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        보증신용장과 화환신용장에 있어 발행은행의 지불거절의 항변에 관한 연구

        박영현 한국무역연구원 2020 무역연구 Vol.16 No.4

        Purpose This paper analyzes the defence for the payment refusal of issuing bank in the standby letter of credit and documentary credit with Germany’s viewpoint. Design/Methodology/Approach In this study, to analyze the defense of the issuing bank’s refusal of payment, it is analyzed through the literature research method, and in this regard, domestic and foreign literature and internet data are used. Findings In particular, since the bank sales counter handles standby letters of credit or independent guarantees used for non-trade transactions at the same time, it is necessary to clearly understand the difference between URDG758 and ISP98 used here. Furthermore, the applicant applying for the issuance of an independent guarantee or Standby letter of credit should select which rule to apply as the applicable rule in consideration of the necessity and structure of their transaction in the guarantee requested by the applicant. Research Implications As issuing bank’s obligation to pay is positioned as an alternative payment system such as trading contracts and subcontracts of the other party, its implementation must be suitable for the definition of substantive law from the viewpoint of the trading law, the subcontract law, etc. To this end, while acknowledging that there are cases in which the abstraction and independence of payment obligations have to be sacrificed to some extent, it is necessary to continuously verify the jurisdiction to the extent that can be endured

      • Tetrahydroberberine의 마우스 自發運動과 常同行動에 대한 中樞 dopamine 과의 관련성

        朴永鉉,趙台淳 성균관대학교 약학연구소 1989 成均藥硏論文集 Vol.1 No.1

        Abstract-The present study was undertaken to elucidate a possible role by brain dopamine in the central depressant action of tetrahydroberberine(THB). In these studies, the central depressant action of THB on the spontaneous motor activity, the stereotyped behavior and the rotational behavior by dopamine agonists was studied under several experimental conditons with specific or nonspecific action on the central dopamine. And also studied dopamine histofluorescence following the administration of THB in rats pretreated with γ-butyrolactone and α-methyl-p-tyrosine. The fluorescence histochemical method was employed to elucidate the brain dopamine and its relationship to behavioral effect of THB in rats. The results were summarized as follows. 1. THB(2∼100㎎/㎏) exhibited dose-related decrease in the spontaneous motor activity and stronger depressant effect than that of berberine in mice. The levorotatory isomer was the strongest among THB isomers. 2. THB caused the suppression of the spontaneous motor activity and the stereotyped behavior induced by apomorphine and methamphetamine in mice. 3. Apomorphine-induced spontaneous motor activity and stereotyped behavior were remarkably inhibited by the pretreatment with THB in mice received 6-hydroxydopamine intraventricularly or α-methyl-p-tyrosine intraperitoneally. 4. Apomorphine produced the contralateral rotation, while methamphetamine induced the ipsilateral rotation in mice with unilateral striatal 6-hydroydopamine-induced lesions. The rotations induced by two agonists were remarkabley suppressed by THB. 5. THB increased slightly the intensity of dopamine histofluorescence in the nucleus accumbens, nucleus caudatus and median eminence in rats pretreated with γ-butyrolactone, however, no increase of the intensity was observed in rats pretreated with α-methyl-p-tyrosine. The above results suggest that the central depressant action of THB be probably mediated by the direct inhibitory effect upon dopamine-containing neurons in rat brain.

      • 토끼에 대한 majarine 과 tetrahydromajarine의 typhoid vaccine에 의한 발열 억제작용

        박영현 순천향대학교 1986 논문집 Vol.9 No.3

        Berberis속인 한국특산 매자나무(Beberis koreana Palibin)에서 분리한 4급 ammonium의 isoquinoline구조를 가진 majarine과 이것을 sodium borohydride촉매하에 환원하여 얻은 tetrahydromajarine은 마우스 복강내 투여시 체온감소 뿐만 아니라, 자발운동량도 감소한다고 한다. 저자는 majarine의 중추신경계에 대한 약리작용을 연구하고 있다. 이전에 majarine의 체온감소는 haloperidol과 cyproheptadine 등의 뇌 monoamine에 작용하는 약물에 의해 dopamine과 serotonin수용체에 관련성이 있다고 보고하였다. 그래서 typhoid vaccine에 의한 발열에 majarine과 tetrahydromajarine의 작용을 보려고 한다. 더욱이 majarine 유도체가 뇌 monoamine에 대한 작용기전에 대해서 dopamine antagonist, haloperidol과 dopamine agonist, apomorphine 등을 토끼 귀정맥내에 투여하여 약물상호작용을 검토하였다. Bacterial endotoxin(typhoid vaccine)을 토끼에 투여시 일어나는 발열을 prostaglandin synthesis inhibitor, aspirin의 해열작용과 majarine과 tetrahydromajarine의 발열에 대한 작용을 비교·검토하여 다음과 같은 결과를 얻었다. 1) Majarine과 tetrahydromajarine(10∼40mg/kg)은 토끼에 투여시 용량의존적인 체온증가를 나타내었다. Tetrahydromajarine의 체온증가는 majarine에 비해 강력하고 작용지속 시간이 길었다. 토끼에 apomorphine을 0.2mg/kg용량으로 투여시 체온감소를 나타내었으나, 2.0 또는 4.0mg/kg 투여시 체온이 증가하였다. 2) Haloperidol 0.05mg/kg전처치시 majarine과 tetrahydromajarine의 체온증가는 차단되지 않으나, 0.5mg/kg용량으로 전처치시 majarine과 tetrahydromajarine의 체온증가는 차단되었다. Apomorphine(2.0∼ 4.0mg/kg)의 체온증가 작용은 haloperidol 0.5mg/kg용량에서는 차단되었으나, 0.05mg/kg용량에서는 차단되지 않았다. 3) 토끼에 typhoid vaccine(0.1∼1.0mg/kg)을 투여시 용량의존적으로 체온증가를 나타내었다. Typhoid vaccine에 의한 발열은 majarine, tetrahydromajarine, aspirin과 apomorphine에 의해 억제되었다. 이와 같은 결과로 보아 토끼의 typhoid vaccine에 의한 발열은 뇌 monoamine기능에 관련이 있다고 사려된다. Majarine isolated from Berberis koreana Palibin(Berberidaceae) is the isoquinoline alkaloid. Tetrahydromajarine with tertiary amine is obtained by reduction of majarine(quaternary ammonium salt) with sodium borohydride. Author had inverstigated its pharmacological action on the central nervous system. In our previous studies, we reported that majarine-induced hypothermia was conected with drugs affecting brain monoamines function in mice. Therefore, in the present study, we have attempted to further assess the possible role of majarine and tetrahydromajarine in fever production. We show that if majarine derivatives may be concerned in the brain monoamine functions, they interfere in some way with effector mechanisms responsible for fever. In addition, the investigation has involved in the effects of majarine, tetrahydromajarine, apomorphine and aspirin on the thermoregulatory responses induced by haloperidol, bacterial endotoxin(typhoid vaccine) in the rabbit. Experimental results were summarized as follows: 1) Majarine(10∼40mg/kg) and tetrahydromajarine(10∼40mg/kg) produced a dose-dependent rise in rectal temperature in rabbits. Administration of tetrahydromajarine induced a prolonged increase in rectal temperature in comparison with responses of majarine. Low dose of apomorphine(0.2gm/kg) produced hypothermia, but large doses(2.0∼4.0mg/kg) produced hyperthermia in neck-restrained rabbits. 2) Pretreatment with haloperidol(0.05mg/kg) did not antagonize the hyperthermia that normally occured in response to majarine(20mg/kg) and tetrahydromajarine(20mg/kg), but pretreatment with haloperidol(0.5mg/kg) completely antagonized the hyperthermia that normally occured in response to majarine(20mg/kg) and tetrahydromajarine(20mg/kg). Low dose of apomorphine(0.2mg/kg) produced hypothermia but large doses(2.0∼4.0mg/kg) produced hyperthermia, in neck-restrained rabbits. Apomorphine-induced hyperthermia was blocked with higher dose of haloperidol (0.5mg/kg), but not blocked with smaller does of haloperidol(0.05mg/kg). 3) The injection, at room temperature(20∼22℃), of typhoid vaccine in doses between 0.1, 0.5 and 1.0ml/kg produced a dose-dependent rise in temperature. The fever induced by intravenous injection of typhoid vaccine was greatly antagonized by after-treatment with intravenous injections of majarine, tetrahydromajarine, aspirin and apomorphine. The data indicates that majarine, tetrahydromajarine and apomorphine are concerned in the brain monoamine functions which mediate the typhoid vaccine-induced fever in rabbits.

      • 2000년 연도표기 문제 해결방안

        박영현,Park, Yeong-Hyeon 한국정보통신집흥협회 1997 정보화사회 Vol.115 No.-

        2000년 문제해결을 위한 접근방법으로는 우선 고객이나 모든 경영자들, 실무자들이 문제를 인식하고 비즈니스 측면, 시스템 측면, 어플리케이션 측면에서 영향평가를 한 뒤에 그 결과에 맞게 규모나 비용, 범위를 산정하여 계획을 수립하고 대응전략의 선정 및 전략계획을 수립하고 이에 패키지 시스템의 업그레이드를 통한 설치 및 조정작업과 수정작업, 그리고 재개발 등의 상세분석 및 이행작업이 이루어져야 한다.

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