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P-70 Ethnic differences of comorbidities in COPD patients
이현,구선혜,신선혜,강단비,조주희,서지영,박혜윤 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Recent chronic obstructive pulmonary disease (COPD) management guidelines put a weight on comorbid conditions of COPD patients. However, the information regarding ethnic differences of comorbidities in COPD patients is limited. We evaluated the prevalence of comorbidities of COPD patients using data from the US National Health and Nutrition Examination Survey (NHANES) for 2007-2012 and from Korea NHANES for 2007-2015. Koreans were more likely to be older male, and current- smoker, while Hispanics were more likely to be overweight or obese than other ethnicity. Non-Hispanic white had the most prevalent smoking history including current and former but there tends to shift from current smoking status to former smoking status, while non-Hispanic Black showed higher current smoking than non-Hispanic White. Regarding comorbidities, non-Hispanic black had the heaviest burden of comorbidities with much higher risk of hypertension, stroke, diabetes and rheumatoid arthritis than non-Hispanic white. Koreans compared to non-Hispanic white, had much lower risk of any comorbid conditions except stroke and diabetes. In conclusion, this study clearly showed that COPD-related comorbidities differed according to ethnicity. Thus, the generation of local map of COPD-related comorbidities and planning different strategies for the diagnosis, treatment, and prevention for COPD-related comorbidities are needed according to ethnicity.
Association of impaired lung function with duration of sex hormone exposure
임준혁,구선혜,강단비,신선혜,서지영,조주희,박혜윤 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Objective: The purpose of this study was to investigate the association between duration of exposure to sex hormones and lung function in postmenopausal women. Methods: We used data from Korean National Health and Nutrition Examination Survey, 2007 to 2016. Eligible population were postmenopausal women aged 40 to 64 years and underwent spirometry (n=6,633). Participants were excluded if they had missing on duration for hormone exposure (n=1,683); or if they were below 35 years in menopause (n=21). Participants were divided based the quintile of duration for hormone exposure and lung function by spirometry was compared between groups. Results: Of 4,929 women, 762 (15.4%), 2,855 (57.9%) and 1,312 (26.7%) patients were categorized into the first, the second to the forth, and the fifth quintile of duration for hormone exposure. Median duration for hormone exposure was 24 years (13-26), 31 years (27-33) and 35 years (34-45). Participants in the first quintile had more impaired lung function (p=0.004) and restrictive or obstructive patterns of lung function (p=0.025) compared to those in the rest quintile. This association persisted even after adjusting for age, body mass index, smoking status, cardiovascular disease, diabetes mellitus, musculoskeletal disease and forced expiratory volume in 1 second, % predicted (odds ratio: 1.69; 95% confidence interval: 1.04 to 2.76). Conclusions: In the postmenopausal women, the proportion of participants with impaired lung function was higher in the group with low exposure of hormone.
강노을,신선혜,구선혜,조주희,정호중,서지영,이현,박혜윤 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: To evaluate the association between low FVC and behavior restrictions in COPD patients. Methods: A cross-sectional study was performed using data from the Korean National Health and Nutrition Surveys conducted between 2007 and 2015. Participants aged 40 years to79 years with spirometry-defined COPD were analyzed to evaluate the association between low FVC (FVC<80% predicted) and behavior restrictions. Results: A total of 3,345 patients with COPD were included. The proportion of subjects with low FVC varied widely according to the severity of airflow limitations (0.8%, 36.1%, and 81.4% in the mild, moderate, and severe-to-very-severe COPD groups, respectively). As compared with moderate COPD subjects with normal FVC, those with low FVC were more likely to be older, never or ex-smokers; have larger waist size with higher body mass index, and have comorbidities such as diabetes, hypertension, dyslipidemia, and osteoporosis. Although there was no significant association between low FVC and behavior restrictions in the mild or severe-to-very-severe COPD groups, low FVC was independently associated with behavior restrictions in subjects with moderate COPD (adjusted odds ratio: 1.64, 95% confidence interval: 1.26-2.12). Conclusion: In moderate COPD patients, low FVC was independently associated with behavior restrictions even after adjusting for confounding factors