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트립토판 열분해물 유발 변이원성에 대한 현미 및 백미의 억제 효과 비교
유정은,전향숙,조정순 대한영양사협회 1997 대한영양사협회 학술지 Vol.3 No.2
The inhibitory effect of rice(Oryza sartiva L., illpumbyeo) against mutagenicity induced by tryptophan pyrolysates were investigated using Salmonella typhimurium reversion assay. Both methanol extracts obtained from brown and white rice were found to possess strong activities of inhibiting the mutagenicities of 3-amino-l,4-dimethyl-5H-pyrido[4,3-b]indol(Trp-P-l) and 3-amino-l-methyl-5H-pyrido[4,3-b]indol(Trp-P-2) on Salmonella typhimurium reversion assay. As the concentration of methanol extract increased, inhibitory effect on mutagenicity increased but reached at steady state as inhibition rate of 90% when the concentration was above l0mg/plate. There was no significant difference(p>0.05) in inhibitory effect of methanol extracts between brown and white rice against tryptophan pyrolysates.
이수향 ( Su Hyang Lee ),김상협 ( Sang Hyeob Kim ),이은주 ( Eun Joo Lee ),박순석 ( Soon Seok Park ),김아영 ( Ah Young Kim ),이은미 ( Eun Mi Lee ),이명미 ( Myeong Mi Lee ),성수은 ( Soo Eun Sung ),황미열 ( Meeyul Hwang ),권영삼 ( You 한국동물위생학회 2015 韓國家畜衛生學會誌 Vol.38 No.3
A 7 years old, female and neutered ferret (Mustela putorius furo) was presented to local animal hospital due to lethargy, anorexia and hypothermia. Radiography, ultrasonography and blood test were performed. On the basis of clinical signs and tests, this case was presumed to be lymphoma. In consideration of this ferret’s condition, chemotherapy was carried out for the treatment. However, the ferret died a few days. After necropsy, metastatic tumors were observed over abdomen. All tumors were packed with homologous lymphocytes with pleomorphic changes and numerous mitotic figures. Consequently, this masses were diagnosed as B-cell gastrointestinal lymphoma, which were negative for CD3 on immunohistochemistry.
Gun-Hee Kim,Yong-Ri Jin,Soon-Hyang You,Hyeong-Jun Han,Jung-Jin Lee,Ji-Yeon Yu,Ji-Hyun Im,Eun-Suk Park,Tack-Joong Kim,Eunyoung Hong,Yeo-Pyo Yun 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.2
The CHCl<sub>3</sub>, EtOAc, and n-BuOH fractions showed a marked inhibition of 5% fatal bovine serum (FBS)-induced cell proliferation. The IC<sub>50</sub> values of the chloroform fractions from leaf, stem, and root as well as the n-BuOH and EtOAc fraction from root on cell proliferation were 1.2±0.4, 17.2±6.4, 81.8±33.2, 40.8±8.0, and 237.1±85.6 μg/mL, respectively. On the other hand, the EtOAc fractions, and the CHCl<sub>3</sub> fraction significantly inhibited collagen-, arachidonic acid-, U46619-, and thrombin-induced platelet aggregations. The IC<sub>50</sub> values of EtOAc fraction from leaf, and the CHCl<sub>3</sub> and EtOAc fraction from stem were 214.1±12.2, 134.3±2.5, and 42.6±7.0 μg/mL with collagen, 312.4±7.5, 158.9±1.7, and 82.2±2.7 μg/mL with arachidonic acid, 31.1±2.4, 48.7±0.3, and 29.7±1.1 μg/mL with U46619, and 36.7±2.4, 69.1±11.3, and 34.2±0.1 μg/mL with thrombin, respectively. Taken together, these data provide new evidence that fractions from Allium victorialis var. platyphyllum (AVP) are able to inhibit vascular smooth muscle cell (VSMC) proliferation and platelet aggregation, which may be a novel resource for the development of anti-atherothrombotic agents.
간경변증 환자에서 신장 Doppler 초음파 - Resistive Index의 예후적 가치
박창영,조용균,김향,이상종,정을순,이영래,김병익,전경홍,유종현 대한소화기학회 1998 대한소화기학회지 Vol.30 No.2
Background/Aims: Kidney dysfunction in cirrhosis is a well recognized complication that often appears to develop abruptly in previously nonazotemic patients. Intrarenal vasoconstriction is an early hallmark of this functional renal failure because e;evatecl serum creatinine is a late feature of the hepatorenal syndrorne. Resistive index(RI) is the most widely used for estimation of intrarenal arteriolar vascular resistance. We have applied renal dup]ex Doppler ultrasonography to identify this early renal vasoconstriction in nonazotemic patients with liver cirrhosis. Methods: We prospectively measured RI, kidney and liver function and plasma level of renin activity, aldosterone and antidiuretic hormone in 12 healthy subjects, 13 cirrhotic patients without ascites, 22 cirrhotic patients with ascites, 7 cirrhotic patients with ascites and renal falure. Tnen, patiens were followed for 6 months. The incidence of renal failure in each groups were recored and ccrrelated with RI, liver and renal function. Results: RI was significantly increased in patients with cirrhosis(0.68±0.06) compared with healthy subjects(0.39±0.04). In 42 cirrhotic patients, it was significantly increased in patients with ascites(0.69±0.05) compared with patients without ascites(0.64±0.05) and correlated significantly to creatinine clearance(Cr=-0.61, p$lt;0.05). RI was significantly increased in patients with intractable ascites(0.72±0.04) compared with diuretics responded ascites(0.68±0.05). Kidney dysfunction subsequently developed in six(37%) of 16., who had an clevated RI.(≥0.70) In contrast, only one(4%) of 26 patients with a normal RI had kidney dysfunction. Conclusions: Renal duplex Doppler ultrasonography can identify high risk group for subsequenl development of renal dysfunction and be useful for treatment of ascites in cirrhotic patients with nonazotemia by detecting renal vasoconstriction.