Brain Topological Correlates of Motor Performance Changes After Repetitive Transcranial Magnetic Stimulation

Park, Chang-hyun,Chang, Won Hyuk,Yoo, Woo-Kyoung,Shin, Yong-Il,Kim, Sung Tae,Kim, Yun-Hee Mary Ann Liebert 2014 Brain connectivity Vol.4 No.4

<P>Repetitive transcranial magnetic stimulation (rTMS) influences the brain temporally beyond the stimulation period and spatially beyond the stimulation site. Application of rTMS over the primary motor cortex (M1) has been shown to lead to plastic changes in interregional connectivity over the motor system as well as alterations in motor performance. With a sequential combination of rTMS over the M1 and functional magnetic resonance imaging (fMRI), we sought changes in the topology of brain networks and specifically the association of brain topological changes with motor performance changes. In a sham-controlled parallel group experimental design, real or sham rTMS was administered to each of the 15 healthy subjects without prior motor-related dysfunctions, over the right M1 at a high frequency of 10 Hz. Before and after the intervention, fMRI data were acquired during a sequential finger motor task using the left, nondominant hand. Changes in the topology of brain networks were assessed in terms of global and local efficiency, which measures the efficiency in transporting information at global and local scales, respectively, provided by graph-theoretical analysis. Greater motor performance changes toward improvements after real rTMS were shown in individuals who exhibited more increases in global efficiency and more decreases in local efficiency. The enhancement of motor performance after rTMS is supposed to be associated with brain topological changes, such that global information exchange is facilitated, while local information exchange is restricted.</P>

Comprehensive Transcriptomic Analysis of Cordyceps militaris Cultivated on Germinated Soybeans

Yoo Chang-Hyuk,Sadat Md. Abu,Kim Wonjae,Park Tae-Sik,Park Dong Ki,Choi Jaehyuk 한국균학회 2022 Mycobiology Vol.50 No.1

The ascomycete fungus Cordyceps militaris infects lepidopteran larvae and pupae and forms characteristic fruiting bodies. Owing to its immune-enhancing effects, the fungus has been used as a medicine. For industrial application, this fungus can be grown on geminated soy- beans as an alternative protein source. In our study, we performed a comprehensive tran- scriptomic analysis to identify core gene sets during C. militaris cultivation on germinated soybeans. RNA-Seq technology was applied to the fungal cultures at seven-time points (2, 4, and 7-day and 2, 3, 5, 7-week old cultures) to investigate the global transcriptomic change. We conducted a time-series analysis using a two-step regression strategy and chose 1460 significant genes and assigned them into five clusters. Characterization of each cluster based on Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases revealed that transcription profiles changed after two weeks of incubation. Gene mapping of cordycepin biosynthesis and isoflavone modification pathways also confirmed that gene expression in the early stage of GSC cultivation is important for these metabolic pathways. Our transcrip- tomic analysis and selected genes provided a comprehensive molecular basis for the cultiva- tion of C. militaris on germinated soybeans.

Cone beam형 전산화단층촬영장치를 이용한 하악 제1대구치 근심 치근의 danger zone에 관한 연구

장유리,최용석,최기운,박상혁 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.2

Purpose : To examine the danger zone of mesial root of mandibular first molar of patient without extraction using CBCT(cone -beam computed tomography) to avoid the risk of root perforation. Materials and Methods : 20 mandibular first molars without caries and restorations were collected. CT images were obtained by CBCT(PSR9000N TM, Asahi Roentgen Co., Japan), reformed and analyzed by V-work 5.0 (CyberMed Inc., Korea). Distance between canal orifice and furcation was measured. In cross sectional images at 3, 4 and 5 mm below the canal orifice, distal wall thickness of mesiobuccal canal (MB-D), distal wall thickness of mesiolingual canal (ML-D), distal wall thickness of central part (C-D), mesial wall thickness of mesiobuccal canal (MB-M) and mesial wall thickness of mesiolingual canal (ML-M) were measured. Results : The mean distance between the canal orifice and the furcation of the roots is 2.40 mm. Distal wall is found to be thinner than mesial wall. Mean dentinal wall thickness of distal wall is about 1 mm. The wall thickness is thinner as the distance from the canal orifice is farther. But significant differences are not noted between 4 mm and 5 mm in MB-D and C-D. MB-D is thinner than ML-D although the differences is not significant. Conclusion : The present study confirmed the anatomical weakness of distal surface of the coronal part of the mesial roots of mandibular first molar by CBCT and provided an anatomical guide line of wall thickness during endodontic treatment.

월경규칙성과 월경시기에 의한 월경주기증상의 유형

한창환,유태혁 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.4

Each of 404 nurses and nurse-aids rated their experience of each of 45 menstrual symptoms on a 4 point scale separately for the menstrual, premenstrual and intermenstrual phase. The 45 symptoms were tested separately by menstrual regularity and phase variable. 1. 4 basic types of menstrual symptoms were emerged which were labeled regularity significant type, phase significant type, regularity-phase significant type, and regularity-phase non-significant type. 2. Among menstrual cyclic symptoms belong to phase significant type and regularity-phase significant type, there are 3 basic subtypes. One(Subtype Ⅰ) is the symptoms which are manifested predominantly during menstrual phase. Second(Subtype Ⅱ) is the symptoms which are manifested predominantly during premenstrual and menstrual phase equally. Third(Subtype Ⅲ) is the symptoms which are manifested predominantly during premenstrual phase, but becomes more severe during menstrual phase. 3. Psychosocial variable such as neurotic trends and suggestions might be considered to be responsible for menstrual regularity. However neuroendocrine change might be considered to be responsible for menstrual phase.

종합병원 입원 환자에서의 불면증의 임상적 특징

이종국,유태혁,한창환 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

The purpose of this study is to investigate the clinical characteristics of insomnia in 300 new inpatients of general hospital with semistructured interview and questionaires. Among 4 clinical groups-129 noninsomniacs, 171 insomniacs (100 insomniacs with past insomnia history and 71 without past history), we compared the following variables ; age, sex, associated significant diseases, usual life habits, environmental variables influencing sleep pattern, types of insomnia, causes of insomnia, coping methods with insomnia, and usage of hypnotics. In insomniacs we also compared the changes of types and causes of insomnia, coping methods with insomnia after admission. The prevalence of insomnia was significantly increased after admission, and was higher in female patients but not significantly different in age. The frequencies of associated significant disease(angina, arrhythmia, asthma, duodenal ulcer etc.), naps, smoking, alcohol and coffee drinking showed no difference between insomniacs and noninsomniacs. Among environmental variables, “apprehension about illness”, “noise”, “nurse's visit”, and “bed discomfort”were significantly more frequent in insomniacs. Presence or absence of past insomnia history gave no significant effect on the types, causes of insomnia and coping methods with insomnia. Difficulty in maintaining sleep(DMS) was significantly increased after admission but difficulty in falling asleep(DFA) was decreased. The causes of insomnia were physical illness, sleep environmental variables, and psychological variables in order ; first two of these were significantly increased after admission. After admission as well as before admission, the most coping method with insomnia was “effort to forget problems”. Among the methods, “exercise or walking” was significantly increased after admission. Afterwards the study on the psychopathology and characteristics of personality which related with insomnia will be needed to broaden our understanding about insomnia and to establish proper management plan of insomnia.

광원의 종류에 따른 복합레진의 중합거동 및 중합률에 관한 연구

류주희,이인복,유현미,김미자,석창인,권혁춘 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.4

Objectives: The purpose of this study was to observe the reaction kinetics and the degree of polymerization of composite resins when cured by different light sources and to evaluate the effectiveness of the blue Light Emitting Diode Light Curing Units (LED LCUs) compared with conventional halogen LGUs. Materials and Methods: First, thermal analysis was performed by a differential scanning calorimeter(DSC). The LED LCU (Elipar Freelight, 320㎽/㎠) and the conventional halogen LCU (XL3000, 400㎽/㎠) were used in this study for curing three composite resins (SureFil, Z-250 and AEliteFLO). Second, the degree of conversion was obtained in the composite resins cured according to the above curing mode with a FTIR. Third, the measurements of depth of cure were carried out in accordance with ISO 4049 standards. Statistical analysis was performed by two-way ANOVA test at 95% levels of confidence and Duncan's procedure for multiple comparisons. Results: The heat of cure was not statistically different among the LCUs (p > 0.05). The composites cured by the LED (Exp) LCUs were statistically more slowly polymerized than by the halogen LCU and the LED (Std) LCU (p< 0.05). The composite resin groups cured by the LED (Exp) LGUs had significantly greater degree of conversion value than by the halogen LCU and the LED (Std) LCU (p = 0.0002). The composite resin groups cured by the LED (Std) LGUs showed significantly greater depth of cure value than by the halogen LCU and the LED (Exp) LGU (p < 0.05).

관상동맥내 스텐트 시술시 Aspirin과 Cilostazol 2개월 병합요법

윤명호,탁승제,염철훈,장혁재,최소연,유상용,안성균,고종훈,신준한,김한수,최병일 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예 : Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET

서욱장,정선미,고수진,이창근,김재승,임주혁,유빈,문희범 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECt also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

The Korean Society of Gastroenterology & SIDDS 2020 : Slide Session ;K-UG-23 : Upper GI Tract ; Does Discharge Hemoglobin Affect Outcome of Patients with Acute Non-Variceal Upper Gastrointestinal Bleeding?

( Jae Min Lee ),( Hoon Jai Chun ),( In Kyung Yoo ),( Seung Joo Nam ),( Seung Han Kim ),( Hyuk Soon Choi ),( Eun Sun Kim ),( Bora Keum ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Chang Duck Kim ),( Ho Sang 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Many patients with gastrointestinal bleeding show anemia and usually need red blood cell transfusion. But clinicians are concerned about low hemoglobin affects prognosis and clinical outcome after discharge. This study aimed to assess whether discharge hemoglobin infi uence on outcomes, or not, in patient with acute non-variceal gastrointestinal bleeding. Methods: Retrospective analysis was carried out on patients who had upper gastrointestinal bleeding between January 2011 and December 2012. We analyzed the patients who had lowest hemoglobin below 10 g/dL during hospitalization. Patients with variceal bleeding, stroke, or cardiovascular disease were excluded. We divided the patients into two groups by discharge hemoglobin (Low discharge hemoglobin group; 8 g/dL = hemoglobin and compared clinical outcomes and hemoglobin level changes. Results: A total of 212 patients with upper gastrointestinal bleeding were undergone the endoscopic hemostasis during study periods. One hundred two patients were satisfi ed the inclusion criteria. fifty patients discharged with hemoglobin level under 10 g/dL and fi fty two patients discharged with hemoglobin level over 10 g/dL. Patients in low discharge hemoglobin group showed a lower consumption of pRBC and shorter hospital days than patients in high discharge hemoglobin group. Hemoglobin levelswere not fully recovered at out-patient department until 7 days after discharge. But, most patients showed hemoglobin recovery at 45 days after discharge.Conclusions: In patients with acute gastrointestinal bleeding, discharge hemoglobin between 8 to 10 g/dL was showed favorable outcomes during out-patient department follow-up. It seems to be tolerable level without additional pRBC transfusion. Our result can increase the evidence available to support restrictive transfusion strategies in patients with acute non-variceal upper gastrointestinal bleeding.

한국 남동해역 시질퇴적물의 물리적 성질

김길영(Gil Young KIM),김대철(Dae Choul KIM),박수철(Soo Chul PARK),유동근(Dong Geun YOO),최진혁(Jin Hyuk CHOI),김정창(Jeong Chang KIM) 한국수산과학회 1996 한국수산과학회지 Vol.29 No.5

Physical properties and textural parameters of thirty-five piston core samples recovered from the southeastern coast of Korea (Korea Strait), were investigated using the autopycnometer. The physical properties (porosity, water content, wet bulk density, dry bulk density, grain density, and void ratio) were measured at rather uniform intervals along each core. Sediment texture (grain size, sand, silt, and clay contents) was also measured at the same subbottom depth. The measured and calculated results are; mean grain size 0.57∼8.09 Φ (average: 3.67 Φ), porosity 26∼81% (average: 55%), water content 16.7∼61.4% (average: 31.6%, wet bulk density 1.37∼2.18 g/㎤ (average: 1.85 g/㎤), dry bulk density 2.55∼3.11 g/㎤ (average: 2.35 g/㎤), grain density 2.40∼3.10 g/㎤ (average: 2.85 g/㎤), and void ratio 0.56∼2.54 (average: 0.94). The sediment texture generally coincides well with the bathymetry indicating the influence of Pleistocene-Holocene sea level changes. Also the contours of physical properties are closely related to the sediment texture. Fluctuation of physical properties are similar to the textural variation. It seems that sediment texture is a significant factor in determining physical property in this study area.