학회 2016 한국원예학회 학술발표요지 Vol.2016 No.10