美国新冠疫苗推广的实践及启示

陈晓琪(Xiaoqi Chen) YIXIN 출판사 2023 Journal of China Studies Vol.1 No.5

重大传染性疾病是我们人类共同的敌人,在全球范围内爆发的新冠疫情是21 世纪最最为严重的突发公共卫生事件之一,给全球公共卫生安全带来巨大挑战,对社会经济造成了深远的影响。在新冠肺炎疫情席卷全球的同时,也波及美国本土所有50 个州。疫苗的研发和推广成为控制疫情的关键,新冠疫苗的推广至关重要,以美国在新冠疫苗推广实践为例,通过对美国在新冠疫苗推广实践的梳理,总结并分析美国在新冠疫苗推广实践过程中的经验和教训。在此基础上,结合目前国际公共卫生的实际情况和具体问题,提出新冠疫苗推广要加强国际合作、经验分享和科研合作,共同应对全球抗疫挑战,是今后更加紧迫的任务,也将有助于构建更强大的全球公共卫生体系,实现社会、经济的可持续发展。 The global outbreak of the COVID-19 pandemic stands as one of the most significant health events of the 21st century, presenting substantial challenges worldwide and profoundly impacting socio-economic dynamics. The development and dissemination of vaccines have emerged as critical strategies for pandemic control. As the COVID-19 pandemic swept across the globe, it also affected all 50 states within the United States.Utilizing the United States as a case study for COVID-19 vaccine distribution practices, this study undertakes a comprehensive review and analysis of the experiences and insights gained from promoting COVID-19 vaccines within the U.S. context. Expanding on this groundwork and considering the current state of international public health and specific concerns, the paper contends that effective promotion of COVID-19 vaccines requires reinforced international cooperation, exchange of experiences, and fostering collaborative research endeavors. Confronting global pandemic challenges collectively has become an increasingly urgent imperative, offering the potential to bolster a more resilient global public health framework and facilitate sustainable social and economic progress.

Structure and physicochemical properties of a new variety of purple rice (Oryza sativa L. indica) starch

Xiaoqi Tao,Qiqi Su,Hai Wu,Lei Zhan,Wei Huang,Jingshao Zheng,Qingling Zhong,Pei Chen 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.6

The investigation of the structure and physicochemical properties of starch extracted from a new variety of purple rice was the aim of this study. Starch extracted from a new variety of purple rice named Tianzi No. 1 (PRS) is different in structure and physicochemical properties compared with waxy rice starch (WRS), japonica rice starch (JRS), and indica rice starch (IRS). PRS granules were diversified in shape, and the birefringence of starch particles were clearly observed. Fourier-transform infrared (FT-IR) spectroscopy exhibited the degree of double helix and low short-range order structure of PRS differed from IRS, JRS and WRS. X-ray diffraction analysis shows that PRS presented a typical A-type XRD pattern and possessed lower crystallinity. Based on rheological experiment results, PRS had the highest apparent viscosity, storage modulus (G′) and loss modulus (G″). According to textural experiments, PRS gels had higher textural paraments before and after retrogradation.

Long-Term Repeated Intensive Prescribed Burning Decreases Soil Carbon and Nitrogen Pools in a Wet Sclerophyll Forest of Southeast Australia

Bushra Muqaddas,Chen Chengrong,Xiaoqi Zhou 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Survey on robotics and automation technologies for civil infrastructure

명현,Yang Wang,Shih-Chung Jessy Kang,XiaoQi Chen 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.6

Over the past several decades, substantial amounts of sensors and sensing systems have beendeveloped for civil infrastructure systems. This special issue focuses on state-of-the-art robotics andautomation technologies, including construction automation, robotics, instrumentation, monitoring,inspection, control, and rehabilitation for civil infrastructure. The issue also covers construction informaticssupporting sensing, analysis and design activities needed to operate smart and sustainable civil infrastructure. Examples include robotic systems applied to civil infrastructure and equipped with various sensingtechnologies, such as optical sensors, laser sensors, wireless sensors, multi-sensor fusion, etc. This specialissue is published in an effort to disseminate current advances of various robotics and automationtechnologies for civil infrastructure and built environment.

Dynamic responses and robustness performance to moving boundary of double-stepped cable during deep-sea mining

Li Yilun,Guo Shuangxi,Guo Yucheng,Yu Xiaoqi,Chen Weimin,Song Jixiang 대한조선학회 2023 International Journal of Naval Architecture and Oc Vol.15 No.-

As the exploration and exploitation of deep-sea oil and gas, along with promising polymetallic nodule&sulfides mining, have been developing toward ultra-deep waters, some innovative concepts of marine cable configuration suitable for ultra-deepwater are proposed, such as stepped cable, hybrid cable and double-stepped cable. For deep-water cables with complex configurations, the structural responses become more complicated due to their non-uniform structural properties. Because the distributed buoyancy modules along cable length might introduce more significant local bending segments. Moreover, the impacts of moving boundary, caused by the motions of top vessel and bottom mining vehicle, should be considered. Through combing the finite element simulations with the hydrodynamic models, the dynamic response analysis approach of ultra-deepwater cables is established in this study. Then the double-stepped cable responses, including axial tension, displacement along with the change of overall configurations caused by moving top vessel and bottom mining vehicle, are calculated. Moreover, wave propagation behaviors during cable response are comprehensively examined, and the influences of non-uniform structural properties on cable response and wave propagation are analyzed using the wave propagation theory of structure with axially varying properties based on the Bessel function. The results show that the presented double-stepped cable can provide suitable configurations during the dynamic response, which has good compliance performance and can effectively buffer its response caused by moving boundary excitation. Finally, we found that the response spatial-temporal evolutions present some interesting phenomena, such as the axially non-uniform characteristics lead to non-monotonic changes in response amplitude and wavelength, with local peaks occurring in the low-tension region, owing to the distributed buoyancy modules, along with axiallyvarying and discontinuous structural properties. And, there exists significant mixed effect coming from both standing waves and traveling waves.

Analysis of Altered Baseline Brain Activity in Drug-Naive Adult Patients with Social Anxiety Disorder Using Resting-State Functional MRI

Changjian Qiu,Yuan Feng,Yajing Meng,Wei Liao,Xiaoqi Huang,Su Lui,Chunyan Zhu,Huafu Chen,Qiyong Gong,Wei Zhang 대한신경정신의학회 2015 PSYCHIATRY INVESTIGATION Vol.12 No.3

ObjectiveaaWe hypothesize that the amplitude of low-frequency fluctuations (ALFF) is involved in the altered regional baseline brain function in social anxiety disorder (SAD). The aim of the study was to analyze the altered baseline brain activity in drug-naive adult patients with SAD. MethodsaaWe investigated spontaneous and baseline brain activities by obtaining the resting-state functional magnetic resonance imaging data of 20 drug-naïve adult SAD patients and 19 healthy controls. Voxels were used to analyze the ALFF values using one- and two-sample t-tests. A post-hoc correlation of clinical symptoms was also performed. ResultsaaOur findings show decreased ALFF in the bilateral insula, left medial superior frontal gyrus, left precuneus, left middle temporal gyrus, right middle temporal pole, and left fusiform gyrus of the SAD group. The SAD patients exhibited significantly increased ALFF in the right inferior temporal gyrus, right middle temporal gyrus, bilateral middle occipital gyrus, orbital superior frontal gyrus, right fusiform gyrus, right medial superior frontal gyrus, and left parahippocampal gyrus. Moreover, the Liebowitz Social Anxiety Scale results for the SAD patients were positively correlated with the mean Z values of the right middle occipital and right inferior occipital but showed a negative correlation with the mean Z values of the right superior temporal gyrus and right medial superior frontal gyrus. ConclusionaaThese results of the altered regional baseline brain function in SAD suggest that the regions with abnormal spontaneous activities are involved in the underlying pathophysiology of SAD patients.

Effervescent cannabidiol solid dispersion-doped dissolving microneedles for boosted melanoma therapy via the “TRPV1-NFATc1-ATF3” pathway and tumor microenvironment engineering

Jiachen Shi,Qiuling Ma,Wenting Su,Congyan Liu,Huangqin Zhang,Yuping Liu,Xiaoqi Li,Xi Jiang,Chang Ge,Fei Kong,Yan Chen,Ding Qu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Conventional dissolving microneedles (DMNs) face significant challenges in anti-melanoma therapy due to the lack of active thrust to achieve efficient transdermal drug delivery and intra-tumoral penetration. Methods In this study, the effervescent cannabidiol solid dispersion-doped dissolving microneedles (Ef/CBD-SD@ DMNs) composed of the combined effervescent components (CaCO3 & NaHCO3) and CBD-based solid dispersion (CBD-SD) were facilely fabricated by the “one-step micro-molding” method for boosted transdermal and tumoral delivery of cannabidiol (CBD). Results Upon pressing into the skin, Ef/CBD-SD@DMNs rapidly produce CO2 bubbles through proton elimination, significantly enhancing the skin permeation and tumoral penetration of CBD. Once reaching the tumors, Ef/CBD-SD@ DMNs can activate transient receptor potential vanilloid 1 (TRPV1) to increase Ca2+ influx and inhibit the downstream NFATc1-ATF3 signal to induce cell apoptosis. Additionally, Ef/CBD-SD@DMNs raise intra-tumoral pH environment to trigger the engineering of the tumor microenvironment (TME), including the M1 polarization of tumor-associated macrophages (TAMs) and increase of T cells infiltration. The introduction of Ca2+ can not only amplify the effervescent effect but also provide sufficient Ca2+ with CBD to potentiate the anti-melanoma efficacy. Such a “one stone, two birds” strategy combines the advantages of effervescent effects on transdermal delivery and TME regulation, creating favorable therapeutic conditions for CBD to obtain stronger inhibition of melanoma growth in vitro and in vivo. Conclusions This study holds promising potential in the transdermal delivery of CBD for melanoma therapy and offers a facile tool for transdermal therapies of skin tumors.

Survey on robotics and automation technologies for civil infrastructure

Myung, Hyun,Wang, Yang,Kang, Shih-Chung Jessy,Chen, XiaoQi Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.6

Over the past several decades, substantial amounts of sensors and sensing systems have been developed for civil infrastructure systems. This special issue focuses on state-of-the-art robotics and automation technologies, including construction automation, robotics, instrumentation, monitoring, inspection, control, and rehabilitation for civil infrastructure. The issue also covers construction informatics supporting sensing, analysis and design activities needed to operate smart and sustainable civil infrastructure. Examples include robotic systems applied to civil infrastructure and equipped with various sensing technologies, such as optical sensors, laser sensors, wireless sensors, multi-sensor fusion, etc. This special issue is published in an effort to disseminate current advances of various robotics and automation technologies for civil infrastructure and built environment.

Protective Effects of Gypenosides against Fatty Liver Disease Induced by High Fat and Cholesterol Diet and Alcohol in Rats

Renan Qin,Hong Nie,Jianyu Zhang,Chuyuan Li,Xiaoqi Zhang,Aihua Xiong,Feng Huang,Zhen Yin,Kongyan Li,Wenyu Qin,Mingzhen Chen,Shubing Zhang,Lingyi Liang,Huiye Zhang,Wencai Ye 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7

In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol. Male SD rats were divided into seven groups: control, model, lovastatin, silymarin, gypenosides high-, medium- and low-treatment groups. The latter 6 groups were fed high-fat and cholesterol diet and administered alcohol intragastricly once a day. Body weight was measured every week for 10 weeks, and the hepatic index was measured after 10 weeks. Compared with model group, levels of serum triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), and low density lipoprotein cholesterol (LDL-C) level, malondialdehyde (MDA), serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, and hepatocyte apoptosis were significantly decreased in gypenosides groups; while serum high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) activity in both serum and hepatic tissue and mRNA and protein level of peroxisome proliferator-activated receptor α (PPAR-α) were significantly increased. Moreover, hepatic steatosis and mitochondrial damage were improved. These results suggested that gypenosides could prevent liver fatty degeneration in fatty liver disease through modulating lipid metabolism, ameliorating liver dysfunction and reducing oxidative stress.

Energy Efficiency Improvement in Photovoltaic Installation Using a Twin-Axis Solar Tracking Mechanism with LDR Sensors Compared with Neuro-Fuzzy Adaptive Inference Structure

Hadroug Nadji,Iratni Abdelhamid,Hafaifa Ahmed,Boudjemline Attia,Alshammari Obaid S.,Jerbi Houssem,Colak Ilhami,Chen XiaoQi 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4

The use of solar energy makes it possible to eliminate the problems associated with conventional energy sources such as fossil and nuclear fuels. The concerns are numerous and include the depletion of these sources and the negative environmental effects on our planet and our health. In this respect, this work focused on energy efficiency improvement in photovoltaic installations for sustainable development by proposing a new implementation idea applied to solar tracking mechanisms. It allows tracking in real-time the apparent movement of the sun and therefore exploits most of the irradiated solar energy. To monitor the photovoltaic systems in real-time, based on two techniques, to track the highest intensity of sunlight. Where, the first comprises configuring the twin-axis solar tracking mechanism using Light-Dependent-Resistor sensors in an easy-to-operate way, with printed circuit boards specific to this configuration. The second technique is based on the use of artificial intelligence concepts, such as neuro-fuzzy technology with an adaptive inference structure, without the use of Light-Dependent-Resistor sensors. This configuration allows the location of the sun to be accurately tracked throughout the year using positional solar track data (azimuth/elevation), ensuring improved efficiency with better performance using the neuro-fuzzy adaptive inference structure. Hence, this twin-axis solar tracking mechanism maximizes the efficiency energy of the examined photovoltaic installation by guaranteeing solar energy gains of up to 24.44% gain compared to a fixed system.