보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 3LL의 항암효과에 미치는 영향

이윤희,김봉석,오중한,임희용,김동우,최빈혜,김상찬,변준석,Lee Yun-Hee,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Kim Sang-Chan,Byun Joon-Seok 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.1

In order to evaluate the anti-tumor and synergic effect of Bojungikkeehapdaechilkitang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Bojungikkeehapdaechilkitang with their concomitant treatment against 3LL(Lewis lung carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to 3LL cell lines. Bojungikkeehapdaechilkitang has only mimic direct anti-tumor effect against to 3LL cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Bojungikkeehapdaechilkitang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and Bojungikkeehapdaechilkitang extracts.

변이계수에 대한 영향함수

이윤희,김홍기,Lee, Yun-Hee,Kim, Hong-Gie 한국통계학회 2008 Communications for statistical applications and me Vol.15 No.4

본 논문에서는 변이계수에 대한 영향함수를 유도한다. 경험적 영향함수와 표본영향함수를 이용하여 유도된 영향함수의 타당성을 입증하고 이를 위하여 정규분포 $N(20,1^2)$와 $N(20,5^2)$에서 각각 확률표본을 추출하여 시뮬레이션을 수행한다. 시뮬레이션 결과로부터, 유도된 변이계수에 대한 영향함수가 한 개의 관찰치가 제거되었을 때 변이계수의 변화량을 매우 정확히 추정하는 것을 확인하였다. We derive the influence function on the coefficient of variation. Empirical influence function and Sample influence function are used to verify the validity of the derived influence function. To show the validity of the influence function, we carry out simulations with random samples from normal distribution $N(20,1^2)$ and $N(20,5^2)$, respectively. The simulation result proves that the derived influence function is very accurate in estimating changes in the coefficient of variation when an observation is deleted.

PWR 사용후핵연료의 Li 환원과정 모사 프로그램 개발

이윤희,신희성,장지운,김호동,윤지섭,Lee, Yun-Hee,Shin, Hee-Sung,Jang, Ji-Woon,Kim, Ho-Dong,Yoon, Ji-Sup 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.4

In this paper a computer program was developed, which simulates the Li reduction process of PWR spent fuel, and the amount of a produced metal or chloride compound was calculated at the various amount of Li with the program. It establishes a database, which is composed of some characteristics related to a chemical reaction equation and thermodynamic data, and it calculates the transformed rate of PWR spent fuel oxide at the certain amount of Li by using the database as input data. As the results of the performance test of the program, it was validated that the transformed values of oxides, except for $Eu_2O_3$ and $Sm_2O_3$, were almost the same to within about a 6 % error with those calculated by the previous code and that the calculated amount of Li was also exactly consistent with the theoretical one, which is used for a complete reaction of each oxide in a single chemical reaction. A relationship between Li and the transformed metal of each oxide was analyzed on the basis of the quantities calculated with the verified development program. Of the results, when the amount of Li was given to be 250 mole, the 83.73 percentage of $UO_2$ was transformed into U while the remainder was still to be $UO_2$. In addition, it was appeared that the 297 mole of Li was needed to completely convert $UO_2$ into U.

보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 MKN-45의 항암효과에 미치는 영향

이윤희,김봉석,오중한,임희용,김동우,최빈혜,변준석,Lee Yun-Hee,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Byun Joon-Seok 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1

In order to evaluate the anti-tumor and synergic effect of BoJungIkKeeHapDaeChilKi-Tang on doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BoJungIkKeeHapDaeChilKi-Tang with their concomitant treatment against MKN-45(Human stomach carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell lines. BoJungIkKeeHapDaeChilKi-Tang has only mimic direct anti-tumor effect against to MKN-45 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that BoJungIkKeeHapDaeChilKi-Tang extracts were reduced by the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and BoJungIkKeeHapDaeChilKi-Tang extracts.

연속압입시험법을 이용한 재료의 강도 , 잔류응력 및 파괴인성 평가

이윤희,이정환,옥명렬,안정훈,권동일 ( Yun Hee Lee,Jeong Hwan Lee,Myoung Ryul Ok,Jeong Hoon Ahn,Dong Il Kwon ) 대한금속재료학회 ( 구 대한금속학회 ) 1997 재료강도 심포지엄 Vol.- No.-

나노 압입곡선의 이론적 분석을 통한 박막의 잔류응력 평가

이윤희,장재일,권동일,Lee, Yun-Hee,Jang, Jae-Il,Kwon, Dong-Il 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.7

Residual stress is a dominant obstacle to efficient production and safe usage of device by deteriorating the mechanical strength and failure properties. Therefore, we proposed a new thin film stress-analyzing technique using a nanoindentation method. For this aim, the shape change in the indentation load-depth curve during the stress-relief in film was theoretically modeled. The change in indentation depth by load-controlled stress relaxation process was related to the increase or decrease in the applied load using the elastic flat punch theory. Finally, the residual stress in thin film was calculated from the changed applied load based on the equivalent stress interaction model. The evaluated stresses for diamond-like carbon films from this nanoindentation analysis were consistent with the results from the conventional curvature method.

동원(東垣) ${\ll}$비위론(脾胃論)${\gg}$ 수록(收錄) 처방(處方)의 치법(治法)에 대(對)한 문헌적(文獻的) 고찰(考察)

이윤희,황희정,김상찬,박순달,변준석,Lee, Yun-Hee,Hwang, Hui-Jeung,Kim, Sang-Chan,Park, Soon-Dal,Byun, Joon-Seok 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

Objectives : 'Pi Wei Lun' is the principal medical work of Li Dongyuan's writings, which contains most of his medical theories. There are sixty-three prescriptions in 'Pi Wei Lun', and fifty-two of them were originated from him. This study was planned to present assistance to those who apply Dongyuan's theory clinically. Methods : We investigated those fifty-two prescriptions literary, and studied them from a viewpoint of the principle and method of treatment. Results : Dongyuan's fifty-two prescriptions can be classified into eight groups from the viewpoint of the principles and methods of treatment which are composed of 'tonify the spleen and stomach & elevate the spleen Yang', 'elevate the spleen Yang & expel fire', 'elevate the spleen Yang & relieve dampness', 'promote blood flow to eliminate blood stasis', 'invigorate the spleen', 'replenish Ki & and dispel phlegm', 'purgation with drugs warm in nature', and 'the other' eight methods. Conclusions : From above, we concluded that Dongyuan considered 'the primordial energy of the spleen and stomach' as the most important when making up prescriptions, but, at the same time, he used diverse methods of treatment on the ground of differentiation of syndromes.

임대주택(賃貸住宅)의 내재적(內在的) 특성(特性)에 관(關)한 연구(硏究) - 서울의 공동거주형(共同居住型) 임대주택(賃貸住宅)의 사례(事例)를 중심(中心)으로 -

이윤희,정재국,Lee, Yun-Hee,Jung, Jae-Kook 한국주거학회 2010 한국주거학회 논문집 Vol.21 No.4

In the modernization process of the city, urbanization raised a variety of social issues. Urbanization brought noticeable changes in dwelling patterns, such as drastic changes in the housing lifestyle, that revolved around the metropolitan areas of Seoul and Busan etc. before and after the expansion of economic growth. Especially in 1985, when 23.8% of the country's population was concentrated in Seoul, the imbalance of housing supply and demand caused a vast range of housing shortage. The shortage, that resulted from public sector mishandling of natural housing demand, lead to the occurrence of private sector rental housing. The occurrence of this abnormal rental housing supply, became a major cause of Korea's typical lease system called 'Co-dwelling', where the leaseholder and tenant physically lives in the same residence. The leaseholder and tenant's 'Co-dwelling' started from partial renting of traditional Korean-style housing and transformed with the transition of dwelling form and time. However, after 1985, legalization of multi-family housing, Korean rental housing started to be planned in the beginning of it's housing construction and to be produced as an independent space with separate circulation. Also in terms of facility, it changed from partial renting of a space within the residence to an assembly of small individual spaces. However, the background of this deep-rooted 'Co-dwelling' lease system, in different forms and periods of residence, is still based on the lack of public sector rental housing supply and private sector supply of rental space to utilize extra space, 'Jeonsei' payment.

20세기 초 중국의 《사닌》 번역과 수용 양상 고찰 ―노신(魯迅), 정진탁(鄭振鐸), 반막화(潘漠華)의 경우를 중심으로

이윤희 ( Lee Yun-hee ) 한국중국어문학회 2018 中國文學 Vol.95 No.-

러시아 작가 아르치바셰프의 장편소설 《사닌》은 1907년 발표 이후 ‘사니니즘’이라는 신조어를 탄생시킬 정도로 화제를 불러일으킨 작품이었다. 육욕의 향락을 삶의 최대 가치로 추구하는 사상, 경향을 이르는 ‘사니니즘’은 혁명 실패 후의 러시아 청년층에게 큰 인기를 얻었다. 또한 《사닌》은 염세주의적·허무주의적 가치관과 니힐리즘, 개인주의적 아나키즘을 선전하는 작품으로도 평가되었다. 이러한 《사닌》과 작가 아르치바셰프는 본국에서보다 중국의 신문학계에서 중시되어 鄭振鐸, 潘漠華, 魯迅 등의 주목을 받았다. 3인은 각기 다른 주안점으로 《사닌》을 평가하였는데, 사실상 《사닌》의 핵심 사상인 막스 슈티르너의 개인주의적 아나키즘을 적확히 이해하지 못한 채 본인의 문제의식에만 근거해 작품을 독해함으로써 인식의 한계를 보여주었다. 이들의 문제의식은 다만 개인의 인식 지평에서 비롯되었다기보다는 20세기 초반 중국 지식인들이 직면한 사회와 문단의 현실에 기인한 것이기도 하였다. 본 논문에서는 《사닌》이 3인에게 수용된 양상을 살피면서 그 인식의 맥락과 한계를 짐작해보고자 한다. 俄羅斯作家阿爾志跋綏夫的長篇小說 《沙寧》1907年正式發表後曾引起過社會各界的强烈反應, 它的影響甚至新制造了 ‘saninism(性解放主義)’一詞。 《沙寧》同時又被評价爲宣傳厭世主義、虛無主義及個人的無治主義(無政府個人主義)思想的作品, 幷受本國批評家嚴厉和刻薄的批判。但頗有興趣的是, 《沙寧》倒在20世紀初中國知識分子那里, 赢得了熱烈的歡迎, 1930年還同時出版了3種不同的譯本。除了鄭振铎、潘漠華等譯者, 魯迅也對 《沙寧》發表過數次意見。然而細讀他們有關 《沙寧》的論述, 就不難發現每個人對待 《沙寧》時各持有不同的關注點, 都站在相異的立場上接受和評价其中心思想和特征。 作爲文學硏究會的代表人物, 鄭振铎就以寫實主義文學的觀點來解釋 《沙寧》的特點, 但同時還將它視爲炫耀幷贊颂性欲的作品。鄭振铎又把主人公沙寧的思想特徵闡釋爲虛無主義和厭世主義, 這樣鄭振铎在 《沙寧》評价上陷入了寫實主義與虛無主義這相距頗遠的兩種精神特點的矛盾之中。 潘漠華與鄭振铎不同, 始終注意到 《沙寧》所顯現的個人主義精神。但他對 《沙寧》這一特點倒表現出兩種逈異的評价, 卽剛開始飜譯時有力主張沙寧的個人主義對中國反封建運動的啓發性, 然而, 將要譯完時却對其個人主義施加反動的罪名。魯迅雖然數次談及 《沙寧》, 說它是阿爾志跋綏夫的代表作, 但幷沒肯定其積極的价値而評爲鼓吹颓廢主義的作品。 現在看來, 當時三人都不大注意阿爾志跋綏夫自己透露的 《沙寧》的思想根源, 卽 《沙寧》是個人主義的抗辯, 也是深受德國哲學家施蒂納的影響的。施蒂納的無政府個人主義其實基於生命的再建與新的誕生的宏旨上, 但魯迅等不能確切了解其原意, 這樣就表露了理解《沙寧》上的局限性。雖然如此, 他們還不能完全擺脫 《沙寧》本身所具備的魅力: 不受一切社會束縛的自由意志及沙寧的生命活力, 這就是他們超越認識上的局限而熱衷于 《沙寧》的主要原因。

지속가능제품의 사회성 평가요소에 대한 연구

이윤희(Lee Yun-Hee),김선영(Kim Sun-Young) 한국디자인학회 2008 한국디자인학회 학술발표대회 논문집 Vol.- No.-