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      • KCI등재후보
      • mGA를 이용한 웨이블렛 퍼지 모델링

        유진영,이연우,주영훈 국립7개대학공동논문집간행위원회 2002 공업기술연구 Vol.2 No.-

        In this paper, we propose a new approach to Wavelet Fuzzy Modeling using messy genetic algorithm(mGA). mGA has more effective and adaptive structure than sGA with respect to using the changeable-length string. We build a fuzzy system model which is equivalent to the wavelet transform after identifying the coefficients of wavelet transform. We can obtain an accurate system model with a small number of coefficients due to the energy compaction property of the wavelet transform. And it means that we can construct a fuzzy system model with a small number of rules. By the conventional fuzzy modeling method, a problem might arise that a function with abrupt changes can hardly be modeled precisely. Hence, we present a solution to this problem by the advantageous property of the wavelet transform. We demonstrate the superiority of our proposed fuzzy system modeling method over the previous results by modeling a highly nonlinear function.

      • KCI등재

        육종에서 p53, c-kit과 CD34의 발현에 대한 조직 미세배열을 이용한 연구

        유진영,박경신,강석진,강창석 대한병리학회 2004 Journal of Pathology and Translational Medicine Vol.38 No.4

        Background : Our objectives in this study were to (1) evaluate the possible role of p53, c-kit and CD34 proteins in sarcomas and to determine their potential relationship; (2) use a tissue microarray to compare the immunohistochemical staining results on both the tissue microarrays and the corresponding whole tissue sections. Methods : Whole sections from 85 sarcomas were studied for the immunohistochemical expression of p53, c-kit and CD34. Tissue microarrays consisting of triplicate 2 mm cores from the corresponding blocks were constructed and stained according to the same protocols as those used for the whole sections. Results : On whole section analysis, p53 protein was expressed in 25 cases (29.4%). Expression of c-kit was observed in 31 specimens (36.5%), whereas CD34 expression was noted in 11 tumors (12.9%). The overall concordance between triplicates was 96% (217/226). The consensus score from the combined triplicates agreed with the results on the whole sections at 91.4% (233/255). The correlations between p53 and CD34, and between c-kit and CD34, were statistically significant (p=.028 and p=.010 respectively). Conclusions : p53 and c-kit express relatively frequently in sarcomas. Tissue microarrays are an effective alternative to whole sections; however, the presence of triplicate punches seems to improve the yield but not the concordance of data.

      • KCI등재
      • KCI등재
      • KCI등재

        유료노인장기요양보호서비스 이용의사 결정요인

        유진영,전진호,Yoo, Jin-Yeong,Chun, Jin-Ho 대한예방의학회 2005 예방의학회지 Vol.38 No.1

        Objectives : To help develop strategies to cope with the changes arising from the rapid aging process by predicting the determining factors of intention to actual use of the charged long-term care services for elderly as perceived by the middle aged who play the major role of supports. Methods : Subjects were the parents (men 177, women 507) in their 40s of the students selected from a university of Busan city. A questionnaire survey was conducted for 4 weeks in October 2003 about the knowledge for long-term care service, the intention of actual use, and the preferences about the type of service suppliers. Data analysis was performed with frequency, chi-square test, and t-test using SPSS program (ver 10.0K), along with data mining using decision tree of Enterprise Miner V8.2 by SAS. Results : About half of the subjects (53.7%) had the actual experiences of elderly supports. Intentions to use the charged services were relatively high in home visiting nursing care service (40.1%) and long-term care facilities service (40.4%), and were influenced by previous knowledge about the services. The intentions were stronger in women, those with higher education, and those with greater income levels. Actual elderly supports were mostly (80%) done by women, and the perceived burdens for the supports were bigger in women and those of lower socioeconomic level. Desired charges were about 10,000 won for the bath service, 20,000 won for the rests services per day, and about 500,000 won for the long-term care facilities service per month. From the result of decision tree analysis, the job professionalism was the most important determining factor of intention to actual use of the services with validation as $63{\sim}71%$. Health and welfare mixed type facilities were preferred, and the most important consideration was the level of professionalism. Conclusions : Intention to actual use of the charged services was largely determined by the aspects of time and cost. Polices to increase the number of service suppliers and to decrease the burdens perceived by actual supporters were strongly recommended.

      • KCI등재

        위암종에서 ras유전자 돌연변이와 ERK1, ERK2 단백의 발현

        유진영,강석진,김병기,강창석 대한병리학회 2002 Journal of Pathology and Translational Medicine Vol.36 No.2

        We investigated stomach cancers for ras abnormalities and expression of ERK1 and ERK2 to determine their significance in the tumor development and/or progression and to evaluate their potential correlation with clinicopathologic parameters. Methods : Seventy gastric adenocarcinomas were studied immunohistochemically in paraffin-embedded tissue sections for the expression of ERK1 and ERK2 proteins. All tumors were further analyzed with the use of a polymerase chain reaction technique and a direct sequence analysis procedure for the presence of the mutated ras gene. Results : ERK1 and/or ERK2 was expressed in 65.7% (46/70) of the tumors; overexpression of ERK1 was observed in 38 (54.3%) tumors, whereas ERK2 was detected in 29 (41.4%). Nine (12.8%) samples demonstrated mutations in the ras gene: 4 in H-ras and 5 in K-ras. Seven of the 9 (77.8%) mutated tumors were of the intestinal type. No association was established between the ras abnormalities and the overexpression of ERK1 and/or ERK2. However, the correlation between ERK2 and progression (early vs. advanced) was statistically significant (p<0.05). Conclusions : These data indicate that ras abnormalities are uncommon events in gastric adenocarcinomas. The majority of ras mutations, however, occurred in intestinal-type tumors, supporting the notion of different molecular mechanisms involved between the intestinal- and diffuse-type lesions. Enhanced ERK2 activity may provide assistance in the determination of tumor penetration in these tumors.

      • 중 · 장년층의 노인부양 실태와 인지하는 부담 정도

        유진영,전진호 白中央醫療院 2004 仁濟醫學 Vol.25 No.1

        Background : Social concerns about elderly supports have been increasing with rapid progress of aging. To propose the data for developing the efficient welfare policy for the aged through observation about the real status and burdens about elderly supports perceived by the middle aged who play the major role. Method : Subjects were the 40~50 aged parents of the students candidated from a university of Busan city. Questionnaire survey about the cognitions, real status, perceived burdens for the elderly attendance was done during 4 weeks from October 2003. Data analysis is operated with frequency, chi-square test, t-test using SPSS program (ver 10.0K). Result : In cognitions, family centered tendency was still strong and, they hoped the paralleled children and nation's charge for the support. They wanted to live separately when the aged healthy. In the status of real supports, the first son had major role. Most of actual supporter were women, 62% of them had been supporting over 2 years, 53% of them charged over 200 thousand won for the supports. The mean level of burdens by Zarit index (0~4) was the highest in concerns to better support (2.0) and in concerns to do more (1.9). The actual needs for help to elderly supports were economic aids (33%), education and counselling about methods of real support (27%), opportunities free from the supports (16%), in order. Conclusions : To decrease the burden of supporters and to improve the quality of life of the aged, the strengthened polices mostly considering the aspects of time and cost would be recommended.

      • KCI등재

        비소세포 폐암종에서 bcl-2, p53, VEGF의 발현: 미세혈관밀도 및 예후와의 상관관계

        유진영,정지한,최현주,강석진,강창석 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.2

        Background : The aim of this study was to investigate the expression of bcl-2, p53 and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC), and to examine the relationship between those protein expressions and neovascularization. We also analyzed the prognostic impact of these biological parameters on the patients' overall survival rate. Methods : The archival tumor tissues from 147 previously untreated patients with NSCLC were examined by immunohistochemistry for bcl-2, p53 and VEGF proteins. The vascularity was measured by the average microvascular density (MVD) of the CD34-positive vessels. Clinical information was obtained through the computerized retrospective database from the tumor registry. Results : Immunoreactivity for bcl-2 was detected in 17% (25/147), p53 in 72% (106/147) and VEGF in 75% (110/147) of the tumors. An inverse association was found between bcl-2 expression and VEGF expression (p=0.012). There was a significant correlation between the bcl-2 expression and the MVD (p=0.009), and also between the p53 expression and the MVD (p=0.045). The mean survival time was associated with the patients' age (p=0.032), the T status (p=0.038), the tumor stage (p=0.009), and expressions of bcl-2 (p=0.016) and VEGF (p=0.039). On multivariate analysis, only the tumor stage and VEGF expression maintained their prognostic influence. Conclusions : Our data suggest that bcl-2 and p53 alterations are involved in the angiogenesis of NSCLC, and are either dependent on or independent of VEGF. It is further noteworthy that the tumor stage and VEGF expression may be useful in predicting patients' survival.

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