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RISS 인기검색어
- 검색키워드
- 저자 : Zhang Mengru (검색결과 3 건)
- 무료
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- 유료
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Zhang Mengru,Morice Alyn H.,Si Fengli,Zhang Li,Chen Qiang,Wang Shengyuan,Zhu Yiqing,Xu Xianghuai,Yu Li,Qiu Zhongmin 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6
Purpose: Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience. Methods: Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up. Results: Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0–72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (P = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (P < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (P < 0.01). Nineteen (7.7–41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (P < 0.01). Coughs with long duration before the initial cough clinic visit (P < 0.01), frequent urinary incontinence (P < 0.01), and being sensitive to “talking” (P < 0.01) or “cold air” (P < 0.01) were less likely to be solved. Conclusions: The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to “talking” or “cold air.”
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Kan Hao,Zhang Ka,Mao Aiqin,Geng Li,Gao Mengru,Feng Lei,You Qingjun,Ma Xin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
The aorta contains numerous cell types that contribute to vascular inflammation and thus the progression of aortic diseases. However, the heterogeneity and cellular composition of the ascending aorta in the setting of a high-fat diet (HFD) have not been fully assessed. We performed single-cell RNA sequencing on ascending aortas from mice fed a normal diet and mice fed a HFD. Unsupervised cluster analysis of the transcriptional profiles from 24,001 aortic cells identified 27 clusters representing 10 cell types: endothelial cells (ECs), fibroblasts, vascular smooth muscle cells (SMCs), immune cells (B cells, T cells, macrophages, and dendritic cells), mesothelial cells, pericytes, and neural cells. After HFD intake, subpopulations of endothelial cells with lipid transport and angiogenesis capacity and extensive expression of contractile genes were defined. In the HFD group, three major SMC subpopulations showed increased expression of extracellular matrix-degradation genes, and a synthetic SMC subcluster was proportionally increased. This increase was accompanied by upregulation of proinflammatory genes. Under HFD conditions, aortic-resident macrophage numbers were increased, and blood-derived macrophages showed the strongest expression of proinflammatory cytokines. Our study elucidates the nature and range of the cellular composition of the ascending aorta and increases understanding of the development and progression of aortic inflammatory disease.
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Simulation and experiment of secondary contact stiffness of rough surface
Guang Zhao,Yingjie Li,Zexin Zhang,Zhiliang Xiong,Shengxiang Li,Mengru Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3
Machined surfaces usually need to be loaded several times during assembly. The surface morphology after the simulation loading may be quite different from the physical loading, which subsequently causes differences between the contact stiffness after secondary simulation loading and secondary physical loading results. The fractal theory was used to reconstruct the measured surface morphology, followed by contact stiffness simulation and test. The results show that contact stiffness of new morphology obtained by the first simulated loading using the elastic-plastic deformation theory are smaller than the first loading test results, with an average error of -9.71 %. Contact stiffness of used morphology obtained by the first simulated loading using the pure elastic deformation theory are in good agreements with the second loading test results, with an average error of 4.71 %. However, the average contact stiffness of new morphology obtained by the second simulated loading using the elastic-plastic deformation theory, which is traditionally used for contact analysis, are 2.15 times larger than the second loading test result. These research results demonstrate a feasible finite element method (FEM) for solving the contact problem of rough surfaces that need to be assembled multiple times.
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