업종에 따른 연 취급 사업장의 기중 연 농도 및 연 노출 수준 평가

이병국,김용배,리갑수,안현철,김화성,이용진,황규윤,장봉기,이성수,안규동 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to obtain an useful information for health management and biological monitoring of lead exposed workers, Authors tried to investigate air lead level and the lead exposed level of workers in lead industry according to occupational category. The subjects in our study were 2074 workers in 7 lead-using industries, and study subjects were divided into 4 occupational categories such as storage battery industry (type 1), primary smelting industry (type 2), secondary smelting industry (type 3) and litharge making industry (type 4). Blood zincprotoporphyrin concentration (ZPP), blood lead concentration (PbB) and urinary δ -aminolevulinic acid (ALAU), hemoglobin (Hb), hematocrit (Hct) were selected as the indices of lead exposure. Personal variables such as age, work duration were also collected. The results were as follows. 1. The geometric mean air lead in 9 lead-using industry was 0.1133±4.3120 ㎎/㎥, and that in type 1, 2, 3 and 4 was 0.1038±3.4952 ㎎/㎥, 0.0429±3.4329 ㎎/㎥, 0.1877±2.5123 ㎎/㎥ and 0.9961±5.2910 ㎎/㎥, respectively. 2. The mean ZPP in 9 lead-using industry was 53.1±28.0 ㎍/㎗, and that in type 1, 2, 3 and 4 was 52.0±24.8 ㎍/㎗, 48.0±16.4 ㎍/㎗, 109.8±85.6 ㎍/㎗ and 74.3±37.8 ㎍/㎗, respectively. There was significant difference in ZPP according to occupational category (P<0.01). The percents of lead workers whose ZPP were above 100 ㎍/㎗ in type 1, 2, 3 and 4 were 4.0%, 1.7%, 34.3% and 21.6%, respectively. 3. The mean PbB in lead-using industry was 26.0±11.2 ㎍/㎗, and that in type 1, 2, 3 and 4 was 25.3±11.1 ㎍/㎗, 26.7±8.8 ㎍/㎗, 50.3±15.2 ㎍/㎗ and 36.4±11.0 ㎍/㎗, respectively. There was significant difference in PbB according to occupational category (P<0.01). The percents of lead workers whose PbB were above 40 ㎍/㎗ in type 1, 2, 3 and 4 were 10.4%, 7.7% 71.9% and 43.2%, respectively. 4. While the correlation of Hb corrected PbB with ZPP was higher than non corrected PbB, the correlation of log-transformed ZPP with PbB was higher than non corrected ZPP. 5. Simple linear regressions of PbB and corrected PbB as independent variable with ZPP, log-transformed ZPP and ALAU as dependent variable were statistically significant (P0.01). Coefficient of determination of corrected PbB with other variables was higher than non corrected PbB. As the result of this study, it was suggested that reconsideration of environmental and biological monitoring program was highly recommended for secondary smelting and litharge making industry.

연작업자들의 신기능 평가에서 요중 δ-aminolevulinic acid 측정의 의의

이병국,이숙,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

To clarify the effect of occupational lead exposure on renal function 241 lead workers working and 56 non lead workers were studied in 5 lead acid battery industries. Study variables for renal effect were urinary N-acetyl-β-D-glucosaminidase(NAG), urinary total protein(U-TP), blood urea nitrogen(BUN), serum creatinine(S-Cr), and serum uric acid(S-Ua). On the other hand, blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), and delta-aminolevulinic acid in urine(δ-ALA) were selected for the variables of lead exposure. Information on age, work duration, smoking and drinking history were also obtained. The results obtained were as follows. While the mean values of lead exposure indicators of lead workers were significantly different from non-exposed ones, the mean values of BUN, U-TP and S-Cr of renal function indicators of exposed were also different from non-exposed. BUN, U-TP and NAG showed statistically significant correlation with PbB and ZPP, and NAG revealed also statistically strongly significant correlation with δ-ALA. On multiple regression using renal fuction indicators as a dependent variable and δ-ALA, age, work duration,lead exposure,smoking and drinking as independent variables, only δ-ALA contributed to NAG.

GC-ECD를 이용한 유기염소계 및 Pyrethroid계 농약 동시 분석법

김우성,이선화,김재이,정지윤,이명자,박영채,이영자,정성욱,이봉헌,박흥재 한국환경과학회 2003 한국환경과학회지 Vol.12 No.4

Pesticides were extracted from samples with 70% acetone and methylene chloride in order, and then cleaned up via open-column chromatography apparatus packed with florisil, and finally analyzed simultaneously the organochlorine and pyrethroid pesticides using GC(ECD). An ultra-2 fused silica capillary column was used to separate and identify the products. The resolution between the last isomeric peak of cypermethrin(59.987min) and the first isomeric peak of flucythrinate(60.043min) was not satisfactory. The last isomeric peak of fenvalerate(62.344min) and the first isomeric peak of fluvalinate(62.397min) were overlapped. Recoveries of soybean sample for the most pesticides were 73.3% to 102.4%. Detection limits were between 0.004 and 0.063 ㎍/㎎ when this method was used.

모 축전지 회사 근로자들의 연폭로 지표에 대한 경시적 관찰

강명식,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

Lead poisoning is still prevalent and one of important occupational disease in Korea. To prevent undue high lead burden and maintain good health condition of lead workers in lead using industries, periodic health examination and regular biological monitoring of lead workers are often required in addition to the fundamental improvement of their working condition. To evaluate the effect of comprehensive occupational health program with regular biological monitoring on the level of lead exposure of lead workers in lead using industries, 11 year database from 1983 to 1994 of one storage battery factory was reviewed. From 1983 to end of 1986 only periodic health examination was provided to the lead workers, but from 1987 comprehensive occupational health program with regular biological monitoring was provided to maintain better health condition of lead workers. Selected study variables for lead exposure were blood lead(PbB), zinc protoporphyrin in blood(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb), hematocrit(HCT). Information on sex, age and work duration was also reviewed. 5 years data from 1983 to 1987 and 3 years data from 1990, 1993 and 1994 were available for all lead exposure indices except ALAU which has only 5 years data from 1983 to 1997. The results of 11 years longitudinal observation of lead indices are all follows: 1. The mean value of ZPP of lead workers in 1983 was 148.7±73.1 ㎍/㎗(Male: 145.5±72.3, Female: 168.1±79.1), whereas that of ZPP of lead workers in 1994 was decreased to 64.3±32.7 ㎍/㎗(Male: 60.2±28.8, Female: 95.2±43.4). 2. The mean value of PbB of lead workers in 1983 was 56.4±18.8 ㎍/㎗(Male: 55.59±19.1, Female: 59.6±19.1), whereas that of PbB of lead workers in 1994 was dcreased to 35.4±11.9 ㎍/㎗(Male: 35.7±12.0, Female: 32.8±10.8). 3. The mean value of Hb of lead workers in 1983 was 14.1±1.4 g/㎗(Male: 14.4±1.1, Female: 11.7±0.8), whereas that of Hb of lead workers in 1994 was increased to 15.6±1.5 g/㎗(Male: 15.9±1.2, Female: 12.9±1.1). 4. Blood lead is most highly correlated with ZPP(r=0.522, male:0.54 and female:0.50) and also correlated with ALAU and work duration also. 5. The simple regression analysis of PbB and ZPP showed different coefficient of regression by the measurement year, but there was no difference of coefficient of regression between sex. The slope of equation of pooled data for 1983-1986 without comprehensive occupational health program was 2.16 and differed from that of pooled data for 1987-1994(1.25). This difference suggests that the unit effect of blood lead on ZPP was relatively smaller in later period of comprehensive occupational health program than carly period without comprehensive program. The slope change in the analysis of linear regression of PbB on ZPP in lead workers can be used to evaluate the possible effect of health intervention to prevent undue high lead absorption in lead using industries. 6. 11 years occupational health service in this storage battery factory brought out considerable improvement of health status of lead workers in terms of decrease of PbB and ZPP and increase of Hb and the improvement was more remarkable after the introduction of comprehensive occupational health program.

모 연취급장 근로자들의 연폭로지표들과 혈압과의 관련성

임상복,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

In order to investigate the relationship between blood lead with other lead exposure indices and blood pressure in occupationally lead exposed male workers, 629 workers(515 lead exposed workers and 114 non lead exposed workers) in a storage battery factory were studied. Blood lead(PbB), zinc protoporphyrin(ZPP) and urinary δ-aminolevulinic acid(ALAU) were selected as an index of lead exposure. Height and weight were also meaured with calibrated automatic height-weight machine to produce fatness index directly. Personal information on smoking and drinking history were also collected. Blood pressure was mearured by trained nurses with automatic sphingomanometer. All workers took at least 30 minute rest before their measurement of blood pressure. The results obtained were as follows: 1. The prevalence rate of hypertension of lead exposed and non-exposed workers were 3.5% in both group without any difference. 2. There were no differences of systolic and diastolic pressure between groups divided by lead exposure, smoking habit, drinking habit. but the increase of age group made the difference of diastolic pressure, and only differenct of systolic pressure observed in age group of less than 20 and that of more than 40. 3. In pearson's correlation analysis, PbB was correlated with systolic pressure significantly, but not with diastolic pressure. PbB was also correlated with pressure difference(systolic pressure-diastolic pressure). 4. There were no significant increase of systolic, diastolic pressure and pressure difference by the increase of PbB and ZPP grouping. 5. Stepwise multiple regression analysis using systolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that PbB, age, drinking habit and fatness in order were significantly contributed to the dependent variable. 6. Stepwise multiple regression analysis using diastolic pressure as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness (weight*0.9/height-100) as independent variables, revealed that ALAU, age and fatness in order were significantly contributed to the dependent variable. 7. Stepwise multiple regression analysis using pressure difference as dependent variable and PbB, ZPP, ALAU, age, work duration, smoking habit, drinking habit and fatness(weight*0.9/height-100) as independent variables, revealed that PbB, age and fatness in order were significantly contributed to the dependent variable. 8. Logistic analysis of hypertensive conditions with categorized blood lead and other selected categorized independent variables indicated that only age(40> and 40≤) and fatness(1.0> and 1.0≤) were significantly contributed to dependent variable with 95% significant odd ratio confidence interval. With above results, lead exposure in terms of blood lead seemed to be minimally contributed to the raise of blood pressure, and the effect of blood lead was found to be more prominent on the pressure difference than the systolic and diastolic pressure themselves.

壬亂 尙州義兵에 관한 硏究

李鳳和 건국대학교 1979 論文集 Vol.9 No.1

When the Japanese Army invaded Korea in the end of 16 century, a great crowd of volunteers against themfrom all over the country, They beat back the invaders here and there and contributed much the union of the people, This thesis will be written down about the uprising of the volunteer corps in Sangjoo province. When Japanese General, Konisi's main force passed through Sangjoo, the inhabitants' severe resistance did damage much to them. ① The motive that Sangjoo Militia rose was due to falling of Sangjoo Castle due to incompetency and defeating of governmentforces and then Japanese Army's brutality became the excessive condition, as the result, in the spiritual base of reserving for his native village and Sovereign and subjects' contracting relation occurred. Moreover, the united literati and people with the character of companionate combination rose an army. From the early days of the war, many of volunteer corps that contains 100 or more than 1,000 soldiers were formed one after another, and the inhabitants' patriotic spirits never allowed them to make compromise with the Japanese for the sake of their life and fought to death. ② In the beginning of war, Sangjoo loyal Soldier had a head on collision with exertion for justice and bow & arrow but they were defeated. After they secured in the maximum military forces and equipments with diversions factics of an ambush and night-attack that gradually made use of ferrain did the decisive action long-time supression of bandits. ③ Sangjoo Militia counted on themselves-consumption arms and military provisions, and the lack of quantity was appropriated by government-mentsupply. For the most part of it was demanded and supplied in the creals of Ho-Sea area, and because the starved-people measure of Sangjoo was very sincere, the hearts of the people did not scatter. ④ In the beginning of raising an army, Sangjoo Militia discorded to government-forces but they petitioned incompetency of government·forces and capture of merits of them to military-governor, and then those who united in the struggle against an enemy wish Chung-Ki Yong, lord of castle, defeated Japanese-Army. In the end, Sangjoo Militia acted with exhibiting the spirit of loving the people and loving of their native place and faithful mind of sovereign and Subjects. When Japanese Army second time invaded, Sangjoo Militia prevented Japanese Army from utilizing the passageway, as the result Sangjoo Militia did without a eminent military-commander is a pattern of militia that countrymen united endeavor.

납 폭로 근로자에서 δ-aminolevulinic acid dehydratase 유전형질이 zinc protoporphyrin 및 δ-aminolevulinic acid에 미치는 영향

이병국,황규윤,장봉기,김용배,리갑수,안현철,김화성,이성수,안규동,박종범 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

The inhibition of δ-aminolevulinic acid dehydratase (ALAD) in the heme synthetic pathway results in increased protophoryphyrin (ZPP) and δ-aminolevulinic acid (ALA) and is responsible for some of toxicological effects of lead. This enzyme is coded by the ALAD gene containing 2 co-dominant alleles. The polymorphisms of ALAD gene may be related to differential effects of lead on ZPP and ALA, ALAD genotype was measured in 975 Korean male lead workers, of whom 897 were homozygous for ALAD1 (ALAD 1-1 genotype) and 96 were heterozygous for ALAD2 (ALAD 1-2 genotype). Blood lead in subjects with ALAD1 was significantly higher than those with ALAD2 (p = 0.01). No difference between ALAD genotypes was found for age, exposure duration, ZPP, ALA, hemoglobin, hematocrit, body mass index, tobacco and alcohol use. After adjustment for possible confounders, ALA and ZPP became significantly elevated in ALAD1 subjects (p = 0.004 and 0.055, respectively). This result suggests that ALAD1 subjects may be more susceptible to the hematotoxicologic effects of lead than ALAD2 subjects.

MMPI-A 검사를 통한 비행청소년의 비행 행동에 따른 성격특성 연구 : 제주특별자치도를 중심으로

이화련,김성봉 濟州大學校 學生生活硏究所 2008 學生生活硏究 Vol.29 No.-

This study aims at figuring out how the existence of structural broken family of delinquent adolescents is related to their personality traits, and as follows are the problems to be studied on. Problem to be studied : What is the relationship between the delinquency of delinquent adolescents and their personality traits like? In order to solve these problems for the study, the hypothesis was set up as follows. Hypothesis : There will be a difference between the juvenile delinquency of delinquent adolescents and their personality traits. 1. There will be a difference between whether or not to drink and personality traits. 2. There will be a difference between whether or not to smoke and personality traits. 3. There will be a difference between start to run away from home by school grade and personality traits. 4. There will be a difference between start to be absent without leave from school by school grade and personality traits. As for the object of the study, 261 sets of MMPI-A questionnaires, of which test was were performed for the delinquent adolescents who had been imprisoned in J juvenile reformatory located in Jeju special self-governing province from 3. 1, 2006 to 2. 28, 2007, and for ones for whom the juvenile court of J district court had requested J juvenile reformatory for the counseling during a certain period of time in order to use its result as the reference for the judgment, were taken as samples. As the device for measurement, the Korean version of Minnesota Multiphasic personality Inventory-Adolescent(MMPI-A) was used: MMPI-A , which was first developed from USA in 1992, has been translated into Korean, and it is a standardized test based upon <2000 Population and Housing Census in Korea>(2001). As follows are the results of this study. First, it was indicated that the delinquent adolescents who smoked or drank were more impulsive, and didn't want to be bound to the regulations than ones who did not drink and smoke: Also, they were not interested in the school life and their course in the future. Therefore, the delinquent adolescents who smoke or drink have higher possibility of delinquency than ones who stay away from drinking and smoking. Second, the delinquent adolescents who started to run away from home or be absent without leave from school from their elementary school days were indicated as more dissatisfied with their family member, rebellious against to the social norm, and short of energy to persue the purposes or to complete the responsibilities than ones who were not absent from school or started to run away from home or be absent without leave from school after their elementary school days. The delinquent adolescents who started to do their delinquent behaviors early had the tendency to be negative for the outside because they had not been supported emotionally good enough in their family or in the society, Considering their circumstances, the their delinquent behaviors can be deepened, If there are the delinquent adolescents whose delinquent behaviors have started in their early ages, their relevant family should realize the severeness of delinquency, and be actively involved in solving the problems; If it is not the case, other counseling institutes or relevant governmental agency should try to prevent the juvenile delinquency from deepening while actively coping with it. Third, it was indicated that the delinquent adolescents who did not run away from home or were not absent without leave from school managed their emotion well while being stable emotionally and having higher self esteem compared to ones who ran away from home or were absent without leave from school: It can be said that the delinquency of adolescents who do not run away from home or are not absent without leave from school has not been deepened yet. Therefore, if their family or society get involved appropriately before it becomes chronical, they can still change into the sound adolescents. As a result, it was indicated that there was a difference in personality traits of the delinquent adolescents according to the existence of broken family and the factors of delinquency, It is required to treat them with interest and affection for the development of personality through their family environment and circumstances not from the prejudice of delinquent adolescents, but from their perspective.

L-N-Benzylaspartic acid의 선택적 에스테르화 반응

이채호,김일광,박승화,이영행,정봉영 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.1

Selective esterification and synthesis of L-N-benzylaspartic acid from L-aspartic acid are described. L-Aspartic acid was transformed into dibenzyl L-asparate p-toluenesulfonate, which was treated with sodium bicarbonate to afford dibenazyl L-asparate. Formation of Schiff base of dibenayl ester with benzaldehyde and subsequent hydrogenation-dehydrogenation of the Schiff base produced L-N-benaylaspartic acid. L-N-Benaylaspartic adcid was transformed into L-N-benzylaspartic anhydride hydrogen bromide, which was treated with methyl alcohol and benzyl alcohol to afford a-methyl and a-benzyl L-N-benzylaspartate and L-N-benaylaspartic acid was transformed into L-N-benaylaspartic acid copper(Ⅱ) salt, which was treated with N,N,N,N-tetramethylguanidine and benzyl bromide to afford β-benzylaspartate

치기공과 임상실습교육 실태 조사

이화식,배봉진,박명호 대구보건대학 2005 대구보건대학 論文集 Vol.25 No.-

This study was conducted by collecting and analyzing curricula of 19 colleges that has the department of dental laboratory technology throughout the country and analyzed by use of a questionnaire designed by the researcher with regard to details of actual operation in each college. Credit points for clinical training that has been conducted based on curricula vary from 3 to 20 points depending on colleges. But around 10 credit points are considered as ideal. For evaluation, the evaluation table was not applied but used as reference only. As criteria for evaluation such as evaluators, evaluation items and criteria for point distribution do not provide objectivity or reliability, development of accurate evaluation tools is required. It dis necessary for the bodies of colleges to maintain a level of mutual trust by visiting the sites of practical training regularly for the formation of progressive industry-academia cooperative relationships. When selecting the sites of practical training, it would be desirable to look for sites with better conditions for practical training in conjunction with related institutions. Besides, regarding clinical training education, in order for students to adapt themselves correctly to work environments and rapidly cultivate practical capabilities at site, systematic and efficient operation of training sites is required.