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A magnetostrictive self-powered biosensor based on Au-BaTiO3-FeGa & PDMS
Qiang Zhang,Meng Xu,Yan Liu,Chunyan Zhang,Rui Zhang,Zhiyuan Fu,Jianlong Ji,Riguang Zhang,Shengbo Sang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-
Piezoelectric flexible sensors have been used to detect biomolecules such as sweat and glucose because oftheir passive, simple structure and high sensitivity. This paper proposes a novel flexible piezoelectric Au-BaTiO3-FeGa & PDMS biosensor in which magnetostrictive deformation amplifies the surface stress generatedby biomolecules combining on the thin film. The modification process of bovine serum albumin(BSA) binding with the sensor was initially determined by the first principles approach. Then, the sensingmechanism was verified by finite-element simulation. Based on the simulation results, flexible Au-BaTiO3-FeGa & PDMS biosensors were prepared, modified, and measured. The structure, modification,and detection of the sensors were analyzed by digital microscopy, Fourier transform infrared spectrometry(FTIR), atomic force microscopy (AFM), and scanning electron microscopy (SEM). The responses ofthe biosensors detecting different BSA solution concentrations under magnetic fields were then investigated. Experimental results indicate that the biosensor has the highest sensitivity under a magnetic fieldof 30 mT.
Potential Therapeutic Targets for the Primary Gallbladder Carcinoma: Estrogen Receptors
Zhang, Ling-Qiang,Zhang, Xiu-De,Xu, Jia,Wan, Yong,Qu, Kai,Zhang, Jing-Yao,Wang, Zhi-Xin,Wei, Ji-Chao,Meng, Fan-Di,Tai, Ming-Hui,Zhou, Lei,Liu, Chang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4
Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.
Junbo Zhang,Shuanghong Yin,Fei Guo,Ren Meng,Chuangfu Chen,Hui Zhang,Zhi-qiang Li,Qiang Fu,Huijun Shi,Shengwei Hu,Wei Ni,Tiansen Li,Ke Zhang 한국미생물학회 2014 The journal of microbiology Vol.52 No.8
Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. However, the current Brucella abortus vaccines (S19 and RB51) are deficient; they can cause abortion in pregnant animals. Moreover, when the vaccine S19 is used, tests cannot differentiate natural from vaccinated infection. Therefore, a safer and more potent vaccine is needed. A Brucella abortus 2308 ery promoter mutant (Δery) was constructed to overcome these drawbacks. The growth of the Δery mutant was significantly attenuated in macrophages and mice and induced high protective immunity in mice. Moreover, Δery induced an anti-Brucellaspecific IgG (immunoglobulin G) response and stimulated the expression of interferon-gamma (INF-γ) and interleukin-4 (IL-4). Furthermore, the expression of EryA antigen allowed for the serological differentiation between natural and vaccinated infection in mice. These results indicate that the Δery mutant is a potential attenuated live vaccine candidate against virulent Brucella abortus 2308 (S2308) infection.
Zhang Mengru,Morice Alyn H.,Si Fengli,Zhang Li,Chen Qiang,Wang Shengyuan,Zhu Yiqing,Xu Xianghuai,Yu Li,Qiu Zhongmin 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6
Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience. Methods: Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up. Results: Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0–72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (P = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (P < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (P < 0.01). Nineteen (7.7–41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (P < 0.01). Coughs with long duration before the initial cough clinic visit (P < 0.01), frequent urinary incontinence (P < 0.01), and being sensitive to “talking” (P < 0.01) or “cold air” (P < 0.01) were less likely to be solved. Conclusions: The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to “talking” or “cold air.”
( Qiang Zhang ),( Zhibo Tian ),( Jianmin Shi ),( Wangda Guo ) 아시아스포츠융합과학회 2021 Asia Pacific Journal of Applied Sport Sciences Vol.2 No.2
PURPOSE The purpose of this study is to investigate a behavioral loyalty model of China Tennis Open spectators and validate the relationships among spectators’’ watching motivation, perceived value, place attachment and behavioral loyalty. METHOD The spectators at the China Tennis Open were targeted as the main research sample. A total of 400 questionnaires were collected. The collected data was analyzed by means of descriptive statistics, confirmatory factor analysis, structural equation modeling, and significance test of difference. RESULT (1) Motivation has a positive effect on perceived value and place attachment, but the behavioral loyalty is not affected. (2) Perceived value directly influence on behavioral loyalty. (3) Place attachment directly influence on behavioral loyalty. CONCLUSION Motivation has a limited influence on the behavioral loyalty. Place attachment and perceived value are important factors in behavioral loyalty of China Tennis Open spectators. The results of this study provides some practical suggestions for the organization, management of tennis events and a direction for future research.
Design of LPG Remote Cargo Operation Simulator with Automatic Bargaining Function
Zhang Qiang,Zhou Xinwei 국제이네비해양경제학회 2019 International Journal of e-Navigation and Maritime Vol.13 No.1
Liquefied gas carrier cargo handling operations are critical to ship safety. In order to improve the quality and efficiency of cargo handling of liquefied gas carriers, the loading and unloading operation of the liquefied gas carrier was studied and a set of LPG remote cargo operation simulator with automatic bargaining function was designed. Introducing the components of the simulator: the console unit and the simulated cargo tank unit in brief, the design ideas and specific functions of the automatic barge and remote control of the core part of the system are introduced in detail. The simulator feasibility verification is carried out by comparing the error between the actual loading and unloading operation with the system simulation loading and unloading operation. The simulation training functions verification is carried out by testing people who use the simulator for training. The final results show that the error is within the acceptable range, and people who use the simulator for training can pass an authoritative comprehensive exam. It is shown that that the system can simulate the important operations in the cargo handling process and has an excellent training effect.
Zhang Jie,Lin Xiao-Tong,Yu Hong-Qiang,Fang Lei,Wu Di,Luo Yuan-Deng,Zhang Yu-Jun,Xie Chuan-Ming 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Metastatic hepatocellular carcinoma (HCC) is the most lethal malignancy and lacks effective treatment. FBXL6 is overexpressed in human hepatocellular carcinoma (HCC), but whether this change drives liver tumorigenesis and lung metastasis in vivo remains unknown. In this study, we aimed to identify FBXL6 (F-Box and Leucine Rich Repeat Protein 6) as a key driver of HCC metastasis and to provide a new paradigm for HCC therapy. We found that elevated FBXL6 expression in hepatocytes drove HCC lung metastasis and was a much stronger driver than Kras mutation (KrasG12D/+;Alb-Cre), p53 haploinsufficiency (p53+/-) or Tsc1 loss (Tsc1fl/fl;Alb-Cre). Mechanistically, VRK2 promoted Thr287 phosphorylation of TKT and then recruited FBXL6 to promote TKT ubiquitination and activation. Activated TKT further increased PD-L1 and VRK2 expression via the ROS-mTOR axis, leading to immune evasion and HCC metastasis. Targeting or knockdown of TKT significantly blocked FBXL6-driven immune evasion and HCC metastasis in vitro and in vivo. Notably, the level of active TKT (p-Thr287 TKT) was increased and was positively correlated with the FBXL6 and VRK2 expression levels in HCC patients. Our work provides novel mechanistic insights into FBXL6-driven HCC metastasis and suggests that targeting the TKT-ROS-mTOR-PD-L1/VRK2 axis is a new paradigm for treating patients with metastatic HCC with high FBXL6 expression.