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최수봉,박선민 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.1
Background: It has been reported that surgical stress increased insulin resistance in human. However, there was no research about insulin resistance induced by surgical sttess in Korea. Catheters needed to be inserted in carotid artery and jugular vein of male Sprague Dawley rats to perform euglycemic hyperinsulinemic clamp procedures. The insertion of catheters in rats is a major surgery, which may increase insulin resistance. The purpose of the study is to determine whether surgical stress influence the insulin resistance. Methods: The euglycemic hyperinsulinemie clamp procedures were performed 5 hours and 7 days after insertion of catheter in carotid artery and jugular vein. A continuous intravenous infusion of insulin was started at a rate of 12 mU/kg/minute and continued for 2 hours. Twenty-five percent glucose solution was infused through the venous line at a various rate to maintain blood glucose at 5.0-5.6 mmol/L and calculated the glucose disposal rate. Blood was collected from arterious line every 5 minutes and measured serum glucose and insulin levels. Results: Prior to the clamp procedures, serum glucose levels of 5 hours and 7 days after catheter insertion were 29.8 +- 9.8 and 7.8 +- 0.9mmol/L, respectively. However, basal serum insulin levels were not different between 5 hours and 7 days after surgery. The glucose disposal rates were remarkably higher in rats who recovered from the surgery (22.0 +- 7.8 mg/kg/minute) than those who did not (2.2 +- 2.7 mg/kg/minute). Thus, surgical stress increased insulin resistance in male Sprague Dawley rats. Conclusion: Since surgery of catheter insertion increased insulin resistance about 10 times, euglycemic hyperinsulinemic clamp study should be performed in rats who completely recovered from the surgical stress (J Kor Soe Endocrinol 14:142~147, 1999).
딥러닝 모델을 사용한 게임 봇 탐지 시스템에서 판단 근거 분석을 위한 기법
최수봉,정영기,이동훈,문종섭 한국차세대컴퓨팅학회 2020 한국차세대컴퓨팅학회 논문지 Vol.16 No.3
As the online game market has grown rapidly in recent years, cheating has frequently occurred to get items in the game. Game bots, which are one of the most representative cheating behaviors, collect items in the game unfairly, causing problems in the game by destroying the balance in the game and rapidly depleting the content to shorten the game life. In this paper, we propose a model that classifies normal users and game bots by applying a Multi-Layer Perceptron(MLP) with user action log as input, and infers the basis of judgment by quantifying the degree to which each action affects the classification. The proposed model was applied to the actual log data of the ‘AION’ game and tested with 10-fold cross-validation, showing an accuracy of about 98.4% and a recall of about 99.6%. 최근 온라인 게임 시장 규모가 급격히 성장하면서, 게임 내 재화를 획득하기 위한 부정행위가 빈번하게 발생하고 있다. 대표적인 부정행위 중 하나인 게임 봇 (game bot)은 게임 내 재화를 부정하게 수집하여, 게임 내 균형을 파괴하고 콘텐츠를 빠르게 고갈시켜 게임 수명을 단축시키는 문제를 야기한다. 본 논문에서는 사용자 행위 로그를 입력으로 하는 다층 퍼셉트론(Multi Layer Perceptron)을 적용하여 정상 사용자와 게임 봇을 분류하고, 각 행위가 분류에 영향을 끼친 정도를 수치화하여 판단 근거를 추론하는 모델을 제안한다. 제안한 모델을 ‘AION’ 게임의 실제 로그 데이터에 적용하여 10겹 교차 검증으로 테스트한 결과 약 98.4%의 정확도와 99.6%의 재현율을 보였다.
당뇨병에서 지속적 피하인슐린주입(Continuous Subcutaneous Insulin Infusion) 치료법의 임상 적용
최수봉 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-
From the experience of treating diabetic patients by continuous subcutaneous insulin infusion during past 12 years, the clinical aspects of continuous subcutaneous insulin infusion therapy in the general hospital setting are summarized. For selection of patients, motivation for the normal glucose control, responsibility, intelligence and financial support ability are considered. All patients are hospitalized and educated intensively about the basic knowledge of diabetes mellitus, home blood glucose monitoring, handling technique of insulin pump, exercise and diet therapy. The blood glucose levels fall from 363.1±42.0(mean SD)㎎/㎗ to 128.7±18.6㎎/㎗ after two weeks' treatment of continuous subcutaneous insulin infusion. Glycosylated hemoglobin levels fall from 10.82±2.52% to 6.01±1.68% after three months' treatment. Eighty-six percent of patients experience well-being sensation after five days' continuous subcutaneous insulin infusion treatment. Twenty-eight percent of patients are in remission state after 1 year's continuous subcutaneous insulin infusion treatment. It is concluded that the continuous subcutaneous insulin infusion treatment is effective for the normalization of blood glucose, the prevention of diabetic complications, and good health maintenance for selected diabetic patients.