The impact of EGFR tyrosine kinase inhibitor on the natural course of ground glass lung nodules

강노을,신선혜,이호연,정병호,이경종,김호중,권오정,엄상원 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: To evaluate the treatment response of EGFR tyrosine kinase inhibitor (EGFR-TKI) for persistent ground-glass nodule (GGN) in patients with stage IV non-small cell lung cancer (NSCLC). Methods: This is a retrospective study from 2010 to 2015. Patients who received EGFR-TKI for stage IV NSCLC and had concurrent GGN(s) that existed more than 3 months on chest CT scans were included in the study. For each nodule, chest CT images before and after treatment of EGFR-TKI were reviewed to evaluate objective response, which was defined as complete or partial response in size. Results: A total of 83 persistent GGNs were identified in 64 patients. Forty-one (64%) were female and the median age was 58.3 (range, 45 - 82). EGFR mutation was identified at the primary tumor or metastatic lesion in 50 (78%) patients. The median duration of EGFR-TKI was 13.0 months. Objective response was observed in 44 (53%) GGNs. EGFR mutation of deletion in exon 19 [odds ratio (OR), 3.04; 95% confidence interval(CI), 1.18-7.88] and EGFR-TKI treatment for more than 1 year [OR, 2.7; 95% CI, 1.09-6.66] were significantly associated with objective response. Conclusion: Half of the persistent GGNs showed objective response to EGFR-TKI treatment in patients with stage IV NSCLC. Objective response was more common in patients with EGFR exon 19 deletion or EGFR-TKI treatment of more than 1 year.

A rare case of numerous thoracolithiasis with chest discomfort

강노을,최연석,임윤주,최준수,김진국,한정호,김태정,김호중 대한내과학회 2018 대한내과학회 추계학술발표논문집 Vol.2018 No.1

사회적 시차와 대사증후군 유병률에 대한 체계적 문헌고찰과 메타분석

강노을,김혜영,양영란 한국간호과학회 2020 한국간호과학회 학술대회 Vol.2020 No.10

암 생존자의 심리사회적 적응 개념분석

강노을,김혜영,양영란,김지영 한국간호과학회 2020 한국간호과학회 학술대회 Vol.2020 No.10

Treatment Modality and Outcomes among Early-Stage NSCLC Patients with COPD : A Cohort Study

강노을,신선혜,노재명,강단비,김호중,권오정,최용수,김진국,조재일,심영목,조주희,박혜윤 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: To evaluate the management and outcomes of early-stage NSCLC in spirometry-defined obstructive lung disease (OLD). Methods: This is a retrospective cohort study from January 2012 to June 2014. Patients with newly diagnosed stage I or II NSCLC with spirometry-defined OLD were enrolled. Medical records were reviewed for socio-demographic information, treatment selection and reasons for not having standard treatment. Overall survivals (OS) were compared using Kaplan-Meier and Cox proportional hazards ratio. Results: 692 patients were included, 599 (86.6%), 49 (7.1%), and 44 (6.3%) received surgical resection, definitive RT, and SC only, respectively. Compared to the surgery group, OS was significantly poor in non-surgery group even after adjustment performance status and lung function [adjusted hazard ratio (HR), 2.32; 95% confidence interval(CI), 1.59-3.38]. Among the non-surgery group, RT group had better OS compared to SC only group [adjusted HR, 2.70; 95% CI 1.37-5.31]. Patients chose RT due to poor lung function, whereas patient’s will led to choose supportive care only. Conclusion: In this large-numbered cohort of early-stage NSCLC patients with OLD, surgical resection showed better OS than non-surgery group and patients with RT had longer survival than SC only group. This information should be taken into consideration in treatment decision.

The Impact of EGFR Tyrosine Kinase Inhibitor on the Natural Course of Concurrent Subsolid Nodules in Patients with Non–Small Cell Lung Cancer

강노을,김기환,정병호,이경종,김호중,권오정,안명주,조정희,이호연,엄상원 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

Purpose The role of epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKIs) in the management of persistent subsolid nodules (SSNs) is unclear. This study aimed to investigate the impact of EGFR-TKIs on concurrent SSNs in patients with stage IV non–small cell lung cancer (NSCLC).Materials and Methods Patients who received an EGFR-TKI for at least 1 month for stage IV NSCLC and had concurrent SSN(s) that had existed for at least 3 months on chest computed tomography were included in this retrospective study. Size change of each nodule before and after EGFR-TKI therapies were evaluated using a cutoff value of 2 mm; increase (≥ 2 mm), decrease (≤ –2 mm), and no change (–2 mm < size change < +2 mm).Results A total of 77 SSNs, 51 pure ground-glass (66.2%) and 26 part-solid nodules (33.8%), were identified in 59 patients who received gefitinib (n=45) and erlotinib (n=14). Among 58 EGFR mutation analysis performed for primary lung cancer, 45 (77.6%) were EGFR mutant. The proportions of decrease group were 19.5% (15/77) on per-nodule basis and 25.4% (15/59) on per-patient basis. Four SSNs (5.2%) disappeared completely. On per-patient based multivariable analysis, EGFR exon 19 deletion positivity for primary lung cancer was associated with a decrease after initial EGFR-TKI therapy (adjusted odds ratio, 4.29; 95% confidence interval, 1.21 to 15.29; p=0.025).Conclusion Approximately 20% of the concurrent SSNs decreased after the initial EGFR-TKI therapy. EGFR exon 19 deletion positivity for primary lung cancer was significantly associated with the size change of concurrent SSNs.

The impact of low forced vital capacity on behavior restrictions in chronic obstructive pulmonary disease patients

강노을,신선혜,구선혜,조주희,정호중,서지영,이현,박혜윤 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: To evaluate the association between low FVC and behavior restrictions in COPD patients. Methods: A cross-sectional study was performed using data from the Korean National Health and Nutrition Surveys conducted between 2007 and 2015. Participants aged 40 years to79 years with spirometry-defined COPD were analyzed to evaluate the association between low FVC (FVC<80% predicted) and behavior restrictions. Results: A total of 3,345 patients with COPD were included. The proportion of subjects with low FVC varied widely according to the severity of airflow limitations (0.8%, 36.1%, and 81.4% in the mild, moderate, and severe-to-very-severe COPD groups, respectively). As compared with moderate COPD subjects with normal FVC, those with low FVC were more likely to be older, never or ex-smokers; have larger waist size with higher body mass index, and have comorbidities such as diabetes, hypertension, dyslipidemia, and osteoporosis. Although there was no significant association between low FVC and behavior restrictions in the mild or severe-to-very-severe COPD groups, low FVC was independently associated with behavior restrictions in subjects with moderate COPD (adjusted odds ratio: 1.64, 95% confidence interval: 1.26-2.12). Conclusion: In moderate COPD patients, low FVC was independently associated with behavior restrictions even after adjusting for confounding factors

XML 및 웹 기반 영어 작문 보조 시스템의 설계 및 구현

강노을,양윤영,정가영,고은정,이기훈 한국정보과학회 2016 데이타베이스 연구 Vol.32 No.3

To improve English communication skills, comprehensive education of reading, writing, listening, and speaking is required. However, many people in Korea have difficulties in writing English because writing education is not successful. In addition, it is financially and temporally limited to receive individual education for English writing. Conventional aiding systems for English writing recommend only words without consideration of grammar. Furthermore, existing systems are inconvenient because they need to have a separate program installation. In this paper, we propose an aiding system for English writing for users of English as a second language. The proposed system suggests a next word and the part of speech of the word in real time as users write an English sentence. To do this, English sentences with high grammatical accuracy are collected, analyzed through natural language processing, and stored as an XML document, which represents syntax trees. Based on the word sequence inputted by the user, XQuery, an XML query language, is used to obtain parts of speech and words to be recommended. In addition, our system allows users to search sentences with desired syntactic structure. Because the system is web-based, there is no need to install a program separately, and it is easy for users to access. Experiments using 550,000 sentence databases and 1000 test sentences showed that the accuracy of our system was 60% for the average and 95% for the nouns. The recommendation process can be done within 1.5 seconds using a PC server. 영어 의사소통능력을 향상시키기 위해서는 읽기, 쓰기, 듣기, 말하기의 종합적인 교육이 필요하나 우리나라에서는 쓰기 교육이 제대로 이루지지 않아 영어 작문에 어려움을 겪는 사람들이 많다. 또한 영어 작문에 대한 개별 교육을 받는 것은 금전적, 시간적으로 한계가 있다. 기존의 영어 작문 보조 시스템들은 문법을 고려하지 않은 채 단어만을 추천하며 별도의 프로그램을 설치해야 하는 불편함이 있다. 본 논문에서는 영어가 제2외국어인 사용자들을 위한 영어 작문 보조 시스템을 제안한다. 제안하는 시스템은 사용자가 영어 문장을 작성할 때 다음에 올 품사와 단어를 실시간으로 추천해준다. 이를 위해 문법적 정확도가 높은 영어 문장들을 수집하고 자연어 처리를 통해 분석한 후 구문 트리를 표현하는 XML 문서로 저장한다. 사용자가 입력한 단어 연속을 기반으로 XML 질의 언어인 XQuery를 이용하여 추천할 품사와 단어를 구한다. 또한 원하는 구문 구조를 가진 문장들을 쉽게 검색할 수 있으며, 웹 기반으로 구현되어 별도의 프로그램 설치가 필요 없고 사용자의 접근이 쉽다. 약 55만개의 문장 데이터베이스와 1000개의 테스트 문장을 이용하여 실험한 결과, 제안한 시스템의 정확도는 평균 60%, 명사에 대해서는 95%이었고, PC 서버에서 1.5초 내에 추천이 가능하였다.

기상청 가뭄정보 서비스

강노을,강혜영,신도식,Gang, No-Eul,Gang, Hye-Yeong,Sin, Do-Sik 한국수자원학회 2016 물과 미래(한국수자원학회지) Vol.49 No.11

Giant Coronary Artery Aneurysm with Thrombosis Complicated in a Patient with Idiopathic Hypereosinophilic Syndrome

강노을,최기홍,김성목,김덕경,성기익,최동철 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.2

Idiopathic hypereosinophilic syndrome (iHES) is a rare systemic disease that is characterized by persistent peripheral eosinophilia (absolute eosinophil count ≥1500/uL) for more than 6 months, with end-organ damage and absence of a primary cause for eosino philia. Coronary artery aneurysm (CAA) is a rare but life-threatening complication. Here, we report a case of CAA with thrombosis in a patient with iHES in whom the disease activity was well-controlled (eosinophil count <500/uL) for several years. Despite mod est control of the disease activity, giant CAA can be associated with iHES; and therefore, close surveillance and monitoring for the development of complications is warranted.