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Jang, Jae-Won,Lee, Jung-Kil,Hur, Hyuk,Seo, Bo-Ra,Lee, Jae-Hyun,Kim, Soo-Han Medknow Publications Pvt Ltd 2011 Surgical neurology international Vol.2 No.-
<P><B>Background:</B></P><P>Although the vertebral artery injuries (VAI) associated with cervical spine trauma are usually clinically occult, they may cause fatal ischemic damage to the brain stem and cerebellum.</P><P><B>Methods:</B></P><P>We performed a prospective study using computed tomographic angiography (CTA) to determine the frequency of VAI associated with cervical spine injuries and investigate the clinical and radiological characteristics. Between January 2005 and August 2007, 99 consecutive patients with cervical spine fractures and/or dislocations were prospectively evaluated for patency of the VA, using the CTA, at the time of injury.</P><P><B>Results:</B></P><P>Complete disruption of blood flow through the VA was demonstrated in seven patients with unilateral occlusion (7.1%). There were four men and three women with a mean age of 43 (range, 33-55 years). Unilateral occlusion of the right vertebral artery occurred in four patients and of the left in three. Regarding the cervical injury type, two cases were cervical burst fractures (C6 and C7), two had C4-5 fracture/dislocations, two had a unilateral transverse foraminal fracture, and one had dens type III fracture. All patients presented with good patency of the contralateral VA. None of the patients developed secondary neurological deterioration due to vertebrobasilar ischemia during the follow-up period with a mean duration of 23 months.</P><P><B>Conclusions:</B></P><P>VAI should be suspected in patients with cervical trauma that have cervical spine fractures and/or dislocations or transverse foramen fractures. CTA was useful as a rapid diagnostic method for ruling out VAI after cervical spine trauma.</P>
Performance Analysis of DS/CDMA DPSK System with PLL Gain
Jang, Moon-Kee,Kim, Joon-Bae,Kim, Won-Sub,Ju, Jong-Hyuk,Park, Jin-Soo 청주대학교 산업과학연구소 2003 産業科學硏究 Vol.20 No.2
이동통신채널에서 수신된 신호는 다중경로 페이딩에 의해 진폭과 위상에 영향을 받게 된다 따라서 본 논문에서는 송수신기 사이에서 발생된 위상차를 Tikhonov 확률밀도함수로 모델링하고 PLL 이득에 따른 DS/CDMA/ DPSK 시스템의 성능을 분석하였다. 그 결과, 본 논문에서 제안된 시스템에 PLL의 이득을 조정함으로써 위상이 완전 동기된 DPSK 시스템의 성능에 근접하게 됨을 알 수 있었다 컴퓨터 모의실험결과, 제안된 시스템에서 PLL 이득이 1dB인 경우 두 시스템간의 성능차는 4.8dB, PLL이득이 7dB인 경우 0.4dB로 근접하는 것을 알 수 있었으며 PLL 이득을 30dB 이상인 경우 제안된 시스템이 완전동기된 DPSK 시스템과 같은 성능을 나타냄을 알 수 있었다 A received signal in mobile communication environments exhibits variation in both amplitude and phase due to the multipath fading Therefore we analyzed the performance of DS/CDMA (Direct Sequence / Code Division Multiple Access) DPSK(Difference Phase Shift Keying) system for the variations of PLL(Phase Locked Loop) gain with Tikhonov probability density function, assuming that the phase difference between transmitter and receiver signals is phase error As a result, it is discovered that the performance of system could be improved by the control of PLL gain in compared w t h the DPSK system which does not consider the phase error If the PLL gain is 1dB, the difference of two systems is 48dB and 04dB at 7dB And if 30dB, it coincides From above, it also verified that the limit of gain is 30dB
Design of a Balloon-Shaped Superconducting Single Spoke Resonator
Hyuk Jin Cha,Junyoung Yoon,Si Won Jang,Kyung-Ryul Kim,Seong Hee Park,Eun-San Kim 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.2
We have investigated designs for a superconducting single spoke resonator with a resonant frequency of 325 MHz and an optimum beta of 0.51. In this paper, we suggest a balloon variant of a spoke cavity having an end-wall structure, which has a distinct advantage from the viewpoint of multipacting suppression. We determined the geometric parameters of the balloon-shaped single spoke resonator through electromagnetic, multipacting, and mechanical simulations. In addition, we discuss the resonant frequency shifts caused by the cavity processing, the power coupling, and the cavity tuning.
Jang, Kang Won,Lee, Kyung Hye,Kim, Soo Hyuk,Jin, Taewon,Choi, Eun Young,Jeon, Hyun Ju,Kim, Eunsuk,Han, Ye Sun,Chung, Ji Hyung Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.12
<P><B>Abstract</B></P><P>Transcriptional factor nuclear factor‐kappaB (NF‐κB) plays a crucial role in human breast cancer cell invasion and metastasis. The carboxyl terminus of Hsc70‐interacting protein (CHIP) is a U‐box‐type ubiquitin ligase that induces ubiquitination and proteasomal degradation of its substrate proteins. In this study, we investigated the role of CHIP in the NF‐κB pathway in the invasion of MDA‐MB‐231 cells, a highly aggressive breast cancer cell line. We showed that overexpression of CHIP significantly inhibits the invasion of the MDA‐MB‐231 cells. The overexpression of CHIP suppressed expression of urokinase plasminogen activator (uPA) and matrix metalloproteinase‐9 (MMP‐9) in MDA‐MB‐231 cells. Moreover, CHIP strongly inhibited the nuclear localization and the transcriptional activity of NF‐κB. The activation of the IkappaB kinase complex (IKK) was also blocked by CHIP overexpression. Importantly, CHIP overexpression resulted in a significant decrease in the level of TNF receptor‐associated factor 2 (TRAF2), an upstream key player in the NF‐κB pathway. However, the level of TRAF2 was restored after treatment with a proteasome inhibitor, MG‐132. Moreover, CHIP overexpression promoted the ubiquitination of TRAF2. We also found cell invasion significantly decreased in cells transfected with TRAF2 small interfering RNA (siRNA). In contrast, when CHIP expression was suppressed by siRNA in poorly invasive MCF‐7 cells, cell invasion significantly increased in conjunction with enhanced NF‐κB activation and TRAF2 levels. Taken together, these results suggest that CHIP regulates NF‐κB‐mediated cell invasion via the down‐regulation of TRAF2. J. Cell. Biochem. 112: 3612–3620, 2011. © 2011 Wiley Periodicals, Inc.</P>
( Won Gu Kim ),( Tae Yong Kim ),( Tae Hyuk Kim ),( Hye Won Jang ),( Young Suk Jo ),( Young Joo Park ),( Sun Wook Kim ),( Won Bae Kim ),( Min Ho Shong ),( Do Joon Park ),( Jae Hoon Chung ),( Young Kee 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.3
Background/Aims: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma(HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine-sufficient areas. In this study we evaluated the clinical behavior, prognosticfactors and treatment outcomes of FTC and HCC in Korea. Methods: This multicenter study included 483 patients with FTC and 80 patientswith HCC who underwent an initial surgery between 1995 and 2006 in one of thefour tertiary referral hospitals in Korea. We evaluated clinicopathological factorsassociated with distant metastases and recurrence during a median of 6 years offollow-up. Results: HCC patients were significantly older (49 years vs. 43 years; p < 0.001) andhad more lymphovascular invasions (22% vs. 14%; p = 0.03) compared with FTCpatients. Distant metastases were confirmed in 40 patients (8%) in the FTC groupand in two patients (3%) in the HCC group (p = 0.07). Distant metastases weresignificantly associated with older age, widely invasive cancer and extrathyroidalinvasion. Only 14 patients (3%) had recurrent disease and there was no significantdifference between FTC and HCC groups (p = 0.38). Recurrence was associatedwith larger tumor size and cervical lymph node metastasis. Conclusions: HCC patients were older and had more lymphovascular invasionsthan FTC patients. However, FTC and HCC patients had similar initial clinicopathologicalfeatures. Older age, wide invasiveness and extrathyroidal invasionwere independent risk factors for predicting distant metastases in FTC and HCCpatients.
Missing Cases in Diagnosis of HCC 2 cm or More Sizes
( Hyuk Jin Moon ),( Sae Hwan Lee ),( Hong Soo Kim ),( Sang Gyune Kim ),( Young Seok Kim ),( Boo Sung Kim ),( Soung Won Jeong ),( Jae Young Jang ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The aim of this study was to analysis the cause of missing cases in diagnosis HCC 2cm or more sizes in Soonchunhyang University College of Medicine Cheonan Hospital about 10 years. Methods: Between March 2006 and February 2014, 111 patients conducted HCC surveillance over 1 year among 726 patients diagnosed HCC by CT or MRI. We analysis retrospectively ultrasonographic finding of missing cases in diagnosis HCC 2cm or more sizes. We define “missing case” in the case of ultrasound performed two or more times within 1 year and diagnosis HCC 2cm or more sizes by CT or MRI after ultrasound. Results: The total missing rate was 23.4% (26/111) in HCC surveillance, respectively. Missing case was 4 patients in chronic hepatitis B group (12 cases) and 22 patients in liver cirrhosis group (92 cases) (33.3% vs. 23.9%, p=0.593). Missing case was 12 patients in surveillance by one operator group (71 cases) and 14 patients in surveillance by multi operator group (40 cases) (16.9% vs. 35%, p=0.094). The total missing rate was 36% (40/111) based on more than 1cm, 23% (26/111) based on more than 2cm, 10% (11/111) based on more than 3cm. Missing rate was 33.8% (24/71) based on more than 1cm, 16% (12/71) based on more than 2cm, 4.2% (3/71) based on more than 3cm in surveillance by one operator group. Missing rate was 40% (16/40) based on more than 1cm, 35% (14/40) based on more than 2cm, 20% (8/40) based on more than 3cm in surveillance by multi operator group. Conclusions: Ultrasonography is important test method to diagnosis and surveillance for HCC. But it affected by the ability of the operator, characteristics of HCC, size, location. To diagnosis small sized HCC, missing rate was lower in surveillance by one operator which know patient’s clinical findings and examination results. In surveillance by one operator, missing cases were “blind spot” (dome, S7,8), isoechoic lesion, diffuse and infiltrative lesion. But all cases were confirmed by repeated ultrasonography after diagnosis by CT or MRI.