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      • SCIESCOPUSKCI등재

        Effect of Genistein on Antioxidative Defence System and Membrane Fluidity in Chick Skeletal Muscle Cells

        Jiang, Z.Y.,Jiang, S.Q.,Lin, Y.C.,Ma, X.Y.,Xi, P.B.,Cao, T.,Wang, X.Q. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.8

        This study was conducted to investigate the protective effect of genistein on the antioxidative defence system and membrane fluidity in chick skeletal muscle cells after supplementation with 0, 20, 40, and $80{\mu}mol/L$ genistein in $50{\mu}mol/L$ $FeSO_4/H_2O_2$ treated cells for 24 h. Genistein supplementation recovered the decreased activity of total superoxide dismutase induced by $FeSO_4/H_2O_2$, significantly increased glutathione peroxidase activity (p<0.05) and decreased malondialdehyde production (p<0.05). The treatment of 80 mol/L genistein in $FeSO_4/H_2O_2$ treated cells decreased the secretion of creatine kinase (p<0.05). Fluorescence polarization values and microviscosities observed with $FeSO_4/H_2O_2$ treated cells were significantly higher than those observed with no $FeSO_4/H_2O_2$ treated cells. The addition of $80{\mu}mol/L$ genistein improved the increased fluorescence polarization value (p<0.05) caused by $FeSO_4/H_2O_2$ treatment. The microviscosity value was significantly decreased by adding genistein (p<0.05). In conclusion, genistein protected skeletal muscle cells from oxidative damage by improving antioxidative status and membrane fluidity.

      • SCIESCOPUSKCI등재

        Effects of Soy Isoflavone on Performance, Meat Quality and Antioxidative Property of Male Broilers Fed Oxidized Fish Oil

        Jiang, S.Q.,Jiang, Z.Y.,Lin, Y.C.,Xi, P.B.,Ma, X.Y. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.8

        This study was conducted to determine the effect of dietary soy isoflavone (ISF, 0 and 20 mg/kg) on performance, meat quality and antioxidative property in male broilers. Six replicates of 45 birds (42 d old) were used for each treatment. The birds were fed soybean meal-free diets containing 3% oxidized fish oil (acid value, 6.76 mg potassium hydroxide/g; and peroxide value, 6.18 meq/kg) for 3 wk. The results showed that average daily gain, feed intake, feed conversion and carcass traits were not affected by soy ISF. Compared with the control group, breast muscle color redness value and water holding capacity were increased (p<0.05) by ISF supplementation. The activity of plasma catalase was increased by supplementing with 20 mg ISF/kg diet. In breast muscle, Broilers fed 20 mg ISF/kg had decreased production of malondialdehyde and lactic acid. The ISF supplementation elevated total antioxidative capacity and activities of total superoxide dismutase and glutathione peroxidase. The results indicated that dietary ISF could increase redness and water holding capacity of meat, and antioxidative property of meat in male broilers fed oxidized fish oil diet.

      • SCOPUS

        Study on Springback Properties of Different Orthodontic Archwires in Archwire Bending Process

        Jiang Jin-gang,Wang Zhao,Zhang Yong-de,Jiang Ji-xiong,Niu Suo-liang,Liu Yi 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12

        The archwire bending is one of processes the most frequently used in the orthodontic treatment. Furthermore, the springback of sheet metal, which is defined as elastic recovery of the part during unloading, should be taken into consideration so as to produce formed archwire within acceptable tolerance limits. In this paper, the springback angle of different alloy archwires (including NiTi alloy wire, Beta-Ti alloy wires, Chinese stainless steel wires, and Australian stainless steel wires) were performed by the theoretical calculation based on large deformation theory and the finite element analysis. A series of numerical simulations has been conducted for the bending test, which physically simulates the actual bending of alloy archwire with a robotic apparatus. The finite element analysis of springback is shown to be very consistent with the theoretical calculation results.

      • KCI등재

        The Therapeutic Effects of Tectorigenin on Chemically Induced Liver Fibrosis in Rats and an Associated Metabonomic Investigation

        Xing-Xi Gao,Jun-Hua Wu,Da-Hua Shi,Yun-Xi Chen,Jiang-Tao Cui,Yu-Rong Wang,Chun-Ping Jiang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

        The aim of this study was to investigate the effects of tectorigenin on chemically induced liver fibrosis in rats. Liver fibrosis was induced in rats with carbon tetrachloride, a diet high in fat, cholesterol and alcohol in the drinking water. Our results indicate that tectorigenin treatment significantly inhibited the increases in the activities of alanine aminotransferase (ALT),aspartate aminotransferase (AST) and the increases in the serum levels of hyaluronate (HA), laminin (LN) and procollagen III N-terminal peptide (PIIIP); tectorigenin treatment also significantly inhibited the increases in the amount of collagen in the livers of the fibrogenic rats. Chemically induced liver fibrosis caused a drop in the serum albumin concentration and a decrease in the ratio of albumin to globulin (A/G). Tectorigenin caused a remarkable increase at a dose of 30 mg/kg, but only a slight increase at the lower doses. Tectorigenin was also able to inhibit the increase in the liver lipid peroxidation (LPO), as well as the decrease in the activities of liver superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), caused by liver fibrosis. In addition, we present a related metabolic profile determined, using a 1H NMR spectroscopy and multivariate pattern recognition techniques. The results were consistent with the pathological examination, liver function analysis and liver fibrosis marker analysis. Furthermore, tectorigenin does not cause acute toxicity.

      • KCI등재

        宋代 藥用 植物 栽培의 新發展

        姜錫東(JIANG Xi-dong),楊小敏(YANG Xiao-min) 한국외국어대학교 역사문화연구소 2020 역사문화연구 Vol.73 No.-

        중국의 傳統藥物은 대부분이 植物藥이었다. 藥用植物의 재배는 여러 분야에서 함께 토론해야 할 주제이다. 이는 醫學과 農學 분야가 함께 연구해야 하는 대상이다. 즉 “醫農相通”으로서 裁培技術에 대한 연구가 다시 진행되어야 할 것이다. 『中國科學技術史』의 農學卷의 “隋唐宋元時期農學” 부분에서는 山居 계열의 農書의 發興과 약초가 농서에 포함되는 과정에 대하여 중점적으로 다루고 있다. 사회과학 분야에서는 주로 약용식물의 재배에서 언급되는 醫學 認識, 農商經濟, 商品性農業과 消費習慣 등의 문제를 주제로 하여 연구를 진행하여왔다. 1980년대부터 말까지 의학과 史學이 분야에서는 宋代 약물 재배 문제에 관심을 두기 시작하였고, 藥材의 파종과 재배뿐만 아니라 藥物文獻과 流通·貿易 등에 관한 연구가 진행되었다. 최근에는 송대 藥物發展에 관한 연구 성과가 증가하는 추세를 보인다. 그렇지만 송대 약용식물의 재배에 관한 새로운 연구가 전문적으로 진행되고 있다. 중국 고대 藥用植物은 자연적인 채집과 인공재배를 통한 수확 등 두 가지 방법이 대표적이다. 위진남북조 시기 이후 醫家와 藥家가 분리가 되었고 隋唐 시기에는 상류층 혹은 개별 문인이 약물 재배에 대한 지식을 갖게 되었지만, 唐代 40種에 관한 약물 재배에 관한 기록이 존재하고 송대에 이르러 약 90 여종에 관한 기록이 존재하였다. 송대 약용식물 재배에 관한 문제는 醫學 분야의 문제일 그뿐만 아니라 중국 고대 사회경제발전상을 구체적으로 보여주고 있는 것이라고도 할 수 있을 것이다. 중국 고대 약용식물은 사가의 개별 園圃에서 재배를 시작하여 점차 넓은 農田으로 확대되었고 이는 송대 약물 재배의 발전에 있어서 가장 큰 특징이 되었다. 구체적으로 살펴보면 약물 재배품종 수량의 증가·파종과 재배기술의 개량과 혁신·전업 재배의 규모화 발전 등 세 분야로 나누어 볼 수 있다. Comparing with the previous dynasties, there were three significant changes in the cultivation of medicinal plants of the Song dynasty: One is in terms of the number of cultivated varieties. The Song dynasty’s medicinal plants including many common medicines and exotic spices were more than twice as large as the Tang dynasty. Second is in terms of cultivation techniques. In Song dynasty, the specific cultivation techniques were mostly improved or innovated. It was recorded which reflects people s understanding and recognition of medicinal plants cultivation by pharmacists in an illustrative way. Third is in the large-scale development of professional cultivation. In the Song dynasty, the relationship between drug family circles and drug fields became increasingly close. There were both general drug family circles that combine gathering and planting, and full-blown large-scale drug family circles that specialize in planting for a living. The large-scale cultivation of commonly used drugs also had an important impact on the initial formation of producing areas. The new progresses of these three aspects were embodied in the professional development path of medicinal plants separated from traditional agriculture. However, in the Ming and Qing dynasties, the several local drug family circles were encouraged to abandon the cultivation of medicinal plants in the name of guaranteeing food production, which was very unfavorable to the large-scale development of medicinal plants cultivation.

      • SCIESCOPUSKCI등재

        Somatic Cell Nuclear Transfer of Oocytes Aspirated from Postovulatory Ovarian Follicles of Superovulated Rabbits

        Shang, Jiang-Hua,Xu, Ru-Xiang,Jiang, Xiao-Dan,Zou, Yu-Xi,Qin, Ling-Sha,Cai, Ying-Qian,Yang, Zhi-Jun,Zheng, Xing,Cui, Sheng Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.9

        The aim of this study was to evaluate if oocytes, aspirated from postovulatory ovarian follicles of superovulated rabbits 14 h post-hCG administration, could be efficiently used as ooplasm recipients for somatic cell nuclear transfer (SCNT). Within a common SCNT protocol, a comparison between oocytes recovered by direct aspiration (aspirated) from available ovarian follicles and oocytes flushed out from oviducts (flushed) was carried out. The results showed that maturation and enucleation rates of aspirated oocytes were 70.7% and 69.2%, significantly lower than 95.3% (p<0.01) and 83.6% (p<0.05), respectively, from flushed oocytes. However, following enucleation of matured oocytes as ooplasm recipients for SCNT, no difference was recorded in fusion and cleavage rates, as well as blastocyst development from cleaved embryos or hatching of blastocysts between aspirated and flushed groups. Additionally, some matured aspirated and flushed oocytes were also used for immediate parthenogenetic activation and the resulting embryo development was not significantly different. Results from this study show the following: i) the majority of oocytes aspirated from postovulatory ovarian follicles of superovulated rabbits 14 h post-hCG administration are matured and can be used directly as ooplasm recipients for SCNT; ii) the reconstructed embryos derived from these oocytes have similar in vitro developmental ability to those flushed from the oviducts.

      • KCI등재

        Relationship between the methylenetetrahydrofolate reductase (MTHFR) rs1801133 SNP and serum homocysteine levels of Zhuang hypertensive patients in the central region of Guangxi

        Hu Xi-Jiang,Su Mei-Ru,Cao Bao-Wei,Ou Fa-Bang,Yin Rui-Xing,Luo An-De 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-

        Background The relationship between the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphism (SNP) and serum homocysteine (Hcy) levels or H-type hypertension in different populations is inconsistent. This study aimed to explore the association between the MTHFR rs1801133 SNP and serum Hcy levels of Zhuang hypertensive patients in the central region of Guangxi. Methods A total of 606 Zhuang inpatients with essential hypertension were recruited in our hospital from August 2016 to December 2018. The patients were divided into H-type hypertension (Hcy > 10 μmol/L, n = 528) and non–Htype hypertension (Hcy ≤ 10 μmol/L, n = 78) groups. At the same time, an age- and sex-matched group of 379 subjects with normal physical examination in our hospital were selected as the control group. Blood biochemical measurements and genotyping of the MTHFR rs1801133 SNP were performed. Results The prevalence of H-type hypertension was 87.13%. The levels of serum Hcy in patients with hypertension were higher than those in control group (14.20 ± 5.78 μmol/L vs. 11.97 ± 5.39 μmol/L, P < 0.001), especially in patients with H-type hypertension (15.08 ± 5.65 μmol/L, P < 0.001). The frequencies of TT genotype (22.73%) and T allele (46.21%) in patients with H-type hypertension were significantly higher than those in control group (11.35% and 30.47%, respectively) and non–H-type hypertension group (10.26% and 28.85%, respectively; P < 0.001 for all). Multivariate linear regression analysis showed that serum Hcy levels were significantly correlated with creatinine, lowdensity lipoprotein cholesterol, endogenous creatinine clearance rate, and the MTHFR rs1801133 genotypes in control group, while serum Hcy levels were significantly correlated with creatinine, triglyceride, low-density lipoprotein cholesterol, endogenous creatinine clearance rate, glycosylated hemoglobin, and the MTHFR rs1801133 genotypes in H-type hypertension group (P < 0.05–0.001). Serum Hcy levels in the T allele carriers were higher than those in the T allele noncarriers in both H-type hypertension and control groups. Conclusions There was closely related between the MTHFR rs1801133 SNP and serum Hcy levels in Zhuang patients with H-type hypertension in the central region of Guangxi. The MTHFR SNP may be an important reason for the increase of serum Hcy levels in Zhuang patients with H-type hypertension in this region.

      • KCI등재

        Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

        Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.

      • KCI등재

        ANNs on Co-occurrence Matrices for Mobile Malware Detection

        ( Xi Xiao ),( Zhenlong Wang ),( Qi Li ),( Qing Li ),( Yong Jiang ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.7

        Android dominates the mobile operating system market, which stimulates the rapid spread of mobile malware. It is quite challenging to detect mobile malware. System call sequence analysis is widely used to identify malware. However, the malware detection accuracy of existing approaches is not satisfactory since they do not consider correlation of system calls in the sequence. In this paper, we propose a new scheme called Artificial Neural Networks (ANNs) on Co-occurrence Matrices Droid (ANNCMDroid), using co-occurrence matrices to mine correlation of system calls. Our key observation is that correlation of system calls is significantly different between malware and benign software, which can be accurately expressed by co-occurrence matrices, and ANNs can effectively identify anomaly in the co-occurrence matrices. Thus at first we calculate co-occurrence matrices from the system call sequences and then convert them into vectors. Finally, these vectors are fed into ANN to detect malware. We demonstrate the effectiveness of ANNCMDroid by real experiments. Experimental results show that only 4 applications among 594 evaluated benign applications are falsely detected as malware, and only 18 applications among 614 evaluated malicious applications are not detected. As a result, ANNCMDroid achieved an F-Score of 0.981878, which is much higher than other methods.

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