니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

복강경담낭절제술에서 수술전 간담도신티그라피와 경구담낭조영술의 의의

문대혁(Dae Hyuk Moon),양승오(Seoung Oh Yang),이희경(Hee Kyung Lee),원경숙(Kyoung Sook Won),류진숙(Jin Sook Ryu),한동복(Dong Bok Han),박철민(Cheol Min Park),이문규(Moon Gyu Lee),박광민(Kwang Min Park),이승규(Sung Gyu Lee) 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.1

N/A 131I-6β-iodomethyl-19-norcholesterol(NP-59) has an advantage to assess adrenal dysfunction caused by adrenal cortical disorders. The aim of this study is to evaluate the clinical usefulness of NP-59 scintigraphy in each adrenral disease. Ten patients who did eleven NP-59 adrenal scintigraphies at Dong-A University Hospital from March 1990 to December 1996 were selected as the subject. Among the subject there were 5 cases of Cushing's syndrome, 2 cases of incidentaloma, 1 case of metastatic adrenal tumor, liver cirrhosis with hirsutism and hypertension respectively. Among 5 case of Cushing's syndrome, there were 2 cases of Cushing's disease, 2 cases of adrenal adenoma and 1 case of adrenal carcinoma. There are no disagreement between clinical diagnosis and scan finding in Cushing's syndrome. In 2 incidentaloma cases, even though one is interpretated as a functioning tumor, both of 2 cases could avoid unnecessary biopsy according to scintigraphy result. One case of hirsutism, clinically adrenal originated, revealed the normal scintigraphic hirsutism was extra-adrenal origin. One case of hypertension took the study to exclude the possibility of primary aldosteronism. Normal suppression scan finding revealed that primary aldosteronism did not exist in this case. In conclusion, NP-59 scintigraphy was very useful in diagnosis and differential diagnosis of Cushing's syndrome and it could avoid unnecessary biopsy in the incidental adrenal tumor.

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

중학교 생물교수전략으로서의 마인드 맵 활용 효과

오성미,김동렬,문두호 부산대학교 사범대학 과학교육연구소 2005 科學敎育硏究報 Vol.32 No.-

Mind mapping is a new creative note taking method by using colors, symbols, lines, and sketches to express main image and key words. The object of this research was to prove how effective the science lesson was for middle school students when it was done using mind map. Experimental group was composed of seventy students who were participated in mind map activity, and control group was composed of seventy students who were participated in traditional teaching method. To analyze the influence of the mind mapping, pretest and posttest for science achievement, inquiry process skill and science-related attitude were applied to both groups. Also the response of students regarding mind mapping strategies was investigated. According to the analysis of these tests, in the pretest the differences of science achievement, inquiry process skill, science-related attitude between two groups were not significant(p>.05). In the posttests on science achievement, inquiry process skill, the scores of the experimental group was higher than those of control group(p<05). In the mind mapping strategy, the students of experimental group were more efficient than those of control group. Most students of experimental group exhibited positive attitude towards the mind mapping strategy. Therefore, mind mapping strategies made a positive effect on students' science achievement, inquiry process skill.

대장균 세포내 칼모듈린 돌연변이체 고발현을 위한 클로닝 및 Chemiluminescence 검출법에 의한 발현분석

오석홍,박윤식,양문식,최동성 우석대학교 자연과학연구소 1996 自然科學硏究論文集 Vol.1 No.-

To obtain a large amount of VU-4 calmodulin (115, Lys to Ile). VU-4 calmodulin gene with Ptac promoter (680 bp) was cloned into a plasmid, pUC18. Newly cloned pUC18/VU-4 was transferred into E. coli UT481. The plasmid isolated from cell extracts of the transformed E. coli was analyzed by restriction mapping and yielded the expected restriction endonuclease map with BamHI and EcoRI. Calmodulin was detected by Western blot analysis using chemiluminescence protocol and the estimated expression level was 60 pmole calmodulin/mg protein. Calmodulin was purified from the E. coli cell extracts by Ca^(2+)-dependent chromatography on a phenyl-Sepharose column. The purified calmodulin was identified as a mutant VU-4 calmodulin by SDS-PAGE and methyltransferase substrate test.

점성·비점성 유동장에서의 Solution-Adaptive Grid 기법연구

오동훈,임영택,김문상 한국항공대학교 항공우주산업기술연구소 2002 航空宇宙産業技術硏究所 硏究誌 Vol.12 No.-

유동장 해석에 있어 격자가 얼마나 잘 구성되어 있는가는 해의 정확도와 수렴성에 큰 영향을 미친다. 가장 이상적인 격자는 모든 격자점에서 오차가 같은 값으로 분배되어 있어야한다. 그러기 위해서는 오차가 크게 생길만한 충격파나 경계층 등에서는 그만큼 많은 수의 격자가 필요하게 된다. 그러나 이를 미리 예측하고 격자를 만들기가 어렵기 때문에 Solution-adaptive grid 생성방법이 사용된다. 이것은 해의 변화가 심하게 나타나 오차가 큰 곳에 격자를 모아주고 상대적으로 오차가 작은 곳은 격자를 펴줌으로써 같은 수의 격자로 효율적인 격자를 생성하는 방법이다. 본 논문은 Elliptic Type의 격자생성법을 이용한Solution-adaptive Grid 방법과 Parameter 영역을 이용한 Solution-adaptive grid 방법을 이용하여 유동장을 계산하였다. One of the most important things for improving solution accuracy and convergency is grid refinements. Ideal grids make the same error distributions in all grid points. For this reason, grid rearrangement is sometimes necessary in some cases. If the flow fields have shock waves or boundary layers, there may be a lot of errors in those regions. Therefore, we should have more grid points in those regions to overcome this defect. Unfortunately, it is very difficult to estimate the regions which needs more grid points unless we have a final solution. So solution-adaptive grid methods are introduced. It is one of the grid refinement methods for making an effective grid in the flow fields. It makes grids be denser in the larger flow gradient regions and be coarser in smaller regions. Generally, two solution-adaptive grid methods are very popular. One of these is a solution adaptive grid generation method using elliptic type partial differential equation and the other is a solution adaptive grid generation methods using bilinear interpolation between physical domain and parametric domain.

악골낭종에 대한 임상적 연구

문철,이동근,민승기,오승환,김태성 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

This clinical study was made of 214 cases of the jaw cysts which were diagnosed histopathologically in the Department of Oral and Maxillofacial Surgery, Wonkwang University Dental Hospital from Jan. 1, 1991 to Dec. 31, 1998. Medical records, radiographs, histopathological reports of 214 cases with jaw cysts were retrospectively reviewed. The results were as follows : 1.Among the total patient of 214 cases, male were 143 cases, and female are 71 cases, male predominated by the ratio of 2.04. 2.The periapical cysts and the dentigerous cyst are the most common cyst, irrespective of 116 cases(54.2%) and 58 cases(27.1%). 3.The periapical cyst has no gender prediction, male were 70 cases and female were 54 cases, the mean ages were 39.3 years(SD=18.4). The most common involving teeth were maxillary anterior teeth(59.7%) . 4.The dentigerous cyst predominantly occurred in third decade (18 cases : 31%), and the mean ages were 31.9 years(SD= 14.8). Dentigerous cysts predominantly occurred in male by the ratio of 7.29 (male : 51 cases, female : 7 cases). Maxillary anterior teeth(43.1%) and mandibular molars(32.8%) were most frequently involved. 5.The odontogenic keratocyst predominantly occurred in second and third decade and mean ages were 23.5 years(SD= 17.2). The mandibular molars(60%) were most frequently involved. 6.All nasopalatine cyst occurred after fourth decade, mean ages were 49.5years(SD= 10.4). In the gender incidence of nasopalatine cyst, 1 case occurred in female and 10 cases occurred in male. 7.In the surgical intervention of jaw cyst, cyst enucleation and marsupialization performed in 156 cases. Cyst enucleation with bone graft performed in 58 cases and iliac autogenous bone grafts most frequently performed in 29cases. 8.The diameter range of cyst enucleation with bone graft were from 15mm to 120mm with a cyst diameter of 33.3mm. (SD = 15.2). The diameter range of cyst enucleation and marsupialization were from 7mm to 82mm with a cyst diameter of 20.4mm.(SD=9.0) The diameter of cyst enucleation with bone graft were significantly greater than diameter of cyst enucleation. (p<0.05) 9.Post-operative complications occurred in 9 cases(15.5%) in which cyst enucleation with bone grafts performed and occurred in 31 cases(19.9% ) in which cyst enucleation.

척수 경막외 혈관 기형에 의한 재발성 척수병증

오동호,김희태,박운규,이영주,김승현,김주한,김명호,박문향 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

供血者에서의 HBsAg 發現率과 生化學的 檢査値에 관한 硏究

문희주,윤기은,김승곤,라동진,김태전,박정오,최범열 서울保健大學 1988 論文集 Vol.8 No.1