폐계허약아(肺系虛弱兒)에 대한 가감보폐양영전(加減保肺養營煎)의 임상적 효능 연구

곡수영,정선경,유선애,이승연,Gok, Su-Yeong,Jung, Sun-Kyung,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.2

Objectives The purpose of this study is to evaluate the clinical effectiveness and prophylactic treatment effectiveness of Gagam-Bopyeyangyeongjeon(GGBYJ) on the Lung Weakness Children(肺系虛弱兒) who catch cold easily. Methods The study has been carried out from 27 children, who were treated with GGBYJ in Department of Pediatrics, $\bigcirc\bigcirc$ Oriental Medical Hospital from August to December in 2009. The study was completed through patient chart review and telephone survey. Results 1. Immediately after the treatment, there was significantly decreasing(p=0.005) on respiratory symptoms in the Lung Weakness Children(肺系虛弱兒) who catch cold easily. 2. After the treatment, when season changes (three months later), there were preventive and continuous effects on reducing morbidity and on decreasing degree of symptoms against new respiratory infections compared to the previous year before taking medicine. 3. GGBYJ improved the respiratory symptoms, and also anorexia, constipation, heights, skin and fatigue. Conclusions In conclusion, there were significant clinical and preventive effectiveness of GGBYJ for the Lung Weakness Children(肺系虛弱兒) who caught a cold easily. Further studies are needed with more clinical cases.

자소엽(紫蘇葉) 에탄올 추출물이 RBL-2H3 비만세포에서 제 1형 알레르기 반응 조절에 미치는 효과

곡수영,유선애,이승연,Gok, Su-Yeong,Yu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.1

Objectives Perillae Folium (PF) has been widely used in Korean herbal medicines used for treatment of acute and chronic inflammatory diseases, such as rhinitis, asthma, and enteritis. In this study, to investigate the protective effect of PF on type 1 allergic response, we determined whether PF inhibits early or late allergic responses. Methods The effect of PF was analyzed by ELISA,. RT-PCR and Western blot in RBL-2H3 cells. Levels of ${\beta}$-hexosaminidase, interleukin (IL)-4 and TNF-${\alpha}$ were measured using enzyme-linked immunosorbent assays (ELISAs). mRNA levels of cytokines and enzymes were analyzed with RT-PCR. Signal transduction was analyzed with Western blot. Results We found that PF suppressed ${\beta}$-hexosaminidase release in RBL-2H3 by the IgE-DNP-HSA stimulation. PF also significantly inhibited enzymes level, such as COX-1, COX-2, iNOS, and HDC2, along with reduced cytokine levels, such as IL-2, IL-3, IL-4, IL-6, IL-13, and TNF-${\alpha}$ in RBL-2H3. In addition, PF suppressed the phospholyation of ERK1/2, JNK1/2, and $I{\kappa}B{\alpha}$. Conclusions Our results indicate that PF protects against type 1 allergic response and exert an anti-inflammatory effect through the inhibition of degranulation and expression of cytokines and enzymes via the suppression of signal transduction.

뇌성마비의 조기치료에 관한 문헌적 고찰 - 최근 중의 잡지 중심으로 -

곡수영,이승연,유선애,Gok, Su-Yeong,Lee, Seung-Yeon,Lyu, Sun-Ae 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : This study has been carried out to look into the methods of early treatment of cerebral palsy and the treatment effect by ages. Methods : The fifteen theses dealing with treatment effects by ages were analyzed, which were selected from the 121 theses retrieved out of the wu-ruan(五軟), wu-chi(五遲), wu-ying(五硬), naotan(腦?), naoxing-tanhuan(腦性??), during the period between the January 2004 to August 2008 by using the China Academic Journal(CAJ) of China National Knowledge Infrastructure(CNKI). Results : 1. Among the study objects in the 15 theses, it was identified that there were 1.97 times more boys with cerebral palsy than that of girls, and it appeared that there was no significant relationship between gender and the treatment. 2. The early treatment referred to the treatment which was carried out based on the early diagnosis within 6 months to one year after the birth. This is the time when the adaptability and plasticity of the brain are high, and it was found out that the treatment effective as babies are young. 3. For the treatment of cerebral palsy, the combination of Traditional Chinese and Western Medicine Therapy was more frequently used than the exclusive Chinese medical treatment method, and it was more effective. Especially in the case, the Chinese medical treatment was focused on the acupuncture and the Tuina Massage. Conclusions : 1. For the treatment of cerebral palsy, when the age between one and two years old was established as the standard. The younger the babies were, the higher treatment effects were obtained. 2. It appeared that the early treatment of oriental medicine had relatively excellent effects on cerebral palsy, but it turned out that we needed more studies for accurate results.

주의력 간섭검사와 허약아 증상에 관한 연구 - 스트룹 아동 색상-단어검사 중심으로-

곡수영,유선애,이승연,Gok, Su-Yeong,Lyu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.3

Objectives The purpose of this study is to find out the correlation between Stroop interference and the symptoms of weak children. Methods Questionnaire and performed Stroop interference test were done by 145 patients in OO Oriental Medical Hospital from May to October 2009. 120 patients who were considered as the weak children were divided into two groups: Stroop Interference T score above average group and below average group, and were surveyed again. Results 1. The study showed that age, the highest marked subject and behavior habits correlate to interference score and subjects characteristics. 2. Weak children groups had the highest tendency of having weak heart followed by weak lung spleen, liver, and kidney. Normally, a patient belonged to more than one of the weak children groups. 3. The study showed that a group of children who has weak heart and lung were related to interference score. The group which earned below average interference score had the highest frequency of being children with weak heart group. The group scored above average, however, had the highest chance of being children with weak lung group. 4. The study showed that interference score was related to four out of fifty questions about the weak children symptoms. Plus, related questions were all about the heart weak children symptoms. Conclusions In conclusion, there were significant correlation between interference score and the group consists of children who were weak: more specifically with children with weak heart.

한약 투여가 사춘기 전 소아의 신장성장에 미치는 영향에 대한 예비 연구

정민정,곡수영,이승연,Jeong, Min-Jeong,Gok, Su-Yeong,Lee, Seung-Yeon 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : The aim of this study was to evaluate the effect to the height-growth after the administration of herbal medicine to the prepuberty children Methods : This clinical study has been carried out with 18 children, who visited to the Department of Pediatrics, Dong-eui oriental medical center from January 2005 to August 2008. They had been treated for height-growth with herbal medicine more than 6 months. This study has been carried out by chart-review to see the effectiveness. Height percentile, BMI and GV(Growth Velocity) after medication was compared with the ones before medication. Results : 1. This clinical study has been carried out with 18 children, 12 boys(66.7%) and six girls(23.3%). Their average age was 10.30 years old. 2. Generally total children's average height percentile was increased compared to after medication. Especially eight of them has significantly increasd height percentile(44.4%). 3. Total children's average GV/6months was also increased after medication. Especially ten of them has significantly increasd GV/6months (55.6%). 4. Total children's average BMI also increased (17.01 to 17.85) after medication. Conclusions : Herbal medicine affects to the growth of pre-puberty children.

한약을 복용한 소아에게 발생한 부작용에 대한 연구

정선경,곡수영,유선애,이승연,Jung, Sun-Kyung,Gok, Su-Yeong,Yu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2010 대한한방소아과학회지 Vol.24 No.3

Objectives: The purpose of this study is to investigate the frequency of side effects, and the range of the side effects from Korean herb medicine on children. Methods: The study has been carried out from 212 children who took Korean herb medicine in Department of Pediatrics, $\bigcirc\;\bigcirc$ Oriental Medical Hospital from September 2009 to February 2010. The study was completed through patients chart review and telephone survey. Results: 1. There were 6 side effect cases on male, and 3 side effect cases on female out of 212 children. The incidence of side effect was 4.2%. 2. The most common side effect was abdominal pain. The most common related organ was digestive organ. 3. The side effect occurred within one to three days after taking Korean herb medicine, and the symptoms were mostly disappeared after taking the Korean herb medicine into divided dose or less dose. Conclusions: The symptom of side effects on children was not as severe as other adverse drug reactions often seen in Western medication. The most common symptom was abdominal pain. Further studies are needed.