음향방출법에 의한 탄소섬유강화 플라스틱의 파괴 특성에 관한 연구 (1)

윤종희,박성완,이장규,우창기 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

The object of this study is to investigate a fracture characteristics of static tensile test as a function of acoustic emission according to the fiber orientation θ=0?in carbon/epoxy composites, CFRP. On tensile loading, it was recognized that the fracture characteristics of CFRP in a unidirectional composites. Using the results of the AE analysis(a=2㎜), it was found that the amplitude distributions of AE signals corresponding the matrix cracking, fiber debonding or delamination, and fiber breaking are 55~70㏈(<200sec), 100㏈(200~600sec), and 80㏈(>600sec).

음향방출법에 의한 탄소섬유강화 플라스틱의 파괴특성에 관한 연구 (2)

윤종희,이장규,박성완,우창기,김봉각,조진호 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

This study is to investigate a fracture characteristics of carbon fiber reinforced plastics (CFRP) under the tensile loading as a function of acoustic emission (AE) according to the frequency analysis (transient mode) and AE source location (location mode). It was found that the fracture mechanism of AE frequency analysis was a useful tool for the estimation of different type of fracture in CFRP, i.e., matrix(epoxy resin) cracking, delamination and fiber breakage same as AE amplitude distribution.

황정(黃精) 추출물의 화학구조결정에 관한 연구 (Ⅰ)

윤중호,박주희,김정주,권기락,안철진,주우홍,강진호,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

본 연구에서는 황정 속에 포함되어 있는 생리활성 물질을 hexane, CHCl₃과 n-butanol층에서 각각의 성분들을 추출하였고, hexane층에서 분리된 화합물 I과 H 중에서, 화합물 I의 봐학구조를 ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC 스펙트럼 및 MS 스펙트럼 등의 분광학적인 방법에 의해 결정하였다. 화합물 I의 구조는 9,12-(9E, 12E)-octadecadienoic acid 임을 확인하였다. In this Paper, biologically active compounds were extracted using organic solvents as hexane. CHC1₃, n-butanol to give each component. Chemical structure of compound I was characterized using ¹H-nmr, ??, DEPT135, COSY, HMQC, HMBC spectrum and MS-spectrum, in separated compound I and Ⅱ from hexane layer. Finally, chemical structure of compound I was determined as 9,12-(9E,12E)-octadecadienoic acid.

맞대기 용접 이음재 인장시험에서 발생한 음향방출 신호의 웨이블릿 변환과 응용

이장규,윤종희,우창기,박성완,김봉각,조대희 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This study was carried out fusion-welded butt joints in SWS 490A high strength steel subjected to tensile test that load-deflection curve. The windowed or short-time Fourier transform (WFT or SIFT) makes possible for the analysis of non-stationary or transient signals into a joint time-frequency domain and the wavelet transform (WT) is used to decompose the acoustic emission (AE) signal into various discrete series of sequences over different frequency bands. In this paper, for acoustic emission signal analysis to use a continuous wavelet transform, in which the Gabor wavelet base on a Gaussian window function is applied to the time-frequency domain. A wavelet transform is demonstrated and the plots are very powerful in the recognition of the acoustic emission features. As a result, the technique of acoustic emission is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.

음향방출 신호를 이용한 SWS 490A 고장력강의 접합성 평가에 대한 실험적 연구

이장규,우창기,윤종희,조진호,조대희,박성완,김봉각,구영덕 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The object of this study is to investigate the effect of joinability by using acoustic emission (AE) signals and doing a pattern recognition for weld heat affected zone (HAZ) in tensile testing. This study was carried out an SWS 490A high tension steel for electric shielded metal arc welding (SMAW), CO₂ gas arc welding and TIG welding. And correspondingly, the root openings are 3, 4 and 2.8㎜. The results of the tensile test of weld HAZ come out electric shield arc welding > CO₂ gas arc welding > TIG welding in case of single welding. It is believed that this is a phenomenon where difference of its root opening or base metal thickness. Also, the technique of AE is ideally suited to study variables which control time and stress dependent fracture or damage process in metallic materials.

SWS 490A 강의 용접 열영향부 음향방출 특성에 대한 연구(1)

이장규,우창기,박성완,윤종희,조진호,김봉각,구영덕 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.4

The object of this study is to investigate the effect of compounded welding through the AE(Acoustic Emission) characteristics for weld HAZ(Heat Affected Zone) under the static tensile test. This study was carried out an SWS 490A, high tension steel for electric shield metal arc welding(SMAW), CO₂gas arc welding and TIG welding. Data displays are based on the measured parameters of the AE signals, along with environmental variables such as time and load. The accumulated AE event curve of HAZ definitely have the point of inflection subject to tensile test. The results of the tensile test of HAZ come out electric shield arc welding > CO₂ gas arc welding >TIG welding in case of single welding, but generally the tensile test of HAZ come out electric shield arc welding > TIG welding > CO₂ gas arc welding. These history plots give us useful and powerful information to analyze the results of material evaluation testing.

음향방출법에 의한 SM 490A 강의 복합용접성 평가(2)

이장규,우창기,김봉각,윤종희,인승현 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The object of this study is to investigate the effect of compounded welding by using an acoustic emission (AE) signals and doing a source location for weld heat affected zone (HAZ) through tensile testing. This study was carried out a SM 490A high tension steel for electronic shielded metal arc welding (SMAW), CO₂ gas arc welding and TIG welding. Data displays are based on the measured parameters of the AE signals, along with environmental variables such as time and load. These history plots are displays showing the chronological course of the test. Also, source location gives the X- and Y-coordinates of the AE source.

고분자 재료의 계장화 충격실험에 관한 연구

최선웅,우창기,윤종희 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.6

Impact behavior of polycarbonate in various defect state was investigated using an instrumented impact tester. A method of analyzing raw impact data was developed and successfully demonstrated the impact behavior in terms of load-displacement and energy-displacement curves. This technique was shown to be capable of separating defect, no-defect initiated fractures as well as their propagation behaviors.

성인 급성 림프구성백혈병 고위험군에서 일차관해시 동종 및 자가 조혈모세포이식의 성적 비교 : 단일기관 치료경험 A Single Center Experience

이석,민우성,민창기,김동욱,이종욱,김유진,박은정,박윤희,김춘추 대한조혈모세포이식학회 2000 대한조혈모세포이식학회지 Vol.5 No.2

배경:성인 ALL에서 동종 조혈모세포이식은 전처치요법 및 이식편대백혈병 효과에 의한 효과적인 백혈병세포의 제거가 가능하다는 측면에서 활발히 시행되고 있으나 자가 조혈모세포이식과 화학요법과의 비교 연구에서는 대상환자의 다양성 등으로 인하여 상이한 결과가 보고되었다. 그러나 최근 진단당시 환자의 임상적·세포생물학적 특성 및 관해유도요법 후의 백혈병세포의 제거 속도 등을 기준으로 한 위험인자가 정의되면서 이를 근간으로 위험도에 따른 관해 후 치료방침의 결정이 타당성 있는 접근방법으로 제시되고 있고, 특히 고위험군에서의 동종 조혈모세포이식의 역할이 강조되고 있다. 방법: 성인 ALL 고위험군에서 일차 완전관해시 동종 조혈모세포이식의 역할을 규명하기 위해 최근 5년간 가톨릭의대 조혈모세포이식센터에서 ALL로 진단 후 일차 완전관해 상태에서 동종 및 자가 조혈모세포이식을 시행받고 임상적 특성과 세포면역학적 특성 및 세포유전학적 검사결과가 모두 확인 가능하였던 환자 중 고위험군에 해당된 50례를 대상으로 후향적 분석을 시행하였다. 고위험군은 진단시 연령이 30세 이상인 경우, 백혈구수가 30,000/μL 이상인 경우, 관해유도기간이 30일 이상 소요된 경우, Ph 혹은 t(4;11)이 동반된 경우 중 하나 이상의 인자를 갖고 있는 경우로 정의하였다. 결과: 대상환자의 중앙연령은 30세(15~43세)이었고, 남녀 비는 27:23이었다. FAB 분류상 L1 29례(58.0%), L2 21례(42.0%)였으며, precursor B-lineage 항원이 양성인 경우는 36례(72.0%), T-세포 항원이 양성인 경우는 9례(18.0%), 골수구계 항원이 동시에 발현된 경우는 5례(10.0%)였다. 세포유전학적 검사상 23례(46.0%)에서 불량한 염색체유형 [Ph 19례, t(4;11) 4례]이 동반되었다. 전체 환자 중 31례에서 동종 조혈모세포이식을 시행하였으며, 19례에서는 자가 조혈모세포이식이 시행되었다. 동종 및 자가 조혈모세포이식 환자군간의 임상적 특성은 양군간의 유의한 차이가 없었다. 대상환자의 중앙 추적관찰기간은 27개월(7~72개월)이었고, 전체 환자의 2년 무병생존율 및 전체생존율은 각각 59.0±7.6%, 68.2±7.1%이었다. 조혈모세포이식에 따른 치료성적을 비교한 결과 전체생존율은 동종 조혈모세포이식군 71.4±8.6%, 자가 조혈모세포이식군 62.7±12.4%로 양군간의 유의한 차이가 없었던 반면, 재발율은 동종 조혈모세포이식군에서 유의하게 낮은 빈도를 보였으며(25.8% vs 52.6%, P=0.05), 무병생존율에 있어서도 각각 70.6±9.0%, 42.1±12.2%로 동종 조혈모세포이식군에서 보다 높은 경향을 보였다(P=0.07). 이식 후 생존율에 영향을 주는 위험인자를 분석한 결과, 진단시 연령, 백혈구수, 관해유도기간에 따른 차이는 관찰되지 않았다. 다만 Ph 혹은 t(4;11)이 동반된 경우에서 무병생존율이 동종(28.5±16.0% vs 94.4±5.4%, P=0.0002) 및 자가 조혈모세포이식군(18.1±11.6% vs 80.0±17.8%, P=0.0046) 모두에서 유의하게 감소되었다. 결론: 본 연구를 통하여 일차관해시 조혈모세포이식을 시행받은 고위험군 성인 ALL에서는 관해 후 치료법으로써 동종 조혈모세포이식이 우선적으로 고려될 수 있는 치료법임을 확인할 수 있었다. 이는 추후 국내에서도 보다 장기간의 추적관찰을 통한 전향적 임상연구를 시행하여 보다 정립된 관해 후 치료방침의 결정 필요성을 제시하였다는 측면에서 임상적 의의가 있을 것으로 사료된다. Background:Optimal postremission therapy remains controversial in adult patients with acute lymphoblastic leukemia (ALL). In this study, we compared allogeneic bone marrow transplantation (alloBMT) with autologous peripheral blood stem cell transplantation (autoPBSCT) using the result of the human leukocyte antigen typing (HLA). Methods:Patients were eligible if they were in first remission (CR1) and had either: adverse cytogenetics [Philadelphia chromosome (Ph), t(4;11)], age >30 years, required more than 1 induction course to achieve remission (time-to-CR1 >30 days) or presenting WBC >30,000/μL. From July 1994 to June 1999, 50 consecutive adult patients with high-risk ALL underwent HLA-matched alloBMT (n=31) or autoPBSCT (n=19) at the Catholic Hemopoietic Stem Cell Transplantation Center. Results:There were 27 males and 23 females with median age 30 (range, 15~43) years. The distribution of phenotype was as follows: L1 (n=29), L2 (n=21), precursor B (n=36), T (n=9), myeloid marker coexpression (n=5). Adverse cytogenetic abnormalities at diagnosis were shown in 23 (46.0%) cases. All pretransplant characteristics were well balanced between these two groups. Most patients were treated with total body irradiation containing regimen as part of the conditioning. With a median follow-up of 27 months in both groups, disease-free survival (DFS) and overall survival probabilities at 2 years were 59.0±7.6% and 68.2±7.1%, respectively. The relapse rates were significantly different between alloBMT and autoPBSCT groups (25.8% vs 52.6%, P=0.05). There was no significant difference in overall survival between the two groups. However, alloBMT had a trend toward better DFS (70.6±9.0% vs 42.1±12.2%, P=0.07). None of the pretransplant characteristics significantly affected outcome after transplantation, except adverse cytogenetics. Prognosis of ALL with Ph or t(4;11) was significantly poorer than that of the remaining high-risk ALL patients (P<0.01). Conclusion: We conclude that alloBMT appears to be more effective than autoPBSCT in prolonging initial CR for high-risk ALL patients. Prospective studies addressing additional clinical variables are needed to guide clinical decision making about transplant choices for adult patients with ALL. New therapeutic strategies for the management of ALL with adverse cytogenetics will be also required.

FISH Karyotype Analysis of Fagopyrum tartaricum Gaerth (Tartary buckwheat) using Repetitive DNAs

Yoon-Ha Ju,Franklin Hinosa Mancia,Seyong Yoon,Heekyung Park,Soeun Yoon,Jiin Park,Sunmi Joung,Su Jeong Kim,Yul Ho Kim,Hwang Bae Sohn,Ki-Byung Lim,Hyun Hee Kim,Yoon-Jung Hwang 한국원예학회 2016 한국원예학회 학술발표요지 Vol.2016 No.10