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임영천(Youngcheon Lim),임형수(Hyungsoo Lim),송성진(Seungjin Song),강신형(Shinhyoung Kang) 한국추진공학회 2009 한국추진공학회 학술대회논문집 Vol.2009 No.11
압축기에 불안정한 특성인 선회실속(Rotating stall)이 발생하면 압력 및 효율이 저하되고, 기계적인 손상도 야기한다. 이러한 불안정성을 개선하고 안정 운전영역을 넓히기 위해 4단 저속 축류압축기에 공기 분사(Air injection) 방법을 적용하여 안정성 개선 실험을 실시하였다. 동익 팁에 축방향으로 공기를 분사할 수 있도록 하기 위해 코안다 효과를 적용한 노즐을 사용하였고, 8개의 인젝터를 1단 동익 상단에 등간격으로 설치하였다. 축류 압축기 80% speed로 운전하면서 선회실속이 발생하기 전에 공기 분사를 실시하였고, 모드(Mode) 발생 유량의 5.4%에 해당하는 공기를 분사하여 약 4%의 안정성 개선효과를 얻었다. A rotating stall, an instable phenomenon of compressor, brings about reducing the pressure rise, the efficiency of compressor and a mechanical demage. In order to improve instability and extend operating range, it was performed that a stability enhancement experiment applying air injection method at the 4-stage low-speed axial compressor. The coanda nozzle was used to inject air in axial direction at rotor tip and 8 injectors were set up at regular interval at the upstream of 1st stage rotor. At 80% speed, injectors were worked before rotating stall happened. As injecting the 5.4% air of mode inception flow rate, the stability of compressor operation enhanced about 4%.
한신하,김광희,Youngcheon Song,Hyunyul Kim,Jeunghak Kwon,이영희,이종길,Sang-Jin Lee,하남주,김경제 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
Auranofin (AF), an orally administered, gold-based, anti-arthritic agent, has emerged as a clinically useful therapeutic drug for the treatment of rheumatoid arthritis. In the present study, we examined the effects of AF on major histocompatibility complex (MHC)-restricted antigen presentation in dendritic cells (DCs), which are the most important accessory cells for the induction of T cell responses. A mouse dendritic cell line, DC2.4 cells, and DCs that were generated from mouse bone marrow cells by culturing with granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin (IL)-4 were each pretreated with AF for 2 hr, and then incubated with ovalbumin (OVA). After the 2-hr incubation, the DCs were fixed, and the amounts of OVA peptide-H-2Kb complexes were assessed using OVA-specific CD8+ T cells. AF inhibited MHC class I-restricted presentation of exogenous OVA. This inhibitory activity of AF appeared to be due not only to the inhibition of the phagocytic activity of DCs, but also to the suppression of MHC molecule expression on DCs. AF also inhibited MHC class II-restricted presentation of exogenous OVA. These results show that AF exerts immunosuppressive activity at least in part by inhibiting MHC-restricted antigen presentation in professional antigen-presenting cells.
Pharmacological and Therapeutic Activities of Aloe vera and Its Major Active Constituent Acemannan
Sang-Hyun Kim,Kyu-Suk Shim,Youngcheon Song,Kyungjae Kim,Chan-Su Park,Chong-Kil Lee 건강기능식품미래포럼 2023 건강기능식품미래포럼 학술지 Vol.3 No.2
Aloe vera, a medicinal herb with a lengthy history in traditional and folk medicine, is widely used today as a common ingredient in various healthcare and beauty products. Extensive research has been conducted to verify its therapeutic effectiveness, understand its mechanisms, and identify the active components responsible for its properties. The plant has been found to possess numerous biological properties, including immune system regulation, anti-inflammatory effects, promotion of wound healing, potential anticancer activity, antiviral properties, management of diabetes, and protection against radiation. While the polysaccharides present in the inner gel, particularly acemannan, have been credited for many of therapeutic effects of A. vera, other constituents such as lectins, alkaloids, anthraquinones, anthrones, chromones, coumarins, and polyphenols also contribute to its diverse and numerous benefits. In this review, we focus on acemannan, a well-studied polysaccharide extracted from A. vera gel, while highlighting the recently discovered effects and applications of this remarkable plant.
Shinha Han,Hyunyul Kim,이영희,Myung Chul Lee,Jeunghak Kwon,이종길,Youngcheon Song,이상진,김광희,김경제 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
Auranofin (AF), a gold compound, is an orally active therapeutic agent used to treat rheumatoid arthritis (RA), a self-perpetuating inflammatory disease. RA is characterized by autoimmune- mediated proliferation of synovial cells that leads to inflammation, pain, and swelling in most major joints. However, the mechanism as to how AF relieves RA symptoms has not been fully elucidated. The object of this study was to examine the ability of AF to immunomodulate macrophages as antigen presenting cells (APCs). Macrophages are recognized as playing an important role in the pathogenesis of RA, in that there is a relative abundance of macrophagederived cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin- 6 (IL-6) in rheumatoid synovium. In this work, we tested whether AF (2.5-20 mM) could inhibit inflammatory activity in the macrophage cell line RAW 264.7. AF decreased production of nitric oxide (NO) and the pro-inflammatory cytokines, TNF-α, IL-1β and IL-6 in macrophages. Furthermore, AF inhibited cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) production in a concentration-dependent manner. In conclusion, these findings may provide an explanation for the clinical effects of AF in patients with RA.
Amelioration of Benign Prostatic Hyperplasia by Costunolide and Dehydrocostus Lactone in Wistar Rats
Choi Dohyun,Kim Jiyeon,An Jinho,Hong Seonhwa,Song Youngcheon,Kong Hyunseok 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.2
Purpose: Sesquiterpene lactones, which are found in plants of the Asteraceae family, contain costunolide (CO) and dehydrocostus lactone (DCL) as indicator material. CO, in particular, has been reported to possess varied pharmacological activity, including anti-inflammatory, antibacterial, and antioxidant effects. This study was designed to characterize the effects of CO and DCL on benign prostate hyperplasia (BPH). Materials and Methods: Rats were injected subcutaneously daily for 8 weeks with 5 mg/kg testosterone to induce prostatic hyperplasia. Wistar rats were randomly divided into 5 groups of 10 animals each and received the following treatment: I. Normal control group; II. BPH-induced group; III. CO group (0.075 mg/kg); IV. DCL group (0.075 mg/kg); and V. Finasteride group (0.8 mg/kg). After treatment, changes in prostate weight and serum biochemical indices, serum dihydrotestosterone level, and mRNA levels of BCL2 were measured and histological examinations performed. Results: Absolute and relative prostate weight in the indicator material treated groups, as well as prostate volume, decreased compared to those in the disease-induced group. Epithelial cell thickness increased significantly in the disease-induced group, with a significant decrease being observed in the CO group. The level of the anti-apoptotic protein BCL2 (B-cell lymphoma 2) tended to decrease to a greater extent in the DCL group than in the disease-induced group. Conclusions: In this study, we confirmed that the indicator materials (CO and DCL) can help suppress the development of BPH.