Selenide-linked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme release for diabetic wound healing

Wenjing Li,Ying Bei,Xiangqiang Pan,Jian Zhu,Zhengbiao Zhang,Tinglin Zhang,Jieting Liu,Dan Wu,Meng Li,Yan Wu,Jie Gao 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Multifunctional hydrogels with controllable degradation and drug release have attracted extensive attention in diabetic wound healing. This study focused on the acceleration of diabetic wound healing with selenidelinked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme release. Methods Herein, selenium-containing hybrid hydrogels, defined as DSeP@PB, were fabricated via the reinforcement of selenol-end capping polyethylene glycol (PEG) hydrogels by polydopamine nanoparticles (PDANPs) and Prussian blue nanozymes in a one-pot approach in the absence of any other chemical additive or organic solvent based on diselenide and selenide bonding-guided crosslinking, making them accessible for large-scale mass production. Results Reinforcement by PDANPs greatly increases the mechanical properties of the hydrogels, realizing excellent injectability and flexible mechanical properties for DSeP@PB. Dynamic diselenide introduction endowed the hydrogels with on-demand degradation under reducing or oxidizing conditions and light-triggered nanozyme release. The bioactivity of Prussian blue nanozymes afforded the hydrogels with efficient antibacterial, ROS-scavenging and immunomodulatory effects, which protected cells from oxidative damage and reduced inflammation. Further animal studies indicated that DSeP@PB under red light irradiation showed the most efficient wound healing activity by stimulating angiogenesis and collagen deposition and inhibiting inflammation. Conclusion The combined merits of DSeP@PB (on-demand degradation, light-triggered release, flexible mechanical robustness, antibacterial, ROS-scavenging and immunomodulatory capacities) enable its high potential as a new hydrogel dressing that can be harnessed for safe and efficient therapeutics for diabetic wound healing.

Mechanical simulation for the bending process of the AMOLED panel pad

Wu Di,Jia Yongzhen,Liao Dunming,Zhang Bo,Liu Chen,Wang Ning,Peng Wenjing,Huang Liting 한국정보디스플레이학회 2023 Journal of information display Vol.24 No.2

Panel pad bending is a critical process to improve the screen-to-body ratio of an active-matrix organic light-emitting diode (AMOLED) panel. The failure analysis of the metal wirings is the key to ensure the reliability of signal transmission when the pad be bent to the back of the panel. In the present work, the sub-modeling technique combined with the periodic boundary condition was used to simulate the stress distribution of the bending area of the pad. The progressive failure of bent metal wirings was investigated by the extended finite element method. It is proved to be rational to prevent the wirings damage if the interlayer dielectric is replaced by an organic layer. In order to reduce stress of metal wirings, it is a measure to replace the original ultraviolet (UV) curable adhesive with a higher-modulus UV adhesive. The simulated results also show that rectangular perforations can avoid the stress concentration caused by the holes compared with circular perforations. For better stress distribution of metal wirings, it is necessary to increase the lengths of the rectangular holes and decrease the widths of that to a certain extent, which is helpful for restraining crack propagation by means of low-stress zones and holes.

Effects of mating on ovarian development and oviposition of Apolygus lucorum

Wenjing Li,Wei Yuan,Xincheng Zhao,Yunhe Li,Kongming Wu 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4

The polyphagous mirid bug Apolygus lucorum (Hemiptera: Miridae) is an important pest of cotton and other crops in China. It would be useful to examine the reproductive biology of A. lucorum for the development of management strategies. In this study, the effect of mating on ovarian development, egg maturation, and oviposition of A. lucorum was investigated. The results showed that mating could induce ovary development and oviposition. During the preoviposition period (< 7 days after emergence), mated females had more follicles than did virgin females at both the vitellogenic and mature stages. The length of the longest ovariole and extent of ovarian development in mated females were also significantly higher than in virgin females. During oviposition, mated females laid more eggs than virgin females, whereas virgin females had more mature follicles than the mated females did. Twenty days after emergence (an old age for this species), the ovaries of mated females had begun to shrink and enter senescence phases, while the ovaries of virgin females still contained 3–5 follicles in each ovariole and remained plump. The results indicate that mating accelerated ovarian development and reproduction of A. lucorum.

Development of EST-SSRs from the ark shell (Scapharca broughtonii) transcriptome and their application in genetic analysis of four populations

Wenjing Wang,Biao Wu,Zhihong Liu,Liqing Zhou,Xiujun Sun,Jiteng Tian,Aiguo Yang 한국유전학회 2021 Genes & Genomics Vol.43 No.6

Background The ark shell (Scapharca broughtonii) is one of the most economically important mollusks in the Bohai Sea and Yellow Sea of China. In recent years, ark shells from the Korean population were introduced to China for seed propagation and culture. Objective To explore the impact of the introduction of Korean ark shell on the genetic diversity of native population in China. Methods Simple sequence repeat (SSR) is efective and widely used tool for genetic analysis. In this study, 180 EST-SSRs were selected and verifed by polymerase chain reaction and polyacrylamide gel electrophoresis. Subsequently, fve polymorphic EST-SSRs were screened and their primers were modifed by fuorescein for use in the genetic analysis of four populations. Results Genetic analysis showed that 361 alleles amplifed by fve SSR loci were detected in the four populations. The number of alleles for the fve SSRs ranged from 8 to 30, with a mean of 18.05 (standard deviation, SD=6.492). The efective number of alleles varied from 2.253 to 22.222, with a mean of 10.596 (SD=4.713). Observed heterozygosity and expected heterozygosity were 0.167–0.833 and 0.566–0.971, with average values of 0.520 (SD=0.177) and 0.891 (SD =0.062), respectively. Polymorphic information content ranged from 0.521 to 0.953, with a mean of 0.865 (SD=0.070). The pairwise genetic diferentiation coefcient (FST) of the four populations ranged from 0.0267 to 0.0477, showing low genetic diferentiation. The phylogenetic tree constructed by neighbor-joining method showed that the genetic distance between the Chinese Dalian native population and three Korean populations was relatively more far than that among those Korean populations. Conclusion The results indicated that the genetic structure of the Dalian wild population was less afected by the introduced Korean wild populations.

Mangiferin loaded magnetic PCEC microspheres: preparation, characterization and antitumor activity studies in vitro

WenJing Xiao,Jun Hou,Jie Ma,BoTao Yu,JianDong Ren,WeiHua Jin,Juan Wu,DeZhi Zheng,KaiHua Fan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8

Mangiferin is a promising effective chemopreventiveagent against various tumors. However, itsclinical use is limited by poor water solubility and lowbioavailability. In this article, mangiferin loaded magneticPCEC microspheres (MG-MS) were designed, characterizedand the antitumor activity of MG-MS was evaluatedin vitro. The magnetic nanoparticles (MNP) were synthesizedvia the high-temperature reaction of ironacetylacetonate in phenyl ether in the presence of oleic acidand oleylamine. Poly (ε-caprolactone)-poly (ethyleneglycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC)copolymers were formed by ring-opening copolymerizationof ε-CL initiated by PEG-diol using Sn(Oct)2 as acatalyst and MG-MS were prepared by solvent diffusionmethod. MNP, PCEC copolymer, and MG-MS werecharacterized by GPC, TEM, XRD, FT-IR, 1H-NMP andMalvern Laser Particle Sizer. Meanwhile, the antiproliferativeactivity in vitro and in vitro release behavior of thismicrospheres were studied in detail. The results indicatethat the obtained magnetic microspheres might have greatpotential as an effective carrier for mangiferin used incancer chemotherapy.

Morphology and properties of poly(2-methoxy-5-(2'-ethyl-hexyloxy)-p-phenylenevinylene) (MEH-PPV): N,N'-bis(1-ethylpropyl)-3,4:9,10-perylene bis(tetracarboxyl diimide) (EP-PTC) based solar cells

Weicai Wu,Leijing Liu,Yinhua Zhou,Shanpeng Wen,Wenjing Tian 한국물리학회 2009 Current Applied Physics Vol.9 No.5

The influence of two components blend ratio, solution concentration and thermal annealing on the morphology of poly(2-methoxy-5-(2'-ethyl-hexyloxy)-p-phenylenevinylene) (MEH-PPV): N,N'-bis(1-ethylpropyl)-3,4:9,10-perylene bis(tetracarboxyl diimide) (EP-PTC) blend films spin-cast from chloroform solutions has been studied using atomic force microscopy (AFM). The AFM images show that the dimension of the phase separation increases with the EP-PTC content and total solution concentration. When the annealing temperature increases from 90 to 150 ℃, the EP-PTC crystal-like clusters grow rapidly. Solar cells based on MEH-PPV:EP-PTC blend films with different weight ratios were fabricated. The device with 1:3 weight ratio has a higher power conversion efficiency (PCE) of 0.072% compared with the devices with 1:1, 1:2 and 1:4 ratio, which increases by about 14 times over that of the device with 1:1 ratio that has a PCE of 0.005%. It is indicated that the optimum performance of the photovoltaic device is strongly related to the finer phase separation between MEH-PPV and EP-PTC on a submicron scale which enables an efficient dissociation of photogenerated excitons, and the pure EP-PTC phase can build up a percolating network with pathways large enough to enhance electron transport.

A temporal–spatiotemporal domain transformation-based modeling method for nonlinear distributed parameter systems

Jin Xi,Wu Daibiao,Yang Haidong,Zhu Chengjiu,Shen Wenjing,Xu Kangkang 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.3

Complex nonlinear distributed parameter systems (DPSs) exist widely in advanced industrial thermal processes. The modeling of such highly nonlinear systems is a challenge for traditional time/space-separation-based methods since they employ linear methods for the model reduction and spatiotemporal reconstruction, which may lead to an inefficient application of the nonlinear spatial structure features represented by the spatial basis functions. To overcome this problem, a novel spatiotemporal modeling framework composed of nonlinear temporal domain transformation and nonlinear spatiotemporal domain reconstruction is proposed in this paper. Firstly, local nonlinear dimension reduction based on the locally linear embedding technique is utilized to perform nonlinear temporal domain transformation of the spatiotemporal output of nonlinear DPSs. In this step, the original spatiotemporal data can be directly transformed into low-order time coefficients. Then, the extreme learning machine (ELM) method is utilized to establish a temporal model. Finally, through the spatiotemporal domain reconstruction based on the kernel-based ELM method, the prediction of the temporal dynamics obtained from the temporal model can be reconstructed back to the spatiotemporal output. The effectiveness and performance of the proposed method are demonstrated in experiments on the thermal processes of a snap curing oven and a lithium-ion battery.

Experimental investigations on detecting lateral buckling for subsea pipelines with distributed fiber optic sensors

Feng, Xin,Wu, Wenjing,Li, Xingyu,Zhang, Xiaowei,Zhou, Jing Techno-Press 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

A methodology based on distributed fiber optic sensors is proposed to detect the lateral buckling for subsea pipelines in this study. Uncontrolled buckling may lead to serious consequences for the structural integrity of a pipeline. A simple solution to this problem is to control the formation of lateral buckles among the pipeline. This firms the importance of monitoring the occurrence and evolution of pipeline buckling during the installation stage and long-term service cycle. This study reports the experimental investigations on a method for distributed detection of lateral buckling in subsea pipelines with Brillouin fiber optic sensor. The sensing scheme possesses the capability for monitoring the pipeline over the entire structure. The longitudinal strains are monitored by mounting the Brillouin optical time domain analysis (BOTDA) distributed sensors on the outer surface of the pipeline. Then the bending-induced strain is extracted to detect the occurrence and evolution of lateral buckling. Feasibility of the method was validated by using an experimental program on a small scale model pipe. The results demonstrate that the proposed approach is able to detect, in a distributed manner, the onset and progress of lateral buckling in pipelines. The methodology developed in this study provides a promising tool for assessing the structural integrity of subsea pipelines.

Experimental investigations on detecting lateral buckling for subsea pipelines with distributed fiber optic sensors

Jing Zhou,Xin Feng,Wenjing Wu,Xingyu Li,Xiaowei Zhang 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

A methodology based on distributed fiber optic sensors is proposed to detect the lateral buckling for subsea pipelines in this study. Uncontrolled buckling may lead to serious consequences for the structural integrity of a pipeline. A simple solution to this problem is to control the formation of lateral buckles among the pipeline. This firms the importance of monitoring the occurrence and evolution of pipeline buckling during the installation stage and long-term service cycle. This study reports the experimental investigations on a method for distributed detection of lateral buckling in subsea pipelines with Brillouin fiber optic sensor. The sensing scheme possesses the capability for monitoring the pipeline over the entire structure. The longitudinal strains are monitored by mounting the Brillouin optical time domain analysis (BOTDA) distributed sensors on the outer surface of the pipeline. Then the bending-induced strain is extracted to detect the occurrence and evolution of lateral buckling. Feasibility of the method was validated by using an experimental program on a small scale model pipe. The results demonstrate that the proposed approach is able to detect, in a distributed manner, the onset and progress of lateral buckling in pipelines. The methodology developed in this study provides a promising tool for assessing the structural integrity of subsea pipelines

Effect of novel intensification structure on drying of particulate materials in spouted beds

Shengning Zhao,Feng Wu,Xiao-Xun Ma,Wenjing Zhou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-

Through the hot air-drying experiment, the differences in drying rate, unit energy consumption, and bedpressure drop of the conventional spouted bed (CSB), the spouted bed with an integral swirling bladenozzle (ISBN), the spouted bed with spherical longitudinal vortex generators (LVGs), and the integralmulti-jet spout-fluidized bed (IMJSFB) were studied. The Weibull distribution function was introducedto fit the drying data, and the differences in moisture diffusion coefficient, scale parameters, and dryingactivation energy of the four types of spouted beds were further discussed. The drying performanceparameters of the four types of spouted beds were comprehensively evaluated. The results show that,compared with the CSB, LVGs and IMJSFB reduce the activation energy of the drying process, while theISBN increases the activation energy of the drying process. The IMJSFB shows more excellent performancein terms of drying rate, scale parameters, unit energy consumption, and bed pressure drop, with the highestcomprehensive score. Compared with CSB, ISBN and LVGs, the IMJSFB is more suitable for drying wetparticles. For the IMJSFB, there exists an optimal value of particle diameter (d = 2 mm) for the drying process,which makes the particle drying rate reach maximum.