제련공정 폐수에서 분리막에 의한 유가금속 회수

유명중,김장규,양의진,정유정,이용 대한환경공학회 2013 대한환경공학회 학술발표논문집 Vol.2013 No.6

일상적인 김치 섭취량의 차이가 건강한 성인의 혈중 지질에 미치는 영향

이상엽,김윤진,민홍기,양의진,김영주,최상한 대한임상건강증진학회 2004 Korean Journal of Health Promotion Vol.4 No.4

Background As eating habits in Korea have changed into western style, the number of cardiovascular disease have surged, and therate of mortality from cardiovascular disease increases each year. Because Kimchi, our traditional food, attracts people asa healthful food to prevent chronic diseases for modern people, the research intends to figure out the relationshipbetween Kimchi intake and plasma lipid and other cardiovascular risk factors.Methods The study sample consisted of 1,682 people (male 922, female 760) with constant Kimchi intake each meal at anuniversity hospital in Busan from January 2002 to December 2002. Subjects were divided into four groups -none, small,moderate, sufficient- according to Kimchi intake degree classified through the food model. Differences in means of plasmalipid leve,l systolic and diastolic blood pressure, and fasting glucose level in four groups were tested using ANOVA withSheffe's post hoc test. After adjusting by dietary caloric intake, interaction between factors associated with plasma lipid,blood pressure, and fasting glucose level and Kimchi intake degree were evaluated using Tests of Between SubjectsEffects of GLM univariate ANOVA. Odds ratios of dyslipidemia according to Kimchi intake classes were evaluated usingbinary logistic regression analysis.Results Mean plasma lipid, fasting glucose level, and blood pressure were not significantly different among Kimchi intake groups.After adjusting by dietary caloric intake, there was no differences in plasma lipid, blood pressure and fasting glucoselevel among Kimchi intake groups and no interaction between Kimchi intake degree and other factor, such as age, bodymass index, alcohol intake. After adjusting by age, dietary caloric intake, body mass index, waist circumference, alcoholdrinking state, Kimchi intake degrees did not affect dyslipidemia, based on ATP-Ⅲ. -연구배경 건강식품으로서의 김치에 대한 관심이 증가하고 있으나 연구가 부족한 실정이다 . 이에 건강한 성인을 대상으로 김치섭취와 혈중 지질을 비롯한 심혈관계 위험인자와의 관련성을 알아보고자 하였다 .방 법 2002년 1월 1일부터 2002년 12월 31일까지 부산의 일개 3차병원에서 종합검진 받은 사람들 중 설문지를 통하여 아침 , 점심, 저녁 김치섭취량이 일정한 사람들 1,682명을 대상으로 김치 섭취량을 조사하였다 . 김치 섭취량은 음식물 모형물을 통해 ‘안 먹는다’, ‘조금 섭취’, ‘보통 섭취’ 및 ‘충분히 섭취’의 4개군으로 범주화하였다. 분산분석을 이용하여 김치 섭취정도에 따른 4개군 사이의 평균 혈중 지질 농도 , 수축기 및 이완기 혈압 , 공복 혈당의 차이를 남녀별로 조사하였다 . 일반화 선형분석의 개체간 분석을 이용하여 영양소 섭취량을 보정한 후 혈중 지질 , 혈압, 공복 혈당에 영향을 미치는 인자를 알아보고 영향 인자들과 김치섭취정도가 혈압 , 혈중 지질, 공복 혈당에 상호작용을 하여 영향을 미치는지 여부를 조사하였다 . 남녀별 김치 섭취군에 따른 이상지질혈증의 교차비를 조사하였다 .결 과 김치 섭취가 많을수록 평균 식이 열량섭취 , 비만정도 및 음주 정도가 높은 것으로 나타났으나 김치 섭취군에 따른 평균 혈중 지질 농도는 남녀 모두에서 유의한 차이가 없었다 . 평균 식이 영양섭취량을 보정한 후에도 김치 섭취군에 따라 평균 혈중 지질 농도의 차이는 없었으며 김치 섭취군별 연령대 , 비만정도 및 음주 정도의 차이도 이러한 결과에 영향을 미치지 않은 것으로 나타났다. 김치 섭취군에 따른 평균의 차이를 보였던 연령 , 영양섭취량, 체질량 지수, 허리둘레, 음주 상태를 보정하였을 때 김치섭취량은 남녀 모두에서 이상지질혈증에 의미있는 영향을 미치지 못했다 .

Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration

이현지,신경화,김형회,양의진,박경희,김민주,권정란,최영실,김준년,신명근,조용곤,김선준,김경희,정세리,공섬김,정유진,이나영,김만진,성문우 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.2

Background: Thalassemia is highly prevalent in Southeast Asia but is rare in Korea; however, Southeast Asian immigrant population is recently rising in Korea. We investigated the prevalence of thalassemia in Korea in the context of increasing immigration. Methods: This prospective, observational, multicenter study was conducted between September 2015 and August 2017. A total of 669 subjects <30 years living in Korea were grouped into the multiethnic (N=314) and Korean (N=355) groups. Hb electrophoresis and complete blood count (CBC) were performed. If low mean corpuscular volume with high red blood cell distribution width coefficient of variation or a high fetal Hb (HbF) or Hb alpha 2 (HbA2) level was observed, genetic testing of the α- and β-globin genes was performed. In addition, the number of potential thalassemia carriers in Korea was estimated by multiplying the prevalence of thalassemia in a specific ethnicity by the number of immigrants of that ethnicity. Results: Twenty-six multiethnic and 10 Korean subjects showed abnormal results for Hb electrophoresis and CBC. Eighteen multiethnic subjects and four Korean subjects were tested for α-globin and β-globin gene mutations. Within the multiethnic group, five subjects (1.5%) were α-thalassemia carriers, and six (1.9%) were β-thalassemia minor. The SEA deletion in HBA1 and HBA2, and c. 126_129delCTTT (p.Phe42Leufs*19) mutation of HBB were the dominant inherited mutations. Conclusions: The prevalence of thalassemia in young people in Korea is increasing due to the increasing number of Southeast Asian immigrants.

Epidemiological Study of Hereditary Hemolytic Anemia in the Korean Pediatric Population during 1997–2016: a Nationwide Retrospective Cohort Study

심예지,정혜림,신희영,강형진,Jung Yoon Choi,하정옥,이제민,임영탁,양의진,백희조,최형수,유건희,박준은,김성구,김지윤,박은실,임호준,최희원,김순기,이재희,유은선,Park Hyeon Jin,Lee Jun Ah,Park Meerim,강현식,박지경,이나희,박상규,이영호,이성욱,Eun Jin Choi,공섬김,Red Blood Cell Disorder Wo 대한의학회 2020 Journal of Korean medical science Vol.35 No.33

Background: Hereditary hemolytic anemia (HHA) is a rare disease characterized by premature red blood cell (RBC) destruction due to intrinsic RBC defects. The RBC Disorder Working Party of the Korean Society of Hematology established and updated the standard operating procedure for making an accurate diagnosis of HHA since 2007. The aim of this study was to investigate a nationwide epidemiology of Korean HHA. Methods: We collected the data of a newly diagnosed pediatric HHA cohort (2007–2016) and compared this cohort's characteristics with those of a previously surveyed pediatric HHA cohort (1997–2006) in Korea. Each participant's information was retrospectively collected by a questionnaire survey. Results: A total of 369 children with HHA from 38 hospitals distributed in 16 of 17 districts of Korea were investigated. RBC membranopathies, hemoglobinopathies, RBC enzymopathies, and unknown etiologies accounted for 263 (71.3%), 59 (16.0%), 23 (6.2%), and 24 (6.5%) of the cases, respectively. Compared to the cohort from the previous decade, the proportions of hemoglobinopathies and RBC enzymopathies significantly increased (P < 0.001 and P = 0.008, respectively). Twenty-three of the 59 hemoglobinopathy patients had immigrant mothers, mostly from South-East Asia. Conclusion: In Korea, thalassemia traits have increased over the past 10 years, reflecting both increased awareness of this disease and increased international marriages. The enhanced recognition of RBC enzymopathies is due to advances in diagnostic technique; however, 6.5% of HHA patients still do not have a clear diagnosis. It is necessary to improve accessibility of diagnosing HHA.

Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group

박경미,유건희,김성구,이재욱,정낙균,주희영,구홍회,류철주,한승민,한정우,최정윤,홍경택,강형진,신희영,임호준,고경남,김혜리,국훈,백희주,김보람,양의진,임재영,박은실,최은진,박상규,이재민,심예지,김지윤,박지경,공섬김,최영배,조빈,임영탁 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1

Purpose Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. Materials and Methods Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Results Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020). Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment. Purpose Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea.Materials and Methods Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively.Results Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10×109/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%±4.4%, 89.7%±5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC < 10×109/L than in those with initial WBC ≥ 10×109/L (p=0.020).Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment.