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Recent progress on photodynamic therapy and photothermal therapy
김희정,YANG MENGYAO,권나현,조문연,HAN JINGJING,Wang Rui,Qi Sujie,Li Haidong,Nguyen Van‐Nghia,Li Xingshu,Cheng Hong‐Bo,윤주영 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.3
Noninvasive treatments for terminal cancer patients constitute a new trend in tumor treatment. Therefore, phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has attracted considerable interest. Light and a photosensitizer (PS) are employed in both treatment methods. For PDT, the PS generates reactive oxygen species (ROS) when exposed to light, whereas for PTT, the PS generates heat. In this regard, the systematic design of new PSs has become an active area of phototherapy research in an effort to solve the problems associated with conventional PSs. In the past decade, acti- vatable and heavy-atom-free PSs have become significant research areas. Therefore, we discuss our recent contributions to the PDT and PTT in this account.
Jin Xi,Wu Daibiao,Yang Haidong,Zhu Chengjiu,Shen Wenjing,Xu Kangkang 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.3
Complex nonlinear distributed parameter systems (DPSs) exist widely in advanced industrial thermal processes. The modeling of such highly nonlinear systems is a challenge for traditional time/space-separation-based methods since they employ linear methods for the model reduction and spatiotemporal reconstruction, which may lead to an inefficient application of the nonlinear spatial structure features represented by the spatial basis functions. To overcome this problem, a novel spatiotemporal modeling framework composed of nonlinear temporal domain transformation and nonlinear spatiotemporal domain reconstruction is proposed in this paper. Firstly, local nonlinear dimension reduction based on the locally linear embedding technique is utilized to perform nonlinear temporal domain transformation of the spatiotemporal output of nonlinear DPSs. In this step, the original spatiotemporal data can be directly transformed into low-order time coefficients. Then, the extreme learning machine (ELM) method is utilized to establish a temporal model. Finally, through the spatiotemporal domain reconstruction based on the kernel-based ELM method, the prediction of the temporal dynamics obtained from the temporal model can be reconstructed back to the spatiotemporal output. The effectiveness and performance of the proposed method are demonstrated in experiments on the thermal processes of a snap curing oven and a lithium-ion battery.
Effect of phosphorus deficiency on erythrocytic morphology and function in cows
Ziwei Zhang,Mingyu Bi,Jie Yang,Haidong Yao,Zhonghua Liu,Shiwen Xu 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.3
The aim of this study was to evaluate the influence of phosphorus (P) deficiency on the morphological and functional characteristics of erythrocytes in cows. Forty Holstein-Friesian dairy cows in mid-lactation were randomly divided into two groups of 20 each and were fed either a low-P diet (0.03% P/kg dry matter [DM]) or a control diet (0.36% P/kg DM). Red blood cell (RBC) indices results showed RBC and mean corpuscular hemoglobin decreased while mean corpuscular volume increased significantly (p < 0.05) in P-deficient cows. Erythrocyte morphology showed erythrocyte destruction in P-deficient cows. Erythrocytes’ functional characteristics results showed total bilirubin and indirect bilirubin concentrations and aspartate transaminase and alanine transaminase activity levels in the serum of P-deficient cows were significantly higher than those in control diet-fed cows. Activities of superoxide dismutase and glutathione peroxidase in erythrocytes were lower, while the malondialdehyde content was greater, in P-deficient cows than in control diet-fed cows. Na+/K+-ATPase and Mg2+-ATPase activities were lower in P-deficient cows than in control diet-fed cows; however, Ca2+-ATPase activity was not significantly different. The phospholipid composition of the erythrocyte membrane changed and membrane fluidity rigidified in P-deficient cows. The results indicate that P deficiency might impair erythrocyte integrity and functional characteristics in cows.
Bai, Rui,Sen, Aritro,Yu, Zhihui,Yang, Gang,Wang, Haidong,Fan, Ruiwen,Lv, Lihua,Lee, Kyung-Bon,Smith, George W,Dong, Changsheng Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.4
The objective of the present studies was to develop and validate a system for isolation, purification and extended culture of pigment-producing cells in alpaca skin (melanocytes) responsible for coat color and to determine the effect of alpha melanocyte stimulating hormone treatment on mRNA expression for the melanocortin 1 receptor, a key gene involved in coat color regulation in other species. Skin punch biopsies were harvested from the dorsal region of 1-3 yr old alpacas and three different enzyme digestion methods were evaluated for effects on yield of viable cells and attachment in vitro. Greatest cell yields and attachment were obtained following dispersion with dispase II relative to trypsin and trypsin-EDTA treatment. Culture of cells in medium supplemented with basic fibroblast growth factor, bovine pituitary extract, hydrocortisone, insulin, 12-O-tetradecanolphorbol-13-acetate and cholera toxin yielded highly pure populations of melanocytes by passage 3 as confirmed by detection of tyrosinase activity and immunocytochemical localization of melanocyte markers including tyrosinase, S-100 and micropthalmia-associated transcription factor. Abundance of mRNA for tyrosinase, a key enzyme in melanocyte pigment production, was maintained through 10 passages showing preservation of melanocyte phenotypic characteristics with extended culture. To determine hormonal responsiveness of cultured melanocytes and investigate regulation of melanocortin 1 receptor expression, cultured melanocytes were treated with increasing concentrations of ${\alpha}$-melanocyte stimulating hormone. Treatment with ${\alpha}$-melanocyte stimulating hormone increased melanocortin receptor 1 mRNA in a dose dependent fashion. The results demonstrated culture of pure populations of alpaca melanocytes to 10 passages and illustrate the potential utility of such cells for studies of intrinsic and extrinsic regulation of genes controlling pigmentation and coat color in fiber-producing species.
Ozone and Daily Mortality Rate in 21 Cities of East Asia: How Does Season Modify the Association?
Chen, Renjie,Cai, Jing,Meng, Xia,Kim, Ho,Honda, Yasushi,Guo, Yue Leon,Samoli, Evangelia,Yang, Xin,Kan, Haidong Oxford University Press 2014 American Journal of Epidemiology Vol.180 No.7
<P>Previous studies in East Asia have revealed that the short-term associations between tropospheric ozone and daily mortality rate were strongest in winter, which is opposite to the findings in North America and Western Europe. Therefore, we investigated the season-varying association between ozone and daily mortality rate in 21 cities of East Asia from 1979 to 2010. Time-series Poisson regression models were used to analyze the association between ozone and daily nonaccidental mortality rate in each city, testing for different temperature lags. The best-fitting model was obtained after adjustment for temperature in the previous 2 weeks. Bayesian hierarchical models were applied to pool the city-specific estimates. An interquartile-range increase of the moving average concentrations of same-day and previous-day ozone was associated with an increase of 1.44% (95% posterior interval (PI): 1.08%, 1.80%) in daily total mortality rate after adjustment for temperature in the previous 2 weeks. The corresponding increases were 0.62% (95% PI: 0.08%, 1.16%) in winter, 1.46% (95% PI: 0.89%, 2.03%) in spring, 1.60% (95% PI: 1.03%, 2.17%) in summer, and 1.12% (95% PI: 0.73%, 1.51%) in fall. We found significant associations between short-term exposure to ozone and higher mortality rate in East Asia that varied considerably from season to season with a significant trough in winter.</P>