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WenJing Xiao,Jun Hou,Jie Ma,BoTao Yu,JianDong Ren,WeiHua Jin,Juan Wu,DeZhi Zheng,KaiHua Fan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
Mangiferin is a promising effective chemopreventiveagent against various tumors. However, itsclinical use is limited by poor water solubility and lowbioavailability. In this article, mangiferin loaded magneticPCEC microspheres (MG-MS) were designed, characterizedand the antitumor activity of MG-MS was evaluatedin vitro. The magnetic nanoparticles (MNP) were synthesizedvia the high-temperature reaction of ironacetylacetonate in phenyl ether in the presence of oleic acidand oleylamine. Poly (ε-caprolactone)-poly (ethyleneglycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC)copolymers were formed by ring-opening copolymerizationof ε-CL initiated by PEG-diol using Sn(Oct)2 as acatalyst and MG-MS were prepared by solvent diffusionmethod. MNP, PCEC copolymer, and MG-MS werecharacterized by GPC, TEM, XRD, FT-IR, 1H-NMP andMalvern Laser Particle Sizer. Meanwhile, the antiproliferativeactivity in vitro and in vitro release behavior of thismicrospheres were studied in detail. The results indicatethat the obtained magnetic microspheres might have greatpotential as an effective carrier for mangiferin used incancer chemotherapy.
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Effect of novel intensification structure on drying of particulate materials in spouted beds
Shengning Zhao,Feng Wu,Xiao-Xun Ma,Wenjing Zhou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Through the hot air-drying experiment, the differences in drying rate, unit energy consumption, and bedpressure drop of the conventional spouted bed (CSB), the spouted bed with an integral swirling bladenozzle (ISBN), the spouted bed with spherical longitudinal vortex generators (LVGs), and the integralmulti-jet spout-fluidized bed (IMJSFB) were studied. The Weibull distribution function was introducedto fit the drying data, and the differences in moisture diffusion coefficient, scale parameters, and dryingactivation energy of the four types of spouted beds were further discussed. The drying performanceparameters of the four types of spouted beds were comprehensively evaluated. The results show that,compared with the CSB, LVGs and IMJSFB reduce the activation energy of the drying process, while theISBN increases the activation energy of the drying process. The IMJSFB shows more excellent performancein terms of drying rate, scale parameters, unit energy consumption, and bed pressure drop, with the highestcomprehensive score. Compared with CSB, ISBN and LVGs, the IMJSFB is more suitable for drying wetparticles. For the IMJSFB, there exists an optimal value of particle diameter (d = 2 mm) for the drying process,which makes the particle drying rate reach maximum.
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