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Prevalence and Clinical Characteristics of the Metabolic Syndrome in Middle-Aged Korean Adults
( Hyuk Sang Kwon ),( Yong Moon Park ),( Hye Jung Lee ),( Jin Hee Lee ),( Yoon Hee Choi ),( Seung Hyun Ko ),( Jung Min Lee ),( Sung Rae Kim ),( So Young Kang ),( Won Chul Lee ),( Myung Sook Ahn ),( Jae 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.4
Background : The aim of this study was to analyze the prevalence and clinical characteristic of the metabolic syndrome of adults, over 40 years old, living in Korea. Methods : This study was carried out for 2 years, 2003-2004, on total 5,330 individuals (2,197 men and 3,133 women) selected by the stratified random cluster sampling among adults over 40 years old. Metabolic syndrome was defined based on both the NCEP-ATP III criteria and Modified ATP III criteria applying the WHO-APR (Asian Pacific Region)`s abdominal obesity criteria (waist circumference > 90 cm in men, 80 cm in women) instead of NCEP-ATP III criteria. Results : Using NCEP-ATP III criteria, the age-adjusted overall prevalence of metabolic syndrome was 24.8% (17.6% in men, 30.0% in women). Age-adjusted overall prevalence of metabolic syndrome as defined by modified-ATP III criteria was 34.3% (26.3% in men, 40.1% in women). The prevalence of metabolic syndrome for each age group (40-49, 50-59, 60-69, ≥ 70) in men was as follows: 18.8%, 17.4%, 18.3%, 14.5%. In women: 22.3%, 32.7%, 39.9%, 39.3%. The prevalence of hypertriglyceridemia (triglycerides ≥ 1.7 mmol/l) was well correlated with the changing pattern of the prevalence of metabolic syndrome both in men and women. Conclusions : The peak age of metabolic syndrome in men was age 40 through 49, and the prevalence decreased with aging. Therefore, early intervention for risk factors of metabolic syndrome might be required in men. On the other hand, prevention for cardiovascular disease will be needed for perimenopausal women due to considerably increased prevalence in the age 50 through 59.
Choi, Sun Young,Lee, Yong Hee,Kim, Hyuk,Koh, Hyun-Ju,Park, Sun-Young,Park, Won-Seok,Bae, Il-Hong,Park, Kui Young,Kim, Beom Joon Informa Healthcare 2014 Journal of cosmetic and laser therapy Vol.16 No.1
<P><I>Background:</I> Within the last few years, hyaluronic acid (HA) fillers and radiofrequency (RF) devices have shown significant promise for skin rejuvenation. But the effects of HA only lasted for a relatively short duration. Therefore, we tried a new combination therapy of intradermal RF and HA filler. <I>Objective:</I> To evaluate the clinical efficacy of combination therapy of intradermal RF and HA filler for nasolabial fold (NLF) wrinkle reduction. <I>Materials and methods:</I> Ten Korean female volunteers with mild to severe NLFs were enrolled. In the control group, five subjects were treated with HA filler alone. In the experimental group, the other five subjects were treated with intradermal RF prior to HA filler. Efficacy was evaluated based on the change on the Wrinkle Severity Rating Scale (WSRS) and the Global Aesthetic Improvement Scale (GAIS) from baseline. <I>Results:</I> At 12 and 24 weeks after treatment, the experimental group showed significantly greater improvement in mean WSRS score compared to the control group. And two (40%) of the five patients in the experimental group achieved ‘very much improved’ and two (40%) showed ‘much improved’ at 12 weeks after treatment. <I>Conclusions:</I> Intradermal RF treatment prior to HA filler injection may provide synergistic and long-lasting effects for the reduction of NLF wrinkles.</P>
Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity<sup>†</sup>
Choi, Won Jun,Chung, Hwa-Jin,Chandra, Girish,Alexander, Varughese,Zhao, Long Xuan,Lee, Hyuk Woo,Nayak, Akshata,Majik, Mahesh S.,Kim, Hea Ok,Kim, Jin-Hee,Lee, Young B.,Ahn, Chang H.,Lee, Sang Kook,Jeon American Chemical Society 2012 Journal of medicinal chemistry Vol.55 No.9
<P>On the basis of the potent biological activity of cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from <SMALL>d</SMALL>-ribose. Among these, the cytosine derivative <B>5a</B> showed highly potent antigrowth effects in a broad range of tumor cell lines and very potent antitumor activity in a nude mouse tumor xenograft model implanted with A549 human lung cancer cells. However, its 2′-deoxycytidine derivative <B>5b</B> did not show any antigrowth effects, indicating that 2′-hydroxyl group is essential for the biological activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2012/jmcmar.2012.55.issue-9/jm3004009/production/images/medium/jm-2012-004009_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3004009'>ACS Electronic Supporting Info</A></P>
Choi, Hyuk,Lee, Heung‐,Man,Nam, Kyoung Won,Choi, Jaesoon,Lee, Jung‐,Joo,Kim, Ho Chul,Song, Seung Joon,Ahn, Chi Bum,Son, Ho Sung,Lim, Choon Hak,Son, Kuk Hui,Park, Yong Doo,Jeong, Gi Seok,Su Blackwell Publishing Inc 2011 Artificial Organs Vol.35 No.6
<P><B>Abstract</B></P><P>In 2002, the paracorporeal pulsatile electro‐mechanical pneumatic ventricular assist device (VAD) began to be developed by the Korea Artificial Organ Center at Korea University under a Health & Medical Technology Research and Development program which finished in 2008. In vitro durability testing was conducted on the paracorporeal pulsatile pneumatic VAD to determine device durability and to evaluate device failures. The 1‐ and 2‐year reliability of the paracorporeal pulsatile pneumatic VAD was shown to be 91.2% and 54.9%, respectively, with an 80% confidence level. Failure modes were analyzed using fault tree analysis, with customized software continuously acquiring data during the test period. After this period, 21 in vivo animal tests were done, with 14 cases of left atrium to left ventricle (LV) inflow cannulation (36Fr)/outflow grafting to descending aorta, and seven cases of apex cannulation of LV to descending aorta (12 mm). The longest postoperative day (182 days) in Korea was recently recorded in in vivo animal testing (bovine, 90 kg, male, 3.5–4.0 L/min flow rate, and 55 bpm).</P>
FIBRED RIEMANNIAN SPACE WITH ALMOST COMPLEX STRUCTURES
Choi, Jin-Hyuk,Kang, Il-Won,Kim, Byung-Hak,Shin, Yang-Mi Korean Mathematical Society 2009 대한수학회지 Vol.46 No.1
We study fibred Riemannian spaces with almost complex structures which are induced by the almost complex structure or the almost contact structure on the base and fibre. We show that if the total space is a complex space form, then the total space is locally Euclidean. Moreover, we deal with the fibred Riemannian space with various Kaehlerian structures.
Reduction of Off-State Currents in Silicon on Glass Thin Film Transistor by Off-State Bias Stress
Choi, Jae Won,Cheon, Jun Hyuk,Oh, Jae Hwan,Jang, Jin,Kim, Sung-Chul,Ahn, Ji-Su,Williams, C. A. Kosik,Couillard, J. G. The Electrochemical Society 2010 Electrochemical and solid-state letters Vol.13 No.7
Bio‐Inspired Complementary Photoconductor by Porphyrin‐Coated Silicon Nanowires
Choi, Sung‐,Jin,Lee, Young‐,Chul,Seol, Myeong‐,Lok,Ahn, Jae‐,Hyuk,Kim, Sungho,Moon, Dong‐,Il,Han, Jin‐,Woo,Mann, Stephen,Yang, Ji‐,Won,Choi, Yang‐,Kyu WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.34
<P><B>A symbiotically bio‐inspired complementary photoconductor</B> is demonstrated using a well‐defined silicon nanowire (SiNW) and porphyrins. The observed direction of the conductance change by light illumination has opposite signs for n‐ and p‐type SiNWs. On the basis of this observation, it is concluded that complementary photoconductors can be used to form functional logic gates of optical input with remarkably low static power dissipation.</P>
Korean Clinical Practice Guideline for the Diagnosis and Treatment of Insomnia in Adults
Choi Hayun,Youn Soyoung,Um Yoo Hyun,Kim Tae Won,Ju Gawon,Lee Hyuk Joo,Lee Chungsuk,Lee Sang Don,Bae Kyungyeol,Kim Seong Jae,Lee Ji Hyun,Kim Tae,Chung Seockhoon 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.11
Objective We aim to present a clinical guideline for the diagnosis and treatment of insomnia in adults by reviewing and integrating existing clinical guidelines. The purpose of this guideline is to assist clinicians who perform evidence-based insomnia treatment.Methods We selected literature that may be appropriate for use in guideline development from evidence-based practice guidelines that have been issued by an academic or governmental institution within the last five years. The core question of this guideline was made in sentence form including Patient/Problem, Intervention, Comparison, Outcome (PICO) elements. After searching PubMed, EMBASE, and medical guideline issuing agencies, three guidelines were judged to be the most appropriately reviewed, up-to-date, and from trusted sources.Results The Appraisal of Guidelines for Research and Evaluation (AGREE) II tool was used to evaluate the quality of the three clinical guidelines. The final outcome of the guideline development process is a total of 15 recommendations that report the strength of the recommendation, the quality of evidence, a summary of content, and considerations in applying the recommendation.Conclusion It is vital for clinical guidelines for insomnia to be developed and continually updated in order to provide more accurate evidence-based treatments to patients.