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류권열,안주원,문광석 釜慶大學校 1999 釜慶大學校 論文集 Vol.4 No.1
In this paper, an adaptive acoustic echo canceller based on the wavelet transform filter banks is proposed. The proposed algorithm improves the performance of AEC with a realtime process. The conjugate quadrature filter by Daubechies D4 wavelet is used for proposed wavelet subband filter banks. Adaptive filter coefficients of each subband are updated using LMS algorithm. Subband output signal vectors of adaptive filter are synthesized by synthesis filter banks. The output of adaptive filter is obtained a widband characteristics. As a result of computer simulation using the practical speech signal, the proposed method reduces noise level about l6dB.
우라늄 오염 금속표면의 제염을 위한 UO_2 용해특성 연구
이성열,최왕규,오원진,유승곤 한국공업화학회 2003 공업화학 Vol.14 No.3
국내의 가동 중지된 우라늄 변환시설의 해체 시 대량으로 발생될 탱크류 및 배관 등 공정 계통 부품으로 이루어진 금속 폐기물의 재팔용 또는 자체처분을 위한 현장 제염기술로 질산 제염공정을 선정하였다. 오염 물질로써 UO_2를 대상으로 UO_2 입자의 용해 거동을 통해 우라늄 화합물로 오염된 금속 폐기물에 대한 질산 용액의 표면제염 적용성을 평가하였고, 우라늄 변환시설 내에서 직접 인출한 UO_2 오염 시편의 제염 실증실험을 통해 제염 공정의 성능을 검증하였다. 질산 제염 용액에서 UO_2 입자의 용해속도는 질산의 농도 및 용액의 온도에 크게 의존하였으며, 산화제로 H_2O_2를 첨가함에 의해서 상온의 저 농도 질산 제염 용액 내에서도 H_2O_2가 첨가되지 않은 경우에 비해서 속도가 현저하게 증가되었다 UO_2로 오염된 시편의 제염에 있어서, H_2O_2가 첨가되지 않은 질산 용액 내에서의 제염계수는 α 방사능에 대해서는 1.8~2.7, β 방사능에 대해서는 1.8~2.3인 반면에 질산 용액에 H_2O_2를 첨가한 경우에는 α 방사능에 대해서 61.7~338.5, β 방사능에 대해서는 20.1~92.4를 나타냄으로써 H_2O_2를 첨가함에 의해서 상온, 저농도 질산 용액 내에서도 UO_2 오염된 금속표면을 효과적으로 제염할 수 있음을 확인하였다. In this study, a decontamination process using nitric acid was selected as an in-situ technology for recycle or disposal of large amount of metallic wastes, which includes process system components such as tanks, piping, etc that are generated as a result of dismantling retired uranium conversion facility in Korea. The applicability of nitric acid solution for surface decontamination of metallic wastes that are contaminated with uranium compounds was evaluated through dissolution of UO_2 powder. The decontamination decontamination performance are verified using UO_2 contaminated specimen that came from an uranium conversion facility. Dissolution rate of UO_2 powder was dependant considerably upon nitric acid concentration and solution temperature. Notable enhancement of dissolution rate was achieved by addition of H_2O_2 as an oxidant even in the condition of low concentration of nitric acid and low temperature. The results for decontamination of the specimen contaminated with UO_2 showed that the decontamination factors (DFs) for nitric acid solution without H_2O_2 were 1.8~2.7 and 1.8~2.3 for α and β-radioactivity. respectively, while DFs for nitric acid solution containing H_2O_2 were 61.7~338.5 and 20.1 ~92.4 for α and β-radioactivity, respectively. Thus, the metallic surfaces contaminated with UO_2 can be decontaminated effectively with low concentration of nitric acid at mom temperature in the presence of H_2O_2.
보험자료 빅데이터를 이용한 사시소아안과 영역에서의 연구
류원열(Won Yeol Ryu) 대한검안학회 2020 Annals of optometry and contact lens Vol.19 No.4
The exponential increasing data are generated from health care including the ophthalmology and the big data has been analyzing for being used in a variety of researches. The national health insurance covers all citizens in South Korea and claims that the data from the National Health Insurance Sharing Service (NHIS) could be useful for the research of big data. The NHIS is a data created from providing health care services that gives all of the information related to the diagnosis, treatment, cost, and personal information. Therefore, it is possible to embark on projects that was difficult to perform previously, such as researches about rare diseases targeted towards a large group of people, or the incidence and prevalence of a certain disorder, a prognosis of the treatment and complications of the epidemiological research, and its relationship with the potential risk. Even though there are some limitations of surgical and coding problems within the field of pediatric ophthalmology and strabismus, it will be possible to make it very useful. In addition, it would be able to apply it to other ophthalmological fields.
Association of the G134A and G184C Polymorphisms in the CYP1A1 Gene with Lung Cancer Incidence
Ryu, Doug-Young,Huang, Ming-Ai,Park, Chang-Bo,Chang, Soo-Im,Im, Ruth,Choi, Seong-Jin,Kim, Na-Young,Park, In-Won,Choi, Byoung-Whui,Kim, Jae-Yeol,Shin, Jong-Wook,Choi, Jae-Chul,Choi, Byung-Sun,Park, Jun Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol.25 No.3
The G184C and G134A single nucleotide polymorphisms(SNPs) of the CYP1A1 gene result in Ala62Pro and Gly45Asp substitutions, respectively. Here, we tested whether these SNPs are associated with an alteration in lung cancer incidence. We examined 80 Korean subjects with lung cancer and 240 age- and sex-matched controls. For each subject, the CYP1A1 gene was PCR amplified and sequenced. We observed that the odds ratio(OR) for lung cancer was 3.37 higher in subjects with the G184C polymorphism than in controls(95% confidence interval(CI), $0.89{\sim}12.73$, P=0.07). In contrast, the OR for lung cancer was 1.23 in subjects with the G134A polymorphism compared to controls(95% CI, $0.68{\sim}2.20$, P=0.49). The G184C polymorphism exacerbated the effects of smoking on lung cancer development. Gene-smoking interaction analyses revealed that past or present smokers with the G184C polymorphism had a higher incidence of lung cancer(OR, 24.72; 95% CI, $4.48{\sim}136.31$; P<0.01) than control smokers(OR, 6.65; 95% CI, $2.72{\sim}16.28$; P<0.01). However, there was only a slight difference in the ORs for lung cancer between control smokers and smokers with the G134A polymorphism. These findings suggest that the G184C polymorphism, but not the G134A polymorphism, is associated with an increased risk of lung cancer.
( Won-mook Choi ),( Jonggi Choi ),( Danbi Lee ),( Ju Hyun Shim ),( Young-suk Lim ),( Han Chu Lee ),( Young-hwa Chung ),( Young-sang Lee ),( Sook Ryun Park ),( Min-hee Ryu ),( Baek-yeol Ryoo ),( So Jun 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Regorafenib and nivolumab are drugs approved for second-line treatment of patients with hepatocellular carcinoma (HCC) after sorafenib failure. However, the effectiveness of regorafenib and nivolumab following sorafenib has not been directly compared. Methods: This study retrospectively evaluated 373 patients with HCC who were treated with regorafenib (n=223) or nivolumab (n=150) after sorafenib failure between July 2017 and February 2019. Results: Progression-free survival (PFS; hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.69-1.06; P=0.150), time to progression (TTP; HR, 0.95; 95% CI, 0.77-1.19; P=0.680), and overall survival (OS; HR, 0.83; 95% CI, 0.64-1.07; P=0.154) did not differ significantly between groups of patients treated with regorafenib and nivolumab, findings consistently observed by multivariable-adjusted, propensity score-matched, and inverse probability treatment weighting (IPTW) analyses. However, the objective response rate was significantly higher in the nivolumab than in the regorafenib group (13.3% vs, 4.0%; P=0.002). When the effectiveness of regorafenib and nivolumab was compared in non-progressors to treatment, defined as patients who achieved complete response, partial response, or stable disease after first response evaluation, PFS (HR, 0.50; 95% CI, 0.33-0.75; P=0.001), TTP (HR, 0.48; 95% CI, 0.31-0.73; P<0.001), and OS (HR, 0.51; 95% CI, 0.31-0.87; P=0.013) were significantly longer in the 59 non-progressors to nivolumab than in the 104 non-progressors to regorafenib, findings also observed by multivariable-adjusted and IPTW analyses. Conclusions: Survival outcomes in patients treated with regorafenib and nivolumab after sorafenib failure did not differ significantly. However, nivolumab may be more effective than regorafenib in non-progressors.
( Won-mook Choi ),( Jonggi Choi ),( Danbi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Young-suk Lim ),( Han Chu Lee ),( Changhoon Yoo ),( Sook Ryun Park ),( Min-hee Ryu ),( Baek-yeol Ryoo ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Nivolumab showed durable response and safety in patients with hepatocellular carcinoma (HCC) in the previous trials. However, real-world data of nivolumab in HCC patients, especially those with Child-Pugh class B, is lacking. We aimed to investigate the efficacy and safety of nivolumab in a real- world cohort of patients with advanced HCC. Methods: This study retrospectively evaluated 203 patients with HCC who were treated with nivolumab between July 2017 to February 2019. Radiologic evaluation was based on mRECIST. Survival outcomes were estimated by Kaplan-Meier method and Cox proportional hazard model. Logistic regression model was used to identify the predictive factors of treatment response. Results: Of 203 patients, 132 patients were within Child-Pugh class A and 71 patients were within Child-Pugh class B. Objective response rate was lower in patients with Child-Pugh class B than A (2.8% vs. 15.9%; P=0.010 by unweighted analysis and P=0.034 by weighted analysis) and Child-Pugh class was an independent predictor for objective response (Odds ratio, 0.21; 95% confidence interval; 0.05-0.93; P=0.040). Median overall survival was shorter in Child-Pugh B patients (11.3 vs. 42.9 weeks; P<0.001 by both unweighted and weighted analyses). However, other efficacy outcomes including disease control rate, time to progression, and progression-free survival were comparable between Child-Pugh A and B patients by unadjusted, adjusted, matched, and weighted analyses. There was no significant difference in terms of safety between Child-Pugh A and B patients. Conclusions: Given the limited treatment options for advanced HCC in Child-Pugh B patients, nivolumab may be a viable option despite lower response in these patients. Further studies are needed in this patient population.
Autonomic Neural Regulation of Sodium Transporters and Water Channels in Rat Submandibular Gland
Ryu, Sun-Yeol,Jung, Hyun,Kim, Ki-Yung,Kim, Mi-Won,Lee, Jong-Un The Korean Society of Pharmacology 2006 The Korean Journal of Physiology & Pharmacology Vol.10 No.2
The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of ${\alpha}1$ subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of ${\alpha}$-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.