심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

Growth Inhibition of Colon Cancer through Inactivation of STAT3 Pathway by IL-10 and IL-1ra Released from Murine Macrophage

Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4

The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

개에서 발생한 양파 섭취에 의한 하인즈 소체 용혈성 빈혈 증례

이미선,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

A 10 month-old Yorkshire Terrier was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of lethargy, bile pigment in urine and anorexia. Blood smear showed Heinz body, polychromatocytosis, schistocytosis, anisocytosis, which were the results from the oxidative injury. Hematology demonstrated a moderate anemia(PCV 22.4%, reference rage 35-55%), which was regeneration based on the degree of RPI (4.03, reference rage > 1). Serum biochemistry demonstrated mild elevation in total bilrubin, and mild decrease in total protein and albumin concentration. A diagnosis of Heinz body hemolytic anemia secondary to onion ingestion was made and treated with fluid therapy, oxygen and antioxidant drugs. The dog recovered without any complication.

SPME와 GC/MS를 이용한 녹나무 향기성분 특성분석

원미미,차은주,윤옥경,김남선,김건,이동선 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-

Recently, land managers have come to realize that, outside Asia, camphor trees grow like street-tree or weeds, infesting forests and displacing native trees. This is because camphor trees are prolific seed producers that do not have serious predators or diseases outside their native range. The camphor tree (Cinnamomum camphora), belongs to lauraceae, is the aromatic evergreen tree from which camphor was derived. Headspace solid-phase microextraction (HS-SPME) and GC-MS were applied for the analysis of volatile fragrances emanated from camphor tree. Divinylbenzene / Carboxen / PDMS fiber was used for HS-SPME adsorption materials. (+)-Camphor (31.00%) and cineol (21.89%) were found as the major volatile aroma components from Chinese camphor tree, whereas (+)-camphor (62.06%) and β-caryophyllene (10.01%) from Japanese camphor tree. Camphor tree is a promising garden tree for well-being.

한지 쌈지 극미량 고체상 추출법을 이용한 레몬과 오렌지 향유 성분 분석

원미미,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-

In this study, headspace mulberry paper bag micro solid phase extraction (HS-MPB-μ-SPE) combined to gas chromatography/mass spectrometry has been applied for the analysis of volatile aromas of liquid essential oils from lemon and orange. The technique uses an adsorbent of Tenax TA contained in a mulberry paper bag, minimal amount of organic solvent and very small amount (10 μL) of sample size. Linearity for the calibration curve was excellent, the LOD value was 10.3 ng/mL. Precision and recovery were generally good. In addition, this method allowed combining extraction, enrichment, and clean-up in a single step. Analysis of aroma components in lemon and orange essential oils were performed successfully using this method.

불소 함유 양성고분자의 분리와 특성

차미선,소원욱,박인준,이수복 한국공업화학회 2004 응용화학 Vol.8 No.1

We describe the synthesis and characterization of amphoteric poly(acrylate), consisting of the F-marcromer and a 2-(dimethyl amino)ethyl methacrylate (2-DMAEMS) The amphoteric polymer were prepared by marcromonomer technique and radical copolymerization. After copolymerization, the resultant rection solution was purified by silica column. In this study, separation of resultant reaction sloution was purified by silica column. In this study, separation of amphoteric poly(acrylate)s and characterization by InfraRed Spectroscopy, Gel Permeation Charomatography. The IR traces showed that the amphoteric poly(acrylate) was separated successfully polymr of p(2-DMAEMA). The amphoteric poly(acrylate) have number average molecular weights(Mw) about 38,000 by GPC.

제6차 교육과정에 따른 초·중·고등학교 생물 영역에 대한 연계성 연구 : 주제별·수준별·대상별·기본 개념별의 강조도 중심으로 The analysis of the emphasis of the theme, level, living thing and basic concept

박원혁,정미선 부산대학교 사범대학 과학교육연구소 1998 科學敎育硏究報 Vol.25 No.-

According to the analysis of the emphasis of the theme, for each grade, variety and singularity, continuity of heredity, life and environment, and structure and function are most smoothly connected but regulation and homeostasis are badly connected in the emphasis of theme. In the emphasis of level, tissue and organ, and individuality are well connected but molecule is badly connected. In the emphasis of living thing, animal and plant are smoothly connected but protozoa is badly connected. In the emphasis of the each basic concept, all concepts are kept well but variety of living thing between middle and high school is badly connected. The connection of biology curriculum is well kept for each grade in general but each grade has a little discrepancy.

경기지역 일부 이주노동자들의 직무스트레스와 우울 증상의 상관성

이선웅,김규상,김태균,류향우,이미영,원용림,송윤희 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 경기지역 일부 이주노동자들의 우울 증상을 파악하고 이에 영향을 미치는 요인을 평가하기 위해 직무스트레스를 중심으로 상관성을 분석하고자 하였다 방법 경기지역 9개 이주노동자 센터에 방문한 이주노동자 488명을 대상으로 12개국 언어로 번역된 구조화된 설문지를 사용하였다 조사항목은 사회 인구학적 및 작업관련 요인 건강행태 과거력 직무스트레스 우울 증상이었으며 직무스트레스는 8개 하부항목이 포함된 한국형 직무스트레스 측정도구K0SS-26을 사용하였다 우울 증상은 조맹제 등이 번역한 CES-D 번역판을 사용하였다 단변량 분석결과 유의한 관련 요인과 직무스트레스를 독립변수로 하여 우울 증상자 유무에 대한 다중 로지스틱희귀분석을 시행하여 관련 위험요인들의 상관성을 평가하였다 결과 연구대상 전체의 우울 증상율은 25.2%였지만 비중국 국적 및 불법 체류자는 각각 32.1%, 32.8%에 달하는 결과를 보였다 관련 혼란변수를 보정한 상태에서 직무스트레스 요인(OR 2.55 95% CI=1.30-4.99)이 우울 증상과 유의한 상관성을 나타내었으며 직무스트레스 하위영역 중 물리환경(OR 2.97 95% CI=1.59-5.53) 직무요구(OR 2.33 95% CI=1.26-4.32) 및 직장문화(OR 3.10 CI=1.49-6.48)가 우울 증상자 발생과 유의한 상관성을 나타냈다 결론 연구대상의 우울 증상율은 국내 일반인구집단과는 비슷한 수준이나 국내 근로자 집단에 비해서는 높았으며 특히 내부집단별로 비 중국국적 및 불법 체류자의 우울 증상율이 높았다 하지만 국적구분과 체류자격의 사회인구학적요인보다 직무스트레스요인이 이주노동자들의 우울증상과 보다 직접적인 상관이 있는 것으로 판단되어 이주노동자들의 우울 증상 발생을 예방하기 위해서는 효과적인 직무스트레스 중재방안이 조치되어야 할 것으로 판단된다. Objectives To investigate the mental health status of migrant workers We focused on the relationship between depressive symptoms and job stress Metheod A questionnaire was administered to 488 migrant workers who visited NGO migrant worker centers located in Kyung-gi province A structured self-reported questionnaire was used to assess each responder's sociodemographics work related characteristics health behaviors past medical history job stress and depression symptoms The job stress questionnaire was used according to K0SS-26 and depression symptoms were measured using CES-D which was translated into Korean We used multiple logistic regression analysis to assess the relationship between risk factors included job stress and depression symptoms Results The prevalence of depression symptoms in survey subjects was 25.2%, but the prevalence of non Chinese nationalities and illegal workers were 32.1% and 32.8% respectively Adjusting for confounding factors job stress (OR 2.55, 95% CI=1.30-4.99) had a statistical meaningful relationship with depression symptoms Among job stress domains, physical environment (OR 2.97 95% CI=1.59-5.53) job demand (OR 2.33 95% CI=1.26 4.32) and occupational climate(0R 3.10 CI=1.49-6.48) were most likely to experience depression symptoms Conclusions The prevalence of depressive symptoms among the study subjects was similar to the prevalence among the general population in Korea but higher than that among the Korean workers In particular, the prevalence among non-Chinese and illegal workers was higher However, the job stress factor appeared to have a more direct correlation with depressive symptoms than the sociodemographic factors of nationality or residential status Hence in order to prevent depressive symptoms of the migrant workers we believe that intervention on job stress is necessary

외래에서 항암화학요법을 받는 암환자들의 영양불량 위험도 연구

김원경,박미선,이영희,허대석 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

Although it is well known that cancer patients suffer from malnutrition, there are few published studies on malnutrition in outpatients receiving chemotherapy in Korea. This study aimed to evaluate nutritional risk in oncology outpatients receiving chemotherapy and to show the baseline data to set up nutritional management programs for cancer patients. This is a retrospective observational analysis on 1,962 patients referred for nutritional education before or during chemotherapy at Seoul National University Hospital Cancer Center from January 2006 to May 2007. According to a malnutrition screening tool, the proportion of patients having malnutrition risk was 23.0%. In the case of upper gastrointestinal cancer, more than 50% of patients were assessed as being at the risk of malnutrition. They showed more than 7% weight loss compared to their usual body weight and poor oral intake; energy intake was less than 100% of Basal Energy Expenditure (BEE) and protein intake was less than or equal to 0.77 g/㎏/d. However, only 6.3% of breast cancer patients had risk of malnutrition and their oral intake was better; energy intake was 121% of BEE, and protein intake was 0.90 g/㎏/d. Outpatients receiving chemotherapy had different nutritional risk depending on their cancer site. Nutritional management program should be conducted differently, depending on the cancer site and upper gastrointestinal cancer patients at high risk of malnutrition should basically have nutritional assessment and intervention.