Sonography of Invasive Apocrine Carcinoma of the Breast in Five Cases

서경진,안영이,황인용,장은덕,강봉주,김성헌,박창숙,김정수,홍현주 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.5

To evaluate the sonographic features of invasive apocrine carcinoma (IAC) of the breast. This study included five pathologically proven cases of IAC, and their sonographic features were retrospectively analyzed according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon. All five lesions involved the left breast and were seen as irregularly shaped masses. All lesions, except one, had a parallel orientation to the chest wall. All five lesions showed noncircumscribed margins and heterogeneous echotexture; however, they showed various posterior features. One lesion had edema as an associated feature. Sonographic assessments were classified as BI-RADS category 4 in all five cases. Invasive apocrine carcinoma sonographic findings are difficult to differentiate from those of invasive ductal carcinoma of no special type.

Dermatomyositis in a Patient with Cholangiocarcinoma Detected by an [18F]-Fluorodeoxyglucose Positron Emission Tomography–Computed Tomography Scan

서경진,박진균,조승철,박현경,백해운,이경분,이동수,이경훈 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Cholangiocarcinoma with paraneoplastic dermatomyositis (DM) is extremely rare, and the whole body positron emission tomography–computed tomography (PET-CT) finding of paraneoplastic DM is rarely reported. We report a 66-year-old woman with metastatic cholangiocarcinoma, initially presented with bilateral proximal muscle uptake on PET-CT without clinical muscle symptoms. The initial interpretation of the high muscle uptake was metastasis to the muscles. However, while awaiting for chemotherapy, muscle weakness evolved and rapidly progressed. The level of creatine phosphokinase was significantly elevated. Electromyography revealed moderate myopathy, and a muscle biopsy showed degenerating myofibers with variable sizes. The diagnosis of paraneoplastic dermatomyositis was made. This case highlights that, although rare, paraneoplastic dermatomyositis can be present with cholangiocarcinoma. Also, muscle inflammation can precede the clinical muscle symptoms, and paraneoplastic DM should be considered as a possible differential diagnosis in the assessment of cancer patients who present with abnormal muscle tracer uptake in PET-CT scans.

경피경간 담배액술 : 175예의 분석

서경진 대한영상의학회 1990 대한영상의학회지 Vol.26 No.4

Percutaneous transhepatic biliary drainage is a safe, effective and palliative means of treatment in biliary obstruction, especially in cases with malignant obstruction which are inoperable. 175 cases of transhepatic biliary drainage were performed on 119 patients with biliary obstruction from January 1985 to June 1989 at kyung-pook National University Hospital. The causes of obstructive jaundice were 110 malignant diseases and 9 benign diseases. The most common indication for drainage was pilliative intervention of obstruction secondary to malignant tumor in 89 cases. 86 cases of external drainage were performed including 3 cases of left duct approach, 29 cases of external-internal drainage and 60 cases of endoprosthesis. In external and external-internal drainages, immediate major complications(11.9%) occured, including not restricted to, but sepsis, bile peritonitis and hemobilia. Delayed major complications942.9%) were mainly catheter related. The delayed major complicatio of endoprosthesis resulted from obstruction of the internal stent. The mean time period to reobstruction of the internal stent was about 12 weeks. To improve management status, regular follow-up is required, as is education of both patients and their families as to when immediate clinical attention is mandated. Close communication amongst the varying medical specialties involved will ber necessary to provide optimal treatment for each patient.

경추 골절의 방사선학적 고찰

서경진 대한영상의학회 1983 대한영상의학회지 Vol.19 No.4

The radiological findings of various cervical spine fractures were analized on the basis of J. Harris classification. It appears to be important for the radiologist to be familiar with radiographic findings of cervical spine fractures, particularly those of unstable fractures which can result in serious medical problems if improperly handled in the department of radilogy. 68 cases of cervical spine fractures were analized. The results are as follows : 1. Stable and unstable fractures were about eual in incidence. 2. Anterior subluxation accounts for 43.4% of stable fractures, 19% of all fractures. 3. Bilateral interfacetal dislocation accounts for 51.1% of unstable fractures, 25% of all fractures. 5. About 80% of the patients is in third through fifth decade.

Platinum제로 항암 치료한 진행성 비소세포폐암종 환자에서 HER-2/neu, ERCC1과 GST-pi에 대한 연구

서경진,심병용,이교영,김훈교,정지한,유진영,강석진 대한병리학회 2008 Journal of Pathology and Translational Medicine Vol.42 No.6

Background : Platinum-based chemotherapy has shown to be an effective first-line treatment for patients with advanced stage, unresectable non-small cell lung cancer (NSCLC). We evaluated the response rate to combination chemotherapy with cisplatin and taxane, and the significance of the HER-2/neu, ERCC1, and GST-pi status as predictive markers for the tumor response. Methods : The HER-2/neu, ERCC1, and GST-pi status were analyzed in the biopsy specimens obtained from 35 patients with advanced stage NSCLC prior to cisplatin plus either paclitaxel or docetaxel chemotherapy. Results : The response rate of the tumors to combination chemotherapy was 62.9% (22/35). HER-2/neu was amplified in 51.4% (18/35) of the tumors, and this was observed exclusively in patients with progressive disease (p=0.014). ERCC1 was overexpressed in 77.2% of the specimens (27/35), and this showed a tendency to correlate with the tumor response (p=0.057). GST-pi was detected in 85.7% of the specimens (30/35). Seventy-seven percent of the patients with a negative HER-2/neu and positive ERCC1 status showed a partial response, which was in contrast to only a 25% response rate for the patients with a positive HER-2/neu and negative ERCC1 status (p=0.006). The overall survival was prolonged in the patients without HER-2/neu amplification (15 vs 8.5 months, respectively, p=0.008). On multivariate analysis, the HER-2/neu status remained the significant predictor of survival (p=0.005). Conclusions : A combination of the ERCC1, HER-2/neu status may define a subset of patients with the most favorable response to combination chemotherapy regimens for treating advanced NSCLC.

Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance

서경진,김기환,김률,변자민,김미소,박진현,김범석,김태민,김진수,최인실,허대석 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.4

Background/Aims: The role of [18F]-f luorodeoxyglucose positron emission tomography- computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear. Methods: Medical costs within the first 3 years of treatment completion and clinical outcomes of 118 patients with DLBCL in first remission with and without surveillance PET/CT (PET/CT [+] group [n = 76] and PET/CT [–] group [n = 42], respectively) were retrospectively analyzed. Results: In a propensity matched cohort with adjustment for International Prognostic Index risk and relapse, the PET/CT (+) group was shown to have similar medical costs as the PET/CT (–) group. Relapse-free survival (RFS) and overall survival (OS) were comparable between the two groups (median RFS not reached [NR] for both groups, p = 0.133; median OS NR, p = 0.542). Among 76 patients with surveillance PET/CT, 31 (40.8%) had findings suggestive of recurrence and 16 of these (51.6%) were later confirmed to have recurrent disease. Fifteen patients (48.4%) were confirmed to not have recurrence after follow-up CT or PET/CT evaluation (n = 10) and biopsy (n = 4). None of the patients with negative PET/CT findings had disease recurrence. Sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT for detection of recurrence were 1, 0.75, 0.52, and 1, respectively. Conclusions: Surveillance PET/CT resulted in similar clinical outcomes and medical costs compared to no surveillance PET/CT. Approximately half of patients with PET/CT findings of recurrence had no recurrence after follow-up imaging and biopsy, which would not have been carried out if PET/CT had not been performed in the first place.

Imaging of the Elbow

서경진 대한견주관절의학회 2011 대한견주관절학회 학술대회논문집 Vol.2011 No.11

연조직종양의 새로운 WHO 분류를 중심으로: 지방세포종, 섬유모세포성/근육섬유모세포성종, 소위섬유조직구종, 평활근종, 혈관주위종과 근골격종에 대하여

서경진,Suh, Kyung-Jin 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.1

연조직종양의 이해는 과거 10년 동안에 걸쳐 주요 변화와 더불어 실질적인 진보가 있었고, 이를 바탕으로 연조직종양의 새로운 분류가 WHO에 의해 2002년에 이루어졌다. 이 개정은 이전에 발표와 상당히 다른 내용의 접근을 하였고, 이 작업에 유전학과 분자생물학 그리고 임상분야의 전문가들이 참여하였다. 여기에서는 과거에 알고 있었거나 특성이 알려진 많은 종양을 포함하여 새로운 큰 변화나 작은 변화가 일어난 부분에 대해서 정리를 하였다. 이러한 내용을 연조직종양의 새로운 WHO 분류를 중심으로 지방세포종, 섬유모세포성/근육섬유모세포 성종과 소위섬유조직구종, 평활근종, 혈관주위종과 근골격종을 중심으로, 큰 변화와 작은 변화로 나누어서 설명하고 새롭게 소개되는 병명을 소개하고 정리하였다. 이 새로운 WHO의 연조직종양의 분류를 이해하여, 종양의 진단과 예후의 재현을 용이하게 하는 필수적인 지침으로 사용할 수 있을 것으로 생각된다. Soft tissue tumor classifications should be an important part of radiology, oncology and, for clinicians and pathologists, they provide diagnostic instruction and prognostic guidelines. In soft tissue tumor classification systems, the World Health Organization (WHO) classifications have become dominant, enabled by the timely publication of new 'blue books' which included detailed text and numerous good illustrations. The new WHO classification of soft tissue tumors was introduced in 2002. Because the classification represents a broad consensus concept, it has gained widespread acceptance around the globe. This article reviews the changes which were introduced the adipose tumors, fibroblastic/myofibroblastic tumors, so-called fibrohistiocytic tumors, smooth muscle tumors, pericytic tumors and skeletal muscle tumors which have been first recognized or properly classified during the past decade.

연조직종양의 새로운 WHO 분류를 중심으로: 혈관종, 연골-골종과 불확실한분화종에 대하여

서경진,Suh, Kyung-Jin 대한근골격종양학회 2008 대한골관절종양학회지 Vol.14 No.2

연조직종양의 분류는 종양학에서 영상의학과의사와 임상을 담당하는 정형외과의사, 종양학자 그리고 병리학자의 진단과 예후의 재현을 용이하게 하는 필수적인 지침이다. 연조직종양의 이해는 과거 10년 동안에 걸쳐 주요 변화와 더불어 진보가 있었고, 이를 바탕으로 연조직종양의 새로운 분류가 WHO에 의해 2002년에 이루어졌다. 이 개정은 이전에 발표된 분류와 많은 부분에서 다른 내용의 접근을 하였고, 이 작업에는 유전학과 분자생물학 그리고 임상분야의 전문가들이 참여하였다. 여기에서는 과거에 알고 있었거나 특성이 알려진 종양을 포함하여 새로운 큰 변화나 작은 변화가 일어난 부분에 대해서 정리를 하였다. 이러한 내용의 연조직종양의 새로운 WHO 분류를 혈관종, 연골-골종 그리고 불확실한분화종을 중심으로, 큰 변화와 작은 변화로 나누어서 설명하고 새롭게 소개되는 병명을 정리하였다. 이 새로운 WHO의 연조직 종양의 분류를 이해하여, 종양의 진단과 예후의 재현을 용이하게 하는 필수적인 지침으로 사용할 수 있을 것으로 생각된다. Soft tissue tumor classifications should be an important part of radiology, oncology and, for orthopedic clinicians and pathologists, they provide diagnostic instruction and prognostic guidelines. In soft tissue tumor classification systems, the World Health Organization (WHO) classifications have become dominant, enabled by the timely publication of new blue books which included detailed text and numerous good illustrations. The new WHO classification of soft tissue tumors was introduced in 2002. Because the classification represents a broad consensus concept, it has gained widespread acceptance around the globe. This article reviews the changes which were introduced the vascular tumors, chondroid-osseous tumors and tumors of uncertain differentiation which have been first recognized or properly classified during the past decade.

대형오피스 빌딩 혼합공조(시스템에어컨+중앙공조)적용사례

서경진,정기호 대한설비공학회 2004 설비저널 Vol.33 No.8

국내 시스템에어컨 시장은 신도시 형성과 주상복합건물 및 중대형 아파트의 전실공조 필요성이 증대하고 빌딩 리노베이션 등 지속적인 건설시장 성장에 따라 수요가 급격히 증가해 왔으며, 중대형 공조설비를 대체할 차세대 공조시스템으로 시장에서 평가받고 있으며, 상업용 공조시장에서 차지하는 비율도 점차 증가하고 있다. 이런 결과 지난해 3,000∼3,500억 원대의 시장 규모는 올해 4,500∼5,000억 원대로 성장이 예상되면, 매년 30% 이상의 지속적인 시장확대가 예측되며, 도입초기에 주상복합, 아파트, 교단, 병원, 중소형 빌딩 등에 한정되었던 시장은 최근에는 중대형 빌딩용 멀티 에어컨의 수요가 꾸준히 늘어나고 있으며 선진시장인 일본에서 중앙공조 및 멀티에어컨의 장점만을 이용한 혼합 공조시스템이 90년대부터 적용되어져 왔으며, 현재에는 대형오피스 빌딩의 경우에도 공조방식이 시스템에어컨 및 혼합공조가 증가하는 추세이다. (중략)